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THE EFFECT OF MENOPAUSE ON NADPH OXIDASE LEVELS AFTER NON-SURGICAL PERIODONTAL TREATMENTS ON PATIENTS WITH PERIODONTITIS

Year 2021, Volume: 24 Issue: 4, 415 - 426, 03.01.2022

Mahmut Kayaaltı , Vildan Bostancı , Halef Dogan

https://doi.org/10.7126/cumudj.1000295

Abstract

ABSTRACT
Objectives: This study evaluated the clinical parameters [ plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL) ] and the levels of Nadph Oxidase (NOX-1) in gingival crevicular fluid (GCF) samples of pre-menopausal and post-menopausal periodontally healthy and periodontitis patients.
Materials and Methods: Study included pre-menopausal periodontitis 15, post-menopausal periodontitis 15, pre-menopausal periodontally healthy 15 and post-menopausal periodontally healthy 15; a total of 60 individuals were included.
Results: Clinical periodontal evaluation indices in the 6th week after treatment were found to be statistically significantly lower than the initial values of PI, GI, PPD, CAL in the periodontitis groups(p<0.05). Pre-treatment baseline NOX-1 values were singificantly higher in both periodontitis groups than healthy groups (p<0.05). While the pre-menopausal and post-menopausal periodontitis groups before treatment had similar PI, PPD and CAL values, the GI was found to be significantly higher in the post-menopausal periodontitis group(p <0.05). While NOX-1 values in pre-treatment GCF samples were similar in pre-menopausal and post-menopausal periodontitis groups, NOX-1 values in the post-menopausal periodontitis group at the 6th week after treatment were found to be statistically higher than the pre-menopausal periodontitis group (p <0.05).
Conclusion: According to the results of our study, oxidative stress that increases with menopause may negatively affect the healing potential after periodontal treatment. Accordingly, antioxidant supplementation can be predicted with hormone replacement during this period.

Keywords

Periodontitis Nox-1 Menopause Oxidative Stress

Supporting Institution

Cumhuriyet University Research Scientific Project

Project Number

DIS-248

References

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Year 2021, Volume: 24 Issue: 4, 415 - 426, 03.01.2022

