A disparity between host defense and periodontopathogens leads to periodontitis, which is an inflammatory disease of the periodontium of high prevalence. The dysregulated host immune response brought on by the disease’s ongoing progression may result in tissue and bone destruction, which ultimately leads to tooth loss. Interpretation of bone metabolism has enhanced as a result of the identification of sclerostin and its function as a bone mass regulator. Primarily, osteocytes express sclerostin, an SOST gene known to inhibit formation of bone. The canonical Wnt pathway involved in bone homeostasis, is significantly suppressed by Sclerostin. It is thought to result in resorption of bone by altering the ratio of OPG and RANKL. Characteristics, mode of action and significance of sclerostin in periodontal diseases are discussed in this review.
|Subjects||Health Care Administration|
|Publication Date||September 29, 2023|
|Submission Date||January 17, 2023|
|Published in Issue||Year 2023Volume: 26 Issue: 3|
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
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