Management of Mandibular Osteomyelitis Combined with Platelet Rich Fibrin (PRF) and Ozone

Hülya Toker

doi:10.7126/cumudj.298877

Case Report

Management of Mandibular Osteomyelitis Combined with Platelet Rich Fibrin (PRF) and Ozone

Year 2016, Volume: 19 Issue: 3, 189 - 196, 24.03.2017

Hülya Toker

https://doi.org/10.7126/cumudj.298877

Cited By: 2

Abstract

Osteomyelitis is inflammation of bone tissue
which is seen in patient with malnutrition and such systemic diseases caused by
decreased resistant to infection. Generally, chronic osteomyelitis is treated
with antibiotics and surgical debridement to remove all the dead bone tissue.
In this case report, the management of mandibular osteomyelitis which is
developed after surgery and application with ozone and platelet-rich fibrin are
presented.

Keywords

Osteomyelitis, Ozone, Platelet rich fibrin

References

Lazzarini L, Mader JT, Calhoun JH. Osteomyelitis in long bones. J Bone Joint Surg Am 2004;86-A:2305-2318.
2. Lew DP, Waldvogel FA. Osteomyelitis. N Engl J Med 1997;336:999-1007.
3. Rubin RJ, Harrington CA, Poon A, Dietrich K, Greene JA, Moiduddin A. The economic impact of Staphylococcus aureus infection in New York City hospitals. Emerg Infect Dis 1999;5:9-17.
4. Kilic B. Diagnostic methods for Osteomyelitis. Advances in Environmental Biology 2014;8:573-581.
5. Uckay I, Jugun K, Gamulin A, Wagener J, Hoffmeyer P, Lew D. Chronic osteomyelitis. Curr Infect Dis Rep 2012;14:566-575.
6. Evans RP, Nelson, C.L., Lange, T.A. Pathophysiology of osteomyelitis. In: Surgery of the musculoskeletal system, 1990;Mc Collister Ewarts (ed):19-35.
7. Calhoun KH, Shapiro RD, Stiernberg CM, Calhoun JH, Mader JT. Osteomyelitis of the mandible. Arch Otolaryngol Head Neck Surg 1988;114:1157-1162.
8. Parsons B, Strauss E. Surgical management of chronic osteomyelitis. Am J Surg 2004;188:57-66.
9. Lew DP, Waldvogel FA. Osteomyelitis. Lancet 2004;364:369-379.
10. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e37-44.
11. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e45-50.
12. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004;91:4-15.
13. Braccini F, Dohan DM. [The relevance of Choukroun's platelet rich fibrin (PRF) during facial aesthetic lipostructure (Coleman's technique): preliminary results]. Rev Laryngol Otol Rhinol (Bord) 2007;128:255-260.
14. O'Connell SM, Impeduglia T, Hessler K, Wang XJ, Carroll RJ, Dardik H. Autologous platelet-rich fibrin matrix as cell therapy in the healing of chronic lower-extremity ulcers. Wound Repair Regen 2008;16:749-756.
15. Azarpazhooh A, Limeback H. The application of ozone in dentistry: a systematic review of literature. J Dent 2008;36:104-116.
16. Srikanth A, Sathish M, Sri Harsha AV. Application of ozone in the treatment of periodontal disease. J Pharm Bioallied Sci 2013;5:S89-94.
17. Tanvetyanon T, Stiff PJ. Management of the adverse effects associated with intravenous bisphosphonates. Ann Oncol 2006;17:897-907.
18. Ficarra G, Beninati F, Rubino I, et al. Osteonecrosis of the jaws in periodontal patients with a history of bisphosphonates treatment. J Clin Periodontol 2005;32:1123-1128.
19. Wang HL, Weber D, McCauley LK. Effect of long-term oral bisphosphonates on implant wound healing: literature review and a case report. J Periodontol 2007;78:584-594.
