Abstract
Son 10 yıl içerisinde, kök hücre biyolojisi
ve doku mühendisliği üzerine yapılan
çalışmalar diş hekimliği alanını olumlu bir yönde etkilemiştir. Rejeneratif
endodontik tedavinin amacı, sağlıklı ve fonksiyonel bir dentin-pulpa
komplesinin yeniden oluşturulmasıdır. Mineral trioksit agregat (MTA) gibi
başarı gösteren materyallerin ve doku mühendisliği konseptlerinin kullanılması
ile kök gelişimini tamamlamamış nekroze dişlerin kök-çevre doku gelişimlerinin
devam etmesi mümkün olmuştur. Kök hücreler ile yapılan çalışmalarda umut vaat
eden sonuçlar elde edilmiş olup halen diş-çevre dokularının rejenerasyonunda
olumlu gelişmeler kaydedilmektedir. Kök hücrelerin kullanımı etik olarak
sorgulandığından, bu materyallerin klinik olarak etkisi henüz bilinmemektedir.
Bu derleme çalışmasında, rejeneratif endodontik tedavi yöntemi, kullanılan
materyaller ve bu alandaki güncel gelişmeler detaylı olarak ele alınmaktadır.
References
- 1. Akgün ÖZ, Polat GG, Altun CA. Rejeneratif pulpa tedavilerinde doku mühendisliği uygulamaları. Klinik bilimler dergisi 2008;2(4):238-244.
- 2. Lesot H, Smith AJ, Tziafas D, Begue-Kirn C, Cassidy N, Ruch JV. Biologically active molecules and dental tissue repair: A comparative review of reactionary and reparative dentinogenesis with the induction of odontoblast differentiation in vitro. Cells Mater 1994; 4: 199-218.
- 3. Murray PE, Windsor U, Smyth TW, Hafez AA, Cox CF. Analysis of pulpal reactions to restorative procedures, materials, pulp capping and future therapies. Crit Rev Oral Biol Med 2002;33(4):377-390.
- 4. Sharma S, Sikri V, Sharma NK, Sharma VM. Regeneration of tooth pulp and dentin: trends and advances. Annals of neurosciences 2010;17(1):31-43.
- 5. Andreasen JO, Farik B, Munksgaard EC. Long-term calcium hydroxide as a root canal dressing may increase risk of root fracture. Dent Traumatol 2002;18:134-137.
- 6. Garcia-Godoy F, Murray PE. Recommandations for using regenerative endodontic procedures in permanent immature traumatized teeth. Dent Traumatol 2012;28:33-41.
- 7. Kumar ARP, Subbiya A. Regenerative endodontic therapy on non-vital immature maxillary incisors: Working protocol and a case report. Journal of Interdiciplinary Dentistry 2011;1(1):55-57.
- 8. Kling M, Cvek M, Mejare I. Rate and predictability of pulp revascularization in therapeutically reimplanted permanent incisors. Endod Dent Traumatol 1986; 2: 83-9.
- 9. Reynolds K, Johnson JD, Cohenca N. Pulp revascularization of necrotic bilateral bicuspids using a modified novel technique to eliminate potential coronal discoloration: a case report. Int Endod J 2009;42:84-92.
- 10. Jadhav GR, Shah N, Logani A. Platelet-rich plasma supplemented revascularization of an immature tooth associated with a periapical lesion in a 40-year-old man. Case reports in Dentistry 2014; 2014: 479584.
- 21. Forghani M, Parisay I, Maghsoudlou A. Apexogenesis and revascularization treatment procedures for two traumatized immature permanent maxillary incisors: A case report. Restor Dent Endod 2013; 38: 178-181.
- 22. Chan BP, Leong KW. Scaffolding in tissue engineering: general approaches and tissue-specific considerations. Eur Spine J 2008; 17: 467-479.
- 23. Hotwani K, Sharma K. Platelet rich fibrin- a novel acumen into regenerative endodontic therpy. Restor Dent Endod 2014; 39: 1-6.
- 24. Sanjana NE, Fuller SB. A fast flexible ink-jet printing method for patterning dissociated neurons in culture. J Neurosci Methods 2004;136:151-163.
- 25. Barron JA, Krizman DB, Ringeisen BR. Laser printing of single cells: statistical analysis, cell viability and stress. Ann Biomed Eng 2005;33(2):121-130.
- 26. Shah N, Logani A, Bhaskar U, Aggarwal V. Efficacy of revascu- larization to induce apexification/ apexogensis in infected, nonvital, immature teeth: a pilot clinical study. J Endod. 2008;34:919-25.
- 27. Cotti E, Mereu M, Lusso D. Regenerative treatment of an imma- ture, traumatized tooth with apical periodontitis: report of a case. J Endod. 2008;34:611-6.
- 28. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, et al. Stem cell properties of human dental pulp stem cells. J Dent Res. 2002;81:531-5.
- 29. Andreasen JO, Farik B, Munksgaard EC. Long-term calcium hydroxide as a root canal dressing may increase risk of root fracture. Dent Traumatol 2002;18:134-137.
- 30. Thibodeau B, Teixeria F, Yamauchi M, Caplan DJ, Trope M. Pulp revascularization of immature dog teeth with apical periodontitis. J Endod 2007;25:197.
Abstract
Withing the last 10 years, the research regarding
stem cell biology and tissue engineering has reaped many rewards in the field
of dentistry. The goal of regenerative endodontic therapy is the regeneration
of a healthy and functional pulp-dentin complex. With the development of
successful materials such as mineral trioxide aggregate (MTA) and the use of
the concept of tissue engineering, treating necrotic immature permanent teeth
and stimulating the continuation of root-surrounding tissue formation has been
made possible. Current stem cell research has also shown promising results and
continues to show progress in the regeneration of dental and surrounding
tissue. Since the ethical aspect of the use of stem cells is still in question,
we have yet to see the potential of these materials in clinical practice. In
this review, regenerative endodontic treatment prodedures, materials and
developments are discussed in detail.
References
- 1. Akgün ÖZ, Polat GG, Altun CA. Rejeneratif pulpa tedavilerinde doku mühendisliği uygulamaları. Klinik bilimler dergisi 2008;2(4):238-244.
- 2. Lesot H, Smith AJ, Tziafas D, Begue-Kirn C, Cassidy N, Ruch JV. Biologically active molecules and dental tissue repair: A comparative review of reactionary and reparative dentinogenesis with the induction of odontoblast differentiation in vitro. Cells Mater 1994; 4: 199-218.
- 3. Murray PE, Windsor U, Smyth TW, Hafez AA, Cox CF. Analysis of pulpal reactions to restorative procedures, materials, pulp capping and future therapies. Crit Rev Oral Biol Med 2002;33(4):377-390.
- 4. Sharma S, Sikri V, Sharma NK, Sharma VM. Regeneration of tooth pulp and dentin: trends and advances. Annals of neurosciences 2010;17(1):31-43.
- 5. Andreasen JO, Farik B, Munksgaard EC. Long-term calcium hydroxide as a root canal dressing may increase risk of root fracture. Dent Traumatol 2002;18:134-137.
- 6. Garcia-Godoy F, Murray PE. Recommandations for using regenerative endodontic procedures in permanent immature traumatized teeth. Dent Traumatol 2012;28:33-41.
- 7. Kumar ARP, Subbiya A. Regenerative endodontic therapy on non-vital immature maxillary incisors: Working protocol and a case report. Journal of Interdiciplinary Dentistry 2011;1(1):55-57.
- 8. Kling M, Cvek M, Mejare I. Rate and predictability of pulp revascularization in therapeutically reimplanted permanent incisors. Endod Dent Traumatol 1986; 2: 83-9.
- 9. Reynolds K, Johnson JD, Cohenca N. Pulp revascularization of necrotic bilateral bicuspids using a modified novel technique to eliminate potential coronal discoloration: a case report. Int Endod J 2009;42:84-92.
- 10. Jadhav GR, Shah N, Logani A. Platelet-rich plasma supplemented revascularization of an immature tooth associated with a periapical lesion in a 40-year-old man. Case reports in Dentistry 2014; 2014: 479584.
- 21. Forghani M, Parisay I, Maghsoudlou A. Apexogenesis and revascularization treatment procedures for two traumatized immature permanent maxillary incisors: A case report. Restor Dent Endod 2013; 38: 178-181.
- 22. Chan BP, Leong KW. Scaffolding in tissue engineering: general approaches and tissue-specific considerations. Eur Spine J 2008; 17: 467-479.
- 23. Hotwani K, Sharma K. Platelet rich fibrin- a novel acumen into regenerative endodontic therpy. Restor Dent Endod 2014; 39: 1-6.
- 24. Sanjana NE, Fuller SB. A fast flexible ink-jet printing method for patterning dissociated neurons in culture. J Neurosci Methods 2004;136:151-163.
- 25. Barron JA, Krizman DB, Ringeisen BR. Laser printing of single cells: statistical analysis, cell viability and stress. Ann Biomed Eng 2005;33(2):121-130.
- 26. Shah N, Logani A, Bhaskar U, Aggarwal V. Efficacy of revascu- larization to induce apexification/ apexogensis in infected, nonvital, immature teeth: a pilot clinical study. J Endod. 2008;34:919-25.
- 27. Cotti E, Mereu M, Lusso D. Regenerative treatment of an imma- ture, traumatized tooth with apical periodontitis: report of a case. J Endod. 2008;34:611-6.
- 28. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, et al. Stem cell properties of human dental pulp stem cells. J Dent Res. 2002;81:531-5.
- 29. Andreasen JO, Farik B, Munksgaard EC. Long-term calcium hydroxide as a root canal dressing may increase risk of root fracture. Dent Traumatol 2002;18:134-137.
- 30. Thibodeau B, Teixeria F, Yamauchi M, Caplan DJ, Trope M. Pulp revascularization of immature dog teeth with apical periodontitis. J Endod 2007;25:197.
Details
| Subjects | Health Care Administration |
|---|---|
| Journal Section | Review |
| Authors | |
| Publication Date | March 24, 2017 |
| Submission Date | February 22, 2015 |
| Published in Issue | Year 2016Volume: 19 Issue: 3 |
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
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