EFFECT OF TIDEGLUSIB WITH BONE GRAFTING ON NEW BONE FORMATION

Berrin İyilikci; Ufuk Taşdemir; Özlem Özmen; Alper Kızıldağ

doi:10.7126/cumudj.943229

EN

EFFECT OF TIDEGLUSIB WITH BONE GRAFTING ON NEW BONE FORMATION

Abstract

ABSTRACT Objectives: The goal of this study was to observe the regenerative potential of Tideglusib in combination with autogenous and xenograft mandibular defects in rats. Material Methods: Our study consists of five groups: one control and four experimental. In 40 Wistar albino rats, 5-mm-diameter critical bone defects were created at the angle of the mandible. In the control group, the defect was not filled. The defects were grafted only Xenograft in Group 1, with Xenograft and tideglusib in Group 2, and with only autogenous bone graft in Group3, and with autogenous bone graft mixed with tideglusib in Group 4. Results: Sterological analyses revealed that enhanced new bone formation in the Group 4 compare to Control and Group 1. Immunohistochemically marked expressions of BMP-2 and VEGF were observed in Group 4. Conclusions: Our results demonstrated that Tideglusib, in combination with bone grafting has an adjuvant effect on BMP-2 and VEGF-A expressions that may accelerate bone regeneration.

Keywords

Supporting Institution

This study was supported by the Scientific Research Project Fund of Pamukkale University

Project Number

Project Number: 2018DİŞF011

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Berrin İyilikci
0000-0003-3602-8999
Türkiye

Ufuk Taşdemir ^*
0000-0002-0631-1665
Türkiye

Özlem Özmen
0000-0002-1835-1082
Türkiye

Alper Kızıldağ
0000-0002-1630-3140
Türkiye

Publication Date

September 15, 2021

Submission Date

May 29, 2021

Acceptance Date

July 1, 2021

Published in Issue

Year 1970 Volume: 24 Number: 3

DOI

https://doi.org/10.7126/cumudj.943229

IZ

https://izlik.org/JA26MG75XR

Cite

RIS / Bibtex

EndNote

İyilikci B, Taşdemir U, Özmen Ö, Kızıldağ A (September 1, 2021) EFFECT OF TIDEGLUSIB WITH BONE GRAFTING ON NEW BONE FORMATION. Cumhuriyet Dental Journal 24 3 224–231.

Cited By

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Odontology

https://doi.org/10.1007/s10266-025-01203-4