BISPHOSPHONATE INDUCED OSTEONECROSIS OF THE JAWS AND CURRENT THERAPIES

Damla Torul; Mehmet Cihan Bereket

doi:10.7126/cumudj.345953

TR EN

Çenelerin Bisfosfonata Bağlı Osteonekrozu ve Güncel Tedaviler

Öz

Bifosfonatlar osteoklastik aktivitenin güçlü inhibitörü olan farmakolojik ajanlardır. Günümüzde osteolitik kemik hastalığı, malignite kaynaklı hiperkalsemi, metastatik kemik hastalıkları ve osteoporoz gibi birçok farklı kemik hastalığı veya ilişkili komplikasyonun tedavisinde kullanılmaktadırlar. Bifosfonatlar bu hastalıkların iskeletsel komplikasyonlarını önemli ölçüde azaltsa da özellikle yüksek kemik döngüsünün görüldüğü çene kemiklerinde tedaviye dirençli, ekspoze nekrotik kemik ile karakterize özgün bir osteonekroza neden olmaktadırlar. Bifosfonat kullanımına bağlı olarak gelişen bu komplikasyonun henüz kesin bir tedavisi bulunmamaktadır. Hastaların, bu durumun ekonomik ve sosyal yönleri nedeniyle mağdur olmasına sebep olan bu komplikasyonla mücadele etmek için yeni tedavi arayışları hala sürmektedir. Bu derlemede bifosfonatların kimyasal yapıları, etki mekanizmaları ve osteonekrozun güncel tanı /tedavi yöntemleri hakkında bilgi verilmesi amaçlanmıştır.

Anahtar Kelimeler

Bifosfonatlar,malign hastalıklar,komplikasyonlar,osteonekroz,tedavi seçenekleri

References

1. Gomez Font R, Martinez Garcia ML, Olmos Martinez JM. Osteochemonecrosis of the jaws due to bisphosphonate treatments. Update. Med Oral Patol Oral Cir Bucal 2008;13(5):E318-24.
2. Fleisch H. Development of bisphosphonates. Breast Cancer Res 2002;4(1):30-4.
3. Fleisch H, Russell RG, Bisaz S, Casey PA, Muhlbauer RC. The influence of pyrophosphate analogues (diphosphonates) on the precipitation and dissolution of calcium phosphate in vitro and in vivo. Calcif Tissue Res 1968:Suppl:10-10a.
4. Franchimont N, Canalis E. Management of glucocorticoid induced osteoporosis in premenopausal women with autoimmune disease. Autoimmun Rev 2003;2(4):224-8.
5. Kamoun-Goldrat A, Ginisty D, Merrer M. Effect of bisphosphonates on tooth eruption in children with osteogenesis imperfecta. Eur J Oral Sci 2008;116:195-8.
6. Katz H. Endodontic implications of bisphosphonate-associated osteonecrosis of the jaws: a report of three cases. J Endod 2005;31(11):831-4.
7. Rodan GA, Fleisch HA. Bisphosphonates: mechanisms of action. J Clin Invest 1996;97(12):2692-6.
8. Senel FC, Saracoglu Tekin U, Durmus A, Bagis B. Severe osteomyelitis of the mandible associated with the use of non-nitrogen-containing bisphosphonate (disodium clodronate): report of a case. J Oral Maxillofac Surg 2007;65(3):562-5.

