Research Article
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Year 2025, Volume: 28 Issue: 3, 397 - 404, 30.09.2025

Havva Bakal , Ayşenur Bakal , Nalan Ünal , Elif Şener , Emıne Zuhal Tugsel , Ahmet Ömer Özütemiz

https://doi.org/10.7126/cumudj.1671395

Abstract

References

  • 1. Proff P. Malocclusion, mastication and the gastrointestinal system. J Orofac Orthop 2010;71:96-107.
  • 2. Biesalski HK. Ernährung. In: Schmidt RF, Lang F (eds). Physiologie des Menschen mit Pathophysiologie. Berlin-Heidelberg: Springer; 2007\:Kap 37.
  • 3. Vaupel P. Funktionen des Magen-Darm-Kanals. In: Schmidt RF, Lang F (eds). Physiologie des Menschen mit Pathophysiologie. Berlin-Heidelberg: Springer; 2007\:Kap 38.
  • 4. N’Gom PI, Woda A. Influence of impaired mastication on nutrition. J Prosthet Dent 2002;87:667-673.
  • 5. Carretero D, Sánchez-Ayala A, Rodriguez A, Lagravère MO, Gonçalves TMSV, Garcia RC. Relationship between non-ulcerative functional dyspepsia, occlusal pairs, and masticatory performance in partially edentulous elderly persons. Gerodontology 2011;28:296-301.
  • 6. Sierpinska T, Golebiewska M, Dlugosz J, Kemona A, Laszewicz W. Connection between masticatory efficiency and pathomorphologic changes in gastric mucosa. Quintessence Int 2007;38:31-37.
  • 7. Kumar A, Almotairy N, Merzo JJ, Wendin K, Rothenberg E, Grigoriadis A, Sandborgh-Englund G, Trulsson M. Chewing and its influence on swallowing, gastrointestinal and nutrition-related factors: a systematic review. Crit Rev Food Sci Nutr 2023;63:11987-12017.
  • 8. Behr M. Braucht der Mensch Zähne? Dtsch Zahnärztl Z 2003;58:393-400.
  • 9. Mahadeva S, Goh KL. Epidemiology of functional dyspepsia: A global perspective. World J Gastroenterol 2006;12:2661-2666.
  • 10. Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, Stanghellini V. Functional gastroduodenal disorders. Gastroenterology 2006;130:1466-1479.
  • 11. Ford AC, Marwaha A, Sood R, Moayyedi P. Global prevalence of, and risk factors for, uninvestigated dyspepsia: A meta-analysis. Gut 2015;64:1049-1057.
  • 12. Talley NJ, Ford AC. Functional dyspepsia. N Engl J Med 2015;373:1853-1863.
  • 13. Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Talley NJ. Do distinct dyspepsia subgroups exist in the community? A population-based study. Am J Gastroenterol 2007;102:1983-1989.
  • 14. Lee K, Kwon CI, Yeniova AÖ, Koyanagi A, Jacob L, Smith L, Lee SW, Rahmati M, Shin JY, Shin JI, Cho W, Yon DK. Global prevalence of functional dyspepsia according to Rome criteria, 1990-2020: a systematic review and meta-analysis. Sci Rep 2024;14:4172.
  • 15. Özden A, Çetinkaya H, Dumlu G. Ankara’da toplumun değişik kesimlerinde dispepsi görülme sıklığı. Türk J Gastroenterol 1996;6:121-124.
  • 16. Coşkun A, Hepatobiliyer hastalıklarda Helicobacter pylori, üst gastrointestinal sistem endoskopik bulguları ve tümör markırlarının değerlendirilmesi. YÖK Tez No: 479929, Tıpta Uzmanlık Tezi, Türkçe, 2005.
  • 17. Özaydın N, Türkyılmaz S, Cali S. TURHEP Turkey Helicobacter Pylori Prevalence Survey, 2003 Survey Report. İstanbul: Eray Basım Hizm Tic Ltd Şti.2007, pp.74
  • 18. Özden A. Dispepsi (Dyspepsia). Güncel Gastroenteroloji 2016;4:272-282.
  • 19. Li W, Liu J, Chen S, Wang Y, Zhang Z. Prevalence of dental erosion among people with gastroesophageal reflux disease in China. J Prosthet Dent 2017;117:48-54.
  • 20. Watanabe M, Nakatani E, Yoshikawa H, Kanno T, Nariai Y, Yoshino A, Vieth M, Kinoshita Y, Sekine J. Oral soft tissue disorders are associated with gastroesophageal reflux disease: Retrospective study. BMC Gastroenterol 2017;17:92.
  • 21. O’Sullivan E, Milosevic A. UK National Clinical Guidelines in Paediatric Dentistry: diagnosis, prevention and management of dental erosion. Int J Paediatr Dent 2008;18(Suppl 1):29-38.
  • 22. Tuğut F, Doğan D, Polat T. Gastroözofagal reflü hastalığı olan bireylerdeki diş erozyon sıklığının araştırılması. Cumhuriyet Dent J 2009;12:29-32.
  • 23. Smith BG, Knight JK. An index for measuring the wear of teeth. Br Dent J 1984;156:435-438.
  • 24. Silva MA, Damante JH, Stipp AC, Tolentino MM, Carlotto PR, Fleury RN. Gastroesophageal reflux disease: New oral findings. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:301-310.
  • 25. Ranjitkar S, Smales RJ, Kaidonis JA. Oral manifestations of gastroesophageal reflux disease. J Gastroenterol Hepatol 2012;27:21-27.
  • 26. el-Omar EM, Banerjee S, Wirz A, McColl KE. The Glasgow Dyspepsia Severity Score--a tool for the global measurement of dyspepsia. Eur J Gastroenterol Hepatol 1996;8:967-976.
  • 27. McColl K, Murray L, El-Omar E, Dickson A, El-Nujumi A, Wirz A, Kelman A, Penny C, Knill-Jones R, Hilditch T. Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med 1998;339:1869-1874.
  • 28. Zhu Y, Hollis JH. Tooth loss and its association with dietary intake and diet quality in American adults. J Dent 2014;42:1428-1435.
  • 29. Jabr CL, Oliveira LP, Pero AC, de Assis Mollo Júnior F, Filho JNA. Masticatory performance, self-perception of oral health, oral health-related quality of life and nutritional status of completely edentulous elderly patients submitted to different rehabilitation treatments: A cross-sectional study. J Oral Rehabil 2024;51:724-732.
  • 30. Miura H, Araki Y, Umenai T. Chewing activity and activities of daily living in the elderly. J Oral Rehabil 1997;24:630-634.
  • 31. Adibi P, Keshteli AH, Saneei M, Saneei P, Savabi O, Esmaillzadeh A. Relationship between tooth loss, functional dyspepsia, and gastro-esophageal reflux disorder among Isfahani adults. Arch Iran Med 2016;19:123-130.
  • 32. Hattori Y, Mito Y, Watanabe M. Gastric emptying rate in subjects with experimentally shortened dental arches: A pilot study. J Oral Rehabil 2008;35:392-397.
  • 33. Keshteli AH, Feizi A, Esmaillzadeh A, Zaribaf F, Feinle-Bisset C, Talley NJ, Adibi P. Patterns of dietary behaviours identified by latent class analysis are associated with chronic uninvestigated dyspepsia. Br J Nutr 2015;113:803-812.
  • 34. Sinn DH, Shin DH, Lim SW, Kim KM, Son HJ, Kim JJ, Rhee JC, Rhee PL. The speed of eating and functional dyspepsia in young women. Gut Liver 2010;4:173-178.
  • 35. Bruno V, Amato M, Catapano S, Iovino P. Dental erosion in patients seeking treatment for gastrointestinal complaints: A case series. J Med Case Rep 2015;9:250.
  • 36. Song JY, Kim HH, Cho EJ, Kim TY. The relationship between gastroesophageal reflux disease and chronic periodontitis. Gut Liver 2014;8:280-287.
  • 37. Zahedi L, Jafari E, Torabi Parizi M, Shafieipour S, Abbasi MH, Moghadam SD, Zahedi MJ. The Association between Oral Hygiene and Gastric Pathology in Patients with Dyspepsia: a Cross-Sectional Study in Southeast Iran. Middle East J Dig Dis 2017;9:33-38.

