Öz
The therapeutic use of autologous platelet-rich fibrin constitutes a relatively new biotechnology that has been a breakthrough in the stimulation and acceleration of soft-tissue and bone healing. The efficiency of this process lies in the local and continuous delivery of a wide range of growth factors and proteins, mimicking the needs of the physiological wound healing and reparative tissue processes.
Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. This easy protocol allows the production of leukocyte and platelet-rich fibrin clots starting from autologous blood samples.
PRF is used especially in clinical Periodontal and Oral and Maxillofacial Surgery applications. The significance of the PRF is gradually increasing
Keywords: Platelet, Autogenous Fibrine, Growth hormone.
ÖZET
Trombositten zengin otojen ürünlerin tedavi amacı ile kullanılması, güncel bir yaklaşım olarak dikkati çekmektedir. Sert ve yumuşak doku iyileşmelerinde kullanılan ve çok çeşitli büyüme faktörleri ve proteinlerin kontrollü salınımlarını içeren bu preparatların doğal yara iyileşmesi için gerekli olan maddeleri yoğun olarak içerdikleri bilinmektedir.
Platelet-rich fibrin (PRF), yeni jenerasyon trombositten zengin otojen ürün olarak bilinmektedir. Kolay uygulanabilir ve biyokimyasal herhangi bir işlem gerektirmeyen PRF protokolü, kişinin kendisinden alınan kan örneklerinden lökositten ve trombositten zengin bir otolog biyomateryal elde edilmesine izin vermektedir.
Diş Hekimliğinde özellikle Periodontoloji ve Ağız, Diş ve Çene Cerrahisi’ndeki klinik uygulamalarda kullanılmaya başlanan PRF’nin önemi giderek artmaktadır.
Anahtar Kelimeler
Kaynakça
- Dohan Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte and platelet rich fibrin (L- PRF). Trends in Biotechonolgy ;27(3):158-167. [CrossRef] Gibble JW, Ness PM. Fibrin glue: the perfect Transfussion CrossRef] Mosesson MW. Siebenlist KR. Mehn DA. The structure and biological features of fibrinogen and fibrin. Ann NY Acad Sci 2001;93(6):11-30. CrossRef]
- Saltz R, Sierra D, Feldman D, Saltz MB, Dirrick A, Vascomez LO. Experimental applications of fibrin glue. Plast Reconstr Surg 1991;88:1005-1017. CrossRef]
- Choukroun J, Antonie D, Alain S. Platelet-rich fibrin (PRF): A second- generation platelet concentrate. Part : Clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e56-60
- David M, Choukroun J, Antonie D. Platelet-rich fibrin (PRF): A second- generation platelet concentrate. Part : Technological concepts and evolution Oral Surg Oral Med Oral Pathol ;101:e37-44
- Choukroun J, Simonpieri A, Girard M, Fioretti F, Dohan S, Dohan D. Platelet-rich fibrin (PRF): A new biomaterial for healing. Part 4: Therapeutic Implantodontie 2004;13:229-235.
- Woodell-May JE, Ridderman DN, Swift MJ, Higgins J. Producing accurate platelet counts for platelet- rich plasma: Validation of a hematology analyzer and preparation techniques for counting. J Craniofac Surg 2005;16:749-756. [CrossRef]
- Zucchelli G, De Sanctis M. Treatment of multiple recession-type defects in patients with esthetic demands. ;71:1506-1514. [CrossRef] Periodontol
- Kowolik MJ, Eckert GJ. Changes in gingival connective tissue grafts for root coverage: Comparison of two procedures. ;79:1346-1354. [CrossRef].
- Jang ES, Park JW, Kweon H, Lee KG, Kang SW, Baek DH, Choi JY, Kim SG. Restoration of peri-implant defects installations by Choukroun platelet- rich fibrin and silk fibroin powder combination graft. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Jun;109(6):831-6. implant
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Review |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Temmuz 2012 |
| Gönderilme Tarihi | 7 Aralık 2011 |
| Yayımlandığı Sayı | Yıl 2012Cilt: 15 Sayı: 3 |
Cited By
Trombositten zengin fibrin ve diş hekimliğinde kullanımı
Journal of Medicine and Palliative Care
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Advancements in Platelet-Rich Products: Obtaining Methods and Applications in Dentistry
Cyprus Journal of Medical Sciences
https://doi.org/10.4274/cjms.2020.1736
TROMBOSİTTEN ZENGİN ÜRÜNLER VE DİŞ HEKİMLİĞİNDEKİ UYGULANMA ALANLARI
Sağlık Akademisi Kastamonu
Mehmet Gagari Caymaz
https://doi.org/10.25279/sak.541936
Assessment of the effects of local platelet-rich fibrin injection and piezocision on orthodontic tooth movement during canine distalization
American Journal of Orthodontics and Dentofacial Orthopedics
İlknur Çağlı Karcı
https://doi.org/10.1016/j.ajodo.2020.03.029
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