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Sigara içen ve içmeyen kronik periodontitisli hastalarda başlangıç periodontal tedavinin dişeti oluğu sıvısı myeloperoksidaz seviyeleri üzerine etkisi

Year 2009, Volume: 12 Issue: 1, 5 - 11, 02.11.2011

Hülya Toker Hakan Ozdemir Kaya Eren

Abstract

Objective: Smoking is an enviromental risk factor in the onset and progression of periodontal diseases. The purpose of this study was to examine the effect of smoking on clinical parameters and GCF MPO levels after initial periodontal therapy in patients with chronic periodontitis.

Material and method: The study included 17 (the average 44,5±6.0) smoker and 18 (42.3±3.2) non-smoker patient with chronic periodontitis as evidenced by clinically and radiographically. Clinical periodontal evaluations were performed by using plaque index (PI), gingival index (GI), probing depth (PD) scores and clinical attachment level (CAL) at baseline and four weeks after initial periodontal therapy. Gingival crevicular fluid (GCF) was collected from four different space with deep periodontal pocket (pocket depth 9 4 mm) in maxilla. DOS MPO samples were assessed by kinetic spectrophotometer method.

Results: At baseline, there were no significant diffirences in clinical periodontal parameters between smokers and non-smokers. All clinical periodontal parameters were significantly decreased after initial periodontal therapy in both groups. All parameters in smokers were lower than non-smokers at 4 weeks after therapy. The GCF MPO levels were significantly decreased only in non-smokers.

Conclusion: Within the limits of this study, we found that smoking effects periodontal healing negatively.

 

ÖZET

Amaç: Sigara kullanımı, periodontal hastalıkların başlamasında ve ilerlemesinde önemli çevresel risk faktörüdür. Bu çalışmada kronik periodontitis teşhisi konulmuş hastalarda sigaranın, başlangıç periodontal tedavinin klinik parametreler ve dişeti oluğu sıvısı (DOS) myeloperoksidaz (MPO) düzeylerine etkisininin değerlendirilmesi amaçlanmaktadır.

Gereç ve Yöntem: Çalışmaya kronik periodontitis tanısı konmuş, sigara içen 17 (yaş ortalaması 44,6 ± 6.0) hasta ile sigara içmeyen 18 (yaş ortalaması 42,3 ± 3,2) hasta olmak üzere toplam 35 birey dahil edildi. Hastaların klinik değerlendirilmesinde başlangıç ve 1. ayda plak indeksi (P3) ve gingival indeks (G3), sondalama cep derinliği (SCD), klinik ataşman seviyesi (AS) ölçümleri yapıldı. Üst çene anterior bölgeden cep derinliği 94mm sahip 4 bölgeden dişeti oluğu sıvısı toplandı. DOS örneklerinin MPO içeriği, kinetik spektrofotometrik yöntemle tayin edildi.

Bulgular: Başlangıçta sigara içen ve içmeyen gruplar arasında klinik parametreler açısından fark bulunamadı. Periodontal tedavi sonrasında başlangıca göre klinik parametrelerde sigara içen ve içmeyen grupta anlamlı derecede azalma gözlendi. Periodontal tedavi sonrasında sigara içen gruba göre sigara içmeyen grupta daha fazla iyileşme gözlendi. DOS MPO aktivitesinde tedavi sonrasında sigara içmeyen grupta anlamlı derecede azalma gözlenirken sigara içen grupta fark gözlenmedi.

Sonuç: Bu çalışmanın sınırları içerisinde, sigaranın periodontal tedavi sonrasında iyileşmeyi olumsuz yönde etkilediği gözlenmiştir.