Investigating the Potential Association between Functional Dyspepsia and Oro-Dental Health

Year 2025, Volume: 28 Issue: 3, 397 - 404, 30.09.2025

Havva Bakal , Ayşenur Bakal , Nalan Ünal , Elif Şener , Emıne Zuhal Tugsel , Ahmet Ömer Özütemiz

https://doi.org/10.7126/cumudj.1671395

Abstract

Objectives: The aim of this study is to assess the relationship between dyspepsia and orodental status in patients diagnosed with functional dyspepsia (FD) and uninvestigated dyspepsia (UD).
Materials and Methods: A cross-sectional study was conducted from February to July 2018, involving orodental examinations of 199 participants. The participants were divided into three groups: FD, UD, and a control group. FD diagnosis was made based on the Rome III criteria. The Glasgow Dyspepsia Severity Score was applied to patients with FD. The orodental examination included the assessment of missing, decayed, and filled teeth, tooth mobility, erosion, and mucosal inflammation. Statistical analysis was performed using multivariate logistic regression.
Results: No significant association was observed between orodental health and FD or the control group. However, subgroup analysis revealed a significant association between decayed teeth, eating within 20 minutes, and oral mucosal inflammation with UD. Additionally, a statistically significant relationship was found between low educational level and functional dyspepsia. No significant relationship was identified between the Glasgow Dyspepsia Severity Score, demographic data, and orodental health.
Conclusion: This study identified a positive association between low educational status and FD, as well as a correlation between decayed teeth, oral mucosal inflammation, and eating habits (specifically eating faster than 20 minutes) with UD.

