Research Article
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The Effect of Platelet-Rich Fibrin and Titanium Prepared Platelet-Rich Fibrin on Early Soft Tissue Healing of Extraction Sites

Year 2018, Volume: 21 Issue: 4, 304 - 310, 30.12.2018

Esra Ercan

https://doi.org/10.7126/cumudj.471947
Cited By: 4

Abstract

Objective: Physiological changes start after
tooth extraction. Some post-operative symptoms may accompany this healing
period, and affect patient's life quality. Many techniques have been developed
to promote healing soft and hard tissue and improve patient's life quality. So,
the aim of this study was to compare the early soft tissue healing of
extraction sites treated with leucocyte-platelet rich fibrin (L-PRF), titanium
prepared platelet rich fibrin (T-PRF) and non-treated control sites.



Material&Methods:A total of
42 single root teeth were enrolled to study. Extraction site was treated by
L-PRF or T-PRF. Spontanous healing sockets were considered as control sites. Landy
Wound Healing Index (LWH) scores and H2O2 bubbling test
results for complete wound epithelization (CWE) were recorded at 1st
and 2nd week. Also, the patient was requested to record the VAS scale
and the number of analgesics that taken during two days after extraction.



Results: The LWH were statistically significantly improved for all
groups at 2nd week according to 1st week (p<0.05). However there was no
difference among three groups in each week. According to H2O2
bubbling test results, the
CWE ratio at 1st week was 7.1%, 53,3% and 69.2% of control, L-PRF and T-PRF
groups, respectively. The control group rate of CWE was statistically
significantly lower than both of the test groups (p<0.05). Both of the test groups at 2nd week showed
100% CWE, however this rate was only 35.7% of control group. The VAS score, at
1st day,  was statistically
significantly higher at control group than both of the test groups at first day
(p<0.05). There was
non-significant difference among groups at 2nd day. There wass also
non-significant difference among groups with regard to number of analgesics.



Conclusion:
Both T-PRF and L-PRF, which are completely autologous biomaterials, enhance
wound epithelzation and reduced post-op discomfort at extraction sockets.

