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Leptin ve periodontal hastalıklar

Year 2009, Volume: 12 Issue: 2, 162 - 167, 30.10.2011

Alparslan Dilsiz , Meltem Zihni Tugba Aydin

Abstract

Leptin, a hormone secreted by adipose tissue, but also by several other tissues, and it plays an important role in protection of the host from inflammation and infection. Periodontal diseases are multi-factorial infectious disorders that lead to destruction of the supporting tissues of the teeth. These diseases are the result of bacterial infections of the gingival tissues. Therapy to decrease the levels of oral microorganisms can reduce gingivitis and stabilize periodontitis. Previous studies have suggested a relationship between periodontal disease and leptin levels. Some researchers reported that there is a strong negative correlation between the gingival crevicular fluid (GCF) leptin level and periodontal disease progression, after the presence of leptin within healthy and inflamed gingiva has been demonstrated. The aim of this paper is to summarize the effect of leptin in the human body and to report relationship between periodontal disease and leptin levels.

ÖZET

Leptin, konağı inflamasyon ve infeksiyondan koruyucu önemli bir rolü olan, yağ dokusundan başka ilave çeşitli dokulardan da salgılanan bir hormondur. Periodontal hastalıklar, dişlerin destek dokularının yıkımına yol açan birden fazla faktörün sebep olduğu infeksiyöz hastalıklardır. Bu hastalıklar gingival dokularda bakteriyel infeksiyonlar sonucu oluşurlar. Oral mikroorganizmaların seviyelerini azaltarak yapılan tedavi, gingivitisi engelleyebildiği gibi, periodontitisi de stabilize edebilir. Daha önceleri yapılan çalışmalar da leptin seviyeleri ile periodontal hastalıklar arasında bir ilişki olduğunu ileri sürmüşlerdir. Bazı araştırıclar, sağlıklı ve hastalıklı gingivada leptinin varlığı gösterildikten sonra dişeti oluğu sıvısı leptin seviyesi ile periodontal hastalığın şiddeti arasında güçlü bir negatif korelasyon olduğunu bildirmişlerdir. Bu derlemenin amacı, leptin seviyeleri ve periodontal hastalık arasındaki ilişkiyi bildirmek ve insan vücuduna leptinin etkilerini özetlemektir.

Anahtar Kelimeler; Hormon, leptin, periodontal hastalık, dişeti, dişeti iltihab ve dişeti oluğu sıvısı

Keywords

Hormone; leptin; periodontal disease; gingiva; gingival inflammation; gingival crevicular fluid

