Research Article
Evaluation of Caffeic Acid Phenethyl Ester Administration in Chronically Stressed Rats with Experimental Periodontitis.
Abstract
References
- 1. Slots J. Periodontology: past, present, perspectives. Periodontol 2000 2013;62:7-19.
- 2. Okoro CA, Strine TW, Eke PI, Dhingra SS, Balluz LS. The association between depression and anxiety and use of oral health services and tooth loss. Community Dent Oral Epidemiol 2012;40:134-144.
- 3. Rai B, Kaur J, Anand SC, Jacobs R. Salivary stress markers, stress, and periodontitis: a pilot study. J Periodontol 2011;82:287-292.
- 4. Gaspersic R, Stiblar-Martincic D, Skaleric U. Influence of restraint stress on ligature-induced periodontitis in rats. Eur J Oral Sci 2002;110:125-129.
- 5. Padgett DA, Marucha PT, Sheridan JF. Restraint stress slows cutaneous wound healing in mice. Brain Behav Immun 1998;12:64-73.
- 6. Allan SM, Tyrrell PJ, Rothwell NJ. Interleukin-1 and neuronal injury. Nat Rev Immunol 2005;5:629-640.
- 7. Simi A, Tsakiri N, Wang P, Rothwell NJ. Interleukin-1 and inflammatory neurodegeneration. Biochem Soc Trans 2007;35:1122-1126.
- 8. de Kloet ER, Joels M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci 2005;6:463-475.
- 9. You Z, Luo C, Zhang W, et al. Pro- and anti-inflammatory cytokines expression in rat's brain and spleen exposed to chronic mild stress: involvement in depression. Behav Brain Res 2011;225:135-141.
- 10. Musazzi L, Milanese M, Farisello P, et al. Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressants. PLoS One 2010;5:e8566.
- 11. Hardingham GE, Fukunaga Y, Bading H. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 2002;5:405-414.12. Samarghandian S, Azimi-Nezhad M, Borji A, Farkhondeh T. Crocus sativus L.(saffron) extract reduces the extent of oxidative stress and proinflammatory state in aged rat kidney. Prog Nutr 2016;18:299-310.
- 13. Genco RJ, Ho AW, Kopman J, Grossi SG, Dunford RG, Tedesco LA. Models to evaluate the role of stress in periodontal disease. Ann Periodontol 1998;3:288-302.14. Akyol S, Ginis Z, Armutcu F, Ozturk G, Yigitoglu MR, Akyol O. The potential usage of caffeic acid phenethyl ester (CAPE) against chemotherapy-induced and radiotherapy-induced toxicity. Cell Biochem Funct 2012;30:438-443.
- 15. Celik S, Gorur S, Aslantas O, Erdogan S, Ocak S, Hakverdi S. Caffeic acid phenethyl ester suppresses oxidative stress in Escherichia coli-induced pyelonephritis in rats. Mol Cell Biochem 2007;297:131-138.16. Ha J, Choi H-S, Lee Y, Lee ZH, Kim H-H. Caffeic acid phenethyl ester inhibits osteoclastogenesis by suppressing NFκB and downregulating NFATc1 and c-Fos. Int Immunopharmacol 2009;9:774-780.
- 17. Kazancioglu HO, Aksakalli S, Ezirganli S, Birlik M, Esrefoglu M, Acar AH. Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture. Drug Des Devel Ther 2015;9:6483-6488.18. Kazancioglu HO, Bereket MC, Ezirganli S, Aydin MS, Aksakalli S. Effects of caffeic acid phenethyl ester on wound healing in calvarial defects. Acta Odontol Scand 2015;73:21-27.
- 19. Koltuksuz U, Mutus HM, Kutlu R, et al. Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats. J Pediatr Surg 2001;36:1504-1509.20. Ucan MC, Koparal M, Agacayak S, et al. Influence of caffeic acid phenethyl ester on bone healing in a rat model. J Int Med Res 2013;41:1648-1654.
- 21. Aguiar JC, Gomes EP, Fonseca-Silva T, et al. Fluoxetine reduces periodontal disease progression in a conditioned fear stress model in rats. J Periodontal Res 2013;48:632-637.22. Gomes EP, Aguiar JC, Fonseca-Silva T, et al. Diazepam reverses the alveolar bone loss and hippocampal interleukin-1beta and interleukin-6 enhanced by conditioned fear stress in ligature-induced periodontal disease in rats. J Periodontal Res 2013;48:151-158.
- 23. Peruzzo DC, Benatti BB, Antunes IB, et al. Chronic stress may modulate periodontal disease: a study in rats. J Periodontol 2008;79:697-704.
