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Matriks metalloproteinazlar: diş dokuları ve çürük üzerine etkileri

Yıl 2011, Cilt: 14 Sayı: 3, 246 - 257, 23.09.2011

Hande Erkli Engin Ersöz

Öz

ÖZET

Oral kavitede görülen hastalıkların mikroorganizmalarla olan ilişkileri ortaya konduktan sonra tedavi seçenekleri bu organizmaları ortadan kaldırmaya yönelik olmuştur. Ancak günümüzde yapılan çalışmalar bu hastalıkların oluşmalarının yalnızca mikroorganizmalar nedeniyle olmadığını aynı zamanda konak cevabının ve konak kaynaklı faktörlerin de hastalığın oluşması ve seyrini etkilediğini gözler önüne sermiştir. Bu konak kaynaklı faktörlerden bir tanesi ise Matriks Metallo Proteinaz (MMP) adı verilen bir enzim grubudur. MMP'ler; yıkımdan sorumlu birçok ekstraselüler matriks proteini ile organogenez, büyüme ve doku dönüşümü sırasında uyum içinde çalışan enzim grubudur. Bu derleme matriks metalloproteinazlarının hem sistemik etkilerine değinecek hem de ağız hastalıklarının seyri ve tedavi seçenekleri içerisinde üstlenebilecekleri rollere ışık tutacak şekilde hazırlanmıştır.

Anahtar kelimeler: Matriks metalloproteinaz, çürük, kollagen, matriks metalloproteinaz doku inhibitörü.

ABSTRACT

Since relationship between oral diseases and microorganisms have been revealed treatment options were focused to terminate those microorganisms. However; today's researches show that host response and host related factors have influence on diseases and their progress. Matrix metalloproteinases (MMP) are one of those host related factors. MMP's act as a degradative extracelular matrix protein during organogenesis, growth and tissue transformation processes. This review is about; systemic effects of MMP's and their roles in disease progression and treatment options.

Key words: Matrix metalloproteinases, caries, kollagen, tissue inhibitors of matrix metalloproteinases.

 

Anahtar Kelimeler

-

Kaynakça

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Matriks metalloproteinazlar: diş dokuları ve çürük üzerine etkileri

Yıl 2011, Cilt: 14 Sayı: 3, 246 - 257, 23.09.2011

Hande Erkli Engin Ersöz

Öz

Oral kavitede görülen hastalıkların mikroorganizmalarla konduktan organizmaları ortadan kaldırmaya yönelik olmuştur. Ancak hastalıkların mikroorganizmalar nedeniyle olmadığını aynı zamanda konak cevabının ve konak kaynaklı faktörlerin de hastalığın oluşması ve seyrini etkilediğini gözler önüne sermiştir. Bu konak kaynaklı faktörlerden bir tanesi ise Matriks Metallo Proteinaz (MMP) adı verilen bir enzim grubudur. MMP'ler; yıkımdan sorumlu birçok ekstraselüler matriks proteini ile organogenez, büyüme ve doku dönüşümü sırasında uyum içinde çalışan enzim grubudur. metalloproteinazlarının hem sistemik etkilerine değinecek hem de ağız hastalıklarının seyri ve tedavi seçenekleri içerisinde üstlenebilecekleri rollere ışık tutacak şekilde hazırlanmıştır