Anahtar kelimeler: Myeloperoksidaz, sigara, periodontitis

Keywords

Myeloperoxidase; smoking; periodontitis

References

  • Aras H. Periodontal hastalkl bireylerde non-steroid antiinflamatuar ilaçlarn dieti oluu svs elastaz ve myeloperoksidaz enzim düzeyleri üzerine etkisinin incelenmesi. Doktora tezi, Hacettepe Ü. SalkBilimleri Enstitüsü, Ankara, 1999.
  • Balo K, Tüccar E,BostancH, Özcan G, Akkaya M, Günhan M. Sigara içmenin klinik doku salna etkileri. Ankara Dihek. Fak. Derg. 1983; 10: 121-130.
  • Bergström J, Preber H. Tobacco use as a risk factor. J Periodontol. 1994; 65: 545-550.
  • Bergström J, Eliasson S, Dock J. A 10-Year prospective study of tobacco smoking and periodontal health. J Periodontol. 2000; 71: 1338-1347.
  • Bergström J, Boström L. Tobacco smoking and periodontal hemorrhagic responsieness. J Clin Periodontol. 2001; 28: 680-685.
  • Bilginer HM. Sigara içenlerde periodontal durum ve sigarann cerrahi olmayan tedavi üzerine etkisinin klinik radyografik ve histopatolojik olarak uzun dönem deerlendirilmesi. Doktora Tezi, Ankara Üniversitesi SalkBilimleri Enstitüsü, 2000.
  • Boutros SM, Michalowicz BS, Smith QT, Aeppli DM. Crevicular Fluid Enzymes from Endosseous Dental Implants and Natural Teeth. Int J Oral Maxillofac Implants. 1996; 11: 322-330.
  • Cao F, Smith QT. Crevicular Fluid Myeloperoxidase at Healthy and Periodontitis Sites. J Clin Periodontol. 1989; 16: 17-20.
  • Carranza FA, Newman MG. Clinical Periodontology. 8th Ed. W.B Saunders Company. USA. 1996.
  • Çalayan F, Yamalk N, Klnç K, ray B. Erikin Periodontitisli Hastalarda Dieti Örneklerinde Myeloperoxidase Düzeylerinin 5ncelenmesi. Hacettepe DiHek Fak Dersi. 1994; 4: 24-27
  • Daniel MA, Van Dyke TE. Alterations in phagocyte function and periodontal infection. J Periodontol. 1996, 67: 1070-1075.
  • Demirer S, Marakolu 5, Poyraz Ö. Sigara içen içmeyen bireylerde balangç periodontal tedavinin dieti oluu svs tümör nekroz faktör-b düzeyleri üzerine etkisi. SÜ Dihek Fak Derg. 2007; 16(2): 7-14.
  • Drisko CH. Nonsurgical periodontal therapy. Periodontol 2000. 2000; 24: 239-252.
  • Erdemir EO, Duran I, Haliloglu S. Effects of smoking on clinical parameters and the gingival crevicular fluid levels of IL-6 and TNF-a in patients with chronic periodontitis. J Clin Periodontol. 2004; 31: 99–104.
  • Fenna RE. Crystallization and Subunit Structure of Canine Myeloperoxidase. J Mol Biol. 1987; 196: 919-925.
  • Genco RJ. Host responses in periodontal diseases: Current concepts. J Periodontol. 1992; 63: 338-355.
  • Genco RJ. Current view of risk factors for periodontal diseases. J Periodontol. 1996; 67: 1041-1049.
  • Genco RJ, Löe H. The role of systemic conditions and disorders in periodontal disease. Periodontology 2000 1993; 2: 98-116.
  • Griffiths GS, Curtis MA, Wilton JM. Selection of a filter paper with optimum properties for the collection of gingival crevicular fluid. J Periodontal Res. 1988; 23(1): 33-38.
  • Grossi SG, Zambon JJ, Machtei EE et al. Effects of smoking and smoking cessation on healing after mechanical periodontal therapy. J Am Dent Assoc. 1997; 128: 599-607.
  • Haber J, Kent RL. Cigarette smoking in a periodontal practice. J Periodontol. 1992; 63: 100-106.
  • Haber J, Wattles J, Crowley M, Mandell R. Evidence for cigarette smoking as a major risk factor for periodontitis. J Periodontol. 1993; 64: 16-23.
  • Kaldahl WB, Johnson GK, Patil KD, Kalkwarf KL. Levels of cigarette consumption and response to periodontal therapy. J Periodontol. 1996; 67(7): 675-678.
  • Kowolik MJ, Grant M. Myeloperoxidase Activity in Human Gingival Crevicular Neutrophils. Archs Oral Biol. 1983; 28: 293-295.
  • Lamster IB,Harper DS, Goldstein S, Celenti RS, Oshrain RL. The effect of sequential sampling on crevicular fluid volume and enzyme activity. J Clin Periodontol. 1989; 16(4): 252-258.
  • Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand. 1963; 21: 533-551.
  • Marigo MA, Lafora A, Santacroce R, Curci E, Montemurro P, Fumarulo R. Nicotine effects on polymorphonuclear cell apoptosis and lipopolisaccharideinduced monocyte functions. A possible role in periodontal disease? J Periodont Res. 2001; 36: 32-39.
  • Miyasaki KT, Wilson ME, Brunetti AJ, Genco RJ. Killing of Actinobacillus actinomycetemcomitans by the Human Neutrophil Myeloperoxidase-Hydrogen Peroxidase-Chloride System. Infect Immun. 1986; 53: 161-165.
  • Nisengard RC, Newman MG, Sanz M. Host response: Basic concepts In ‘Clinical Periodontology’ Ed. by Carranza FA and Newman MG 111-120, W. B Saunders Company Philadelphia. 1996.
  • Over C, Yamalik N, Yavuzyilmaz E, Ersoy F, Eratalay K. Myeloperoxidase activity in peripheral blood, neutrophil crevicular fluid and whole saliva of patients with periodontal disease. J Nihon Univ Sch Dent. 1993; 35(4): 235-40.
  • Pabst MJ, Pabst KM, Collier JA, Coleman TC, Godat MS, Waring MB, Babu JP. Inhibition of neutrophil and monocyte defensive functions by nicotine. J Periodontol. 1995; 66: 1047-1055.
  • Rivera-Hidalgo F. Smoking and periodontal disease A review of the literature. J Periodontol. 1986; 57: 617-624.
  • Rudin HJ, Overdiek HF, Rateitschak KH. Correlation between sulcus fluid rate and clinical and histolocal inflammation of the marginal gingival. Helv Odontol Acta. 1970; 14: 21-26.
  • Silness J, Löe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1964; 22: 121-135.
  • Smith QT, Freese PL, Osborn JB, Stoltenberg JL. Five Parameters of Gingival Crevicular Fluid from Eight Surfaces in Periodontal Health and Diseases. J Periodontol 1992; 27: 466-475.
  • Smith GT, Greenbaum CJ, Johnson BD, Rutger G. Short-term responses to periodontal therapy in insulin-dependent diabetic patients. J Periodontol 1996;67:794-802.
  • Suzuki K, Ota H, Sasagawa S, Sakatani S, Fujikura T. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal. Biochem. 1983; 132: 345-352.
  • Wolff LF, Smith QT, Synder WK, Bedrick JA, Liljemark WF, Aeppli DA, Bandt CL. Relationship Between Lactate Dehydrogenase and Myeloperoxidase Levels in Human Gingival Crevicular Fluid and Clinical Microbial Measurements. J Clin Periodontol. 1988; 15: 110-115.
  • Van der Weijden GA, De Slegte C, Timmerman MF, Van der Velden U. Periodontitis in smokers and non-smokers: intra-oral distribution of pockets. J Clin Periodontol. 2001; 28: 955-960.
  • Yamalk N, Caglayan F, Klnç K, Klnç A ve Tümer C. The importance of data presentation regarding gingival crevicular fluid myeloperoxidase and elastase–like activity in periodontal disease and health status. J Periodontol. 2000; 71: 460-467.
  • Yu GP, Hsieh CC, Peng J. Risk factors associated with the prevalence of pulmonary tuberculosis among sanitary workers in Shanghai. Tubercle 1988; 69: 105-12.

S GARA ÇEN VE ÇMEYEN KRON K PER ODONT T SL HASTALARDA BA LANGIÇ PER ODONTAL TEDAV N N D ET OLU U SIVISI MYELOPEROKS DAZ SEV YELER ÜZER NE ETK S

Year 2009, Volume: 12 Issue: 1, 5 - 11, 02.11.2011

Hülya Toker Hakan Ozdemir Kaya Eren

Abstract

Amaç: Sigara kullan m , periodontal hastal klar n ba lamas nda ve ilerlemesinde önemli çevresel risk faktörüdür. Bu çal mada kronik periodontitis te hisi konulmu hastalarda sigaran n, ba lang ç periodontal tedavinin klinik parametreler ve di eti olu u s v s (DOS) myeloperoksidaz (MPO) düzeylerine etkisininin de erlendirilmesi amaçlanmaktad r. Gereç ve Yöntem: Çal maya kronik periodontitis tan s konmu ,sigara içen 17 (ya ortalamas 44,6 ± 6.0) hasta ile sigara içmeyen 18 (ya ortalamas 42,3 ± 3,2) hasta olmak üzere toplam 35 birey dahil edildi. Hastalar n klinik de erlendirilmesinde ba lang ç ve 1. ayda plak indeksi (P3) ve gingival indeks (G3), sondalama cep derinli i (SCD), klinik ata man seviyesi (AS) ölçümleri yap ld . Üst çene anterior bölgeden cep derinli i 94mm sahip 4 bölgeden di eti olu u s v s topland . DOS örneklerinin MPO içeri i, kinetik spektrofotometrik yöntemle tayin edildi. Bulgular: Ba lang çta sigara içen ve içmeyen gruplar aras nda klinik parametreler aç s ndan fark bulunamad . Periodontal tedavi sonras nda ba lang ca göre klinik parametrelerde sigara içen ve içmeyen grupta anlaml derecede azalma gözlendi. Periodontal tedavi sonras nda sigara içen gruba göre sigara içmeyen grupta daha fazla iyile me gözlendi. DOS MPO aktivitesinde tedavi sonras nda sigara içmeyen grupta anlamlgözlenirken sigara içen grupta fark gözlenmedi. derecede azalma Sonuç: Bu çal man n s n rlar içerisinde, sigaran n periodontal tedavi sonras nda iyile meyi olumsuz yönde etkiledi i gözlenmi tir