Keywords

dyspepsia tooth loss mastication tooth oral hygiene

References

  • 1. Proff P. Malocclusion, mastication and the gastrointestinal system. J Orofac Orthop 2010;71:96-107.
  • 2. Biesalski HK. Ernährung. In: Schmidt RF, Lang F (eds). Physiologie des Menschen mit Pathophysiologie. Berlin-Heidelberg: Springer; 2007\:Kap 37.
  • 3. Vaupel P. Funktionen des Magen-Darm-Kanals. In: Schmidt RF, Lang F (eds). Physiologie des Menschen mit Pathophysiologie. Berlin-Heidelberg: Springer; 2007\:Kap 38.
  • 4. N’Gom PI, Woda A. Influence of impaired mastication on nutrition. J Prosthet Dent 2002;87:667-673.
  • 5. Carretero D, Sánchez-Ayala A, Rodriguez A, Lagravère MO, Gonçalves TMSV, Garcia RC. Relationship between non-ulcerative functional dyspepsia, occlusal pairs, and masticatory performance in partially edentulous elderly persons. Gerodontology 2011;28:296-301.
  • 6. Sierpinska T, Golebiewska M, Dlugosz J, Kemona A, Laszewicz W. Connection between masticatory efficiency and pathomorphologic changes in gastric mucosa. Quintessence Int 2007;38:31-37.
  • 7. Kumar A, Almotairy N, Merzo JJ, Wendin K, Rothenberg E, Grigoriadis A, Sandborgh-Englund G, Trulsson M. Chewing and its influence on swallowing, gastrointestinal and nutrition-related factors: a systematic review. Crit Rev Food Sci Nutr 2023;63:11987-12017.
  • 8. Behr M. Braucht der Mensch Zähne? Dtsch Zahnärztl Z 2003;58:393-400.
  • 9. Mahadeva S, Goh KL. Epidemiology of functional dyspepsia: A global perspective. World J Gastroenterol 2006;12:2661-2666.
  • 10. Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, Stanghellini V. Functional gastroduodenal disorders. Gastroenterology 2006;130:1466-1479.
  • 11. Ford AC, Marwaha A, Sood R, Moayyedi P. Global prevalence of, and risk factors for, uninvestigated dyspepsia: A meta-analysis. Gut 2015;64:1049-1057.
  • 12. Talley NJ, Ford AC. Functional dyspepsia. N Engl J Med 2015;373:1853-1863.
  • 13. Choung RS, Locke GR, Schleck CD, Zinsmeister AR, Talley NJ. Do distinct dyspepsia subgroups exist in the community? A population-based study. Am J Gastroenterol 2007;102:1983-1989.
  • 14. Lee K, Kwon CI, Yeniova AÖ, Koyanagi A, Jacob L, Smith L, Lee SW, Rahmati M, Shin JY, Shin JI, Cho W, Yon DK. Global prevalence of functional dyspepsia according to Rome criteria, 1990-2020: a systematic review and meta-analysis. Sci Rep 2024;14:4172.
  • 15. Özden A, Çetinkaya H, Dumlu G. Ankara’da toplumun değişik kesimlerinde dispepsi görülme sıklığı. Türk J Gastroenterol 1996;6:121-124.
  • 16. Coşkun A, Hepatobiliyer hastalıklarda Helicobacter pylori, üst gastrointestinal sistem endoskopik bulguları ve tümör markırlarının değerlendirilmesi. YÖK Tez No: 479929, Tıpta Uzmanlık Tezi, Türkçe, 2005.
  • 17. Özaydın N, Türkyılmaz S, Cali S. TURHEP Turkey Helicobacter Pylori Prevalence Survey, 2003 Survey Report. İstanbul: Eray Basım Hizm Tic Ltd Şti.2007, pp.74
  • 18. Özden A. Dispepsi (Dyspepsia). Güncel Gastroenteroloji 2016;4:272-282.
  • 19. Li W, Liu J, Chen S, Wang Y, Zhang Z. Prevalence of dental erosion among people with gastroesophageal reflux disease in China. J Prosthet Dent 2017;117:48-54.
  • 20. Watanabe M, Nakatani E, Yoshikawa H, Kanno T, Nariai Y, Yoshino A, Vieth M, Kinoshita Y, Sekine J. Oral soft tissue disorders are associated with gastroesophageal reflux disease: Retrospective study. BMC Gastroenterol 2017;17:92.
  • 21. O’Sullivan E, Milosevic A. UK National Clinical Guidelines in Paediatric Dentistry: diagnosis, prevention and management of dental erosion. Int J Paediatr Dent 2008;18(Suppl 1):29-38.
  • 22. Tuğut F, Doğan D, Polat T. Gastroözofagal reflü hastalığı olan bireylerdeki diş erozyon sıklığının araştırılması. Cumhuriyet Dent J 2009;12:29-32.
