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Evaluation of prevalence and dimension of Pineal Gland Calcification by cone-beam computed tomography (CBCT)

Yıl 2022, Cilt 25, Sayı 3, 258 - 262, 01.10.2022
https://doi.org/10.7126/cumudj.1111722

Öz

Abstract Objective: This study aimed to investigate the prevalence and dimensions of pineal gland calcification using cone-beam computed tomography (CBCT) in patients undergoing dental treatment. Materials and Methods: CBCTs that localized pineal gland in the fov range was selected in this retrospective study. The presence of pineal gland calcification (PGC) was noted. Vertical, horizontal and areal measurements were made by a single observer (M.S). Variables such as age, gender for each patient were recorded using previous clinical examination data. Results: The prevalence of pineal gland calcification was 33.64% (female to male ratio 3:2). The difference between males and females was not significant (p>0.05). PGC was highly seen in older patients when compared with younger patients (p:000). The average vertical and horizontal dimension of PGC was 2,56±0,98mm and 3,39±1,29 mm respectively. The average total calcified area was 5,45±3,75 mm2. Conclusion: This study did not find any correlation between age, gender, and linear measurements. However, the average calcified are in men was found to be significantly higher than in women.

Kaynakça

  • 1. Reiter RJ. The Mammalian Pineal Gland: Structure and function. Am J Anat. 1981; 162(4):287-313.
  • 2. Kappers AJ: The mammalian pineal gland, a survey. Acta neurochir, 1976; 34(1-4): 109-149.
  • 3. Palaoğlu S, Beşkonaklı, E. Pineal bez ve yaşlanma. Turkish Journal of Geriatrics,1998; 1(1):13-18.
  • 4. Pandi-Perumal SR, Srinivasan V, Maestroni GJM, Cardinali DP, Poeggeler B, Hardeland R. Melatonin: nature's most versatile biological signal? The FEBS journal. 2006;273(13): 2813-38.
  • 5. Reiter RJ. Melatonin: clinical relevance. Best practice & research clinical endocrinology & metabolism.2003; 17(2): 273-85, 2003.
  • 6. Scharenberger K, and liss,L. the histological structure of the human pineal body. progress in brain research. 1965; 10: 193-217.
  • 7. A. Schüller, Roentgen Diagnosis of Diseases of the Head, C.V. MosbyComp., St. Louis, 1918, p. 156.
  • 8. TurgutA, Karakaş HM, Özsunar Y, Altın L, Çeken K, Alıcıoğlu B, et.al. Age-related changes in the incidence of pineal gland calcification in Turkey: A prospective multicenter CT study. Pathophysiology.2008; 15(1): 41-48.
  • 9. Wurtman RJ, Axelrod J, Barchas JD. Age and enzyme activity in human pineal, J. Clin. Endocrinol. Metab.1964;24: 299– 301.
  • 10. Haghighi MH, Rezaei V, Zarrintan S, Pourfathi H. Intracranial physiological calcifications in adults on computed tomography in Tabriz, Iran. Folia Morphol 2007; 66: 115–119.
  • 11. Whitehead MT, Oh C, Raju A, Choudhri AF. Physiologic pineal region, choroid plexus, and dural calcifications in the first decade of life. AJNR Am J Neuroradiol 2015; 36: 575-80.
  • 12. Doyle AJ, Anderson GD. Physiologic calcification of the pineal gland in children on computed tomography: prevalence, observer reliability and association with choroid plexus calcification. Acad Radiol 2006; 13: 822-6.