Keywords

Myeloperoksidaz sigara periodontitis

References

  • Aras H. Periodontal hastalkl bireylerde non-steroid antiinflamatuar ilaçlarn dieti oluu svs elastaz ve myeloperoksidaz enzim düzeyleri üzerine etkisinin incelenmesi. Doktora tezi, Hacettepe Ü. SalkBilimleri Enstitüsü, Ankara, 1999.
  • Balo K, Tüccar E,BostancH, Özcan G, Akkaya M, Günhan M. Sigara içmenin klinik doku salna etkileri. Ankara Dihek. Fak. Derg. 1983; 10: 121-130.
  • Bergström J, Preber H. Tobacco use as a risk factor. J Periodontol. 1994; 65: 545-550.
  • Bergström J, Eliasson S, Dock J. A 10-Year prospective study of tobacco smoking and periodontal health. J Periodontol. 2000; 71: 1338-1347.
  • Bergström J, Boström L. Tobacco smoking and periodontal hemorrhagic responsieness. J Clin Periodontol. 2001; 28: 680-685.
  • Bilginer HM. Sigara içenlerde periodontal durum ve sigarann cerrahi olmayan tedavi üzerine etkisinin klinik radyografik ve histopatolojik olarak uzun dönem deerlendirilmesi. Doktora Tezi, Ankara Üniversitesi SalkBilimleri Enstitüsü, 2000.
  • Boutros SM, Michalowicz BS, Smith QT, Aeppli DM. Crevicular Fluid Enzymes from Endosseous Dental Implants and Natural Teeth. Int J Oral Maxillofac Implants. 1996; 11: 322-330.
  • Cao F, Smith QT. Crevicular Fluid Myeloperoxidase at Healthy and Periodontitis Sites. J Clin Periodontol. 1989; 16: 17-20.
  • Carranza FA, Newman MG. Clinical Periodontology. 8th Ed. W.B Saunders Company. USA. 1996.
  • Çalayan F, Yamalk N, Klnç K, ray B. Erikin Periodontitisli Hastalarda Dieti Örneklerinde Myeloperoxidase Düzeylerinin 5ncelenmesi. Hacettepe DiHek Fak Dersi. 1994; 4: 24-27
  • Daniel MA, Van Dyke TE. Alterations in phagocyte function and periodontal infection. J Periodontol. 1996, 67: 1070-1075.
  • Demirer S, Marakolu 5, Poyraz Ö. Sigara içen içmeyen bireylerde balangç periodontal tedavinin dieti oluu svs tümör nekroz faktör-b düzeyleri üzerine etkisi. SÜ Dihek Fak Derg. 2007; 16(2): 7-14.
  • Drisko CH. Nonsurgical periodontal therapy. Periodontol 2000. 2000; 24: 239-252.
  • Erdemir EO, Duran I, Haliloglu S. Effects of smoking on clinical parameters and the gingival crevicular fluid levels of IL-6 and TNF-a in patients with chronic periodontitis. J Clin Periodontol. 2004; 31: 99–104.
  • Fenna RE. Crystallization and Subunit Structure of Canine Myeloperoxidase. J Mol Biol. 1987; 196: 919-925.
  • Genco RJ. Host responses in periodontal diseases: Current concepts. J Periodontol. 1992; 63: 338-355.
  • Genco RJ. Current view of risk factors for periodontal diseases. J Periodontol. 1996; 67: 1041-1049.
  • Genco RJ, Löe H. The role of systemic conditions and disorders in periodontal disease. Periodontology 2000 1993; 2: 98-116.
  • Griffiths GS, Curtis MA, Wilton JM. Selection of a filter paper with optimum properties for the collection of gingival crevicular fluid. J Periodontal Res. 1988; 23(1): 33-38.
  • Grossi SG, Zambon JJ, Machtei EE et al. Effects of smoking and smoking cessation on healing after mechanical periodontal therapy. J Am Dent Assoc. 1997; 128: 599-607.
  • Haber J, Kent RL. Cigarette smoking in a periodontal practice. J Periodontol. 1992; 63: 100-106.
  • Haber J, Wattles J, Crowley M, Mandell R. Evidence for cigarette smoking as a major risk factor for periodontitis. J Periodontol. 1993; 64: 16-23.
  • Kaldahl WB, Johnson GK, Patil KD, Kalkwarf KL. Levels of cigarette consumption and response to periodontal therapy. J Periodontol. 1996; 67(7): 675-678.
  • Kowolik MJ, Grant M. Myeloperoxidase Activity in Human Gingival Crevicular Neutrophils. Archs Oral Biol. 1983; 28: 293-295.
