Abstract
References
- 1. Littlewood SJ, Kandasamy S, Huang G. Retention and relapse in clinical practice. Aust Dent J 2017; 62:51–7
- 2. Vaida L, Todor BI, Lile IE, Mut A-M, Mihaiu A, Todor L. Contention following the orthodontic treatment and prevalence of relapse. HMV Bioflux 2019;11:37-42
- 3. Franzen TJ, Brudvik P, Vandevska-Radunoviv V. Periodontal tissue reaction during orthodontic relapse in rat molars. Eur J Orthod 2013;35:152-9
- 4. Schneider DA, Smith SM, Campbell C, Hayami T, Kapila S, Hatch NE. Locally limited inhibition of bone resorption and orthodontic relapse by recombinant osteoprotegerin protein. Orthod Craniofac Res 2015;18:187-95
- 5. Zhao N, Lin J, Kanzaki H, Ni J, Chen Z, Liang W, et al. Local osteoprotegerin gene transfer inhibits relapse of orthodontic tooth movement. Am J Orthod Dentofacial Orthop 2012;141:30-40
- 6. Krishnan S, Pandian S, Kumar SA. Effect of bisphosphonates on orthodontic tooth movement—an update. J Clin Diagn Res 2015; 9:ZE01-ZE05
- 7. George EL, Lin Y-L, Saunders MM. Bisphosphonate-related osteonecrosis of the jaw: a mechanobiology perspective. Bone Reports 2018;8:104-9
- 8. Otto S. Medication-related osteonecrosis of the jaws: bisphosphonate, denosumab, and new agents. Germany: Springer-Verlag Berlin Heidelberg 2015.
- 9. Vaisman DN, McCarthy AD, Cortizo AM. Bone-specific alkaline phosphatase activity is inhibited by bisphosphonates: role of divalent cations. Biol Trace Elem Res 2005;104:131-40
- 10. De Ponte FS. Bisphosphonates and osteonecrosis of the jaw: a multidisciplinary approach. Messina/ Italy: Springer-Verlag Mailand 2012.
- 11. Kwok HB, Kim JY, Kim KJ, Choi M-K, Kim J-J, Kim KM, et al. Risedronate directly inhibits osteoclast differentiation and inflammatory bone loss. Biol Pharm Bull 2009;32:1193-8
- 12. Kalfas IH. Principles of bone healing. Neurosurg Focus 2001;10:E1
- 13. Zarina ZAI, Hisham ZAS, Rohaya MAW, Sahidan S, Zaidah ZA. Osteoclast and osteoblast development of Mus musculus haemopoietic mononucleated cells. Journal of Biological Sciences 2008;8:506-16
- 14. Sabokbar A, Millett PJ, Myer B, Rushton N. A rapid, quantitative assay for measuring alkaline phosphatase activity in osteoblastic cells in vitro. Bone Miner 1994;27:57–67.
- 15. Dhopatkar AA, Sloan AJ, Rock WP, Cooper PR, Smith AJ. A novel in vitro culture model to investigate the reaction of the dentine-pulp complex to orthodontic force. J Orthod 2005;32:122-32.
- 16. Perinetti G, Paolantonio M, Serra E, D’Archivio D, D’Ercole S, Festa F, et al. Longitudinal monitoring of subgingival colonization by Actinobacillus actinomycetemcomitans, and crevicular alkaline phosphatase and aspartate aminotransferase activities around orthodontically treated teeth. J Clin Periodontol 2004;31:60-7
- 17. Saito T, Tabata Y. Preparation of gelatin hydrogels incorporating low-molecular-weight heparin for anti-fibrotic therapy. Acta Biomater 2012;8:646-52
- 18. Boateng JS, Matthews KH, Stevens HNE, Eccleston GM. Wound healing dressing and drug delivery systems: a review. J Pharm Sci 2008; 97:2892-923
- 19. Santoso MIE. Buku ajar etik penelitian kesehatan [Health research ethics textbook]. Malang: Universitas Brawijaya Press 2011. [in Indonesian]
- 20. Ikada Y, Tabata Y. Protein release from gelatin matrices. Adv Drug Deliv Rev 1998; 31:288-301
- 21. Asma AAA, Rohaya MAW, Hisham ZAS. Crevicular alkaline phosphatase activity during orthodontic tooth movement: canine retraction stage. J Med Sci 2008;8:228–33
- 22. Batra P, Kharbanda Op, Duggal R, Singh N, Parkash H. Alkaline phosphatase activity in gingival crevicular fluid during canine retraction. Orthod Craniofac Res 2006;9:44-51
- 23. Im G-I, Qureshi SA, Kenney J, Rubash HE, Shanbhag AS. Osteoblast proliferation and maturation by bisphosphonates. Biomaterials 2004;25:4105–15
- 24. Baron R, Neff L, Tran-Va P, Nefussi JR, Vignery A. Kinetic and cytochemical identification of osteoclast precursors and their differentiation into multinucleated osteoclast. Am J Pathol 1986; 122:363-78
- 25. Lerner UH. New molecules in the tumor necrosis factor ligand and receptor superfamilies with importance for physiological and pathological bone resorption. Crit Rev Oral Biol Med 2004;15:64-81
- 26. Kasperk C. Human bone cell phenotypes differ depending on their skeletal site of origin. J Clin Endocrinol Metab 1995;80:2511-7
- 27. Maltha JC, Vandevska-Radunovic V, Kuijpers-Jagtman AM. The biological background of relapse of orthodontic tooth movement. In: Krishnan V, Davidovitch Z. Biological mechanisms of tooth movement. NJ: John Wiley & Sons Ltd 2015.
