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Periodontal tedavide mikrobeslenme: Antioksidanlar

Year 2016, Volume: 19 Issue: 1, 57 - 72, 03.01.2016

Hulya Toker

Abstract

Periodontitisle ilişkili birçok sistemik hastalıkta (fazla kiloluluk ve obezite, hipertansiyon,

dislipidemi, tip 2 diyabet, kardiyovasküler hastalıklar, osteoporoz) beslenme ile ilişkili faktörler

rol oynamaktadır. Ayrıca periodontitis düşük serum/plazma mikrobesin seviyeleri ile ilişkilidir.

Son yıllarda rafine karbonhidrat ve doymuş yağlardan zengin diyetin proenflamatuvar, doymamış

yağlar, antioksidan mikrobesinlerin (meyve, sebze, orman meyveleri) antienflamatuar etkili

olduğu ile ilgili güçlü kanıtlar bulunmaktadır.

Mikrobesinler ve periodontal hastalıklar arasındaki ilişkiyi araştıran çok sayıda invitro ve

deneysel çalışma olmasına rağmen insanlarda girişimsel çalışmalar azdır. Periodontal hastalık ile

ilişkileri açısından C vitamin, E vitamin (alfa tokoferol), karotenoidler, polifenoller, flavonoidler

ve diğer antioksidan içerikli fitobileşikler çalışılmıştır. Kesitsel çalışmalardan elde edilen bir

dizi kanıt bitkisel kaynaklı antioksidan besinlerin alımının periodontal tedavi sonuçlarını

geliştirebileceğini gösterir.

Bu derlemede günlük vitamin ve antioksidan ajanların alım tavsiyeleri ile periodontal

hastalıkların tedavisinde mikrobesinlerin muhtemel rolü literatür bilgileri ışığında tartışılacaktır.

Keywords

Periodontitis Mikrobesinler Antioksidanlar

References

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  • Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J. P., Colette, C. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA, 2006. 295(14): p. 1681-7.
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  • Brock, G. R., Butterworth, C. J., Matthews, J. B., Chapple, I.L. Local and systemic total antioxidant capacity in periodontitis and health. J Clin Periodontol, 2004. 31(7): p. 515-21.
  • Chapple, I.L., Milward, M.R., Dietrich, T. The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations. J Nutr, 2007. 137(3): p. 657-64.
  • Toker, H., Akpinar, A., Aydin, H., Poyraz, O. Influence of smoking on interleukin-1beta level, oxidant status and antioxidant status in gingival crevicular fluid from chronic periodontitis patients before and after periodontal treatment. J Periodontal Res, 2012. 47(5): p. 572-7.
  • Akalin, F. A., Baltacioglu, E., Alver, A., Karabulut, E. Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. J Clin Periodontol, 2007. 34(7): p. 558-65.
  • Staudte, H., Guntsch, A., Volpel, A., Sigusch, B. W. Vitamin C attenuates the cytotoxic effects of Porphyromonas gingivalis on human gingival fibroblasts. Arch Oral Biol, 2010. 55(1): p. 40-5.
  • Feghali, K., Feldman, M., La, V. D., Santos, J., Grenier, D. Cranberry Proanthocyanidins: Natural Weapons against Periodontal Diseases. J Agric Food Chem, 2011.
  • Nakamura, H., Ukai, T., Yoshimura, A., Kozuka, Y., Yoshioka, H., Yoshinaga, Y., Abe, Y., Hara, Y. Green tea catechin inhibits lipopolysaccharide-induced bone resorption in vivo. J Periodontal Res, 2010. 45(1): p. 23-30.
  • Carvalho, R. R., Pellizzon, C. H., Justulin, L., Jr., Felisbino, S. L., Vilegas, W., Bruni, F., Lopes-Ferreira, M., Hiruma- Lima, C. A. Effect of mangiferin on the development of periodontal disease: involvement of lipoxin A4, anti- chemotaxic action in leukocyte rolling. Chem Biol Interact, 2009. 179(2-3): p. 344-50.
  • Uchiyama, S., Yamaguchi, M. Oral administration of beta-cryptoxanthin prevents bone loss in ovariectomized rats. Int J Mol Med, 2006. 17(1): p. 15-20.
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  • Toker, H., Akpinar, A., Aydin, H., Poyraz, O. A morphometric and histopathologic evaluation of the effects of propolis on alveolar bone loss in experimental periodontitis in rats. J Periodontol, 2008. 79(6): p. 1089-94.
  • Govindaraj, J.Emmadi, P., Deepalakshmi, Rajaram, V., Prakash, G., Puvanakrishnan, R. Protective effect of proanthocyanidins on endotoxin induced experimental periodontitis in rats. Indian J Exp Biol, 2010. 48(2): p. 133-42.
  • Maruyama, T., Tomofuji, T., Endo, Y., Irie, K., Azuma, T., Ekuni, D., Tamaki, N., Yamamoto, T., Morita, M. Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation. Arch Oral Biol, 2011. 56(1): p. 48-53.
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Micronutrition in periodontal treatment: Antioxidants

