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Periodontal tedavide mikrobeslenme: Antioksidanlar

Yıl 2016, Cilt: 19 Sayı: 1, 57 - 72, 03.01.2016

Hulya Toker

Öz

Periodontitisle ilişkili birçok sistemik hastalıkta (fazla kiloluluk ve obezite, hipertansiyon,

dislipidemi, tip 2 diyabet, kardiyovasküler hastalıklar, osteoporoz) beslenme ile ilişkili faktörler

rol oynamaktadır. Ayrıca periodontitis düşük serum/plazma mikrobesin seviyeleri ile ilişkilidir.

Son yıllarda rafine karbonhidrat ve doymuş yağlardan zengin diyetin proenflamatuvar, doymamış

yağlar, antioksidan mikrobesinlerin (meyve, sebze, orman meyveleri) antienflamatuar etkili

olduğu ile ilgili güçlü kanıtlar bulunmaktadır.

Mikrobesinler ve periodontal hastalıklar arasındaki ilişkiyi araştıran çok sayıda invitro ve

deneysel çalışma olmasına rağmen insanlarda girişimsel çalışmalar azdır. Periodontal hastalık ile

ilişkileri açısından C vitamin, E vitamin (alfa tokoferol), karotenoidler, polifenoller, flavonoidler

ve diğer antioksidan içerikli fitobileşikler çalışılmıştır. Kesitsel çalışmalardan elde edilen bir

dizi kanıt bitkisel kaynaklı antioksidan besinlerin alımının periodontal tedavi sonuçlarını

geliştirebileceğini gösterir.

Bu derlemede günlük vitamin ve antioksidan ajanların alım tavsiyeleri ile periodontal

hastalıkların tedavisinde mikrobesinlerin muhtemel rolü literatür bilgileri ışığında tartışılacaktır.

Anahtar Kelimeler

Periodontitis Mikrobesinler Antioksidanlar

Kaynakça

  • Palacios, C., Joshipura, K., Willett, W. Nutrition and health: guidelines for dental practitioners. Oral Dis, 2009. 15(6): p.369-81.
  • O’Keefe, J.H., Gheewala, N.M., O’Keefe, J.O. Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol, 2008. 51(3): p. 249-55.
  • O’Keefe, J. H., Bell, D. S. Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol, 2007. 100(5): p. 899-904.
  • Pischon, N., Heng, N., Bernimoulin, J. P., Kleber, B. M., Willich, S. N., Pischon, T. Obesity, inflammation, and periodontal disease. J Dent Res, 2007. 86(5): p. 400-9.
  • Joshipura, K. J., Ritchie, C. Can the relation between tooth loss and chronic disease be explained by socioeconomic status? Eur J Epidemiol, 2005. 20(3): p. 203-4.
  • Joshipura, K. J., Willett, W. C., Douglass, C. W. The impact of edentulousness on food and nutrient intake. J Am Dent Assoc, 1996. 127(4): p. 459-67.
  • Walls, A. W., Steele, J. G. The relationship between oral health and nutrition in older people. Mech Ageing Dev, 2004. 25(12): p. 853-7.
  • Hung, H. C., Colditz, G., Joshipura, K. J. The association between tooth loss and the selfreported intake of selected CVD related nutrients and foods among US women. Community Dent Oral Epidemiol, 2005. 33(3): p. 167-73.
  • Van der Velden, U., Kuzmanova, D., Chapple, I.L. Micronutritional approaches to periodontal therapy. J Clin Periodontol, 2011. 38 Suppl 11: p. 142-58.
  • Staudte, H., Kranz, S., Volpel, A., Schutze, J., Sigusch, B. W. Comparison of nutrient intake between patients with periodontitis and healthy subjects. Quintessence Int, 2012. 43(10): p. 907-16.
  • Chapple, I. L. Reactive oxygen species and antioxidants in inflammatory diseases. J Clin Periodontol, 1997; 24(5): p.287-96.
  • Chapple, I. L., Brock, G. R., Milward, M. R., Ling, N., Matthews, J. B. Compromised GCF total antioxidant capacity in periodontitis: cause or effect? J Clin Periodontol, 2007. 34(2): p. 103-10.
  • Chapple, I.L., Matthews, J.B. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000, 2007. 43: p. 160-232.
  • D’Aiuto, F., Nibali, L., Parkar, M., Patel, K., Suvan, J., Donos, N. Oxidative stress, systemic inflammation, and severe periodontitis. J Dent Res, 2010. 89(11): p.1241-46.
  • Chapple, I.L. Potential mechanisms underpinning the nutritional modulation of periodontal inflammation. J Am Dent Assoc, 2009. 140(2): p. 178-84.
  • Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J. P., Colette, C. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA, 2006. 295(14): p. 1681-7.
  • Doğan, B., Yılmaz, G., Fentoğlu, Ö., Kırzıoğlu, F. Y. Antioksidan vitaminlerin periodontal sağlıktaki rolü. S.D.Ü. Sağlık Bilimleri Enstitüsü Dergisi, 2010. 1(2): p. 133-41.
  • Brock, G. R., Butterworth, C. J., Matthews, J. B., Chapple, I.L. Local and systemic total antioxidant capacity in periodontitis and health. J Clin Periodontol, 2004. 31(7): p. 515-21.
  • Chapple, I.L., Milward, M.R., Dietrich, T. The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations. J Nutr, 2007. 137(3): p. 657-64.
  • Toker, H., Akpinar, A., Aydin, H., Poyraz, O. Influence of smoking on interleukin-1beta level, oxidant status and antioxidant status in gingival crevicular fluid from chronic periodontitis patients before and after periodontal treatment. J Periodontal Res, 2012. 47(5): p. 572-7.
  • Akalin, F. A., Baltacioglu, E., Alver, A., Karabulut, E. Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. J Clin Periodontol, 2007. 34(7): p. 558-65.
  • Staudte, H., Guntsch, A., Volpel, A., Sigusch, B. W. Vitamin C attenuates the cytotoxic effects of Porphyromonas gingivalis on human gingival fibroblasts. Arch Oral Biol, 2010. 55(1): p. 40-5.
  • Feghali, K., Feldman, M., La, V. D., Santos, J., Grenier, D. Cranberry Proanthocyanidins: Natural Weapons against Periodontal Diseases. J Agric Food Chem, 2011.
  • Nakamura, H., Ukai, T., Yoshimura, A., Kozuka, Y., Yoshioka, H., Yoshinaga, Y., Abe, Y., Hara, Y. Green tea catechin inhibits lipopolysaccharide-induced bone resorption in vivo. J Periodontal Res, 2010. 45(1): p. 23-30.
  • Carvalho, R. R., Pellizzon, C. H., Justulin, L., Jr., Felisbino, S. L., Vilegas, W., Bruni, F., Lopes-Ferreira, M., Hiruma- Lima, C. A. Effect of mangiferin on the development of periodontal disease: involvement of lipoxin A4, anti- chemotaxic action in leukocyte rolling. Chem Biol Interact, 2009. 179(2-3): p. 344-50.
  • Uchiyama, S., Yamaguchi, M. Oral administration of beta-cryptoxanthin prevents bone loss in ovariectomized rats. Int J Mol Med, 2006. 17(1): p. 15-20.
  • Tomofuji, T., Ekuni, D., Irie, K., Azuma, T., Endo, Y., Tamaki, N., Sanbe, T., Murakami, J., Yamamoto, T., Morita, M. Preventive effects of a cocoa-enriched diet on gingival oxidative stress in experimental periodontitis. J Periodontol, 2009. 80(11): p. 1799-808.
  • Toker, H., Akpinar, A., Aydin, H., Poyraz, O. A morphometric and histopathologic evaluation of the effects of propolis on alveolar bone loss in experimental periodontitis in rats. J Periodontol, 2008. 79(6): p. 1089-94.
  • Govindaraj, J.Emmadi, P., Deepalakshmi, Rajaram, V., Prakash, G., Puvanakrishnan, R. Protective effect of proanthocyanidins on endotoxin induced experimental periodontitis in rats. Indian J Exp Biol, 2010. 48(2): p. 133-42.
  • Maruyama, T., Tomofuji, T., Endo, Y., Irie, K., Azuma, T., Ekuni, D., Tamaki, N., Yamamoto, T., Morita, M. Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation. Arch Oral Biol, 2011. 56(1): p. 48-53.
  • Ozdemir, H., Kara, M. I., Erciyas, K., Ozer, H., Ay, S. Preventive effects of thymoquinone in a rat periodontitis model: a morphometric and histopathological study. J Periodontal Res, 2012. 47(1): p. 74-80.
  • Mazzotta, M.Y. Nutrition and wound healing. J Am Pediatr Med Assoc, 1994. 84(9): p. 456-62.
  • MacKay, D., Miller, A.L. Nutritional support for wound healing. Altern Med Rev, 2003. 8(4): p. 359-77.
  • Sanbe, T., Tomofuji, T., Ekuni, D., Azuma, T., Tamaki, N., Yamamoto, T. Oral administration of vitamin C prevents alveolar bone resorption induced by high dietary cholesterol in rats. J Periodontol, 2007. 78(11): p. 2165-70.
  • Tomofuji, T., Azuma, T., Kusano, H., Sanbe, T., Ekuni, D., Tamaki, N., Yamamoto, T., Watanabe, T. Oxidative damage of periodontal tissue in the rat periodontitis model: effects of a high-cholesterol diet. FEBS Lett, 2006. 580(15): p. 3601-4.
  • Tomofuji, T., Ekuni, D., Sanbe, T., Irie, K., Azuma, T., Maruyama, T., Tamaki, N., Murakami, J., Kokeguchi, S., Yamamoto, T. Effects of vitamin C intake on gingival oxidative stress in rat periodontitis. Free Radic Biol Med, 2009. 46(2): p. 163-8.
  • Jacob, R. A., Omaye, S. T., Skala, J. H., Leggott, P. J., Rothman, D. L., Murray, P. A. Experimental vitamin C depletion and supplementation in young men. Nutrient interactions and dental health effects. Ann N Y Acad Sci, 1987. 498: p. 333-46.
  • Leggott, P. J., Robertson, P. B., Rothman, D. L., Murray, P. A., Jacob, R. A. The effect of controlled ascorbic acid depletion and supplementation on periodontal health. J Periodontol, 1986. 57(8): p. 480-5.
  • Leggott, P. J., Robertson, P. B., Jacob, R. A., Zambon, J. J., Walsh, M., Armitage, G. C. Effects of ascorbic acid depletion and supplementation on periodontal health and subgingival microflora in humans. J Dent Res, 1991. 70(12): p. 1531-6.
  • Nishida, M., Grossi, S. G., Dunford, R. G., Ho, A. W., Trevisan, M., Genco, R. J. Dietary vitamin C and the risk for periodontal disease. J Periodontol, 2000. 71(8): p. 1215-23.
  • Vogel, R. I., Lamster, I. B., Wechsler, S. A., Macedo, B., Hartley, L. J., Macedo, J. A. The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis. J Periodontol, 1986. 57(8): p. 472-9.
  • Woolfe, S. N., Kenney, E. B., Hume, W. R., Carranza, F. A., Jr. Relationship of ascorbic acid levels of blood and gingival tissue with response to periodontal therapy. J Clin Periodontol, 1984. 11(3): p. 159-65.
  • Abou Sulaiman, A.E., Shehadeh, R.M. Assessment of total antioxidant capacity and the use of vitamin C in the treatment of non-smokers with chronic periodontitis. J Periodontol, 2010. 81(11): p. 1547-54.
  • Munoz, C. A., Kiger, R. D., Stephens, J. A., Kim, J., Wilson, A. C. Effects of a nutritional supplement on periodontal status. Compend Contin Educ Dent, 2001. 22(5): p. 425-8.
  • Staudte, H., Sigusch, B.W., Glockmann, E. Grapefruit consumption improves vitamin C status in periodontitis patients. Br Dent J, 2005. 199(4): p. 213-7.
  • Levine, M., Wang, Y., Katz, A., Eck, P., Kwon, O., Chen, S., Lee, J. H., Padayatty, S. J. Ideal vitamin C intake. Biofactors, 2001; 15 (2-4): p.71-4.
  • Collins, A. R., Harrington, V., Drew, J., Melvin, R. Nutritional modulation of DNA repair in a human intervention study. Carcinogenesis, 2003. 24(3): p. 511-5.
  • Duttaroy, A. K., Jorgensen, A. Effects of kiwi fruit consumption on platelet aggregation and plasma lipids in healthy human volunteers. Platelets, 2004. 15(5): p. 287-92.
  • Kaye, E. K. Nutrition, dieatary guidelines and optimal periodontal health. Periodontology 2000, 2012. 58: p. 93-111.
  • Linden, G. J., McClean, K. M., Woodside, J. V., Patterson, C. C.,Evans, A. Young, I. S., Kee, F. Antioxidants and periodontitis in 60-70-year-old men. J Clin Periodontol, 2009. 36(10): p. 843-9.
  • Watzl, B., Kulling, S.E., Möseneder, J., Barth, S. W., Bub, A. A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men. Am J Clin Nutr 2005;82: p.1052-8.