  • 13. Mutalik S,Tadinada A. Prevalence of pineal gland calcification as an incidental finding in patients referred for implant dental therapy. Imaging science in dentistry. 2017; 47(3): 175-180.
  • 14. Tharnpanich, T, Johns J, Subongkot S, Johns NP, Kitkhuandee A, Toomsan Y, Luengpailinc S.Association between high pineal fluoride content and pineal calcification in a low fluoride area. Fluoride. 2016;49(4): 472-484.
  • 15. Kitkhuandee A, Sawanyawisuth K, Johns NP, Kanpittaya J, Johns J. Pineal calcification is associated with symptomatic cerebral infarction. J Stroke Cerebrovasc Dis 2014; 23: 249-53.
  • 16. Mahlberg R, Walther S, Kalus P, Bohner G, Handel S, Reischies FM, et al. Pineal calcification in Alzheimer’s disease: an in vivo study using computed tomography. Neurobiol Aging 2008; 29: 203-9.
  • 17. Yalcin A, Ceylan M, Bayraktutan O F, Sonkaya A R, Yuce I. Age and gender related prevalence of intracranial calcifications in CT imaging; data from 12,000 healthy subjects. Journal of chemical neuroanatomy.2016;78: 20-24.
  • 18. E. Y. Choi, J. Y. Jin, J. Y. Lee, J. I. Choi, I. S. Choi, and S. J. Kim, “Melatonin inhibits Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-κB and STAT1 activity,” Journal of Pineal Research.2011;50(2): 197-206.
  • 19. C. Mechin and C. Toury, “Action of cariogenic diet on fixation and retention of skeleton and teeth strontium in rats,” Revue Odonto Stomatologique.1973; 20(1): 55–59.
  • 20. Hossain MF, Uddin MS, Uddin GMS, Sumsuzzman DM, Islam MS, Barreto GE, Mathew B, Ashraf GM. Melatonin in Alzheimer's Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer's Neuropathology. Mol Neurobiol. 2019;56(12):8255-8276.
  • 21. Kay SR, Sandyk R. Experimental models of schizophrenia. Int. J. Neurosci. 1991;58: 69-82.
  • 22. Sedghizadeh PP, Nguyen M, Enciso R. Intracranial physiological calcifications evaluated with cone beam CT. Dentomaxillofac Radiol. 2012; 41: 675-8.
  • 23. Abbassioun K, Aarabi B, Zarabi M. A comparative study of physiologic intracranial calcifications. Pahlavi Med J. 1978; 9: 152–166.
  • 24. Mohammed KA, Boakye EA, Ismail HA, Geneus CJ, Tobo BB, Buchanan PM, Zelicoff AP. Pineal gland calcification in Kurdistan: a cross-sectional study of 480 roentgenograms. PloS one. 2016;11(7): e0159239
  • 25. Barghan S, Tahmasbi Arashlow M, Nair MK. Incidental findings on cone-beam computed tomography studies outside of the maxillofacial skeleton. Int J Dent. 2016; 2016: 9196503.
  • 26. Pette GA, Norkin FJ, Ganeles J, Hardigan P, Lask E, Zfaz S, et al. “Incidental findings from a retrospective study of 318 cone-beam computed tomography consultation reports.,” The International Journal ofOral& Maxillofacial Implants. 2 012; 27(3): 595-603.
  • 27. Admassie D, Mekonnen A. “Incidence of normal pineal and choroid plexus calcification on brain CT (computerized tomography) at Tikur Anbessa TeachingHospital Addis Ababa, Ethiopia,” Ethiopian Medical Journal. 2009; 47(1): 55-60.
  • 28. Deepak S, Jayakumar B, Shanavas. “Extensive intracranial calcification,” Journal of Association of Physicians of India.2005; 53: 948.
  • 29. Grech, R, Grech S, Mizzi A. Intracranial Calcifications: A Pictorial Review. The neuroradiology journal. 2012; 25(4): 427-451.
  • 30. Mechin JA, Toury C. “Action of melatonin on caries development in rats,” Journal of Dental Research.1976; 55(3): 555.