Year 2016, Volume: 19 Issue: 1, 57 - 72, 03.01.2016

Hulya Toker

Abstract

Nutritional factors are implicated in several systemic diseases and conditions, including

overweight and obesity, hypertension, dyslipidemia, type 2 diabetes, cardiovascular disease,

osteoporosis that are associated with periodontitis. Also, periodontitis is associated with low

serum/plasma micronutrient levels. In recent years, strong evidence has emerged that diets

rich in refined carbohydrates and saturated fats are pro-inflammatory, whereas those rich in

polyunsaturated fats (fish oils), antioxidant micronutrients (fruits, berries and vegetables) are

anti-inflammatory.

Although numerous studies evaluated the relationship between micronutrients and periodontal

disease, intervention studies in humans are scarce. In relation to periodontal disease, number

of studies have been conducted and include vitamin C, vitamin E (tocopherol), carotenoids,

polyphenols, flavonoids and other pyhtonutrients. There is a body of evidence from crosssectional

studies that support the potential to improve periodontal outcomes by using dietary

antioxidants.

This lecture will discuss the possible role of some micronutrients in the etiology and therapy of

periodontal diseases and makes recommendations for daily nutritional intake for vitamins and

antioxidants.

Keywords

Periodontitis Micronutrition Antioxidants

References

  • Palacios, C., Joshipura, K., Willett, W. Nutrition and health: guidelines for dental practitioners. Oral Dis, 2009. 15(6): p.369-81.
  • O’Keefe, J.H., Gheewala, N.M., O’Keefe, J.O. Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol, 2008. 51(3): p. 249-55.
  • O’Keefe, J. H., Bell, D. S. Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol, 2007. 100(5): p. 899-904.
  • Pischon, N., Heng, N., Bernimoulin, J. P., Kleber, B. M., Willich, S. N., Pischon, T. Obesity, inflammation, and periodontal disease. J Dent Res, 2007. 86(5): p. 400-9.
  • Joshipura, K. J., Ritchie, C. Can the relation between tooth loss and chronic disease be explained by socioeconomic status? Eur J Epidemiol, 2005. 20(3): p. 203-4.
  • Joshipura, K. J., Willett, W. C., Douglass, C. W. The impact of edentulousness on food and nutrient intake. J Am Dent Assoc, 1996. 127(4): p. 459-67.
  • Walls, A. W., Steele, J. G. The relationship between oral health and nutrition in older people. Mech Ageing Dev, 2004. 25(12): p. 853-7.
  • Hung, H. C., Colditz, G., Joshipura, K. J. The association between tooth loss and the selfreported intake of selected CVD related nutrients and foods among US women. Community Dent Oral Epidemiol, 2005. 33(3): p. 167-73.
  • Van der Velden, U., Kuzmanova, D., Chapple, I.L. Micronutritional approaches to periodontal therapy. J Clin Periodontol, 2011. 38 Suppl 11: p. 142-58.
  • Staudte, H., Kranz, S., Volpel, A., Schutze, J., Sigusch, B. W. Comparison of nutrient intake between patients with periodontitis and healthy subjects. Quintessence Int, 2012. 43(10): p. 907-16.
  • Chapple, I. L. Reactive oxygen species and antioxidants in inflammatory diseases. J Clin Periodontol, 1997; 24(5): p.287-96.
  • Chapple, I. L., Brock, G. R., Milward, M. R., Ling, N., Matthews, J. B. Compromised GCF total antioxidant capacity in periodontitis: cause or effect? J Clin Periodontol, 2007. 34(2): p. 103-10.
  • Chapple, I.L., Matthews, J.B. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000, 2007. 43: p. 160-232.
  • D’Aiuto, F., Nibali, L., Parkar, M., Patel, K., Suvan, J., Donos, N. Oxidative stress, systemic inflammation, and severe periodontitis. J Dent Res, 2010. 89(11): p.1241-46.
  • Chapple, I.L. Potential mechanisms underpinning the nutritional modulation of periodontal inflammation. J Am Dent Assoc, 2009. 140(2): p. 178-84.
  • Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J. P., Colette, C. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA, 2006. 295(14): p. 1681-7.
  • Doğan, B., Yılmaz, G., Fentoğlu, Ö., Kırzıoğlu, F. Y. Antioksidan vitaminlerin periodontal sağlıktaki rolü. S.D.Ü. Sağlık Bilimleri Enstitüsü Dergisi, 2010. 1(2): p. 133-41.
  • Brock, G. R., Butterworth, C. J., Matthews, J. B., Chapple, I.L. Local and systemic total antioxidant capacity in periodontitis and health. J Clin Periodontol, 2004. 31(7): p. 515-21.
  • Chapple, I.L., Milward, M.R., Dietrich, T. The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations. J Nutr, 2007. 137(3): p. 657-64.
  • Toker, H., Akpinar, A., Aydin, H., Poyraz, O. Influence of smoking on interleukin-1beta level, oxidant status and antioxidant status in gingival crevicular fluid from chronic periodontitis patients before and after periodontal treatment. J Periodontal Res, 2012. 47(5): p. 572-7.
  • Akalin, F. A., Baltacioglu, E., Alver, A., Karabulut, E. Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. J Clin Periodontol, 2007. 34(7): p. 558-65.
  • Staudte, H., Guntsch, A., Volpel, A., Sigusch, B. W. Vitamin C attenuates the cytotoxic effects of Porphyromonas gingivalis on human gingival fibroblasts. Arch Oral Biol, 2010. 55(1): p. 40-5.
  • Feghali, K., Feldman, M., La, V. D., Santos, J., Grenier, D. Cranberry Proanthocyanidins: Natural Weapons against Periodontal Diseases. J Agric Food Chem, 2011.
  • Nakamura, H., Ukai, T., Yoshimura, A., Kozuka, Y., Yoshioka, H., Yoshinaga, Y., Abe, Y., Hara, Y. Green tea catechin inhibits lipopolysaccharide-induced bone resorption in vivo. J Periodontal Res, 2010. 45(1): p. 23-30.
  • Carvalho, R. R., Pellizzon, C. H., Justulin, L., Jr., Felisbino, S. L., Vilegas, W., Bruni, F., Lopes-Ferreira, M., Hiruma- Lima, C. A. Effect of mangiferin on the development of periodontal disease: involvement of lipoxin A4, anti- chemotaxic action in leukocyte rolling. Chem Biol Interact, 2009. 179(2-3): p. 344-50.
  • Uchiyama, S., Yamaguchi, M. Oral administration of beta-cryptoxanthin prevents bone loss in ovariectomized rats. Int J Mol Med, 2006. 17(1): p. 15-20.
  • Tomofuji, T., Ekuni, D., Irie, K., Azuma, T., Endo, Y., Tamaki, N., Sanbe, T., Murakami, J., Yamamoto, T., Morita, M. Preventive effects of a cocoa-enriched diet on gingival oxidative stress in experimental periodontitis. J Periodontol, 2009. 80(11): p. 1799-808.
  • Toker, H., Akpinar, A., Aydin, H., Poyraz, O. A morphometric and histopathologic evaluation of the effects of propolis on alveolar bone loss in experimental periodontitis in rats. J Periodontol, 2008. 79(6): p. 1089-94.
  • Govindaraj, J.Emmadi, P., Deepalakshmi, Rajaram, V., Prakash, G., Puvanakrishnan, R. Protective effect of proanthocyanidins on endotoxin induced experimental periodontitis in rats. Indian J Exp Biol, 2010. 48(2): p. 133-42.
  • Maruyama, T., Tomofuji, T., Endo, Y., Irie, K., Azuma, T., Ekuni, D., Tamaki, N., Yamamoto, T., Morita, M. Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation. Arch Oral Biol, 2011. 56(1): p. 48-53.
  • Ozdemir, H., Kara, M. I., Erciyas, K., Ozer, H., Ay, S. Preventive effects of thymoquinone in a rat periodontitis model: a morphometric and histopathological study. J Periodontal Res, 2012. 47(1): p. 74-80.
  • Mazzotta, M.Y. Nutrition and wound healing. J Am Pediatr Med Assoc, 1994. 84(9): p. 456-62.
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There are 73 citations in total.

Details

Journal Section Review
Authors

Hulya Toker

Publication Date January 3, 2016
Submission Date December 6, 2016
Published in Issue Year 2016Volume: 19 Issue: 1

Cite

EndNote Toker H (January 1, 2016) Micronutrition in periodontal treatment: Antioxidants. Cumhuriyet Dental Journal 19 1 57–72.

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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