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Aktinik şelitis tedavisinde 5-fluorourasıl (5-fu) kullanımı: derleme ve iki olgunun sunumu

Year 2009, Volume: 12 Issue: 1, 56 - 63, 01.11.2011

Abstract

Actinic (solar) cheilitis is an epithelial precancerous lesion with a predilection of lower lip rather than upper lip. Clinically they may be undistinguishable from squamous cell carcinomas. Therefore actinic cheilitis should not be left untreated and the effected area should be protected from exposure to excess sun light. Two patients complaining of chronic ulcers and burning sensation on their lower lips were referred to the oral surgery clinic. Clinical examination revealed keratotic areas and superficial ulcers on lower lip vermillion. Patients’ history and the clinical findings led us to a clinical diagnosis of actinic cheilitis in both cases. The diagnoses were confirmed histopathologically, treatment was with topical 5-FU and one of the cases is still under our review. Clinical appearance of actinic cheilitis can be similar to lip carcinomas and there is the risk of transformation to squamous cell carcinoma. For this reason it is imperative that a biopsy is taken promptly to confirm the diagnosis. Recurrence is possible after treatment and this necessitates regular review appointments. Patient compliance is a must, and to improve this, treatment options should be discussed with the patient and their preferences should be considered.

ÖZET

Aktinik (solar) şelitis daha çok alt dudakta görülen epitelyal prekanseröz bir oluşumdur. Klinik olarak, skuamoz hücreli karsinomdan ayrılması güç olabilir. Bu nedenle aktinik şelitis tedavisiz bırakılmamalı ve etkilenen bölge güneş ışığından korunmalıdır. Alt dudaklarında iyileşmeyen yara ve yanma şikayeti olan 2 olgu, Ağız Diş Çene Hastalıkları ve Cerrahisi Anabilim Dalı kliniğine başvurmuşlardır. Muayenede alt dudak vermilyonlarında iyileşmeyen yüzeyel ülserler ve keratotik alanlar içeren lezyonlar saptanmıştır. Her iki olgunun da hikayeleri ve klinik muayeneleri sonucunda aktinik şelitis ön tanısı konmuştur. Tanılar histopatolojik tetkikle doğrulandıktan sonra topikal 5-FU tedavisi uygulanmış olup, olgulardan birinin kontrolleri halen devam etmektedir. Aktinik şelitisin klinik görünümü dudak karsinomuna benzeyebileceği gibi, skuamoz hücreli karsinoma dönüşme riski de bulunmaktadır. Bu nedenle klinik tanının doğrulanması için en kısa sürede biyopsi alınmalıdır. Tedavi sonrasında nüks ihtimali olduğundan hastaların düzenli aralıklarla kontrolü önem taşır. Tedavide hasta uyumunu ve memnuniyetini önemsemek gerekir ki, bu nedenle olası tedavi seçenekleri hakkında hasta bilgilendirilmeli ve tedaviye tercih edilen yöntem ile başlanmalıdır.