20. Altundal H, Gursoy B. The influence of alendronate on bone formation after autogenous free bone grafting in rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99:285-291.
21. Jan A, Sandor GK, Brkovic BB, Peel S, Evans AW, Clokie CM. Effect of hyperbaric oxygen on grafted and nongrafted calvarial critical-sized defects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:157-163.
22. Garcia VG, da Conceicao JM, Fernandes LA, et al. Effects of LLLT in combination with bisphosphonate on bone healing in critical size defects: a histological and histometric study in rat calvaria. Lasers Med Sci 2013;28:407-414.
23. Chen CE, Shih ST, Fu TH, Wang JW, Wang CJ. Hyperbaric oxygen therapy in the treatment of chronic refractory osteomyelitis: a preliminary report. Chang Gung Med J 2003;26:114-121.
24. Handschel J, Brussermann S, Depprich R, et al. [Evaluation of hyperbaric oxygen therapy in treatment of patients with osteomyelitis of the mandible]. Mund Kiefer Gesichtschir 2007;11:285-290.
25. Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 2006;37:425-435.
26. Polydorou O, Halili A, Wittmer A, Pelz K, Hahn P. The antibacterial effect of gas ozone after 2 months of in vitro evaluation. Clin Oral Investig 2012;16:545-550.
27. Polydorou O, Pelz K, Hahn P. Antibacterial effect of an ozone device and its comparison with two dentin-bonding systems. Eur J Oral Sci 2006;114:349-353.
28. Huth KC, Jakob FM, Saugel B, et al. Effect of ozone on oral cells compared with established antimicrobials. Eur J Oral Sci 2006;114:435-440.
29. Ozdemir H, Toker H, Balci H, Ozer H. Effect of ozone therapy on autogenous bone graft healing in calvarial defects: a histologic and histometric study in rats. J Periodontal Res 2013;48:722-726.
30. Kazancioglu HO, Ezirganli S, Aydin MS. Effects of laser and ozone therapies on bone healing in the calvarial defects. J Craniofac Surg 2013;24:2141-2146.
31. Bocci V. Scientific and medical aspects of ozone therapy. State of the art Archives of Medical Research 2006a;37.
32. Kim HS, Noh, S.U., Han, Y.W., Kim, K.M., Kang, H., Kim, H.O., Park, Y.M. Therapeutic effects of topical application of ozone on acute cutaneous wound healing. . Journal of Korean Medical Science 2009;24: 368-374.
33. Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 2009;80:244-252.
34. Pradeep AR, Rao NS, Agarwal E, Bajaj P, Kumari M, Naik SB. Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of 3-wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol 2012;83:1499-1507.
35. Sharma A, Pradeep AR. Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial. J Periodontol 2011;82:1396-1403.
36. Mazor Z, Horowitz RA, Del Corso M, Prasad HS, Rohrer MD, Dohan Ehrenfest DM. Sinus floor augmentation with simultaneous implant placement using Choukroun's platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol 2009;80:2056-2064.
37. Nassar H, Kantarci A, van Dyke TE. Diabetic periodontitis: a model for activated innate immunity and impaired resolution of inflammation. Periodontology 2000 2007;43:233-244.
38. Berti-Couto SA, Vasconcelos AC, Iglesias JE, Figueiredo MA, Salum FG, Cherubini K. Diabetes mellitus and corticotherapy as risk factors for alendronate-related osteonecrosis of the jaws: a study in Wistar rats. Head Neck 2014;36:84-93.
39. Ellen R, Wald, M.D. Risk Factors for Osteomyelitis The American Journal of Medicine 1985;78(suppl 6B).