Mahmut Kayaaltı , Vildan Bostancı , Halef Dogan

https://doi.org/10.7126/cumudj.1000295

Abstract

Project Number

DIS-248

References

  • 1. Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Prim. 2017;3:17038. doi:10.1038/nrdp.2017.38
  • 2. Lamster IB, Novak MJ. Host mediators in gingival crevicular fluid: implications for the pathogenesis of periodontal disease. Crit Rev oral Biol Med an Off Publ Am Assoc Oral Biol. 1992;3(1-2):31-60. doi:10.1177/10454411920030010501
  • 3. Van Dyke TE. The management of inflammation in periodontal disease. J Periodontol. 2008;79(8 Suppl):1601-1608. doi:10.1902/jop.2008.080173
  • 4. Kinane DF. Causation and pathogenesis of periodontal disease. Periodontol 2000. 2001;25:8-20. doi:10.1034/j.1600-0757.2001.22250102.x
  • 5. Loesche WJ, Grossman NS. Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clin Microbiol Rev. 2001;14(4):727-752, table of contents. doi:10.1128/CMR.14.4.727-752.2001
  • 6. Kornman KS. Mapping the pathogenesis of periodontitis: a new look. J Periodontol. 2008;79(8 Suppl):1560-1568. doi:10.1902/jop.2008.080213
  • 7. Harzallah O, Kerkeni A, Baati T, Mahjoub S. Oxidative stress: correlation with Behçet’s disease duration, activity and severity. Eur J Intern Med. 2008;19(7):541-547. doi:10.1016/j.ejim.2008.08.001
  • 8. Shah D, Mahajan N, Sah S, Nath SK, Paudyal B. Oxidative stress and its biomarkers in systemic lupus erythematosus. J Biomed Sci. 2014;21(1):23. doi:10.1186/1423-0127-21-23
  • 9. Suzuki K, Ito Y, Ochiai J, et al. Relationship between obesity and serum markers of oxidative stress and inflammation in Japanese. Asian Pac J Cancer Prev. 2003;4(3):259—266. http://europepmc.org/abstract/MED/14507248
  • 10. Dupuy C, Ohayon R, Valent A, Noël-Hudson MS, Dème D, Virion A. Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas. J Biol Chem. 1999;274(52):37265-37269. doi:10.1074/jbc.274.52.37265
  • 11. Bedard K, Krause K-H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007;87(1):245-313. doi:10.1152/physrev.00044.2005
  • 12. Daffu G, del Pozo CH, O’Shea KM, Ananthakrishnan R, Ramasamy R, Schmidt AM. Radical roles for RAGE in the pathogenesis of oxidative stress in cardiovascular diseases and beyond. Int J Mol Sci. 2013;14(10):19891-19910. doi:10.3390/ijms141019891
  • 13. Azumi H, Inoue N, Ohashi Y, et al. Superoxide generation in directional coronary atherectomy specimens of patients with angina pectoris: important role of NAD(P)H oxidase. Arterioscler Thromb Vasc Biol. 2002;22(11):1838-1844. doi:10.1161/01.atv.0000037101.40667.62
  • 14. Gavazzi G, Deffert C, Trocme C, Schäppi M, Herrmann FR, Krause K-H. NOX1 deficiency protects from aortic dissection in response to angiotensin II. Hypertens (Dallas, Tex 1979). 2007;50(1):189-196. doi:10.1161/HYPERTENSIONAHA.107.089706
  • 15. Arbiser JL, Petros J, Klafter R, et al. Reactive oxygen generated by Nox1 triggers the angiogenic switch. Proc Natl Acad Sci U S A. 2002;99(2):715-720. doi:10.1073/pnas.022630199
  • 16. Thum T, Borlak J. Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism? Circ Res. 2004;94(1):e1-13. doi:10.1161/01.RES.0000110081.03480.E9
  • 17. Paik Y-H, Iwaisako K, Seki E, et al. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. 2011;53(5):1730-1741. doi:10.1002/hep.24281
  • 18. Dikalov SI, Dikalova AE, Bikineyeva AT, Schmidt HHHW, Harrison DG, Griendling KK. Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free Radic Biol Med. 2008;45(9):1340-1351. doi:10.1016/j.freeradbiomed.2008.08.013
  • 19. Battino M, Bullon P, Wilson M, Newman H. Oxidative injury and inflammatory periodontal diseases: the challenge of anti-oxidants to free radicals and reactive oxygen species. Crit Rev oral Biol Med an Off Publ Am Assoc Oral Biol. 1999;10(4):458-476. doi:10.1177/10454411990100040301
  • 20. Libermann TA, Baltimore D. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol. 1990;10(5):2327-2334. doi:10.1128/mcb.10.5.2327
  • 21. Chapple ILC. Oxidative stress, nutrition and neutrogenomics in periodontal health and disease. Int J Dent Hyg. 2006;4 Suppl 1:12-15. doi:10.1111/j.1601-5037.2006.00197.x
  • 22. Takahashi TA, Johnson KM. Menopause. Med Clin North Am. 2015;99(3):521-534. doi:10.1016/j.mcna.2015.01.006
  • 23. Mascarenhas P, Gapski R, Al-Shammari K, Wang H-L. Influence of sex hormones on the periodontium. J Clin Periodontol. 2003;30(8):671-681. doi:10.1034/j.1600-051x.2003.00055.x