  • Yamaguchi, M., Uchiyama, S. Combination of beta-cryptoxanthin and zinc has potent effects on apoptotic cell death and suppression of bone resorption-related gene expression in osteoclastic cells. Int J Mol Med, 2008. 22(2): p. 221-8.
  • Yamaguchi, M., Uchiyama, S. Receptor activator of NF-kappaB ligandstimulated osteoclastogenesis in mouse marrow culture is suppressed by zinc in vitro. Int J Mol Med, 2004. 14(1): p. 81-5.
  • Chandra, R. V., Sandhya, Y. P., Nagarajan, S., Reddy, B. H.,Naveen, A., Murthy, K. R. Efficacy of lycopene as a locally delivered gel in the treatment of chronic periodontitis: smokers vs nonsmokers. Quintessence Int, 2012. 43(5): p. 401-11.
  • Chandra, R. V., Srinivas, G., Reddy, A. A., Reddy, B. H., Reddy, C., Nagarajan, S., et al. Locally delivered antioxidant gel as an adjunct to nonsurgical therapy improves measures of oxidative stress and periodontal disease. J Periodontal Implant Sci, 2013; 43(3): p.121-9.
  • Arora, N., Avula, H., Avula, J. K. The adjunctive use of systemic antioxidant therapy (lycopene) in nonsurgical treatment of chronic periodontitis: a short-term evaluation. Quintessence Int, 2013. 44(6): p. 395-405.
  • Cohen, R. E., Ciancio, S. G., Mather, M. L., Curro, F. A., Effect of vitamin E gel, placebo gel and chlorhexidine on periodontal disease. Clin Prev Dent, 1991. 13(5): p. 20-4.
  • Cohen, M. E., Meyer, D. M. Effect of dietary vitamin E supplementation and rotational stress on alveolar bone loss in rice rats. Arch Oral Biol, 1993. 38(7): p. 601-6.
  • Asman, B.,Wijkander, P., Hjerpe, A. Reduction of collagen degradation in experimental granulation tissue by vitamin E znd selenium. J Clin Periodontol, 1994. 21(1): p. 45-7.
  • Chapple, I.L., Matthews, J.B., Wright, H.J., Scott, A.E., Griffiths, H.R., Grant, M.M. Ascorbate and α-tocopherol differentially modulate reactive oxygen species generation by neutrophils in response to FcγR and TLR agonists. Innate Immun, 2013. 19(2): p.152-9.
  • Singh, N., Narula, S.C., Sharma, R.K., Tewari, S., Sehgal, P.K. Vitamin E Supplementation, Superoxide Dismutase Status and Outcome of Scaling and Root Planing in Chronic Periodontitis Patients: A Randomized Clinical Trial. J Periodontol, Mayıs 2013 yılında basılmak üzere kabul edilmiştir.
  • Prakash, S., Sunitha, J., Hans, M. Role of coenzyme Q(10) as an antioxidant and bioenergizer in periodontal diseases. Indian J Pharmacol, 2010. 42(6): p. 334-7.
  • Battino, M., Bompadre, S., Politi, A., Fioroni, M., Rubini, C., Bullon, P. Antioxidant status (CoQ10 and Vit. E levels) and immunohitochemical analysis of soft tissues in periodontal diseases. Biofactors, 2005. 25(1-4): p. 213-7.
  • Hans, M., Prakash, S., Gupta, S. Clinical evaluation of topical application of perio-Q gel (Coenzyme Q(10)) in chronic periodontitis patients. J Indian Soc Periodontol, 2012; 16(2): p.193-9.
  • Chatterjee, A., Kandwal, A., Singh N., Singh, A. Evaluation of Co-Q10 antigingivitis effect on plaque induced gingivitis: A randomized controlled clinical trial. J Indian Soc Periodontol, 2012. 16(4): p. 539-42.
  • Kushiyama, M., Shimazaki, Y., Murakami, M., Yamashita, Y. Relationship between intake of green tea and periodontal disease. J Periodontol, 2009. 80(3): p. 372-7.
  • Hirasawa, M., Takada, K., Makimura, M., Otake, S. Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study. J Periodontal Res, 2002. 37(6): p. 433-8.
  • Tonetti, M. S., Chapple, I. L. Working Group 3 of Seventh European Workshop on Periodontology. Biological approaches to the development of novel periodontal therapies--consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol, 2011;38 Suppl 11: p.114-8.
  • Reynolds, M. A., Dawson, D. R., Novak, K. F., Ebersole, J. L., Gunsolley, J. C., Branch-Mays, G. L., Holt, S. C., Mattison, J. A., Ingram, D. K., Novak, M. J. Effects of caloric restriction on inflammatory periodontal disease. Nutrition, 2009. 25(1): p. 88-97.
  • Merchant, A. T., Pitiphat, W., Franz, M., Joshipura, K. J., Whole-grain and fiber intakes and periodontitis risk in men. Am J Clin Nutr, 2006. 83(6): p. 1395-400.
  • Jenzsch, A., Eick, S., Rassoul, F., Purschwitz, R., Jentsch, H. Nutritional intervention in patients with periodontal disease: clinical, immunological and microbiological variables during 12 months. Br J Nutr, 2009. 101(6): p. 879-85.
  • Chapple, I. L., Milward, M. R., Ling-Mountford, N., Weston, P., Carter, K., Askey, K., Dallal, G. E., De Spirt, S., Sies, H., Patel, D., Matthews, J. B. Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT. J Clin Periodontol, 2012. 39(1): p. 62-72.
  • Baumgartner, S., Imfeld, T., Schicht, O., Rath, C., Persson, R. E., Persson, G. R. The impact of the stone age diet on gingival conditions in the absence of oral hygiene. J Periodontol, 2009. 80(5): p. 759‑68.

