Biomimetic Implant Surface Functionalization with Concentrated Platelet-Rich Fibrin

Aparna Ayyalasomayajula; Muthukumar Santhanakrishnan; Sri Vidhya Marimuthu; Ravindranath Dhulipalla; Ramanarayana Boyapati

doi:10.7126/cumudj.1614883

EN

Biomimetic Implant Surface Functionalization with Concentrated Platelet-Rich Fibrin

Abstract

Objective: With high long-term survival and success rates, implant-supported oral rehabilitation has progressively expanded the treatment options available to edentulous patients. However, osseointegration may be impacted by certain medical conditions. In order to enhance osseointegration and encourage fibrin adherence, surfaces with particular micro- and nanotopographies and biomimetic properties have been developed. Recently, there has been interest in a potential strategy that involves using the patient's autologous blood to functionalise the implant surface just prior to placement. The objective of this in vitro study is to analyse the physiochemical characterization of three commercially available dental implant surfaces and evaluate the interaction between the implant surface and C-PRF Materials and Methods: Three commercially available implants with different macro-morphology and surface treatments - Straumann® BLX Roxolid®, Zimmer® Trabecular MetalTM, and Laser-Lok® were analysed for physiochemical characterization and biofunctionalization using C-PRF Field emission scanning electron microscope (FESEM) Results: All the surfaces appeared visibly rough to varying degrees under FESEM with EDS. The topographies were qualitatively different for all three implant systems- Straumann® BLX Roxolid®, Zimmer® Trabecular MetalTM, and Laser-Lok® that were analysed, and showed different elemental compositions. Every dental implant immersed in C-PRF had a fibrin mesh covering it. Nonetheless, distinct noncontact regions were noted, and the fibrin orientation varied across all implant surfaces. Conclusions: There are notable differences in the initial interaction between the fibrin network and various implant surfaces. The therapeutic significance of these findings in the osseointegration process of dental implants requires further investigation.

Keywords

Supporting Institution

Sri Ramachandra Institute of Higher Education and Research, Chennai

Ethical Statement

Ethical clearance was obtained from Institutional Ethics Committee, Sri Ramachandra Institute of Higher Education and Research, Chennai Ref: CSP/21/NOV/102/588.

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Details

Primary Language

English

Subjects

Periodontics

Journal Section

Research Article

Authors

Aparna Ayyalasomayajula
0000-0002-3483-114X
India

Muthukumar Santhanakrishnan ^*
0000-0001-9688-1516
India

Sri Vidhya Marimuthu
0009-0001-5071-8358
India

Ravindranath Dhulipalla
0000-0003-4103-455X
India

Ramanarayana Boyapati
0000-0002-9196-0183
India

Publication Date

June 30, 2025

Submission Date

January 7, 2025

Acceptance Date

April 9, 2025

Published in Issue

Year 2025 Volume: 28 Number: 2

DOI

https://doi.org/10.7126/cumudj.1614883

IZ

https://izlik.org/JA45NP85KB

Cite

RIS / Bibtex

EndNote

Ayyalasomayajula A, Santhanakrishnan M, Marimuthu SV, Dhulipalla R, Boyapati R (June 1, 2025) Biomimetic Implant Surface Functionalization with Concentrated Platelet-Rich Fibrin. Cumhuriyet Dental Journal 28 2 174–186.

Öz

Biomimetic Implant Surface Functionalization with Concentrated Platelet-Rich Fibrin

Abstract

Keywords

Supporting Institution

Ethical Statement

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite