Trombositler
hemostaz ve yara iyileşmesinde çok önemli bir rol oynamakta ve ihtiva ettikleri
büyüme faktörleri ve sitokinler sayesinde rejeneratif tedavinin potansiyel
hücreleri arasında yer almaktadırlar. Bu durum, rejeneratif tedavide, trombosit
ve trombosit konsantrasyonlarına olan ilgiyi arttırmıştır. Geçmişten günümüze
kadar çeşitli trombosit konsantrasyonları elde edilmiş ve bu ürünler tek başına
veya başka biomateryallerle kombine kullanıldığında, iyileşme sürecine olan
olumlu katkıları görülmüştür. Trombosit konsantrasyonları, sert ve yumuşak doku
ile ilgili cerrahi prosedürlerde kullanıldığında, içeriğinde bulunan yoğun
sitokin ve büyüme faktörlerinin kontrollü salınımı sağlar. Bu durum doğal yara
iyileşme sürecini hızlandırmaktadır. Ayrıca, otojen kaynaklı olduklarından
herhangi bir immünolojik reaksiyon ve enfeksiyona yol açmamaları en önemli
avantajlarıdır. Tam kan farklı devirlerde ve farklı sürelerde santrifüj
edildiğinde içeriği birbirinden farklı olan trombosit kaynaklı ürünler elde
edilmiştir. PRP, PRGF, PRF ve CGF gibi ürünlere bakıldığında yeni keşfedilen
her ürünün bir öncekine göre daha gelişmiş özellikleri olduğu görülmektedir. Bu derlemenin amacı; PRP, PRGF, PRF ve CGF gibi
trombosit konsantrasyonlarının tarihsel gelişimi ve özellikleri hakkında bilgi
vermektir.
trombosit konsantreleri Trombositten zengin plazma Plazmadan zengin fibrin Konsantre büyüme faktörü
Platelets
are playing a very important role in wound healing and hemostasis and are among
the potential cells of regenerative therapy due to the growth factors and
cytokines they contain. This has increased the interest in platelet and
platelet concentrates in regenerative therapy. Various platelet concentrates
from the past to the present day were obtained, and when these products were
used alone or in combination with other biomaterials, positive contributions to
the healing process were observed. When platelet concentrates are used in
surgical procedures involving hard and soft tissue, they provide controlled
release of intense cytokines and growth factors in their contents. This
situation is accelerating the natural wound healing process. In addition, they
are the most important advantages because they do not cause any immunological
reaction and infection since they are autogenous. When whole blood is
centrifuged at different cycle and different times, platelet derived products
with different contents are obtained. Looking at the products such as PRP,
PRGF, PRF and CGF, it is seen that each newly discovered product has more
advanced characteristics than the previous one. The aim of review; platelet concentrate's such as PRP, PRGF,
PRF, CGF give information about the historical development and properties.
Primary Language | Turkish |
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Subjects | Health Care Administration |
Journal Section | Review |
Authors | |
Publication Date | July 20, 2018 |
Submission Date | January 19, 2018 |
Published in Issue | Year 2018Volume: 21 Issue: 2 |
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
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