9. Crepin S, Laroche ML, Sarry B, Merle L. Osteonecrosis of the jaw induced by clodronate, an alkylbiphosphonate: case report and literature review. Eur J Clin Pharmacol 2010;66(6):547-54.
10. Leite AF, Figueiredo PT, Melo NS, et al. Bisphosphonate-associated osteonecrosis of the jaws. Report of a case and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102(1):14-21.
11. Drake MT, Clarke BL, Khosla S. Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc 2008;83(9):1032-45.
12. van Beek ER, Cohen LH, Leroy IM, et al. Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates. Bone 2003;33(5):805-11.
13. Gutta R, Louis PJ. Bisphosphonates and osteonecrosis of the jaws: science and rationale. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104(2):186-93.
14. Otto S, Pautke C, Opelz C, et al. Osteonecrosis of the jaw: effect of bisphosphonate type, local concentration, and acidic milieu on the pathomechanism. J Oral Maxillofac Surg 2010;68(11):2837-45.
15. Hughes DE, Wright KR, Uy HL, et al. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 1995;10(10):1478-87.
16. Vitte C, Fleisch H, Guenther HL. Bisphosphonates induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption. Endocrinology 1996;137(6):2324-33.
17. Kimmel DB. Mechanism of action, pharmacokinetic and pharmacodynamic profile, and clinical applications of nitrogen-containing bisphosphonates. J Dent Res 2007;86(11):1022-33.
18. Mashiba T, Mori S, Burr DB, et al. The effects of suppressed bone remodeling by bisphosphonates on microdamage accumulation and degree of mineralization in the cortical bone of dog rib. J Bone Miner Metab 2005;23 Suppl:36-42.
19. Vincenzi B, Santini D, Dicuonzo G, et al. Zoledronic acid-related angiogenesis modifications and survival in advanced breast cancer patients. J Interferon Cytokine Res 2005;25(3):144-51.
20. Wood J, Bonjean K, Ruetz S, et al. Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther 2002;302(3):1055-61.
21. Grey A, Reid IR. Differences between the bisphosphonates for the prevention and treatment of osteoporosis. Ther Clin Risk Manag 2006;2(1):77-86.
22. Fraunfelder FW, Fraunfelder FT, Jensvold B. Scleritis and other ocular side effects associated with pamidronate disodium. Am J Ophthalmol 2003;135(2):219-22.
23. Marx RE, Cillo JE, Jr., Ulloa JJ. Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment. J Oral Maxillofac Surg 2007;65(12):2397-410.
24. Wysowski DK. Reports of esophageal cancer with oral bisphosphonate use. N Engl J Med 2009;360(1):89-90.
25. Cummings SR, Schwartz AV, Black DM. Alendronate and atrial fibrillation. N Engl J Med 2007;356(18):1895-6.
26. Halabe A, Lifschitz BM, Azuri J. Liver damage due to alendronate. N Engl J Med 2000;343(5):365-6.
27. Aghaloo TL, Kang B, Sung EC, et al. Periodontal disease and bisphosphonates induce osteonecrosis of the jaws in the rat. J Bone Miner Res 2011;26(8):1871-82.
28. Marx RE. Uncovering the cause of "phossy jaw" Circa 1858 to 1906: oral and maxillofacial surgery closed case files-case closed. J Oral Maxillofac Surg 2008;66(11):2356-63.
29. Somerman MJ, McCauley L. Bisphosphonates: sacrificing the jaw to save the skeleton? IBMS 2006;3:8-12.
30. Dixon RB. Bone turnoverin elderly canina mandible and tibia. j dent res 1997:76:336.
31. Lehrer S, Montazem A, Ramanathan L, et al. Bisphosphonate-induced osteonecrosis of the jaws, bone markers, and a hypothesized candidate gene. J Oral Maxillofac Surg 2009;67(1):159-61.
32. Tanvetyanon T, Stiff PJ. Management of the adverse effects associated with intravenous bisphosphonates. Ann Oncol 2006;17(6):897-907.
33. Hughes JP, Baron R, Buckland DH, et al. Phosphorus necrosis of the jaw: a present-day study. Br J Ind Med 1962;19:83-99.
34. Ruggiero SL, Dodson TB, Assael LA, et al. American association of oral and maxillofacial surgeons position paper on bisphosphonate- related osteonecrosis of the jaws-2009 update. J Oral Maxillofac Surg 2009; 67:2-12
35. Marx RE, Sawatari Y, Fortin M, Broumand V. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg 2005;63(11):1567-75.
36. Kim JW, Kong KA, Kim SJ, et al. Prospective biomarker evaluation in patients with osteonecrosis of the jaw who received bisphosphonates. Bone 2013;57(1):201-5.