Micronutrition in periodontal treatment: Antioxidants

Yıl 2016, Cilt: 19 Sayı: 1, 57 - 72, 03.01.2016

Hulya Toker

Öz

Nutritional factors are implicated in several systemic diseases and conditions, including

overweight and obesity, hypertension, dyslipidemia, type 2 diabetes, cardiovascular disease,

osteoporosis that are associated with periodontitis. Also, periodontitis is associated with low

serum/plasma micronutrient levels. In recent years, strong evidence has emerged that diets

rich in refined carbohydrates and saturated fats are pro-inflammatory, whereas those rich in

polyunsaturated fats (fish oils), antioxidant micronutrients (fruits, berries and vegetables) are

anti-inflammatory.

Although numerous studies evaluated the relationship between micronutrients and periodontal

disease, intervention studies in humans are scarce. In relation to periodontal disease, number

of studies have been conducted and include vitamin C, vitamin E (tocopherol), carotenoids,

polyphenols, flavonoids and other pyhtonutrients. There is a body of evidence from crosssectional

studies that support the potential to improve periodontal outcomes by using dietary

antioxidants.

This lecture will discuss the possible role of some micronutrients in the etiology and therapy of

periodontal diseases and makes recommendations for daily nutritional intake for vitamins and

antioxidants.