  • 24. Reinhardt RA, Payne JB, Maze CA, Patil KD, Gallagher SJ, Mattson JS. Influence of estrogen and osteopenia/osteoporosis on clinical periodontitis in postmenopausal women. J Periodontol. 1999;70(8):823-828. doi:10.1902/jop.1999.70.8.823
  • 25. Friedlander AH. The physiology, medical management and oral implications of menopause. J Am Dent Assoc. 2002;133(1):73-81. doi:10.14219/jada.archive.2002.0025
  • 26. Krejci CB, Bissada NF. Women’s health issues and their relationship to periodontitis. J Am Dent Assoc. 2002;133(3):323-329. doi:10.14219/jada.archive.2002.0171
  • 27. Famili P, Cauley J, Suzuki JB, Weyant R. Longitudinal study of periodontal disease and edentulism with rates of bone loss in older women. J Periodontol. 2005;76(1):11-15. doi:10.1902/jop.2005.76.1.11
  • 28. Fleiss JL, Park MH, Chilton NW, Alman JE, Feldman RS, Chauncey HH. Representativeness of the “Ramfjord teeth” for epidemiologic studies of gingivitis and periodontitis. Community Dent Oral Epidemiol. 1987;15(4):221-224. doi:10.1111/j.1600-0528.1987.tb00525.x
  • 29. Cassol-Spanemberg J, Campillo E, Jané-Salas E, Lopez Lopez J. Burning Mouth Syndrome: Update. Oral Health Dent Manag. 2014;13:418-424. doi:10.12974/2311-8695.2014.02.01.2
  • 30. Charleston L 4th. Burning mouth syndrome: a review of recent literature. Curr Pain Headache Rep. 2013;17(6):336. doi:10.1007/s11916-013-0336-9
  • 31. Gardner A, Carpenter G, So P-W. Salivary Metabolomics: From Diagnostic Biomarker Discovery to Investigating Biological Function. Metabolites. 2020;10(2):47. doi:10.3390/metabo10020047
  • 32. Akalin FA, Baltacioğlu E, Alver A, Karabulut E. Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. J Clin Periodontol. 2007;34(7):558-565. doi:10.1111/j.1600-051X.2007.01091.x
  • 33. Tsai CC, Chen HS, Chen SL, et al. Lipid peroxidation: a possible role in the induction and progression of chronic periodontitis. J Periodontal Res. 2005;40(5):378-384. doi:10.1111/j.1600-0765.2005.00818.x
  • 34. Konopka T, Król K, Kopeć W, Gerber H. Total antioxidant status and 8-hydroxy-2’-deoxyguanosine levels in gingival and peripheral blood of periodontitis patients. Arch Immunol Ther Exp (Warsz). 2007;55(6):417-422. doi:10.1007/s00005-007-0047-1
  • 35. Reher VGS, Zenóbio EG, Costa FO, Reher P, Soares R V. Nitric oxide levels in saliva increase with severity of chronic periodontitis. J Oral Sci. 2007;49(4):271-276. doi:10.2334/josnusd.49.271
  • 36. Wei D, Zhang X-L, Wang Y-Z, Yang C-X, Chen G. Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy. Aust Dent J. 2010;55(1):70-78. doi:10.1111/j.1834-7819.2009.01123.x
  • 37. Güllü C, Ozmeric N, Tokman B, Elgün S, Balos K. Effectiveness of scaling and root planing versus modified Widman flap on nitric oxide synthase and arginase activity in patients with chronic periodontitis. J Periodontal Res. 2005;40(2):168-175. doi:10.1111/j.1600-0765.2005.00784.x
  • 38. Batista AC, Silva TA, Chun JH, Lara VS. Nitric oxide synthesis and severity of human periodontal disease. Oral Dis. 2002;8(5):254-260. doi:10.1034/j.1601-0825.2002.02852.x
  • 39. Norderyd OM, Grossi SG, Machtei EE, et al. Periodontal status of women taking postmenopausal estrogen supplementation. J Periodontol. 1993;64(10):957-962. doi:10.1902/jop.1993.64.10.957
  • 40. Tezal M, Wactawski-Wende J, Grossi SG, Ho AW, Dunford R, Genco RJ. The relationship between bone mineral density and periodontitis in postmenopausal women. J Periodontol. 2000;71(9):1492-1498. doi:10.1902/jop.2000.71.9.1492
  • 41. Geurs NC, Lewis CE, Jeffcoat MK. Osteoporosis and periodontal disease progression. Periodontol 2000. 2003;32:105-110. doi:10.1046/j.0906-6713.2003.03208.x
  • 42. Mariotti A, Mawhinney M. Endocrinology of sex steroid hormones and cell dynamics in the periodontium. Periodontol 2000. 2013;61(1):69-88. doi:10.1111/j.1600-0757.2011.00424.x
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There are 59 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Research Articles
Authors

Mahmut Kayaaltı 0000-0002-6660-3053

Vildan Bostancı 0000-0002-4460-301X

Halef Dogan 0000-0001-8738-0760

Project Number DIS-248
Publication Date January 3, 2022
Submission Date September 24, 2021
Published in Issue Year 2021Volume: 24 Issue: 4

Cite

EndNote Kayaaltı M, Bostancı V, Dogan H (January 1, 2022) THE EFFECT OF MENOPAUSE ON NADPH OXIDASE LEVELS AFTER NON-SURGICAL PERIODONTAL TREATMENTS ON PATIENTS WITH PERIODONTITIS. Cumhuriyet Dental Journal 24 4 415–426.
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Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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