Yıl 2022, Cilt 25, Sayı 3, 258 - 262, 01.10.2022
https://doi.org/10.7126/cumudj.1111722

Öz

Kaynakça

  • 1. Reiter RJ. The Mammalian Pineal Gland: Structure and function. Am J Anat. 1981; 162(4):287-313.
  • 2. Kappers AJ: The mammalian pineal gland, a survey. Acta neurochir, 1976; 34(1-4): 109-149.
  • 3. Palaoğlu S, Beşkonaklı, E. Pineal bez ve yaşlanma. Turkish Journal of Geriatrics,1998; 1(1):13-18.
  • 4. Pandi-Perumal SR, Srinivasan V, Maestroni GJM, Cardinali DP, Poeggeler B, Hardeland R. Melatonin: nature's most versatile biological signal? The FEBS journal. 2006;273(13): 2813-38.
  • 5. Reiter RJ. Melatonin: clinical relevance. Best practice & research clinical endocrinology & metabolism.2003; 17(2): 273-85, 2003.
  • 6. Scharenberger K, and liss,L. the histological structure of the human pineal body. progress in brain research. 1965; 10: 193-217.
  • 7. A. Schüller, Roentgen Diagnosis of Diseases of the Head, C.V. MosbyComp., St. Louis, 1918, p. 156.
  • 8. TurgutA, Karakaş HM, Özsunar Y, Altın L, Çeken K, Alıcıoğlu B, et.al. Age-related changes in the incidence of pineal gland calcification in Turkey: A prospective multicenter CT study. Pathophysiology.2008; 15(1): 41-48.
  • 9. Wurtman RJ, Axelrod J, Barchas JD. Age and enzyme activity in human pineal, J. Clin. Endocrinol. Metab.1964;24: 299– 301.
  • 10. Haghighi MH, Rezaei V, Zarrintan S, Pourfathi H. Intracranial physiological calcifications in adults on computed tomography in Tabriz, Iran. Folia Morphol 2007; 66: 115–119.
  • 11. Whitehead MT, Oh C, Raju A, Choudhri AF. Physiologic pineal region, choroid plexus, and dural calcifications in the first decade of life. AJNR Am J Neuroradiol 2015; 36: 575-80.
  • 12. Doyle AJ, Anderson GD. Physiologic calcification of the pineal gland in children on computed tomography: prevalence, observer reliability and association with choroid plexus calcification. Acad Radiol 2006; 13: 822-6.
  • 13. Mutalik S,Tadinada A. Prevalence of pineal gland calcification as an incidental finding in patients referred for implant dental therapy. Imaging science in dentistry. 2017; 47(3): 175-180.
  • 14. Tharnpanich, T, Johns J, Subongkot S, Johns NP, Kitkhuandee A, Toomsan Y, Luengpailinc S.Association between high pineal fluoride content and pineal calcification in a low fluoride area. Fluoride. 2016;49(4): 472-484.
  • 15. Kitkhuandee A, Sawanyawisuth K, Johns NP, Kanpittaya J, Johns J. Pineal calcification is associated with symptomatic cerebral infarction. J Stroke Cerebrovasc Dis 2014; 23: 249-53.
  • 16. Mahlberg R, Walther S, Kalus P, Bohner G, Handel S, Reischies FM, et al. Pineal calcification in Alzheimer’s disease: an in vivo study using computed tomography. Neurobiol Aging 2008; 29: 203-9.
  • 17. Yalcin A, Ceylan M, Bayraktutan O F, Sonkaya A R, Yuce I. Age and gender related prevalence of intracranial calcifications in CT imaging; data from 12,000 healthy subjects. Journal of chemical neuroanatomy.2016;78: 20-24.
  • 18. E. Y. Choi, J. Y. Jin, J. Y. Lee, J. I. Choi, I. S. Choi, and S. J. Kim, “Melatonin inhibits Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-κB and STAT1 activity,” Journal of Pineal Research.2011;50(2): 197-206.
  • 19. C. Mechin and C. Toury, “Action of cariogenic diet on fixation and retention of skeleton and teeth strontium in rats,” Revue Odonto Stomatologique.1973; 20(1): 55–59.
  • 20. Hossain MF, Uddin MS, Uddin GMS, Sumsuzzman DM, Islam MS, Barreto GE, Mathew B, Ashraf GM. Melatonin in Alzheimer's Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer's Neuropathology. Mol Neurobiol. 2019;56(12):8255-8276.
  • 21. Kay SR, Sandyk R. Experimental models of schizophrenia. Int. J. Neurosci. 1991;58: 69-82.
  • 22. Sedghizadeh PP, Nguyen M, Enciso R. Intracranial physiological calcifications evaluated with cone beam CT. Dentomaxillofac Radiol. 2012; 41: 675-8.
  • 23. Abbassioun K, Aarabi B, Zarabi M. A comparative study of physiologic intracranial calcifications. Pahlavi Med J. 1978; 9: 152–166.
  • 24. Mohammed KA, Boakye EA, Ismail HA, Geneus CJ, Tobo BB, Buchanan PM, Zelicoff AP. Pineal gland calcification in Kurdistan: a cross-sectional study of 480 roentgenograms. PloS one. 2016;11(7): e0159239
  • 25. Barghan S, Tahmasbi Arashlow M, Nair MK. Incidental findings on cone-beam computed tomography studies outside of the maxillofacial skeleton. Int J Dent. 2016; 2016: 9196503.
  • 26. Pette GA, Norkin FJ, Ganeles J, Hardigan P, Lask E, Zfaz S, et al. “Incidental findings from a retrospective study of 318 cone-beam computed tomography consultation reports.,” The International Journal ofOral& Maxillofacial Implants. 2 012; 27(3): 595-603.
  • 27. Admassie D, Mekonnen A. “Incidence of normal pineal and choroid plexus calcification on brain CT (computerized tomography) at Tikur Anbessa TeachingHospital Addis Ababa, Ethiopia,” Ethiopian Medical Journal. 2009; 47(1): 55-60.
  • 28. Deepak S, Jayakumar B, Shanavas. “Extensive intracranial calcification,” Journal of Association of Physicians of India.2005; 53: 948.
  • 29. Grech, R, Grech S, Mizzi A. Intracranial Calcifications: A Pictorial Review. The neuroradiology journal. 2012; 25(4): 427-451.
  • 30. Mechin JA, Toury C. “Action of melatonin on caries development in rats,” Journal of Dental Research.1976; 55(3): 555.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Yayınlanma Tarihi Güz
Bölüm Original Research Articles
Yazarlar

Muazzez SUZEN> (Sorumlu Yazar)
Istanbul Medipol University, Faculty of Dentistry, Department of Oral And Maxillofacial surgery
0000-0001-5121-9158
Türkiye


Emrah DİLAVER>
İstanbul Medipol University,School of dentistry,Deparment of Oral and Maxillofacial Surgery
0000-0003-4522-1424
Türkiye


Sina UÇKAN>
Istanbul Medipol University,School of dentistry,Deparment of Oral and Maxillofacial Surgery
0000-0003-1077-7342
Türkiye

Yayımlanma Tarihi 1 Ekim 2022
Başvuru Tarihi 30 Nisan 2022
Kabul Tarihi 7 Eylül 2022
Yayınlandığı Sayı Yıl 2022, Cilt 25, Sayı 3

Kaynak Göster

EndNote %0 Cumhuriyet Dental Journal Evaluation of prevalence and dimension of Pineal Gland Calcification by cone-beam computed tomography (CBCT) %A Muazzez Suzen , Emrah Dilaver , Sina Uçkan %T Evaluation of prevalence and dimension of Pineal Gland Calcification by cone-beam computed tomography (CBCT) %D 2022 %J Cumhuriyet Dental Journal %P 1302-5805-2146-2852 %V 25 %N 3 %R doi: 10.7126/cumudj.1111722 %U 10.7126/cumudj.1111722

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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