Anahtar Kelimeler

Periodontitis Micronutrition Antioxidants

Kaynakça

  • Palacios, C., Joshipura, K., Willett, W. Nutrition and health: guidelines for dental practitioners. Oral Dis, 2009. 15(6): p.369-81.
  • O’Keefe, J.H., Gheewala, N.M., O’Keefe, J.O. Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol, 2008. 51(3): p. 249-55.
  • O’Keefe, J. H., Bell, D. S. Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol, 2007. 100(5): p. 899-904.
  • Pischon, N., Heng, N., Bernimoulin, J. P., Kleber, B. M., Willich, S. N., Pischon, T. Obesity, inflammation, and periodontal disease. J Dent Res, 2007. 86(5): p. 400-9.
  • Joshipura, K. J., Ritchie, C. Can the relation between tooth loss and chronic disease be explained by socioeconomic status? Eur J Epidemiol, 2005. 20(3): p. 203-4.
  • Joshipura, K. J., Willett, W. C., Douglass, C. W. The impact of edentulousness on food and nutrient intake. J Am Dent Assoc, 1996. 127(4): p. 459-67.
  • Walls, A. W., Steele, J. G. The relationship between oral health and nutrition in older people. Mech Ageing Dev, 2004. 25(12): p. 853-7.
  • Hung, H. C., Colditz, G., Joshipura, K. J. The association between tooth loss and the selfreported intake of selected CVD related nutrients and foods among US women. Community Dent Oral Epidemiol, 2005. 33(3): p. 167-73.
  • Van der Velden, U., Kuzmanova, D., Chapple, I.L. Micronutritional approaches to periodontal therapy. J Clin Periodontol, 2011. 38 Suppl 11: p. 142-58.
  • Staudte, H., Kranz, S., Volpel, A., Schutze, J., Sigusch, B. W. Comparison of nutrient intake between patients with periodontitis and healthy subjects. Quintessence Int, 2012. 43(10): p. 907-16.
  • Chapple, I. L. Reactive oxygen species and antioxidants in inflammatory diseases. J Clin Periodontol, 1997; 24(5): p.287-96.
  • Chapple, I. L., Brock, G. R., Milward, M. R., Ling, N., Matthews, J. B. Compromised GCF total antioxidant capacity in periodontitis: cause or effect? J Clin Periodontol, 2007. 34(2): p. 103-10.
  • Chapple, I.L., Matthews, J.B. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000, 2007. 43: p. 160-232.
  • D’Aiuto, F., Nibali, L., Parkar, M., Patel, K., Suvan, J., Donos, N. Oxidative stress, systemic inflammation, and severe periodontitis. J Dent Res, 2010. 89(11): p.1241-46.
  • Chapple, I.L. Potential mechanisms underpinning the nutritional modulation of periodontal inflammation. J Am Dent Assoc, 2009. 140(2): p. 178-84.
  • Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J. P., Colette, C. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA, 2006. 295(14): p. 1681-7.
  • Doğan, B., Yılmaz, G., Fentoğlu, Ö., Kırzıoğlu, F. Y. Antioksidan vitaminlerin periodontal sağlıktaki rolü. S.D.Ü. Sağlık Bilimleri Enstitüsü Dergisi, 2010. 1(2): p. 133-41.
  • Brock, G. R., Butterworth, C. J., Matthews, J. B., Chapple, I.L. Local and systemic total antioxidant capacity in periodontitis and health. J Clin Periodontol, 2004. 31(7): p. 515-21.
  • Chapple, I.L., Milward, M.R., Dietrich, T. The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations. J Nutr, 2007. 137(3): p. 657-64.
  • Toker, H., Akpinar, A., Aydin, H., Poyraz, O. Influence of smoking on interleukin-1beta level, oxidant status and antioxidant status in gingival crevicular fluid from chronic periodontitis patients before and after periodontal treatment. J Periodontal Res, 2012. 47(5): p. 572-7.
  • Akalin, F. A., Baltacioglu, E., Alver, A., Karabulut, E. Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. J Clin Periodontol, 2007. 34(7): p. 558-65.
  • Staudte, H., Guntsch, A., Volpel, A., Sigusch, B. W. Vitamin C attenuates the cytotoxic effects of Porphyromonas gingivalis on human gingival fibroblasts. Arch Oral Biol, 2010. 55(1): p. 40-5.
  • Feghali, K., Feldman, M., La, V. D., Santos, J., Grenier, D. Cranberry Proanthocyanidins: Natural Weapons against Periodontal Diseases. J Agric Food Chem, 2011.
  • Nakamura, H., Ukai, T., Yoshimura, A., Kozuka, Y., Yoshioka, H., Yoshinaga, Y., Abe, Y., Hara, Y. Green tea catechin inhibits lipopolysaccharide-induced bone resorption in vivo. J Periodontal Res, 2010. 45(1): p. 23-30.
  • Carvalho, R. R., Pellizzon, C. H., Justulin, L., Jr., Felisbino, S. L., Vilegas, W., Bruni, F., Lopes-Ferreira, M., Hiruma- Lima, C. A. Effect of mangiferin on the development of periodontal disease: involvement of lipoxin A4, anti- chemotaxic action in leukocyte rolling. Chem Biol Interact, 2009. 179(2-3): p. 344-50.
  • Uchiyama, S., Yamaguchi, M. Oral administration of beta-cryptoxanthin prevents bone loss in ovariectomized rats. Int J Mol Med, 2006. 17(1): p. 15-20.
  • Tomofuji, T., Ekuni, D., Irie, K., Azuma, T., Endo, Y., Tamaki, N., Sanbe, T., Murakami, J., Yamamoto, T., Morita, M. Preventive effects of a cocoa-enriched diet on gingival oxidative stress in experimental periodontitis. J Periodontol, 2009. 80(11): p. 1799-808.