- 24. Gurkan A, Emingil G, Nizam N, et al. Therapeutic efficacy of vasoactive intestinal peptide in escherichia coli lipopolysaccharide-induced experimental periodontitis in rats. J Periodontol 2009;80:1655-1664.
- 25. Llavaneras A, Ramamurthy NS, Heikkila P, et al. A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats. J Periodontol 2001;72:1069-1077.
- 26. Lutfioglu M, Sakallioglu U, Sakallioglu EE, Baris S, Gurgor P. The impact of dietary induced hyperparathyroidism on healthy and diseased periodontia: an experimental study in rats. J Clin Periodontol 2012;39:264-271.
- 27. Yilmaz HR, Uz E, Altunbasak A, Sakalli E, Ozcelik N. Anticlastogenic effect of caffeic acid phenethyl ester on cisplatin-induced chromosome aberrations in rat bone marrow cells. Toxicol Ind Health 2010;26:33-37.
- 28. Esen C, Alkan BA, Kirnap M, Akgul O, Isikoglu S, Erel O. The effects of chronic periodontitis and rheumatoid arthritis on serum and gingival crevicular fluid total antioxidant/oxidant status and oxidative stress index. J Periodontol 2012;83:773-779.
- 29. Arabaci T, Kermen E, Ozkanlar S, et al. Therapeutic Effects of Melatonin on Alveolar Bone Resorption After Experimental Periodontitis in Rats: A Biochemical and Immunohistochemical Study. J Periodontol 2015;86:874-881.
- 30. Correa MG, Gomes Campos ML, Marques MR, et al. Outcome of enamel matrix derivative treatment in the presence of chronic stress: histometric study in rats. J Periodontol 2014;85:e259-267.
- 31. Yigit U, Kirzioglu FY, Uguz AC, Naziroglu M, Ozmen O. Is caffeic acid phenethyl ester more protective than doxycycline in experimental periodontitis? Arch Oral Biol 2017;81:61-68.
- 32. Araujo AA, Souza TO, Moura LM, et al. Effect of telmisartan on levels of IL-1, TNF-alpha, down-regulated COX-2, MMP-2, MMP-9 and RANKL/RANK in an experimental periodontitis model. J Clin Periodontol 2013;40:1104-1111.
- 33. Wang R-p, Yao Q, Xiao Y-b, et al. Toll-like receptor 4/nuclear factor-kappa B pathway is involved in myocardial injury in a rat chronic stress model. Stress 2011;14:567-575.
- 34. Kose O, Arabaci T, Kara A, et al. Effects of Melatonin on Oxidative Stress Index and Alveolar Bone Loss in Diabetic Rats With Periodontitis. J Periodontol 2016;87:e82-90.
- 35. Samarghandian S, Azimi-Nezhad M, Borji A, Samini M, Farkhondeh T. Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats. BMC Complement Altern Med 2017;17:249.
- 36. Ekuni D, Tomofuji T, Tamaki N, et al. Mechanical stimulation of gingiva reduces plasma 8-OHdG level in rat periodontitis. Arch Oral Biol 2008;53:324-329.
- 37. Agarwal S, Piesco NP, Johns LP, Riccelli AE. Differential expression of IL-1 beta, TNF-alpha, IL-6, and IL-8 in human monocytes in response to lipopolysaccharides from different microbes. J Dent Res 1995;74:1057-1065.
- 38. Kose O, Arabaci T, Kizildag A, et al. Melatonin prevents radiation-induced oxidative stress and periodontal tissue breakdown in irradiated rats with experimental periodontitis. J Periodontal Res 2017;52:438-446.
Evaluation of Caffeic Acid Phenethyl Ester Administration in Chronically Stressed Rats with Experimental Periodontitis.
Abstract
Objectives: The aim of the present study was to investigate the therapeutic effects of systemic caffeic acid phenethyl ester treatment on oxidative stress and alveolar bone destruction in lipopolysaccharide (LPS)-induced periodontitis in chronically stressed rats.