References

  • Karthikeyan BV, Pradeep AR. Leptin levels in gingival crevicular fluid in periodontal health and disease. J Periodontal Res. 2007; :300-4
  • Karthikeyan BV, Pradeep AR. Gingival crevicular fluid and serum leptin: their relationship to periodontal health and disease. J Clin Periodontol. 2007; 34:467-72
  • Bozkurt FY, Yetkin Ay Z, Sütçü R, Deliba N, Demirel R. Gingival crevicular fluid leptin levels in periodontitis patients with long-term and heavy smoking. J Periodontol. 2006; 77:634-40
  • Ritchie, C.S. Various measures of increased adiposity are associated with periodontal disease. The Journal of Evidence-Based Dental Practice, 2004; 4:169-171.
  • Johnson RB, Serio FG. Leptin within healthy and diseased human gingiva. J Periodontol. 2001; 72:1254-7
  • Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, Syversen U, Reseland JE. Adiponectin and its tereptors are expressed in bone-forming cells. Bone 2004; 35: 842-49.
  • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994; 372:425-32.
  • Ingalls AM, Dickie MM, Snell GD. Obese, a new mutation in the mouse. J Hered. 1950; 41:317-18.
  • Hummel KP, Dickie MM, Coleman DL. Diabetes, a new mutation in the mouse. Science 1966; 153:1127-28.
  • Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 1973; 9: 294-98.
  • Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight- reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269:543-46.
  • Pelleymounter MA, Cullen MJ, Baker MB, Hect R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269:540-43.
  • Sinha MK. Human leptin: the hormone of adipose tissue. Eur J Endocrinol 1997; 136:461–4.
  • Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI. Identification and expression cloning of a leptin receptor. OB-R. Cell. 1995; 83: 1263-71.
  • Hoggard N, Mercer JG, Rayner DV, Moar K, Trayhurn P, Williams LM. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 1996 Jun ;387:113-16.
  • Tartaglia LA. The leptin receptor. J Biol Chem. 1997; 272:6093
  • Ahima RS, Osei SY. Leptin signaling. Phys Behav 2004; 81:223
  • Ahima RS, Flier JS. Leptin. Annu Rev Physiol. 2000; 62:413-37.
  • Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol. 2000; 68:437-46.
  • Frühbeck G, Jebb SA, Prentice AM. Leptin: physiology and pathophysiology. Clin Physiol. 1998; 18:399-419.
  • Castracane VD, Kraemer RR, Franken MA, Kraemer GR, Gimpel T. Serum leptin concentration in women: effect of age, obesity and estrogen administration. Fertil Steril 1998; 70:472-7.
  • Sinha MK, Opentanova I, Ohannesian JP, Kolaczynski JW, Heiman ML, Hale J. Evidence of free and bound leptin in human circulation. J Clin Invest 1996; 98:1277–82.
  • Brabant G, Nave H, Mayr B, Behrend M, van Harmelen V, Arner P. Secretion of free and protein-bound leptin from subcutaneous adipose tissue of lean and obese women. J Clin Endocrinol Metab ; 87: 3966-70.
  • Friedman JM. The function of leptin in nutrition, weight and physiology. Nutr Rev 2002; 60:514.
  • Spitzweg C, Heufelder AE. More clues from fat mice: leptin acts as an opponent of the hypothalamic neuropeptide Y system. Eur J Endocrinol 1997; 136:590–91.
  • Sowers JR. Obesity as a cardiovascular risc factor. AM J Med ; 115:37-41
  • Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL. Serum immunoreactive leptin concentrations in normal weight and obese humans. N Engl J Med 1995; 834:292-95.
  • W\odarski K, W\odarski P. Leptin as a modulator of osteogenesis. Ortop Traumatol Rehabil. 2009; 11:1-6.
  • Cornish J, Callon KE, Bava U, Lin C, Naot D, Hill BL, Grey AB, Broom N, Myers DE, Nicholson GC, Reid IR. Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol. 2002; 175:405-15.
  • Thomas T, Burguera B, Atkinson EJ. Role of serum leptin, insulin and estrogen levels as potential mediators of the relationship between fat mass bone mineral dansity in men versus women. Bone 2001; :114-210.
  • Marie P, Debias F, Cohen SM, Vernejoul MC. New factors controlling bone remodeling. Joint Bone Spine 2000; 67:150-156
  • Holloway WR, Collier FM, Aitken CJ, Myers DE, Hodge JM, Malakellis M, Gough TJ, Collier GR, Nicholson GC. Leptin inhibits osteoclast generation. J Bone Miner Res. 2002; 17:200-209.
  • Chehab FF, Mounzih K, Lu R, Lim ME. Early onset of reproductive function in normal female mice treated with leptin. Science 1997; 275:88-90.
  • Kiess W, Blum WF. Leptin, puberty and reproductive function: lessons from animal studies and observations in humans. Eur J Endoc ; 138:26-29. Paolisso G, Tagliamonte MR, Galderisi M, Zito GA, Petrocelli A, Carella C, de Divitiis O, Varricchio M. Plasma leptin level is associated with myocardial wall thickness in hypertensive insulin resistant men. Hypertension 1999; 34:1047-52.
  • Yegen B. .nfeksiyon ve inflamasyonda leptin. Genel T p Dergisi ; 13: 2. Aslan K, Serdar Z, Tokullugil A. Multifonksiyonel Hormon: Leptin. Uluda Üniversitesi T p Fakültesi Dergisi 2004; 30:113-118.
  • Ünal M. Leptin. .st. T p Fak. Mecmuas 2004; 67:1. Yaz "ma Adresi:
  • Yrd.Doç.Dr.Alparslan D.LS.Z Atatürk Üniversitesi Di Hekimli i Fakültesi Periodontoloji Anabilim Dal ERZURUM Tel Faks : 0 442 236 09 45 E-posta : aydilsiz@yahoo.com

LEPTIN AND PERIODONTAL DISEASES: A REVIEW

Year 2009, Volume: 12 Issue: 2, 162 - 167, 30.10.2011

Alparslan Dilsiz , Meltem Zihni Tugba Aydin

Abstract

Leptin, bir rolü olan, ya dokusundan ba ka ilave çe itli dokulardan da salg lanan bir hormondur

Keywords

Hormon leptin periodontal hastal k di eti di eti iltihab ve di eti olu u s v s

References

  • Karthikeyan BV, Pradeep AR. Leptin levels in gingival crevicular fluid in periodontal health and disease. J Periodontal Res. 2007; :300-4
  • Karthikeyan BV, Pradeep AR. Gingival crevicular fluid and serum leptin: their relationship to periodontal health and disease. J Clin Periodontol. 2007; 34:467-72
  • Bozkurt FY, Yetkin Ay Z, Sütçü R, Deliba N, Demirel R. Gingival crevicular fluid leptin levels in periodontitis patients with long-term and heavy smoking. J Periodontol. 2006; 77:634-40
  • Ritchie, C.S. Various measures of increased adiposity are associated with periodontal disease. The Journal of Evidence-Based Dental Practice, 2004; 4:169-171.
  • Johnson RB, Serio FG. Leptin within healthy and diseased human gingiva. J Periodontol. 2001; 72:1254-7
  • Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, Syversen U, Reseland JE. Adiponectin and its tereptors are expressed in bone-forming cells. Bone 2004; 35: 842-49.
  • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994; 372:425-32.
  • Ingalls AM, Dickie MM, Snell GD. Obese, a new mutation in the mouse. J Hered. 1950; 41:317-18.
  • Hummel KP, Dickie MM, Coleman DL. Diabetes, a new mutation in the mouse. Science 1966; 153:1127-28.
  • Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 1973; 9: 294-98.
  • Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight- reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269:543-46.
  • Pelleymounter MA, Cullen MJ, Baker MB, Hect R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269:540-43.
  • Sinha MK. Human leptin: the hormone of adipose tissue. Eur J Endocrinol 1997; 136:461–4.
  • Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI. Identification and expression cloning of a leptin receptor. OB-R. Cell. 1995; 83: 1263-71.
  • Hoggard N, Mercer JG, Rayner DV, Moar K, Trayhurn P, Williams LM. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 1996 Jun ;387:113-16.
  • Tartaglia LA. The leptin receptor. J Biol Chem. 1997; 272:6093
  • Ahima RS, Osei SY. Leptin signaling. Phys Behav 2004; 81:223
  • Ahima RS, Flier JS. Leptin. Annu Rev Physiol. 2000; 62:413-37.
  • Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol. 2000; 68:437-46.
  • Frühbeck G, Jebb SA, Prentice AM. Leptin: physiology and pathophysiology. Clin Physiol. 1998; 18:399-419.
  • Castracane VD, Kraemer RR, Franken MA, Kraemer GR, Gimpel T. Serum leptin concentration in women: effect of age, obesity and estrogen administration. Fertil Steril 1998; 70:472-7.
  • Sinha MK, Opentanova I, Ohannesian JP, Kolaczynski JW, Heiman ML, Hale J. Evidence of free and bound leptin in human circulation. J Clin Invest 1996; 98:1277–82.
  • Brabant G, Nave H, Mayr B, Behrend M, van Harmelen V, Arner P. Secretion of free and protein-bound leptin from subcutaneous adipose tissue of lean and obese women. J Clin Endocrinol Metab ; 87: 3966-70.
  • Friedman JM. The function of leptin in nutrition, weight and physiology. Nutr Rev 2002; 60:514.
  • Spitzweg C, Heufelder AE. More clues from fat mice: leptin acts as an opponent of the hypothalamic neuropeptide Y system. Eur J Endocrinol 1997; 136:590–91.
  • Sowers JR. Obesity as a cardiovascular risc factor. AM J Med ; 115:37-41
  • Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL. Serum immunoreactive leptin concentrations in normal weight and obese humans. N Engl J Med 1995; 834:292-95.
  • W\odarski K, W\odarski P. Leptin as a modulator of osteogenesis. Ortop Traumatol Rehabil. 2009; 11:1-6.
  • Cornish J, Callon KE, Bava U, Lin C, Naot D, Hill BL, Grey AB, Broom N, Myers DE, Nicholson GC, Reid IR. Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol. 2002; 175:405-15.
  • Thomas T, Burguera B, Atkinson EJ. Role of serum leptin, insulin and estrogen levels as potential mediators of the relationship between fat mass bone mineral dansity in men versus women. Bone 2001; :114-210.
  • Marie P, Debias F, Cohen SM, Vernejoul MC. New factors controlling bone remodeling. Joint Bone Spine 2000; 67:150-156
  • Holloway WR, Collier FM, Aitken CJ, Myers DE, Hodge JM, Malakellis M, Gough TJ, Collier GR, Nicholson GC. Leptin inhibits osteoclast generation. J Bone Miner Res. 2002; 17:200-209.
  • Chehab FF, Mounzih K, Lu R, Lim ME. Early onset of reproductive function in normal female mice treated with leptin. Science 1997; 275:88-90.
  • Kiess W, Blum WF. Leptin, puberty and reproductive function: lessons from animal studies and observations in humans. Eur J Endoc ; 138:26-29. Paolisso G, Tagliamonte MR, Galderisi M, Zito GA, Petrocelli A, Carella C, de Divitiis O, Varricchio M. Plasma leptin level is associated with myocardial wall thickness in hypertensive insulin resistant men. Hypertension 1999; 34:1047-52.
  • Yegen B. .nfeksiyon ve inflamasyonda leptin. Genel T p Dergisi ; 13: 2. Aslan K, Serdar Z, Tokullugil A. Multifonksiyonel Hormon: Leptin. Uluda Üniversitesi T p Fakültesi Dergisi 2004; 30:113-118.
  • Ünal M. Leptin. .st. T p Fak. Mecmuas 2004; 67:1. Yaz "ma Adresi:
  • Yrd.Doç.Dr.Alparslan D.LS.Z Atatürk Üniversitesi Di Hekimli i Fakültesi Periodontoloji Anabilim Dal ERZURUM Tel Faks : 0 442 236 09 45 E-posta : aydilsiz@yahoo.com
There are 37 citations in total.

Details

Primary Language English
Journal Section Review
Authors

Alparslan Dilsiz

Meltem Zihni

Tugba Aydin

Publication Date October 30, 2011
Submission Date October 30, 2011
Published in Issue Year 2009Volume: 12 Issue: 2

Cite

EndNote Dilsiz A, Zihni M, Aydin T (October 1, 2011) Leptin ve periodontal hastalıklar. Cumhuriyet Dental Journal 12 2 162–167.

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


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