  • Toker, H., Akpinar, A., Aydin, H., Poyraz, O. A morphometric and histopathologic evaluation of the effects of propolis on alveolar bone loss in experimental periodontitis in rats. J Periodontol, 2008. 79(6): p. 1089-94.
  • Govindaraj, J.Emmadi, P., Deepalakshmi, Rajaram, V., Prakash, G., Puvanakrishnan, R. Protective effect of proanthocyanidins on endotoxin induced experimental periodontitis in rats. Indian J Exp Biol, 2010. 48(2): p. 133-42.
  • Maruyama, T., Tomofuji, T., Endo, Y., Irie, K., Azuma, T., Ekuni, D., Tamaki, N., Yamamoto, T., Morita, M. Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation. Arch Oral Biol, 2011. 56(1): p. 48-53.
  • Ozdemir, H., Kara, M. I., Erciyas, K., Ozer, H., Ay, S. Preventive effects of thymoquinone in a rat periodontitis model: a morphometric and histopathological study. J Periodontal Res, 2012. 47(1): p. 74-80.
  • Mazzotta, M.Y. Nutrition and wound healing. J Am Pediatr Med Assoc, 1994. 84(9): p. 456-62.
  • MacKay, D., Miller, A.L. Nutritional support for wound healing. Altern Med Rev, 2003. 8(4): p. 359-77.
  • Sanbe, T., Tomofuji, T., Ekuni, D., Azuma, T., Tamaki, N., Yamamoto, T. Oral administration of vitamin C prevents alveolar bone resorption induced by high dietary cholesterol in rats. J Periodontol, 2007. 78(11): p. 2165-70.
  • Tomofuji, T., Azuma, T., Kusano, H., Sanbe, T., Ekuni, D., Tamaki, N., Yamamoto, T., Watanabe, T. Oxidative damage of periodontal tissue in the rat periodontitis model: effects of a high-cholesterol diet. FEBS Lett, 2006. 580(15): p. 3601-4.
  • Tomofuji, T., Ekuni, D., Sanbe, T., Irie, K., Azuma, T., Maruyama, T., Tamaki, N., Murakami, J., Kokeguchi, S., Yamamoto, T. Effects of vitamin C intake on gingival oxidative stress in rat periodontitis. Free Radic Biol Med, 2009. 46(2): p. 163-8.
  • Jacob, R. A., Omaye, S. T., Skala, J. H., Leggott, P. J., Rothman, D. L., Murray, P. A. Experimental vitamin C depletion and supplementation in young men. Nutrient interactions and dental health effects. Ann N Y Acad Sci, 1987. 498: p. 333-46.
  • Leggott, P. J., Robertson, P. B., Rothman, D. L., Murray, P. A., Jacob, R. A. The effect of controlled ascorbic acid depletion and supplementation on periodontal health. J Periodontol, 1986. 57(8): p. 480-5.
  • Leggott, P. J., Robertson, P. B., Jacob, R. A., Zambon, J. J., Walsh, M., Armitage, G. C. Effects of ascorbic acid depletion and supplementation on periodontal health and subgingival microflora in humans. J Dent Res, 1991. 70(12): p. 1531-6.
  • Nishida, M., Grossi, S. G., Dunford, R. G., Ho, A. W., Trevisan, M., Genco, R. J. Dietary vitamin C and the risk for periodontal disease. J Periodontol, 2000. 71(8): p. 1215-23.
  • Vogel, R. I., Lamster, I. B., Wechsler, S. A., Macedo, B., Hartley, L. J., Macedo, J. A. The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis. J Periodontol, 1986. 57(8): p. 472-9.
  • Woolfe, S. N., Kenney, E. B., Hume, W. R., Carranza, F. A., Jr. Relationship of ascorbic acid levels of blood and gingival tissue with response to periodontal therapy. J Clin Periodontol, 1984. 11(3): p. 159-65.
  • Abou Sulaiman, A.E., Shehadeh, R.M. Assessment of total antioxidant capacity and the use of vitamin C in the treatment of non-smokers with chronic periodontitis. J Periodontol, 2010. 81(11): p. 1547-54.
  • Munoz, C. A., Kiger, R. D., Stephens, J. A., Kim, J., Wilson, A. C. Effects of a nutritional supplement on periodontal status. Compend Contin Educ Dent, 2001. 22(5): p. 425-8.
  • Staudte, H., Sigusch, B.W., Glockmann, E. Grapefruit consumption improves vitamin C status in periodontitis patients. Br Dent J, 2005. 199(4): p. 213-7.
  • Levine, M., Wang, Y., Katz, A., Eck, P., Kwon, O., Chen, S., Lee, J. H., Padayatty, S. J. Ideal vitamin C intake. Biofactors, 2001; 15 (2-4): p.71-4.
  • Collins, A. R., Harrington, V., Drew, J., Melvin, R. Nutritional modulation of DNA repair in a human intervention study. Carcinogenesis, 2003. 24(3): p. 511-5.
  • Duttaroy, A. K., Jorgensen, A. Effects of kiwi fruit consumption on platelet aggregation and plasma lipids in healthy human volunteers. Platelets, 2004. 15(5): p. 287-92.
  • Kaye, E. K. Nutrition, dieatary guidelines and optimal periodontal health. Periodontology 2000, 2012. 58: p. 93-111.
  • Linden, G. J., McClean, K. M., Woodside, J. V., Patterson, C. C.,Evans, A. Young, I. S., Kee, F. Antioxidants and periodontitis in 60-70-year-old men. J Clin Periodontol, 2009. 36(10): p. 843-9.
  • Watzl, B., Kulling, S.E., Möseneder, J., Barth, S. W., Bub, A. A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men. Am J Clin Nutr 2005;82: p.1052-8.
  • Yamaguchi, M., Uchiyama, S. Combination of beta-cryptoxanthin and zinc has potent effects on apoptotic cell death and suppression of bone resorption-related gene expression in osteoclastic cells. Int J Mol Med, 2008. 22(2): p. 221-8.