37. Pasoff M. C-terminal cross-linking telopeptide as a serologic marker for bisphosphonate-related osteonecrosis of the jaw: review of 2 cases. J Can Dent Assoc 2013;79:d51.
38. Ficarra G, Beninati F. Bisphosphonate-related osteonecrosis of the jaws: an update on clinical, pathological and management aspects. Head Neck Pathol 2007;1(2):132-40.
39. Montebugnoli L, Felicetti L, Gissi DB, et al. Biphosphonate-associated osteonecrosis can be controlled by nonsurgical management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104(4):473-7.
40. Phal PM, Myall RW, Assael LA, Weissman JL. Imaging findings of bisphosphonate-associated osteonecrosis of the jaws. AJNR Am J Neuroradiol 2007;28(6):1139-45.
41. Bedogni A, Blandamura S, Lokmic Z, et al. Bisphosphonate-associated jawbone osteonecrosis: a correlation between imaging techniques and histopathology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105(3):358-64.
42. Bisdas S, Chambron Pinho N, Smolarz A, et al. Bisphosphonate-induced osteonecrosis in the jaws: CT and MRI spectrum of findings in 32 patients. . Clin radiol 2008; 63:71-7.
43. Chiandussi S, Biasotto M, Dore F, et al. Clinical and diagnostic imaging of bisphosphonate-associated osteonecrosis of the jaws. Dentomaxillofac Radiol 2006;35(4):236-43.
44. Stockmann P, Hinkmann FM, Lell MM, et al. Panoramic radiograph, computed tomography or magnetic resonance imaging. Which imaging technique should be preferred in bisphosphonate-associated osteonecrosis of the jaw? A prospective clinical study. Clin Oral Investig 2010;14(3):311-7.
45. Dore F, Filippi L, Biasotto M, et al. Bone scintigraphy and SPECT/CT of bisphosphonate-induced osteonecrosis of the jaw. J Nucl Med 2009;50(1):30-5.
46. Treister N, Sheehy N, Bae EH, et al. Dental panoramic radiographic evaluation in bisphosphonate-associated osteonecrosis of the jaws. Oral Dis 2009;15(1):88-92.
47. Bianchi SD, Scoletta M, Cassione FB, Migliaretti G, Mozzati M. Computerized tomographic findings in bisphosphonate-associated osteonecrosis of the jaw in patients with cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104(2):249-58.
48. Krishnan A, Arslanoglu A, Yildirm N, Silbergleit R, Aygun N. Imaging findings of bisphosphonate-related osteonecrosis of the jaw with emphasis on early magnetic resonance imaging findings. J Comput Assist Tomogr 2009;33(2):298-304.
49. Marx RE. Oral and Intravenous Bisphosphonates-Induced Osteonecrosis of the Jaws: History, etiology, prevention and treatment. Hanover Park: Quintessence Books. 2006.
50. Adapted from advisory task force on bisphosphonate-related osteonecrosis of jaws, American Association of Oral and Maxillofacial Surgerons. American Association of Oral and Maxillofacial Surgerons position paper on bisphosphonate related osteonecrosis of the jaws. J Oral Maxillofac Surg 2007;65:369-76.
51. Carlson ER, Basile JD. The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 2009;67:85-95.
52. Kademani D, Koka S, Lacy MQ, Rajkumar SV. Primary surgical therapy for osteonecrosis of the jaw secondary to bisphosphonate therapy. Mayo Clin Proc 2006;81(8):1100-3.
53. Adornato MC, Morcos I, Rozanski J. The treatment of bisphosphonate-associated osteonecrosis of the jaws with bone resection and autologous platelet-derived growth factors. J Am Dent Assoc 2007;138(7):971-7.
54. Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004;62(4):489-96.
55. Stubinger S, Dissmann JP, Pinho NC, et al. A preliminary report about treatment of bisphosphonate related osteonecrosis of the jaw with Er:YAG laser ablation. Lasers Surg Med 2009;41(1):26-30.
56. Agrillo A, Petrucci MT, Tedaldi M, et al. New therapeutic protocol in the treatment of avascular necrosis of the jaws. J Craniofac Surg 2006;17(6):1080-3.
57. Niinikoski JH. Clinical hyperbaric oxygen therapy, wound perfusion, and transcutaneous oximetry. World J Surg 2004;28(3):307-11.
58. Odvina CV, Zerwekh JE, Rao DS, et al. Severely suppressed bone turnover: a potential complication of alendronate therapy. J Clin Endocrinol Metab 2005;90(3):1294-301.
59. Rupel K, Ottaviani G, Gobbo M, et al. A systematic review of therapeutical approaches in bisphosphonates-related osteonecrosis of the jaw (BRONJ). Oral Oncol 2014;50(11):1049-57.
60. Martins MA, Martins MD, Lascala CA, et al. Association of laser phototherapy with PRP improves healing of bisphosphonate-related osteonecrosis of the jaws in cancer patients: a preliminary study. Oral Oncol 2012;48(1):79-84.
