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İkinci nesil trombosit konsantrasyonunun klinik uygulamaları

Year 2012, Volume: 15 Issue: 3, 279 - 287, 30.07.2012
https://doi.org/10.7126/cdj.2012.1238

Abstract

The therapeutic use of autologous platelet-rich fibrin constitutes a relatively new biotechnology that has been a breakthrough in the stimulation and acceleration of soft-tissue and bone healing. The efficiency of this process lies in the local and continuous delivery of a wide range of growth factors and proteins, mimicking the needs of the physiological wound healing and reparative tissue processes.

Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. This easy protocol allows the production of leukocyte and platelet-rich fibrin clots starting from autologous blood samples.

PRF is used especially in clinical Periodontal and Oral and Maxillofacial Surgery applications. The significance of the PRF is gradually increasing

Keywords: Platelet, Autogenous Fibrine, Growth hormone.

 

ÖZET

Trombositten zengin otojen ürünlerin tedavi amacı ile kullanılması, güncel bir yaklaşım olarak dikkati çekmektedir. Sert ve yumuşak doku iyileşmelerinde kullanılan ve çok çeşitli büyüme faktörleri ve proteinlerin kontrollü salınımlarını içeren bu preparatların doğal yara iyileşmesi için gerekli olan maddeleri yoğun olarak içerdikleri bilinmektedir.

Platelet-rich fibrin (PRF), yeni jenerasyon trombositten zengin otojen ürün olarak bilinmektedir. Kolay uygulanabilir ve biyokimyasal herhangi bir işlem gerektirmeyen PRF protokolü, kişinin kendisinden alınan kan örneklerinden lökositten ve trombositten zengin bir otolog biyomateryal elde edilmesine izin vermektedir.

Diş Hekimliğinde özellikle Periodontoloji ve Ağız, Diş ve Çene Cerrahisi’ndeki klinik uygulamalarda kullanılmaya başlanan PRF’nin önemi giderek artmaktadır.

 

 

References

  • Dohan Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte and platelet rich fibrin (L- PRF). Trends in Biotechonolgy ;27(3):158-167. [CrossRef] Gibble JW, Ness PM. Fibrin glue: the perfect Transfussion CrossRef] Mosesson MW. Siebenlist KR. Mehn DA. The structure and biological features of fibrinogen and fibrin. Ann NY Acad Sci 2001;93(6):11-30. CrossRef]
  • Saltz R, Sierra D, Feldman D, Saltz MB, Dirrick A, Vascomez LO. Experimental applications of fibrin glue. Plast Reconstr Surg 1991;88:1005-1017. CrossRef]
  • Choukroun J, Antonie D, Alain S. Platelet-rich fibrin (PRF): A second- generation platelet concentrate. Part : Clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e56-60
  • David M, Choukroun J, Antonie D. Platelet-rich fibrin (PRF): A second- generation platelet concentrate. Part : Technological concepts and evolution Oral Surg Oral Med Oral Pathol ;101:e37-44
  • Choukroun J, Simonpieri A, Girard M, Fioretti F, Dohan S, Dohan D. Platelet-rich fibrin (PRF): A new biomaterial for healing. Part 4: Therapeutic Implantodontie 2004;13:229-235.
  • Woodell-May JE, Ridderman DN, Swift MJ, Higgins J. Producing accurate platelet counts for platelet- rich plasma: Validation of a hematology analyzer and preparation techniques for counting. J Craniofac Surg 2005;16:749-756. [CrossRef]
  • Zucchelli G, De Sanctis M. Treatment of multiple recession-type defects in patients with esthetic demands. ;71:1506-1514. [CrossRef] Periodontol
  • Kowolik MJ, Eckert GJ. Changes in gingival connective tissue grafts for root coverage: Comparison of two procedures. ;79:1346-1354. [CrossRef].
  • Jang ES, Park JW, Kweon H, Lee KG, Kang SW, Baek DH, Choi JY, Kim SG. Restoration of peri-implant defects installations by Choukroun platelet- rich fibrin and silk fibroin powder combination graft. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Jun;109(6):831-6. implant
Year 2012, Volume: 15 Issue: 3, 279 - 287, 30.07.2012
https://doi.org/10.7126/cdj.2012.1238

Abstract

References

  • Dohan Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte and platelet rich fibrin (L- PRF). Trends in Biotechonolgy ;27(3):158-167. [CrossRef] Gibble JW, Ness PM. Fibrin glue: the perfect Transfussion CrossRef] Mosesson MW. Siebenlist KR. Mehn DA. The structure and biological features of fibrinogen and fibrin. Ann NY Acad Sci 2001;93(6):11-30. CrossRef]
  • Saltz R, Sierra D, Feldman D, Saltz MB, Dirrick A, Vascomez LO. Experimental applications of fibrin glue. Plast Reconstr Surg 1991;88:1005-1017. CrossRef]
  • Choukroun J, Antonie D, Alain S. Platelet-rich fibrin (PRF): A second- generation platelet concentrate. Part : Clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e56-60
  • David M, Choukroun J, Antonie D. Platelet-rich fibrin (PRF): A second- generation platelet concentrate. Part : Technological concepts and evolution Oral Surg Oral Med Oral Pathol ;101:e37-44
  • Choukroun J, Simonpieri A, Girard M, Fioretti F, Dohan S, Dohan D. Platelet-rich fibrin (PRF): A new biomaterial for healing. Part 4: Therapeutic Implantodontie 2004;13:229-235.
  • Woodell-May JE, Ridderman DN, Swift MJ, Higgins J. Producing accurate platelet counts for platelet- rich plasma: Validation of a hematology analyzer and preparation techniques for counting. J Craniofac Surg 2005;16:749-756. [CrossRef]
  • Zucchelli G, De Sanctis M. Treatment of multiple recession-type defects in patients with esthetic demands. ;71:1506-1514. [CrossRef] Periodontol
  • Kowolik MJ, Eckert GJ. Changes in gingival connective tissue grafts for root coverage: Comparison of two procedures. ;79:1346-1354. [CrossRef].
  • Jang ES, Park JW, Kweon H, Lee KG, Kang SW, Baek DH, Choi JY, Kim SG. Restoration of peri-implant defects installations by Choukroun platelet- rich fibrin and silk fibroin powder combination graft. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Jun;109(6):831-6. implant
There are 9 citations in total.

Details

Primary Language Turkish
Journal Section Review
Authors

İsmail Koçyiğit

Mustafa Tunalı

Hakan Özdemir

Yasemin Kartal

Berkay Süer

Publication Date July 30, 2012
Submission Date December 7, 2011
Published in Issue Year 2012Volume: 15 Issue: 3

Cite

EndNote Koçyiğit İ, Tunalı M, Özdemir H, Kartal Y, Süer B (July 1, 2012) İkinci nesil trombosit konsantrasyonunun klinik uygulamaları. Cumhuriyet Dental Journal 15 3 279–287.

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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