  • Yamaguchi, M., Uchiyama, S. Receptor activator of NF-kappaB ligandstimulated osteoclastogenesis in mouse marrow culture is suppressed by zinc in vitro. Int J Mol Med, 2004. 14(1): p. 81-5.
  • Chandra, R. V., Sandhya, Y. P., Nagarajan, S., Reddy, B. H.,Naveen, A., Murthy, K. R. Efficacy of lycopene as a locally delivered gel in the treatment of chronic periodontitis: smokers vs nonsmokers. Quintessence Int, 2012. 43(5): p. 401-11.
  • Chandra, R. V., Srinivas, G., Reddy, A. A., Reddy, B. H., Reddy, C., Nagarajan, S., et al. Locally delivered antioxidant gel as an adjunct to nonsurgical therapy improves measures of oxidative stress and periodontal disease. J Periodontal Implant Sci, 2013; 43(3): p.121-9.
  • Arora, N., Avula, H., Avula, J. K. The adjunctive use of systemic antioxidant therapy (lycopene) in nonsurgical treatment of chronic periodontitis: a short-term evaluation. Quintessence Int, 2013. 44(6): p. 395-405.
  • Cohen, R. E., Ciancio, S. G., Mather, M. L., Curro, F. A., Effect of vitamin E gel, placebo gel and chlorhexidine on periodontal disease. Clin Prev Dent, 1991. 13(5): p. 20-4.
  • Cohen, M. E., Meyer, D. M. Effect of dietary vitamin E supplementation and rotational stress on alveolar bone loss in rice rats. Arch Oral Biol, 1993. 38(7): p. 601-6.
  • Asman, B.,Wijkander, P., Hjerpe, A. Reduction of collagen degradation in experimental granulation tissue by vitamin E znd selenium. J Clin Periodontol, 1994. 21(1): p. 45-7.
  • Chapple, I.L., Matthews, J.B., Wright, H.J., Scott, A.E., Griffiths, H.R., Grant, M.M. Ascorbate and α-tocopherol differentially modulate reactive oxygen species generation by neutrophils in response to FcγR and TLR agonists. Innate Immun, 2013. 19(2): p.152-9.
  • Singh, N., Narula, S.C., Sharma, R.K., Tewari, S., Sehgal, P.K. Vitamin E Supplementation, Superoxide Dismutase Status and Outcome of Scaling and Root Planing in Chronic Periodontitis Patients: A Randomized Clinical Trial. J Periodontol, Mayıs 2013 yılında basılmak üzere kabul edilmiştir.
  • Prakash, S., Sunitha, J., Hans, M. Role of coenzyme Q(10) as an antioxidant and bioenergizer in periodontal diseases. Indian J Pharmacol, 2010. 42(6): p. 334-7.
  • Battino, M., Bompadre, S., Politi, A., Fioroni, M., Rubini, C., Bullon, P. Antioxidant status (CoQ10 and Vit. E levels) and immunohitochemical analysis of soft tissues in periodontal diseases. Biofactors, 2005. 25(1-4): p. 213-7.
  • Hans, M., Prakash, S., Gupta, S. Clinical evaluation of topical application of perio-Q gel (Coenzyme Q(10)) in chronic periodontitis patients. J Indian Soc Periodontol, 2012; 16(2): p.193-9.
  • Chatterjee, A., Kandwal, A., Singh N., Singh, A. Evaluation of Co-Q10 antigingivitis effect on plaque induced gingivitis: A randomized controlled clinical trial. J Indian Soc Periodontol, 2012. 16(4): p. 539-42.
  • Kushiyama, M., Shimazaki, Y., Murakami, M., Yamashita, Y. Relationship between intake of green tea and periodontal disease. J Periodontol, 2009. 80(3): p. 372-7.
  • Hirasawa, M., Takada, K., Makimura, M., Otake, S. Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study. J Periodontal Res, 2002. 37(6): p. 433-8.
  • Tonetti, M. S., Chapple, I. L. Working Group 3 of Seventh European Workshop on Periodontology. Biological approaches to the development of novel periodontal therapies--consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol, 2011;38 Suppl 11: p.114-8.
  • Reynolds, M. A., Dawson, D. R., Novak, K. F., Ebersole, J. L., Gunsolley, J. C., Branch-Mays, G. L., Holt, S. C., Mattison, J. A., Ingram, D. K., Novak, M. J. Effects of caloric restriction on inflammatory periodontal disease. Nutrition, 2009. 25(1): p. 88-97.
  • Merchant, A. T., Pitiphat, W., Franz, M., Joshipura, K. J., Whole-grain and fiber intakes and periodontitis risk in men. Am J Clin Nutr, 2006. 83(6): p. 1395-400.
  • Jenzsch, A., Eick, S., Rassoul, F., Purschwitz, R., Jentsch, H. Nutritional intervention in patients with periodontal disease: clinical, immunological and microbiological variables during 12 months. Br J Nutr, 2009. 101(6): p. 879-85.
  • Chapple, I. L., Milward, M. R., Ling-Mountford, N., Weston, P., Carter, K., Askey, K., Dallal, G. E., De Spirt, S., Sies, H., Patel, D., Matthews, J. B. Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT. J Clin Periodontol, 2012. 39(1): p. 62-72.
  • Baumgartner, S., Imfeld, T., Schicht, O., Rath, C., Persson, R. E., Persson, G. R. The impact of the stone age diet on gingival conditions in the absence of oral hygiene. J Periodontol, 2009. 80(5): p. 759‑68.
Toplam 73 adet kaynakça vardır.

Ayrıntılar

Bölüm Review
Yazarlar

Hulya Toker

Yayımlanma Tarihi 3 Ocak 2016
Gönderilme Tarihi 6 Aralık 2016
Yayımlandığı Sayı Yıl 2016Cilt: 19 Sayı: 1

Kaynak Göster

EndNote Toker H (01 Ocak 2016) Micronutrition in periodontal treatment: Antioxidants. Cumhuriyet Dental Journal 19 1 57–72.

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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