Sclerostin - The silent bone breaker

K B Roshni; Neetha J Shetty; Deepa Giridhar Kamath

doi:10.7126/cumudj.1235788

EN

Sclerostin - The silent bone breaker

Abstract

A disparity between host defense and periodontopathogens leads to periodontitis, which is an inflammatory disease of the periodontium of high prevalence. The dysregulated host immune response brought on by the disease’s ongoing progression may result in tissue and bone destruction, which ultimately leads to tooth loss. Interpretation of bone metabolism has enhanced as a result of the identification of sclerostin and its function as a bone mass regulator. Primarily, osteocytes express sclerostin, an SOST gene known to inhibit formation of bone. The canonical Wnt pathway involved in bone homeostasis, is significantly suppressed by Sclerostin. It is thought to result in resorption of bone by altering the ratio of OPG and RANKL. Characteristics, mode of action and significance of sclerostin in periodontal diseases are discussed in this review.

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Review

Authors

K B Roshni
0000-0001-8097-2800
India

Neetha J Shetty ^*
0000-0001-8841-6235
India

Deepa Giridhar Kamath
0000-0002-8546-9590
India

Publication Date

September 29, 2023

Submission Date

January 17, 2023

Acceptance Date

August 21, 2023

Published in Issue

Year 2023 Volume: 26 Number: 3

DOI

https://doi.org/10.7126/cumudj.1235788

IZ

https://izlik.org/JA42DK87DK

Cite

RIS / Bibtex

EndNote

Roshni KB, Shetty NJ, Giridhar Kamath D (September 1, 2023) Sclerostin - The silent bone breaker. Cumhuriyet Dental Journal 26 3 328–331.

Sclerostin - The silent bone breaker

Öz

Anahtar Kelimeler

Sclerostin - The silent bone breaker

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite