Matriks metalloproteinazlar: diş dokuları ve çürük üzerine etkileri

Hande Erkli; Engin Ersöz

EN TR

Matriks metalloproteinazlar: diş dokuları ve çürük üzerine etkileri

Abstract

ÖZET

Oral kavitede görülen hastalıkların mikroorganizmalarla olan ilişkileri ortaya konduktan sonra tedavi seçenekleri bu organizmaları ortadan kaldırmaya yönelik olmuştur. Ancak günümüzde yapılan çalışmalar bu hastalıkların oluşmalarının yalnızca mikroorganizmalar nedeniyle olmadığını aynı zamanda konak cevabının ve konak kaynaklı faktörlerin de hastalığın oluşması ve seyrini etkilediğini gözler önüne sermiştir. Bu konak kaynaklı faktörlerden bir tanesi ise Matriks Metallo Proteinaz (MMP) adı verilen bir enzim grubudur. MMP'ler; yıkımdan sorumlu birçok ekstraselüler matriks proteini ile organogenez, büyüme ve doku dönüşümü sırasında uyum içinde çalışan enzim grubudur. Bu derleme matriks metalloproteinazlarının hem sistemik etkilerine değinecek hem de ağız hastalıklarının seyri ve tedavi seçenekleri içerisinde üstlenebilecekleri rollere ışık tutacak şekilde hazırlanmıştır.

Anahtar kelimeler: Matriks metalloproteinaz, çürük, kollagen, matriks metalloproteinaz doku inhibitörü.

ABSTRACT

Since relationship between oral diseases and microorganisms have been revealed treatment options were focused to terminate those microorganisms. However; today's researches show that host response and host related factors have influence on diseases and their progress. Matrix metalloproteinases (MMP) are one of those host related factors. MMP's act as a degradative extracelular matrix protein during organogenesis, growth and tissue transformation processes. This review is about; systemic effects of MMP's and their roles in disease progression and treatment options.

Key words: Matrix metalloproteinases, caries, kollagen, tissue inhibitors of matrix metalloproteinases.

Keywords

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References

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Primary Language

Turkish

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-

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Hande Erkli

Engin Ersöz

Publication Date

September 23, 2011

Submission Date

October 22, 2010

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Year 1970 Volume: 14 Number: 3

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Erkli H, Ersöz E (September 1, 2011) Matriks metalloproteinazlar: diş dokuları ve çürük üzerine etkileri. Cumhuriyet Dental Journal 14 3 246–257.

Matriks metalloproteinazlar: diş dokuları ve çürük üzerine etkileri

Matriks metalloproteinazlar: diş dokuları ve çürük üzerine etkileri

Abstract

Keywords

Matriks metalloproteinazlar: diş dokuları ve çürük üzerine etkileri

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

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