Anahtar kelimeler: Aktinik şelitis, şelitis, 5-fluorourasil

References

  • Salasche SJ. Epidemiology of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol.2000; 42: 4-7.
  • Braun-Falco O, Plewig G, Wolff HH, Burgdorf WHC. Dermatology. 2nd ed. Berlin: Springer; 2000. p.1449-53.
  • Leffell DJ. The scientific bases of skin cancer. J Am Acad Dermatol 2000; 42: 18-22.
  • Dinehart SM. The treatment of actinic keratoses. J Am Acad Dermatol 2000; 42: 25-8.
  • Chakrabarty AK, Mraz S, Geisse JK, Anderson NJ. Apthous ulcers associated with imiquimod and the treatment of actinic cheilitis. J Am Acad Dermatol 2005; 52: 35-7.
  • Smith KJ, Germain LCDRM, Yeager CDRJ, Skelton M. Topical 5% imiquimod therapy of actinic cheilitis. J Am Acad Dermatol 2002; 47: 497-501.
  • Grimaitre M, Etienne A, Fathi M, Piletta PA, Saurat JH. Topical coclchicine therapy for actinic keratoses. Dermatology 2000; 200: 346-8.
  • Sevaux RGL, Smit JV, De Jong EMG, Van de Kerkhof PCM, Hoitsima AJ. Acitretin treatment of premalignant and malignant skin disorders in renal transplant recipients: Clinical effects of a randomized trial comparing two doses of acitretin. J Am Acad Dermatol 2003; 49: 407-12.
  • Rivers JK, McLean DI. An open study to assess the efficacy and safety of topical 3% diclofenac in a 2.5%hyaluronic acid gel for the treatment of actinic keratoses. Arch Dermatol 1997; 133: 1239-42.
  • Ulrich C, Forschner T, Ulrich M, Stockfleth E, Sterry W, Termeer C. Management of actinic cheilitis using diclofenac 3% gel: a report of six cases. Br J Dermatol 2007; 156: 43-46.
  • Alexiades-Armenakas M. Laser-mediated photodynamic therapy. Clin Dermatol 2006; 24: 16-25.
  • Rossi R, Assad GB, Buggiani G, Lotti T. Photodynamic therapy: treatment of choice for actinic cheilitis? Dermatol Ther 2008; 21: 412-15.
  • Berking C, Herzinger T, Flaig MJ, Brenner M, Borelli C, Degitz K. The efficacy of photodynamic therapy in actinic cheilitis of the lower lip: A prospective study of 15 patients. Dermatol Surg 2007; 33: 825-830.
  • Kurth D.A.B.M.E. “Lip shave” or vermilionectomy: Indications and technique. Br J Plast Surg 1957; 10: 156-162.
  • Huang CC. The lips excision and repair. Dermatologic Clinics January 1998; 16: 127-143.
  • Hruza CJ. Laser treatment of epidermal and dermal lesions. Dermatol Clin 2002; 20: 147-164.
  • Lubritz RR, Smolewski SA. Cryosurgery cure rate of actinic keratosis. J Am Acad Dermatol 1982; 7: 631-2.
  • Salman SM, KibbiA-G, Zaynoun S. Actinic lichen planus: A clinicopathologic study of 16 patients. J Am Acad Dermatol 1989; 20: 226-31.
  • Nico MMS, Rivitti EA, Lourenço SV. Actinic cheilitis: Histologic study of the entire vermillion and comparison with previous biopsy. J Cutan Pathol 2007; 34: 309-314.
  • Cavalcante ASR, Anbinder AL, Carvalho YR. Actinic cheilitis: Clinical and histological features. J Oral Maxillofac Surg 2008; 66: 498-503.
  • Rojas IG, Martinez A, Brethauer U, Grez P, Yefi R, Luza S, Marchesani FJ. Actinic cheilitis: Epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2. Oral Oncol 2009; 45: 284-90.
  • Chou A, Dekker N, Jordan RCK. Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: 535-41.

AKT N K EL T S TEDAV S NDE 5-FLUOROURASIL (5-FU) KULLANIMI: DERLEME VE K OLGUNUN SUNUMU#

Year 2009, Volume: 12 Issue: 1, 56 - 63, 01.11.2011

Abstract

Aktinik prekanseröz bir olu umdur. Klinik olarak, skuamoz hücreli karsinomdan ayr lmas güç olabilir. Bu nedenle aktinik elitis tedavisiz b rak lmamal ve etkilenen bölge günekorunmal d r