Anahtar Kelimeler

Matriks metalloproteinaz çürük kollagen matriks metalloproteinaz doku inhibitörü

Kaynakça

  • 1. Sorsa T, Tjaderhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis 2004;10:311–318.
  • 2. Katz S, Park KK, Palenick CJ. In vitro root surface caries studies. J Oral Med 1987;42:40-48.
  • 3. van Strijp AJ, van Steenbergen TJ, de Graaff J, ten Cate JM. Bacterial colonization and degradation of demineralized dentin matrix in situ. Caries Res 1994;28:21-27.
  • 4. Armstrong WG. Further studies on the action of collagenase on sound and carious human dentin. J Dent Res 1958;37:1001-1015.
  • 5. Brinckerhoff CE, Matrisian LM. Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 2002;3:207-214.
  • 6. Birkedal-Hansen H. Role of matrix metalloproteinases in human periodontal diseases. J Periodontol 1993;64:474-484.
  • 7. Nagase H, Woessner JF Jr. Matrix metalloproteinases. J Biol Chem 1999; 274:21491-21494.
  • 8. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 2003;92:827-839.
  • 9. Sognnaes RF. Introduction to the problem of caries. Ann NY Acad Sci 1965;131:687-689.
  • 10. Tjäderhane L, Larjava H, Sorsa T, Uitto VJ, Larmas M, Salo T. The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions. J Dent Res 1998;77:1622-1629.
  • 11. Uitto VJ, Overall CM, McCulloch C. Proteolytic host enzymes in gingival crevice fluid. Periodontology 2003;31:77–104.
  • 12. Bauer EA, Stricklin GP, Jeffrey JJ, Eisen AZ. Collagenase production by human skin fibroblasts. Biochem Biophys Res Commun 1975;64:232- 240. Cumhuriyet Dent J 2011;14(3):246-257 252 E
  • 13. Woolley DE, Roberts DR, Evanson JM. Inhibition of human collagenase activity by a small molecular weight serum protein. Biochem Biophys Res Commun 1975;66:747-754.
  • 14. Chang YC, Yang SF, Lai CC, Liu JY, Hsieh YS. Regulation of matrix metalloproteinase production by cytokines, pharmacological agents and periodontal pathogens in human periodontal ligament fibroblast cultures. J Periodontal Res 2002;37:196-203.
  • 15. Kerkelä E, Saarialho-Kere U. Matrix metalloproteinases in tumor progression: focus on basal and squamous cell skin cancer. Exp Dermatol 2003;12:109-125.
  • 16. Lambert E, Dasse E, Haye B, Petitfrere E. TIMPs as multifacial proteins. Crit Rev Oncol Hematol 2004;49:187-198.
  • 17. Snoek-van Beurden PAM, Von den Hoff JW. Zymographic techniques for the analysis of matrix metalloproteinases and their inhibitors. Biotechniques 2005;38:73-83.
  • 18. Olson MW, Gervasi DC, Mobashery S, Fridman R. Kinetic analysis of the binding of human matrix metalloproteinase-2 and -9 to tissue inhibitor of metalloproteinase (TIMP)- 1 and TIMP-2. J Biol Chem 1997;272:29975-29983.
  • 19. English WR, Velasco G, Stracke JO, Knäuper V, Murphy G. Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25). FEBS Lett 2001;491:137-142.
  • 20. Baker AH, Edwards DR, Murphy G. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 2002;115:3719-3727.
  • 21. Hayakawa T, Yamashita K, Tanzawa K, Uchijima E, Iwata K. Growthpromoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide-range of cells. A possible new growth factor in serum. FEBS Lett 1992;298:29-32.
  • 22. Hayakawa T, Yamashita K, Ohuchi E, Shinagawa A. Cell growthpromoting activity of tissue inhibitor of metalloproteinases-2 (TIMP-2). J Cell Sci 1994;107:2373-2379.
  • 23. Luparello C, Avanzato G, Carella C, Pucci-Minafra I. Tissue inhibitor of metalloprotease (TIMP)-1 and proliferative behaviour of clonal breast cancer cells. Breast Cancer Res Treat 1999;54:235-244.
  • 24. Würtz SØ, Christensen IJ, Schrohl AS, Mouridsen H, Lademann U, Jensen V. Measurement of the uncomplexed fraction of tissue inhibitor of metalloproteinases-1 in the prognostic evaluation of primary breast cancer patients. Mol Cell Proteomics 2005;4:483-491.
  • 25. Würtz SØ, Schrohl AS, Sørensen NM, Lademann U, Christensen IJ, Mouridsen H, Brünner N. Tissue inhibitor of metalloproteinases-1 in breast cancer. Endocr Relat Cancer 2005;12:215-227.
  • 26. Akahane T, Akahane M, Shah A, Thorgeirsson UP. TIMP-1 stimulates proliferation of human aortic smooth muscle cells and Ras effector pathways. Biochem Biophys Res Commun 2004;324:440-445.
  • 27. Guedez L, Courtemanch L, StetlerStevenson M. Tissue inhibitor of metalloproteinase (TIMP)-1 induces differentiation and an antiapoptotic phenotype in germinal center B cells. Blood 1998;92:1342-1349.
  • 28. Guedez L, Stetler-Stevenson WG, Wolff L, Wang J, Fukushima P, Mansoor A, et al. In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1. J Clin Invest 1998;102:2002-2010.
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Toplam 92 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Review
Yazarlar

Hande Erkli

Engin Ersöz

Yayımlanma Tarihi 23 Eylül 2011
Gönderilme Tarihi 22 Ekim 2010
Yayımlandığı Sayı Yıl 2011Cilt: 14 Sayı: 3

Kaynak Göster

EndNote Erkli H, Ersöz E (01 Eylül 2011) Matriks metalloproteinazlar: diş dokuları ve çürük üzerine etkileri. Cumhuriyet Dental Journal 14 3 246–257.

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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