- 28. Noxon SJ, King GJ, Gu G, Huang G. Osteoclast clearance from periodontal tissues during orthodontic tooth movement. Am J Orthod Dentofacial Orthop 2001;120:466–76
- 29. Von Knoch F, Jaquiery C, Kowalsky C, Schaeren S, Alabre C, Martin I, et al. Effects of bisphosphonates on proliferation and osteoblast differentiation of human bone marrow stromal cells. Biomaterials 2005;26:6941–9
- 30. Rodan GA, Martin TJ. Therapeutic approaches to bone diseases. Science 2000;289:1508–14
- 31. Maruotti N, Corrado A, Neve A, Cantatore FP. Bisphosphonates: effects on osteoblast. Eur J Clin Pharmacol 2012;68:1013-8
- 32. Cetinkaya BO, Keles GC, Ayas B, Gurgor P. Effects of risedronate on alveolar bone loss and angiogenesis: a stereologic study in rats. J Periodontol 2008;79(10):1950-61
THE EFFECT OF BISPHOSPHONATE RISEDRONATE HYDROGEL ON ALKALINE PHOSPHATASE AND OSTEOCLASTS DURING RELAPSE MOVEMENT
Abstract
Objectives: To analyze the effect of risedronate hydrogel on enzyme alkaline phosphatase (ALP) and osteoclast/osteoblast ratio during tooth relapse movement
Materials and methods: The research design is experimental with time series. The lower incisors of 75 guinea pigs are distally moved using open coil spring. The guinea pigs were divided into three groups: without risedronate (group A; n = 25); given 250 µmol/L of risedronate hydrogel (group B; n = 25), and given 500 µmol/L of risedronate hydrogel (group C; n = 25). Risedronate were applied intrasulcularly in the mesial part of the gingival sulcus every 3 days. After 14 days of stabilization, the open coil spring was removed (bisphosphonate administration was continued). The relapsed teeth and ALP levels on days 0, 3, 7, 14, and 21 were measured. The osteoclast/osteoblast ratio was measured by hematoxylin and eosin staining. ANOVA test was used to determine the difference in the three groups and their interactions with concentration and time.
Results: There was a significant difference in osteoclast/osteoblast ratio on day 3 (p = 0.019, p <0.05) and 14 (p = 0.019, p <0.05): the ratio was higher in group A than in groups B and C on day 3, and the ratio was higher in group C than in groups A and B on day 14. ALP levels were significantly different on day 14 (p = 0.006, p <0.05) and 21 (p = 0.012, p <0.05). Conclusions: The intrasulcular application of bisphosphonate risedronate affected the osteoclast/osteoblast ratio and increased ALP levels.
References
- 1. Littlewood SJ, Kandasamy S, Huang G. Retention and relapse in clinical practice. Aust Dent J 2017; 62:51–7
- 2. Vaida L, Todor BI, Lile IE, Mut A-M, Mihaiu A, Todor L. Contention following the orthodontic treatment and prevalence of relapse. HMV Bioflux 2019;11:37-42
- 3. Franzen TJ, Brudvik P, Vandevska-Radunoviv V. Periodontal tissue reaction during orthodontic relapse in rat molars. Eur J Orthod 2013;35:152-9
- 4. Schneider DA, Smith SM, Campbell C, Hayami T, Kapila S, Hatch NE. Locally limited inhibition of bone resorption and orthodontic relapse by recombinant osteoprotegerin protein. Orthod Craniofac Res 2015;18:187-95
- 5. Zhao N, Lin J, Kanzaki H, Ni J, Chen Z, Liang W, et al. Local osteoprotegerin gene transfer inhibits relapse of orthodontic tooth movement. Am J Orthod Dentofacial Orthop 2012;141:30-40
- 6. Krishnan S, Pandian S, Kumar SA. Effect of bisphosphonates on orthodontic tooth movement—an update. J Clin Diagn Res 2015; 9:ZE01-ZE05
- 7. George EL, Lin Y-L, Saunders MM. Bisphosphonate-related osteonecrosis of the jaw: a mechanobiology perspective. Bone Reports 2018;8:104-9
- 8. Otto S. Medication-related osteonecrosis of the jaws: bisphosphonate, denosumab, and new agents. Germany: Springer-Verlag Berlin Heidelberg 2015.
- 9. Vaisman DN, McCarthy AD, Cortizo AM. Bone-specific alkaline phosphatase activity is inhibited by bisphosphonates: role of divalent cations. Biol Trace Elem Res 2005;104:131-40
- 10. De Ponte FS. Bisphosphonates and osteonecrosis of the jaw: a multidisciplinary approach. Messina/ Italy: Springer-Verlag Mailand 2012.
- 11. Kwok HB, Kim JY, Kim KJ, Choi M-K, Kim J-J, Kim KM, et al. Risedronate directly inhibits osteoclast differentiation and inflammatory bone loss. Biol Pharm Bull 2009;32:1193-8
- 12. Kalfas IH. Principles of bone healing. Neurosurg Focus 2001;10:E1
- 13. Zarina ZAI, Hisham ZAS, Rohaya MAW, Sahidan S, Zaidah ZA. Osteoclast and osteoblast development of Mus musculus haemopoietic mononucleated cells. Journal of Biological Sciences 2008;8:506-16
- 14. Sabokbar A, Millett PJ, Myer B, Rushton N. A rapid, quantitative assay for measuring alkaline phosphatase activity in osteoblastic cells in vitro. Bone Miner 1994;27:57–67.
- 15. Dhopatkar AA, Sloan AJ, Rock WP, Cooper PR, Smith AJ. A novel in vitro culture model to investigate the reaction of the dentine-pulp complex to orthodontic force. J Orthod 2005;32:122-32.
- 16. Perinetti G, Paolantonio M, Serra E, D’Archivio D, D’Ercole S, Festa F, et al. Longitudinal monitoring of subgingival colonization by Actinobacillus actinomycetemcomitans, and crevicular alkaline phosphatase and aspartate aminotransferase activities around orthodontically treated teeth. J Clin Periodontol 2004;31:60-7
- 17. Saito T, Tabata Y. Preparation of gelatin hydrogels incorporating low-molecular-weight heparin for anti-fibrotic therapy. Acta Biomater 2012;8:646-52
- 18. Boateng JS, Matthews KH, Stevens HNE, Eccleston GM. Wound healing dressing and drug delivery systems: a review. J Pharm Sci 2008; 97:2892-923
- 19. Santoso MIE. Buku ajar etik penelitian kesehatan [Health research ethics textbook]. Malang: Universitas Brawijaya Press 2011. [in Indonesian]
- 20. Ikada Y, Tabata Y. Protein release from gelatin matrices. Adv Drug Deliv Rev 1998; 31:288-301
- 21. Asma AAA, Rohaya MAW, Hisham ZAS. Crevicular alkaline phosphatase activity during orthodontic tooth movement: canine retraction stage. J Med Sci 2008;8:228–33
- 22. Batra P, Kharbanda Op, Duggal R, Singh N, Parkash H. Alkaline phosphatase activity in gingival crevicular fluid during canine retraction. Orthod Craniofac Res 2006;9:44-51
- 23. Im G-I, Qureshi SA, Kenney J, Rubash HE, Shanbhag AS. Osteoblast proliferation and maturation by bisphosphonates. Biomaterials 2004;25:4105–15
- 24. Baron R, Neff L, Tran-Va P, Nefussi JR, Vignery A. Kinetic and cytochemical identification of osteoclast precursors and their differentiation into multinucleated osteoclast. Am J Pathol 1986; 122:363-78
- 25. Lerner UH. New molecules in the tumor necrosis factor ligand and receptor superfamilies with importance for physiological and pathological bone resorption. Crit Rev Oral Biol Med 2004;15:64-81
- 26. Kasperk C. Human bone cell phenotypes differ depending on their skeletal site of origin. J Clin Endocrinol Metab 1995;80:2511-7
- 27. Maltha JC, Vandevska-Radunovic V, Kuijpers-Jagtman AM. The biological background of relapse of orthodontic tooth movement. In: Krishnan V, Davidovitch Z. Biological mechanisms of tooth movement. NJ: John Wiley & Sons Ltd 2015.
- 28. Noxon SJ, King GJ, Gu G, Huang G. Osteoclast clearance from periodontal tissues during orthodontic tooth movement. Am J Orthod Dentofacial Orthop 2001;120:466–76
- 29. Von Knoch F, Jaquiery C, Kowalsky C, Schaeren S, Alabre C, Martin I, et al. Effects of bisphosphonates on proliferation and osteoblast differentiation of human bone marrow stromal cells. Biomaterials 2005;26:6941–9
- 30. Rodan GA, Martin TJ. Therapeutic approaches to bone diseases. Science 2000;289:1508–14
- 31. Maruotti N, Corrado A, Neve A, Cantatore FP. Bisphosphonates: effects on osteoblast. Eur J Clin Pharmacol 2012;68:1013-8
- 32. Cetinkaya BO, Keles GC, Ayas B, Gurgor P. Effects of risedronate on alveolar bone loss and angiogenesis: a stereologic study in rats. J Periodontol 2008;79(10):1950-61
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Research Articles |
| Authors | |
| Publication Date | June 30, 2022 |
| Submission Date | May 8, 2021 |
| Published in Issue | Year 2022Volume: 25 Issue: 2 |
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https://doi.org/10.47748/tjvr.1372322
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