Materials and Methods: Fourty male Sprague Dawley rats were divided into four groups: 1) control group, 2) experimental periodontitis (EP), 3) EP and chronic stress (CS) group (EP-CS), and 4) EP-CS treated with CAPE (EP-CS-CAPE). To induce periodontitis, LPS was administered into the buccal gingiva of the test groups, and pure saline was administered for the control group. Two test groups were exposed to restraint stress and one group of these groups was treated with only a single dose of CAPE (10 mmol/kg). Likewise, saline was administered in the control, EP, and EP-CS groups. After 14 days, serum samples were collected from the heart, and all rats were sacrificed for analyses. Oxidative stress and interleukin (IL)-1β were investigated. The receptor activator of the nuclear factor kappa B ligand (RANKL) and alveolar bone loss were determined by immunohistochemical analysis
Results: The oxidative stress, alveolar bone loss, IL-1β and RANKL levels were found significantly higher in the EP-CS group compared with control and EP groups (p<0.05). However, the administration of CAPE significantly reduced oxidative stress and IL-1β in the EP-CS-CAPE group compared with the EP-CS group (p<0.05). Also, CAPE treatment significantly reduced RANKL and alveolar bone loss in the EP-CS-CAPE group compared with the EP-CS group (p<0.05)
Conclusions: The present results indicated that CAPE may inhibit alveolar bone loss by modulating the immune response and inflammatory process.
Keywords
References
- 1. Slots J. Periodontology: past, present, perspectives. Periodontol 2000 2013;62:7-19.
- 2. Okoro CA, Strine TW, Eke PI, Dhingra SS, Balluz LS. The association between depression and anxiety and use of oral health services and tooth loss. Community Dent Oral Epidemiol 2012;40:134-144.
- 3. Rai B, Kaur J, Anand SC, Jacobs R. Salivary stress markers, stress, and periodontitis: a pilot study. J Periodontol 2011;82:287-292.
- 4. Gaspersic R, Stiblar-Martincic D, Skaleric U. Influence of restraint stress on ligature-induced periodontitis in rats. Eur J Oral Sci 2002;110:125-129.
- 5. Padgett DA, Marucha PT, Sheridan JF. Restraint stress slows cutaneous wound healing in mice. Brain Behav Immun 1998;12:64-73.
- 6. Allan SM, Tyrrell PJ, Rothwell NJ. Interleukin-1 and neuronal injury. Nat Rev Immunol 2005;5:629-640.
- 7. Simi A, Tsakiri N, Wang P, Rothwell NJ. Interleukin-1 and inflammatory neurodegeneration. Biochem Soc Trans 2007;35:1122-1126.
- 8. de Kloet ER, Joels M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci 2005;6:463-475.
- 9. You Z, Luo C, Zhang W, et al. Pro- and anti-inflammatory cytokines expression in rat's brain and spleen exposed to chronic mild stress: involvement in depression. Behav Brain Res 2011;225:135-141.
- 10. Musazzi L, Milanese M, Farisello P, et al. Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressants. PLoS One 2010;5:e8566.
- 11. Hardingham GE, Fukunaga Y, Bading H. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 2002;5:405-414.12. Samarghandian S, Azimi-Nezhad M, Borji A, Farkhondeh T. Crocus sativus L.(saffron) extract reduces the extent of oxidative stress and proinflammatory state in aged rat kidney. Prog Nutr 2016;18:299-310.
- 13. Genco RJ, Ho AW, Kopman J, Grossi SG, Dunford RG, Tedesco LA. Models to evaluate the role of stress in periodontal disease. Ann Periodontol 1998;3:288-302.14. Akyol S, Ginis Z, Armutcu F, Ozturk G, Yigitoglu MR, Akyol O. The potential usage of caffeic acid phenethyl ester (CAPE) against chemotherapy-induced and radiotherapy-induced toxicity. Cell Biochem Funct 2012;30:438-443.
- 15. Celik S, Gorur S, Aslantas O, Erdogan S, Ocak S, Hakverdi S. Caffeic acid phenethyl ester suppresses oxidative stress in Escherichia coli-induced pyelonephritis in rats. Mol Cell Biochem 2007;297:131-138.16. Ha J, Choi H-S, Lee Y, Lee ZH, Kim H-H. Caffeic acid phenethyl ester inhibits osteoclastogenesis by suppressing NFκB and downregulating NFATc1 and c-Fos. Int Immunopharmacol 2009;9:774-780.
- 17. Kazancioglu HO, Aksakalli S, Ezirganli S, Birlik M, Esrefoglu M, Acar AH. Effect of caffeic acid phenethyl ester on bone formation in the expanded inter-premaxillary suture. Drug Des Devel Ther 2015;9:6483-6488.18. Kazancioglu HO, Bereket MC, Ezirganli S, Aydin MS, Aksakalli S. Effects of caffeic acid phenethyl ester on wound healing in calvarial defects. Acta Odontol Scand 2015;73:21-27.
- 19. Koltuksuz U, Mutus HM, Kutlu R, et al. Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats. J Pediatr Surg 2001;36:1504-1509.20. Ucan MC, Koparal M, Agacayak S, et al. Influence of caffeic acid phenethyl ester on bone healing in a rat model. J Int Med Res 2013;41:1648-1654.