61. Atalay B, Yalcin S, Emes Y, et al. Bisphosphonate-related osteonecrosis: laser-assisted surgical treatment or conventional surgery? Lasers Med Sci 2011;26(6):815-23.
62. Chiu CT, Chiang WF, Chuang CY, Chang SW. Resolution of oral bisphosphonate and steroid-related osteonecrosis of the jaw--a serial case analysis. J Oral Maxillofac Surg 2010;68(5):1055-63.
63. Graziani F, Vescovi P, Campisi G, et al. Resective surgical approach shows a high performance in the management of advanced cases of bisphosphonate-related osteonecrosis of the jaws: a retrospective survey of 347 cases. J Oral Maxillofac Surg 2012;70(11):2501-7.
64. Kim JW, Kim SJ, Kim MR. Leucocyte-rich and platelet-rich fibrin for the treatment of bisphosphonate-related osteonecrosis of the jaw: a prospective feasibility study. Br J Oral Maxillofac Surg 2014;52(9):854-9.
65. Longo F, Guida A, Aversa C, et al. Platelet rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw: personal experience and review of the literature. Int J Dent 2014;2014:298945.
66. Altay MA, Tasar F, Tosun E, Kan B. Low-level laser therapy supported surgical treatment of bisphosphonate related osteonecrosis of jaws: a retrospective analysis of 11 cases. Photomed Laser Surg 2014;32(8):468-75.
67. Blus C, Szmukler-Moncler S, Giannelli G, Denotti G, Orru G. Use of Ultrasonic Bone Surgery (Piezosurgery) to Surgically Treat Bisphosphonate-Related Osteonecrosis of the Jaws (BRONJ). A Case Series Report with at Least 1 Year of Follow-Up. Open Dent J 2013;7:94-101.
68. Jabbour Z, El-Hakim M, Mesbah-Ardakani P, Henderson JE, Albuquerque R, Jr. The outcomes of conservative and surgical treatment of stage 2 bisphosphonate-related osteonecrosis of the jaws: a case series. Int J Oral Maxillofac Surg 2012;41(11):1404-9.
69. Kim KM, Park W, Oh SY, et al. Distinctive role of 6-month teriparatide treatment on intractable bisphosphonate-related osteonecrosis of the jaw. Osteoporos Int 2014;25(5):1625-32.
70. Pautke C, Bauer F, Otto S, et al. Fluorescence-guided bone resection in bisphosphonate-related osteonecrosis of the jaws: first clinical results of a prospective pilot study. J Oral Maxillofac Surg 2011;69(1):84-91.
71. Rugani P, Acham S, Truschnegg A, Obermayer-Pietsch B, Jakse N. Bisphosphonate -associated osteonecrosis of the jaws: surgical treatment with ErCrYSGG-laser. Case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110(6):e1-6.
72. Spinelli G, Torresetti M, Lazzeri D, et al. Microsurgical reconstruction after bisphosphonate- related osteonecrosis of the jaw: our experience with fibula free flap. J Craniofac Surg 2014;25(3):788-92.
73. Anitua E, Begona L, Orive G. Treatment of hemimandibular paresthesia in a patient with bisphosphonate-related osteonecrosis of the jaw (BRONJ) by combining surgical resection and PRGF-Endoret. Br J Oral Maxillofac Surg 2013;51(8):e272-4.
74. Bodem JP, Schaal C, Kargus S, et al. Surgical management of bisphosphonate-related osteonecrosis of the jaw stages II and III. Oral Surg Oral Med Oral Pathol Oral Radiol 2016;121(4):367-72.
75. Gallego L, Junquera L, Pelaz A, Hernando J, Megias J. The use of pedicled buccal fat pad combined with sequestrectomy in bisphosphonate-related osteonecrosis of the maxilla. Med Oral Patol Oral Cir Bucal 2012;17(2):e236-41.
76. Porcaro G, Amosso E, Scarpella R, Carini F. Doxycycline fluorescence-guided Er:YAG laser ablation combined with Nd:YAG/diode laser biostimulation for treating bisphosphonate -related osteonecrosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol 2015;119(1):e6-e12.

Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Review

Authors

Damla Torul

Mehmet Cihan Bereket

Publication Date

August 31, 2017

Submission Date

June 1, 2016

Acceptance Date

June 6, 2016

Published in Issue

Year 2017 Volume: 20 Number: 2

DOI

https://doi.org/10.7126/cumudj.345953

IZ

https://izlik.org/JA76CW83UC

Cite

RIS / Bibtex

EndNote

Torul D, Bereket MC (August 1, 2017) BISPHOSPHONATE INDUCED OSTEONECROSIS OF THE JAWS AND CURRENT THERAPIES. Cumhuriyet Dental Journal 20 2 122–131.

BISPHOSPHONATE INDUCED OSTEONECROSIS OF THE JAWS AND CURRENT THERAPIES

Çenelerin Bisfosfonata Bağlı Osteonekrozu ve Güncel Tedaviler

Öz

Anahtar Kelimeler