References

  • Salasche SJ. Epidemiology of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol.2000; 42: 4-7.
  • Braun-Falco O, Plewig G, Wolff HH, Burgdorf WHC. Dermatology. 2nd ed. Berlin: Springer; 2000. p.1449-53.
  • Leffell DJ. The scientific bases of skin cancer. J Am Acad Dermatol 2000; 42: 18-22.
  • Dinehart SM. The treatment of actinic keratoses. J Am Acad Dermatol 2000; 42: 25-8.
  • Chakrabarty AK, Mraz S, Geisse JK, Anderson NJ. Apthous ulcers associated with imiquimod and the treatment of actinic cheilitis. J Am Acad Dermatol 2005; 52: 35-7.
  • Smith KJ, Germain LCDRM, Yeager CDRJ, Skelton M. Topical 5% imiquimod therapy of actinic cheilitis. J Am Acad Dermatol 2002; 47: 497-501.
  • Grimaitre M, Etienne A, Fathi M, Piletta PA, Saurat JH. Topical coclchicine therapy for actinic keratoses. Dermatology 2000; 200: 346-8.
  • Sevaux RGL, Smit JV, De Jong EMG, Van de Kerkhof PCM, Hoitsima AJ. Acitretin treatment of premalignant and malignant skin disorders in renal transplant recipients: Clinical effects of a randomized trial comparing two doses of acitretin. J Am Acad Dermatol 2003; 49: 407-12.
  • Rivers JK, McLean DI. An open study to assess the efficacy and safety of topical 3% diclofenac in a 2.5%hyaluronic acid gel for the treatment of actinic keratoses. Arch Dermatol 1997; 133: 1239-42.
  • Ulrich C, Forschner T, Ulrich M, Stockfleth E, Sterry W, Termeer C. Management of actinic cheilitis using diclofenac 3% gel: a report of six cases. Br J Dermatol 2007; 156: 43-46.
  • Alexiades-Armenakas M. Laser-mediated photodynamic therapy. Clin Dermatol 2006; 24: 16-25.
  • Rossi R, Assad GB, Buggiani G, Lotti T. Photodynamic therapy: treatment of choice for actinic cheilitis? Dermatol Ther 2008; 21: 412-15.
  • Berking C, Herzinger T, Flaig MJ, Brenner M, Borelli C, Degitz K. The efficacy of photodynamic therapy in actinic cheilitis of the lower lip: A prospective study of 15 patients. Dermatol Surg 2007; 33: 825-830.
  • Kurth D.A.B.M.E. “Lip shave” or vermilionectomy: Indications and technique. Br J Plast Surg 1957; 10: 156-162.
  • Huang CC. The lips excision and repair. Dermatologic Clinics January 1998; 16: 127-143.
  • Hruza CJ. Laser treatment of epidermal and dermal lesions. Dermatol Clin 2002; 20: 147-164.
  • Lubritz RR, Smolewski SA. Cryosurgery cure rate of actinic keratosis. J Am Acad Dermatol 1982; 7: 631-2.
  • Salman SM, KibbiA-G, Zaynoun S. Actinic lichen planus: A clinicopathologic study of 16 patients. J Am Acad Dermatol 1989; 20: 226-31.
  • Nico MMS, Rivitti EA, Lourenço SV. Actinic cheilitis: Histologic study of the entire vermillion and comparison with previous biopsy. J Cutan Pathol 2007; 34: 309-314.
  • Cavalcante ASR, Anbinder AL, Carvalho YR. Actinic cheilitis: Clinical and histological features. J Oral Maxillofac Surg 2008; 66: 498-503.
  • Rojas IG, Martinez A, Brethauer U, Grez P, Yefi R, Luza S, Marchesani FJ. Actinic cheilitis: Epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2. Oral Oncol 2009; 45: 284-90.
  • Chou A, Dekker N, Jordan RCK. Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: 535-41.
There are 22 citations in total.

Details

Primary Language English
Journal Section Case Reports
Authors

Candan Efeoglu

Huseyin Koca

Taha Unal

Publication Date November 1, 2011
Submission Date November 1, 2011
Published in Issue Year 2009Volume: 12 Issue: 1

Cite

EndNote Efeoglu C, Koca H, Unal T (November 1, 2011) Aktinik şelitis tedavisinde 5-fluorourasıl (5-fu) kullanımı: derleme ve iki olgunun sunumu. Cumhuriyet Dental Journal 12 1 56–63.

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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