- 21. Aguiar JC, Gomes EP, Fonseca-Silva T, et al. Fluoxetine reduces periodontal disease progression in a conditioned fear stress model in rats. J Periodontal Res 2013;48:632-637.22. Gomes EP, Aguiar JC, Fonseca-Silva T, et al. Diazepam reverses the alveolar bone loss and hippocampal interleukin-1beta and interleukin-6 enhanced by conditioned fear stress in ligature-induced periodontal disease in rats. J Periodontal Res 2013;48:151-158.
- 23. Peruzzo DC, Benatti BB, Antunes IB, et al. Chronic stress may modulate periodontal disease: a study in rats. J Periodontol 2008;79:697-704.
- 24. Gurkan A, Emingil G, Nizam N, et al. Therapeutic efficacy of vasoactive intestinal peptide in escherichia coli lipopolysaccharide-induced experimental periodontitis in rats. J Periodontol 2009;80:1655-1664.
- 25. Llavaneras A, Ramamurthy NS, Heikkila P, et al. A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats. J Periodontol 2001;72:1069-1077.
- 26. Lutfioglu M, Sakallioglu U, Sakallioglu EE, Baris S, Gurgor P. The impact of dietary induced hyperparathyroidism on healthy and diseased periodontia: an experimental study in rats. J Clin Periodontol 2012;39:264-271.
- 27. Yilmaz HR, Uz E, Altunbasak A, Sakalli E, Ozcelik N. Anticlastogenic effect of caffeic acid phenethyl ester on cisplatin-induced chromosome aberrations in rat bone marrow cells. Toxicol Ind Health 2010;26:33-37.
- 28. Esen C, Alkan BA, Kirnap M, Akgul O, Isikoglu S, Erel O. The effects of chronic periodontitis and rheumatoid arthritis on serum and gingival crevicular fluid total antioxidant/oxidant status and oxidative stress index. J Periodontol 2012;83:773-779.
- 29. Arabaci T, Kermen E, Ozkanlar S, et al. Therapeutic Effects of Melatonin on Alveolar Bone Resorption After Experimental Periodontitis in Rats: A Biochemical and Immunohistochemical Study. J Periodontol 2015;86:874-881.
- 30. Correa MG, Gomes Campos ML, Marques MR, et al. Outcome of enamel matrix derivative treatment in the presence of chronic stress: histometric study in rats. J Periodontol 2014;85:e259-267.
- 31. Yigit U, Kirzioglu FY, Uguz AC, Naziroglu M, Ozmen O. Is caffeic acid phenethyl ester more protective than doxycycline in experimental periodontitis? Arch Oral Biol 2017;81:61-68.
- 32. Araujo AA, Souza TO, Moura LM, et al. Effect of telmisartan on levels of IL-1, TNF-alpha, down-regulated COX-2, MMP-2, MMP-9 and RANKL/RANK in an experimental periodontitis model. J Clin Periodontol 2013;40:1104-1111.
- 33. Wang R-p, Yao Q, Xiao Y-b, et al. Toll-like receptor 4/nuclear factor-kappa B pathway is involved in myocardial injury in a rat chronic stress model. Stress 2011;14:567-575.
- 34. Kose O, Arabaci T, Kara A, et al. Effects of Melatonin on Oxidative Stress Index and Alveolar Bone Loss in Diabetic Rats With Periodontitis. J Periodontol 2016;87:e82-90.
- 35. Samarghandian S, Azimi-Nezhad M, Borji A, Samini M, Farkhondeh T. Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats. BMC Complement Altern Med 2017;17:249.
- 36. Ekuni D, Tomofuji T, Tamaki N, et al. Mechanical stimulation of gingiva reduces plasma 8-OHdG level in rat periodontitis. Arch Oral Biol 2008;53:324-329.
- 37. Agarwal S, Piesco NP, Johns LP, Riccelli AE. Differential expression of IL-1 beta, TNF-alpha, IL-6, and IL-8 in human monocytes in response to lipopolysaccharides from different microbes. J Dent Res 1995;74:1057-1065.
- 38. Kose O, Arabaci T, Kizildag A, et al. Melatonin prevents radiation-induced oxidative stress and periodontal tissue breakdown in irradiated rats with experimental periodontitis. J Periodontal Res 2017;52:438-446.
There are 32 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Research Articles |
| Authors | |
| Publication Date | March 13, 2019 |
| Submission Date | January 16, 2019 |
| Published in Issue | Year 2019Volume: 22 Issue: 1 |
Cited By
Effects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review
Drug Design, Development and Therapy
Sophia Ogechi Ekeuku
https://doi.org/10.2147/DDDT.S287280
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