  • 23. Smith BG, Knight JK. An index for measuring the wear of teeth. Br Dent J 1984;156:435-438.
  • 24. Silva MA, Damante JH, Stipp AC, Tolentino MM, Carlotto PR, Fleury RN. Gastroesophageal reflux disease: New oral findings. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:301-310.
  • 25. Ranjitkar S, Smales RJ, Kaidonis JA. Oral manifestations of gastroesophageal reflux disease. J Gastroenterol Hepatol 2012;27:21-27.
  • 26. el-Omar EM, Banerjee S, Wirz A, McColl KE. The Glasgow Dyspepsia Severity Score--a tool for the global measurement of dyspepsia. Eur J Gastroenterol Hepatol 1996;8:967-976.
  • 27. McColl K, Murray L, El-Omar E, Dickson A, El-Nujumi A, Wirz A, Kelman A, Penny C, Knill-Jones R, Hilditch T. Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med 1998;339:1869-1874.
  • 28. Zhu Y, Hollis JH. Tooth loss and its association with dietary intake and diet quality in American adults. J Dent 2014;42:1428-1435.
  • 29. Jabr CL, Oliveira LP, Pero AC, de Assis Mollo Júnior F, Filho JNA. Masticatory performance, self-perception of oral health, oral health-related quality of life and nutritional status of completely edentulous elderly patients submitted to different rehabilitation treatments: A cross-sectional study. J Oral Rehabil 2024;51:724-732.
  • 30. Miura H, Araki Y, Umenai T. Chewing activity and activities of daily living in the elderly. J Oral Rehabil 1997;24:630-634.
  • 31. Adibi P, Keshteli AH, Saneei M, Saneei P, Savabi O, Esmaillzadeh A. Relationship between tooth loss, functional dyspepsia, and gastro-esophageal reflux disorder among Isfahani adults. Arch Iran Med 2016;19:123-130.
  • 32. Hattori Y, Mito Y, Watanabe M. Gastric emptying rate in subjects with experimentally shortened dental arches: A pilot study. J Oral Rehabil 2008;35:392-397.
  • 33. Keshteli AH, Feizi A, Esmaillzadeh A, Zaribaf F, Feinle-Bisset C, Talley NJ, Adibi P. Patterns of dietary behaviours identified by latent class analysis are associated with chronic uninvestigated dyspepsia. Br J Nutr 2015;113:803-812.
  • 34. Sinn DH, Shin DH, Lim SW, Kim KM, Son HJ, Kim JJ, Rhee JC, Rhee PL. The speed of eating and functional dyspepsia in young women. Gut Liver 2010;4:173-178.
  • 35. Bruno V, Amato M, Catapano S, Iovino P. Dental erosion in patients seeking treatment for gastrointestinal complaints: A case series. J Med Case Rep 2015;9:250.
  • 36. Song JY, Kim HH, Cho EJ, Kim TY. The relationship between gastroesophageal reflux disease and chronic periodontitis. Gut Liver 2014;8:280-287.
  • 37. Zahedi L, Jafari E, Torabi Parizi M, Shafieipour S, Abbasi MH, Moghadam SD, Zahedi MJ. The Association between Oral Hygiene and Gastric Pathology in Patients with Dyspepsia: a Cross-Sectional Study in Southeast Iran. Middle East J Dig Dis 2017;9:33-38.
There are 37 citations in total.

Details

Primary Language English
Subjects Oral Medicine and Pathology, Public Health Dentistry, Dentistry (Other)
Journal Section RA
Authors

Havva Bakal 0000-0002-2729-8439

Ayşenur Bakal 0009-0006-3257-7607

Nalan Ünal 0000-0001-8870-2450

Elif Şener 0000-0003-1402-9392

Emıne Zuhal Tugsel 0000-0001-6723-4440

Ahmet Ömer Özütemiz 0000-0002-6960-4043

Publication Date September 30, 2025
Submission Date April 8, 2025
Acceptance Date May 9, 2025
Published in Issue Year 2025 Volume: 28 Issue: 3

Cite

EndNote Bakal H, Bakal A, Ünal N, Şener E, Tugsel EZ, Özütemiz AÖ (September 1, 2025) Investigating the Potential Association between Functional Dyspepsia and Oro-Dental Health. Cumhuriyet Dental Journal 28 3 397–404.
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