Year 2016, Volume: 19 Issue: 3, 189 - 196, 24.03.2017

Hülya Toker

https://doi.org/10.7126/cumudj.298877

Cited By: 2

Abstract

References

Lazzarini L, Mader JT, Calhoun JH. Osteomyelitis in long bones. J Bone Joint Surg Am 2004;86-A:2305-2318.
2. Lew DP, Waldvogel FA. Osteomyelitis. N Engl J Med 1997;336:999-1007.
3. Rubin RJ, Harrington CA, Poon A, Dietrich K, Greene JA, Moiduddin A. The economic impact of Staphylococcus aureus infection in New York City hospitals. Emerg Infect Dis 1999;5:9-17.
4. Kilic B. Diagnostic methods for Osteomyelitis. Advances in Environmental Biology 2014;8:573-581.
5. Uckay I, Jugun K, Gamulin A, Wagener J, Hoffmeyer P, Lew D. Chronic osteomyelitis. Curr Infect Dis Rep 2012;14:566-575.
6. Evans RP, Nelson, C.L., Lange, T.A. Pathophysiology of osteomyelitis. In: Surgery of the musculoskeletal system, 1990;Mc Collister Ewarts (ed):19-35.
7. Calhoun KH, Shapiro RD, Stiernberg CM, Calhoun JH, Mader JT. Osteomyelitis of the mandible. Arch Otolaryngol Head Neck Surg 1988;114:1157-1162.
8. Parsons B, Strauss E. Surgical management of chronic osteomyelitis. Am J Surg 2004;188:57-66.
9. Lew DP, Waldvogel FA. Osteomyelitis. Lancet 2004;364:369-379.
10. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e37-44.
11. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e45-50.
12. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004;91:4-15.
13. Braccini F, Dohan DM. [The relevance of Choukroun's platelet rich fibrin (PRF) during facial aesthetic lipostructure (Coleman's technique): preliminary results]. Rev Laryngol Otol Rhinol (Bord) 2007;128:255-260.
14. O'Connell SM, Impeduglia T, Hessler K, Wang XJ, Carroll RJ, Dardik H. Autologous platelet-rich fibrin matrix as cell therapy in the healing of chronic lower-extremity ulcers. Wound Repair Regen 2008;16:749-756.
15. Azarpazhooh A, Limeback H. The application of ozone in dentistry: a systematic review of literature. J Dent 2008;36:104-116.
16. Srikanth A, Sathish M, Sri Harsha AV. Application of ozone in the treatment of periodontal disease. J Pharm Bioallied Sci 2013;5:S89-94.
17. Tanvetyanon T, Stiff PJ. Management of the adverse effects associated with intravenous bisphosphonates. Ann Oncol 2006;17:897-907.
18. Ficarra G, Beninati F, Rubino I, et al. Osteonecrosis of the jaws in periodontal patients with a history of bisphosphonates treatment. J Clin Periodontol 2005;32:1123-1128.
19. Wang HL, Weber D, McCauley LK. Effect of long-term oral bisphosphonates on implant wound healing: literature review and a case report. J Periodontol 2007;78:584-594.
20. Altundal H, Gursoy B. The influence of alendronate on bone formation after autogenous free bone grafting in rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99:285-291.
21. Jan A, Sandor GK, Brkovic BB, Peel S, Evans AW, Clokie CM. Effect of hyperbaric oxygen on grafted and nongrafted calvarial critical-sized defects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:157-163.
22. Garcia VG, da Conceicao JM, Fernandes LA, et al. Effects of LLLT in combination with bisphosphonate on bone healing in critical size defects: a histological and histometric study in rat calvaria. Lasers Med Sci 2013;28:407-414.
23. Chen CE, Shih ST, Fu TH, Wang JW, Wang CJ. Hyperbaric oxygen therapy in the treatment of chronic refractory osteomyelitis: a preliminary report. Chang Gung Med J 2003;26:114-121.
24. Handschel J, Brussermann S, Depprich R, et al. [Evaluation of hyperbaric oxygen therapy in treatment of patients with osteomyelitis of the mandible]. Mund Kiefer Gesichtschir 2007;11:285-290.
25. Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 2006;37:425-435.
26. Polydorou O, Halili A, Wittmer A, Pelz K, Hahn P. The antibacterial effect of gas ozone after 2 months of in vitro evaluation. Clin Oral Investig 2012;16:545-550.
27. Polydorou O, Pelz K, Hahn P. Antibacterial effect of an ozone device and its comparison with two dentin-bonding systems. Eur J Oral Sci 2006;114:349-353.
28. Huth KC, Jakob FM, Saugel B, et al. Effect of ozone on oral cells compared with established antimicrobials. Eur J Oral Sci 2006;114:435-440.
29. Ozdemir H, Toker H, Balci H, Ozer H. Effect of ozone therapy on autogenous bone graft healing in calvarial defects: a histologic and histometric study in rats. J Periodontal Res 2013;48:722-726.
30. Kazancioglu HO, Ezirganli S, Aydin MS. Effects of laser and ozone therapies on bone healing in the calvarial defects. J Craniofac Surg 2013;24:2141-2146.
31. Bocci V. Scientific and medical aspects of ozone therapy. State of the art Archives of Medical Research 2006a;37.
32. Kim HS, Noh, S.U., Han, Y.W., Kim, K.M., Kang, H., Kim, H.O., Park, Y.M. Therapeutic effects of topical application of ozone on acute cutaneous wound healing. . Journal of Korean Medical Science 2009;24: 368-374.
33. Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 2009;80:244-252.
34. Pradeep AR, Rao NS, Agarwal E, Bajaj P, Kumari M, Naik SB. Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of 3-wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial. J Periodontol 2012;83:1499-1507.
35. Sharma A, Pradeep AR. Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial. J Periodontol 2011;82:1396-1403.
36. Mazor Z, Horowitz RA, Del Corso M, Prasad HS, Rohrer MD, Dohan Ehrenfest DM. Sinus floor augmentation with simultaneous implant placement using Choukroun's platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol 2009;80:2056-2064.
37. Nassar H, Kantarci A, van Dyke TE. Diabetic periodontitis: a model for activated innate immunity and impaired resolution of inflammation. Periodontology 2000 2007;43:233-244.
38. Berti-Couto SA, Vasconcelos AC, Iglesias JE, Figueiredo MA, Salum FG, Cherubini K. Diabetes mellitus and corticotherapy as risk factors for alendronate-related osteonecrosis of the jaws: a study in Wistar rats. Head Neck 2014;36:84-93.
39. Ellen R, Wald, M.D. Risk Factors for Osteomyelitis The American Journal of Medicine 1985;78(suppl 6B).

There are 39 citations in total.

Details

Subjects	Health Care Administration
Journal Section	Case Reports
Authors	Hülya Toker
Publication Date	March 24, 2017
Submission Date	November 2, 2015
Published in Issue	Year 2016Volume: 19 Issue: 3

Cite

EndNote	Toker H (March 1, 2017) Management of Mandibular Osteomyelitis Combined with Platelet Rich Fibrin (PRF) and Ozone. Cumhuriyet Dental Journal 19 3 189–196.

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Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.

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