Keywords

tooth extraction platelet-rich fibrin wound healing

References

  • 1. Tan WL, Wong TL, Wong MC, Lang NP. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implants Res 2012;23 Suppl 5:1-21.
  • 2. Araujo MG, Silva CO, Misawa M, Sukekava F. Alveolar socket healing: what can we learn? Periodontol 2000 2015;68:122-134.
  • 3. Schropp L, Wenzel A, Kostopoulos L, Karring T. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent 2003;23:313-323.
  • 4. Bui CH, Seldin EB, Dodson TB. Types, frequencies, and risk factors for complications after third molar extraction. J Oral Maxillofac Surg 2003;61:1379-1389.
  • 5. Chan HL, Lin GH, Fu JH, Wang HL. Alterations in bone quality after socket preservation with grafting materials: a systematic review. Int J Oral Maxillofac Implants 2013;28:710-720.
  • 6. Anwandter A, Bohmann S, Nally M, Castro AB, Quirynen M, Pinto N. Dimensional changes of the post extraction alveolar ridge, preserved with Leukocyte- and Platelet Rich Fibrin: A clinical pilot study. J Dent 2016;52:23-29.
  • 7. Maiorana C, Poli PP. Alveolar socket preservation with demineralised bovine bone mineral and a collagen matrix. 2017;47:194-210.
  • 8. Yerke LM, Jamjoom A, Zahid TM, Cohen RE. The Effect of Platelet-Rich Fibrin, Calcium Sulfate Hemihydrate, Platelet-Rich Plasma and Resorbable Collagen on Soft Tissue Closure of Extraction Sites. J Funct Biomater 2017;8.
  • 9. Calasans-Maia M, Resende R, Fernandes G, Calasans-Maia J, Alves AT, Granjeiro JM. A randomized controlled clinical trial to evaluate a new xenograft for alveolar socket preservation. Clinical oral implants research 2014;25:1125-1130.
  • 10. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 2009;27:158-167.
  • 11. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e51-55.
  • 12. Roy S, Driggs J, Elgharably H, et al. Platelet-rich fibrin matrix improves wound angiogenesis via inducing endothelial cell proliferation. Wound Repair Regen 2011;19:753-766.
  • 13. Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e56-60.
  • 14. Tunali M, Ozdemir H, Kucukodaci Z, et al. A novel platelet concentrate: titanium-prepared platelet-rich fibrin. Biomed Res Int 2014;2014:209548.
  • 15. Tunali M, Ozdemir H, Kucukodaci Z, Akman S, Firatli E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg 2013;51:438-443.
  • 16. Ustaoglu G, Ercan E, Tunali M. The role of titanium-prepared platelet-rich fibrin in palatal mucosal wound healing and histoconduction. Acta Odontol Scand 2016;74:558-564.
  • 17. Uzun BC, Ercan E, Tunali M. Effectiveness and predictability of titanium-prepared platelet-rich fibrin for the management of multiple gingival recessions. Clin Oral Investig 2018;22:1345-1354.
  • 18. Kızıltoprak M, Uslu, M.Ö. Historical Development and Properties of Platelet Concentrates in Dentistry. Cumhuriyet Dental Journal 2018;21:152-166.
  • 19. Lindeboom JA, Mathura KR, Aartman IH, Kroon FH, Milstein DM, Ince C. Influence of the application of platelet-enriched plasma in oral mucosal wound healing. Clin Oral Implants Res 2007;18:133-139.
  • 20. Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three-dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane. J Periodontol 2010;81:546-555.
  • 21. Pinto JR, Bosco AF, Okamoto T, Guerra JB, Piza IG. Effects of nicotine on the healing of extraction sockets in rats. A histological study. Braz Dent J 2002;13:3-9.
  • 22. Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 1999;14:529-535.
  • 23. Ogundipe OK, Ugboko VI, Owotade FJ. Can autologous platelet-rich plasma gel enhance healing after surgical extraction of mandibular third molars? J Oral Maxillofac Surg 2011;69:2305-2310.
  • 24. Alissa R, Esposito M, Horner K, Oliver R. The influence of platelet-rich plasma on the healing of extraction sockets: an explorative randomised clinical trial. Eur J Oral Implantol 2010;3:121-134.
  • 25. El-Sharkawy H, Kantarci A, Deady J, et al. Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties. J Periodontol 2007;78:661-669.
  • 26. Mozzati M, Martinasso G, Pol R, et al. The impact of plasma rich in growth factors on clinical and biological factors involved in healing processes after third molar extraction. J Biomed Mater Res A 2010;95:741-746.
  • 27. Rutkowski JL, Johnson DA, Radio NM, Fennell JW. Platelet rich plasma to facilitate wound healing following tooth extraction. J Oral Implantol 2010;36:11-23.

Year 2018, Volume: 21 Issue: 4, 304 - 310, 30.12.2018

Esra Ercan

https://doi.org/10.7126/cumudj.471947
Cited By: 4

Abstract

References

  • 1. Tan WL, Wong TL, Wong MC, Lang NP. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implants Res 2012;23 Suppl 5:1-21.
  • 2. Araujo MG, Silva CO, Misawa M, Sukekava F. Alveolar socket healing: what can we learn? Periodontol 2000 2015;68:122-134.
  • 3. Schropp L, Wenzel A, Kostopoulos L, Karring T. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent 2003;23:313-323.
  • 4. Bui CH, Seldin EB, Dodson TB. Types, frequencies, and risk factors for complications after third molar extraction. J Oral Maxillofac Surg 2003;61:1379-1389.
  • 5. Chan HL, Lin GH, Fu JH, Wang HL. Alterations in bone quality after socket preservation with grafting materials: a systematic review. Int J Oral Maxillofac Implants 2013;28:710-720.
  • 6. Anwandter A, Bohmann S, Nally M, Castro AB, Quirynen M, Pinto N. Dimensional changes of the post extraction alveolar ridge, preserved with Leukocyte- and Platelet Rich Fibrin: A clinical pilot study. J Dent 2016;52:23-29.
  • 7. Maiorana C, Poli PP. Alveolar socket preservation with demineralised bovine bone mineral and a collagen matrix. 2017;47:194-210.
  • 8. Yerke LM, Jamjoom A, Zahid TM, Cohen RE. The Effect of Platelet-Rich Fibrin, Calcium Sulfate Hemihydrate, Platelet-Rich Plasma and Resorbable Collagen on Soft Tissue Closure of Extraction Sites. J Funct Biomater 2017;8.
  • 9. Calasans-Maia M, Resende R, Fernandes G, Calasans-Maia J, Alves AT, Granjeiro JM. A randomized controlled clinical trial to evaluate a new xenograft for alveolar socket preservation. Clinical oral implants research 2014;25:1125-1130.
  • 10. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 2009;27:158-167.
  • 11. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e51-55.
  • 12. Roy S, Driggs J, Elgharably H, et al. Platelet-rich fibrin matrix improves wound angiogenesis via inducing endothelial cell proliferation. Wound Repair Regen 2011;19:753-766.
  • 13. Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e56-60.
  • 14. Tunali M, Ozdemir H, Kucukodaci Z, et al. A novel platelet concentrate: titanium-prepared platelet-rich fibrin. Biomed Res Int 2014;2014:209548.
  • 15. Tunali M, Ozdemir H, Kucukodaci Z, Akman S, Firatli E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg 2013;51:438-443.
  • 16. Ustaoglu G, Ercan E, Tunali M. The role of titanium-prepared platelet-rich fibrin in palatal mucosal wound healing and histoconduction. Acta Odontol Scand 2016;74:558-564.
  • 17. Uzun BC, Ercan E, Tunali M. Effectiveness and predictability of titanium-prepared platelet-rich fibrin for the management of multiple gingival recessions. Clin Oral Investig 2018;22:1345-1354.
  • 18. Kızıltoprak M, Uslu, M.Ö. Historical Development and Properties of Platelet Concentrates in Dentistry. Cumhuriyet Dental Journal 2018;21:152-166.
  • 19. Lindeboom JA, Mathura KR, Aartman IH, Kroon FH, Milstein DM, Ince C. Influence of the application of platelet-enriched plasma in oral mucosal wound healing. Clin Oral Implants Res 2007;18:133-139.
  • 20. Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three-dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane. J Periodontol 2010;81:546-555.
  • 21. Pinto JR, Bosco AF, Okamoto T, Guerra JB, Piza IG. Effects of nicotine on the healing of extraction sockets in rats. A histological study. Braz Dent J 2002;13:3-9.
  • 22. Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 1999;14:529-535.
  • 23. Ogundipe OK, Ugboko VI, Owotade FJ. Can autologous platelet-rich plasma gel enhance healing after surgical extraction of mandibular third molars? J Oral Maxillofac Surg 2011;69:2305-2310.
  • 24. Alissa R, Esposito M, Horner K, Oliver R. The influence of platelet-rich plasma on the healing of extraction sockets: an explorative randomised clinical trial. Eur J Oral Implantol 2010;3:121-134.
  • 25. El-Sharkawy H, Kantarci A, Deady J, et al. Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties. J Periodontol 2007;78:661-669.
  • 26. Mozzati M, Martinasso G, Pol R, et al. The impact of plasma rich in growth factors on clinical and biological factors involved in healing processes after third molar extraction. J Biomed Mater Res A 2010;95:741-746.
  • 27. Rutkowski JL, Johnson DA, Radio NM, Fennell JW. Platelet rich plasma to facilitate wound healing following tooth extraction. J Oral Implantol 2010;36:11-23.
There are 27 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Research Articles
Authors

Esra Ercan 0000-0002-8696-4198

Publication Date December 30, 2018
Submission Date October 18, 2018
Published in Issue Year 2018Volume: 21 Issue: 4

Cite

EndNote Ercan E (December 1, 2018) The Effect of Platelet-Rich Fibrin and Titanium Prepared Platelet-Rich Fibrin on Early Soft Tissue Healing of Extraction Sites. Cumhuriyet Dental Journal 21 4 304–310.

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