Case Report
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Traumatic Ulcerative Granuloma with Stromal Eosinophilia (TUGSE)-A Precursor of Oral Squamous Cell Carcinoma?

Year 2020, Volume: 23 Issue: 1, 68 - 71, 18.03.2020
https://doi.org/10.7126/cumudj.648880

Abstract

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a
benign, chronic, reactive, self-healing lesion. It is composed of abundant
eosinophils and small lymphocytes. Several studies have shown varying observations on the relation of
tissue eosinophilia with the prognosis of oral cancer. Here, we present
a case of a 65-year-old male who presented with a non-healing ulcer on the
lateral border of tongue, which was suggestive of TUGSE on histopathological
examination. Patient was kept on strict monthly follow up and the second
re-biopsy was suggestive of moderately differentiated squamous cell carcinoma.
Literature does not support the transformation of TUGSE to oral squamous cell
carcinoma; however, our experience suggests a close vigilance of such lesions
due to its high clinical resemblance to malignancy. Hence, repeat biopsies on
regular basis is mandatory in cases where the clinical picture is highly
suspicious.

Supporting Institution

Not applicable

Project Number

Not applicable

Thanks

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References

  • 1. Medicum C. Ulcerative Granuloma With Stromal Case Report and Short Literature Review. POL J Pathol. 2011;172–5.
  • 2. Hirshberg A, Amariglio N, Akrish S, Yahalom R, Rosenbaum H, Okon E, et al. Traumatic ulcerative granuloma with stromal eosinophilia: A reactive lesion of the oral mucosa. Am J Clin Pathol. 2006;126(4):522–9.
  • 3. Saravani S, Kadeh H, Derakhshanfar G. Tumor-Associated Tissue Eosinophilia in Squamous Cell Carcinoma of Head and Neck. Dent Clin Exp J. 2016;In Press(In Press):90–4.
  • 4. Bankur R, Rodrigues C, Anjaly D, Gopinathan P, Bankur P. Quantitative analysis of tumor-associated tissue eosinophilia in different histological grades of oral squamous cell carcinoma. Indian J Dent Res. 2016;27(5):463.
  • 5. Jain M, Kasetty S, Khan S, Jain NK. Tissue eosinophilia in head and neck squamous neoplasia: An update. Exp Oncol. 2014;36(3):157–61.
  • 6. Yellapurkar S, Natarajan S, Boaz K, Baliga M, Shetty P, Manaktala N, et al. Tumour-associated tissue eosinophilia in oral squamous cell carcinoma- A boon or a bane? J Clin Diagnostic Res. 2016;10(4):ZC65–8.
  • 7. Falconieri G, Luna MA, Pizzolitto S, DeMaglio G, Angione V, Rocco M. Eosinophil-rich squamous carcinoma of the oral cavity: a study of 13 cases and delineation of a possible new microscopic entity. Ann Diagn Pathol. 2008;12(5):322–7.
  • 8. Lowe D, Jorizzo J, Hutt MSR. Tumour-associated eosinophilia: A review. J Clin Pathol. 1981;34(12):1343–8.
  • 9. Landman G, Lauris JRP, Kowalski LP, Latorre MRDO, Oliveira DT, Dorta RG. Tumour-associated tissue eosinophilia as a prognostic factor in oral squamous cell carcinomas. Histopathology. 2003;41(2):152–7.
  • 10. Rakesh N, Devi Y, Majumdar K, Reddy SS, Agarwal K. Tumour associated tissue eosinophilia as a predictor of locoregional recurrence in oral squamous cell carcinoma. J Clin Exp Dent. 2015;7(1):e1–6.
Year 2020, Volume: 23 Issue: 1, 68 - 71, 18.03.2020
https://doi.org/10.7126/cumudj.648880

Abstract

Project Number

Not applicable

References

  • 1. Medicum C. Ulcerative Granuloma With Stromal Case Report and Short Literature Review. POL J Pathol. 2011;172–5.
  • 2. Hirshberg A, Amariglio N, Akrish S, Yahalom R, Rosenbaum H, Okon E, et al. Traumatic ulcerative granuloma with stromal eosinophilia: A reactive lesion of the oral mucosa. Am J Clin Pathol. 2006;126(4):522–9.
  • 3. Saravani S, Kadeh H, Derakhshanfar G. Tumor-Associated Tissue Eosinophilia in Squamous Cell Carcinoma of Head and Neck. Dent Clin Exp J. 2016;In Press(In Press):90–4.
  • 4. Bankur R, Rodrigues C, Anjaly D, Gopinathan P, Bankur P. Quantitative analysis of tumor-associated tissue eosinophilia in different histological grades of oral squamous cell carcinoma. Indian J Dent Res. 2016;27(5):463.
  • 5. Jain M, Kasetty S, Khan S, Jain NK. Tissue eosinophilia in head and neck squamous neoplasia: An update. Exp Oncol. 2014;36(3):157–61.
  • 6. Yellapurkar S, Natarajan S, Boaz K, Baliga M, Shetty P, Manaktala N, et al. Tumour-associated tissue eosinophilia in oral squamous cell carcinoma- A boon or a bane? J Clin Diagnostic Res. 2016;10(4):ZC65–8.
  • 7. Falconieri G, Luna MA, Pizzolitto S, DeMaglio G, Angione V, Rocco M. Eosinophil-rich squamous carcinoma of the oral cavity: a study of 13 cases and delineation of a possible new microscopic entity. Ann Diagn Pathol. 2008;12(5):322–7.
  • 8. Lowe D, Jorizzo J, Hutt MSR. Tumour-associated eosinophilia: A review. J Clin Pathol. 1981;34(12):1343–8.
  • 9. Landman G, Lauris JRP, Kowalski LP, Latorre MRDO, Oliveira DT, Dorta RG. Tumour-associated tissue eosinophilia as a prognostic factor in oral squamous cell carcinomas. Histopathology. 2003;41(2):152–7.
  • 10. Rakesh N, Devi Y, Majumdar K, Reddy SS, Agarwal K. Tumour associated tissue eosinophilia as a predictor of locoregional recurrence in oral squamous cell carcinoma. J Clin Exp Dent. 2015;7(1):e1–6.
There are 10 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Reports
Authors

Mathangi Kumar 0000-0003-1245-2314

Ravindranath Vineetha 0000-0002-8932-9982

Keerthilatha M Pai 0000-0003-0967-5867

Abhay T Kamath 0000-0001-6412-3550

Chetana Chandrashekar 0000-0002-1061-0502

Project Number Not applicable
Publication Date March 18, 2020
Submission Date November 20, 2019
Published in Issue Year 2020Volume: 23 Issue: 1

Cite

EndNote Kumar M, Vineetha R, M Pai K, T Kamath A, Chandrashekar C (March 1, 2020) Traumatic Ulcerative Granuloma with Stromal Eosinophilia (TUGSE)-A Precursor of Oral Squamous Cell Carcinoma?. Cumhuriyet Dental Journal 23 1 68–71.

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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