  • Lamster IB,Harper DS, Goldstein S, Celenti RS, Oshrain RL. The effect of sequential sampling on crevicular fluid volume and enzyme activity. J Clin Periodontol. 1989; 16(4): 252-258.
  • Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand. 1963; 21: 533-551.
  • Marigo MA, Lafora A, Santacroce R, Curci E, Montemurro P, Fumarulo R. Nicotine effects on polymorphonuclear cell apoptosis and lipopolisaccharideinduced monocyte functions. A possible role in periodontal disease? J Periodont Res. 2001; 36: 32-39.
  • Miyasaki KT, Wilson ME, Brunetti AJ, Genco RJ. Killing of Actinobacillus actinomycetemcomitans by the Human Neutrophil Myeloperoxidase-Hydrogen Peroxidase-Chloride System. Infect Immun. 1986; 53: 161-165.
  • Nisengard RC, Newman MG, Sanz M. Host response: Basic concepts In ‘Clinical Periodontology’ Ed. by Carranza FA and Newman MG 111-120, W. B Saunders Company Philadelphia. 1996.
  • Over C, Yamalik N, Yavuzyilmaz E, Ersoy F, Eratalay K. Myeloperoxidase activity in peripheral blood, neutrophil crevicular fluid and whole saliva of patients with periodontal disease. J Nihon Univ Sch Dent. 1993; 35(4): 235-40.
  • Pabst MJ, Pabst KM, Collier JA, Coleman TC, Godat MS, Waring MB, Babu JP. Inhibition of neutrophil and monocyte defensive functions by nicotine. J Periodontol. 1995; 66: 1047-1055.
  • Rivera-Hidalgo F. Smoking and periodontal disease A review of the literature. J Periodontol. 1986; 57: 617-624.
  • Rudin HJ, Overdiek HF, Rateitschak KH. Correlation between sulcus fluid rate and clinical and histolocal inflammation of the marginal gingival. Helv Odontol Acta. 1970; 14: 21-26.
  • Silness J, Löe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1964; 22: 121-135.
  • Smith QT, Freese PL, Osborn JB, Stoltenberg JL. Five Parameters of Gingival Crevicular Fluid from Eight Surfaces in Periodontal Health and Diseases. J Periodontol 1992; 27: 466-475.
  • Smith GT, Greenbaum CJ, Johnson BD, Rutger G. Short-term responses to periodontal therapy in insulin-dependent diabetic patients. J Periodontol 1996;67:794-802.
  • Suzuki K, Ota H, Sasagawa S, Sakatani S, Fujikura T. Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal. Biochem. 1983; 132: 345-352.
  • Wolff LF, Smith QT, Synder WK, Bedrick JA, Liljemark WF, Aeppli DA, Bandt CL. Relationship Between Lactate Dehydrogenase and Myeloperoxidase Levels in Human Gingival Crevicular Fluid and Clinical Microbial Measurements. J Clin Periodontol. 1988; 15: 110-115.
  • Van der Weijden GA, De Slegte C, Timmerman MF, Van der Velden U. Periodontitis in smokers and non-smokers: intra-oral distribution of pockets. J Clin Periodontol. 2001; 28: 955-960.
  • Yamalk N, Caglayan F, Klnç K, Klnç A ve Tümer C. The importance of data presentation regarding gingival crevicular fluid myeloperoxidase and elastase–like activity in periodontal disease and health status. J Periodontol. 2000; 71: 460-467.
  • Yu GP, Hsieh CC, Peng J. Risk factors associated with the prevalence of pulmonary tuberculosis among sanitary workers in Shanghai. Tubercle 1988; 69: 105-12.
There are 41 citations in total.

Details

Primary Language English
Journal Section Original Research Articles
Authors

Hülya Toker

Hakan Ozdemir

Kaya Eren

Publication Date November 2, 2011
Submission Date November 2, 2011
Published in Issue Year 2009Volume: 12 Issue: 1

Cite

EndNote Toker H, Ozdemir H, Eren K (November 1, 2011) Sigara içen ve içmeyen kronik periodontitisli hastalarda başlangıç periodontal tedavinin dişeti oluğu sıvısı myeloperoksidaz seviyeleri üzerine etkisi. Cumhuriyet Dental Journal 12 1 5–11.

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