Trombosit Zengin Fibrin ve Rifamisinin Bir Allogreft ile Kombinasyonda Kemik Büyütme Üzerindeki Etkilerinin Tavşan Tibiasında Eşzamanlı İmplant Yerleştirmesiyle Histomorfometrik Olarak Değerlendirilmesi
Abstract
Amaç:
Yüksek profilli dental implant yerleştirilmesinde yönlendirilmiş doku
augmentasyonunu geliştirmek için plateletten zengin fibrin (PRF) ve rifamisin
uygulamasının potansiyelinin değerlendirilmesi.
Materyal
ve metod: İki mm’lik koronal kısmı kemik dışında kalan
dental implantlar kubbe şeklinde sert kaplayıcı titanyum membran ile kapatılmış
ve membranın içi demineralize dondurularak kurutulmuş kemik allogrefti (DFDBA)+salin
(7 tavşan), DFDBA+rifamisin (8 tavşan) veya DFDBA+PRF (8 tavşan) ile
doldurulmuştur.
Bulgular:
Kemik implant kontağı (KİK) salin grubunda 58.43±1.92%, rifamisin grubunda
68.34±20.37% ve PRF grubunda 80.70±2.55% olarak tespit edilmiştir. Sırasıyla
yeni kemik oluşum yüzdesi de 36.90±0.94, 45.26±0.60 ve 51.82±0.82 olarak
bulunmuştur.
Sonuç:
Hem PRF hem de rifamisinin yönlendirilmiş doku augmentasyonunu geliştirici
potansiyeli olduğu ve yüksek profilli dental implant uygulamalarında sert
kaplayıcı titanyum membran altında DFDBA + PRF veya DFDBA + rifamisin
kullanılmasının hem KİK değerini hem de yeni kemik oluşum yüzdesini
artırabileceği görülmüştür.
Keywords
Kemik Takviyesi Trombosit bakımından zengin fibrin rifamisin Yüksek profilli diş implantları
References
- Referans1. Rocchietta I, Fontana F, Simion M. Clinical outcomes of vertical bone augmentation to enable dental implant placement: a systematic review. J Clin Periodontol 2008;35:203-215.
- Referans2. Dahlin C, Linde A, Gottlow J, Nyman S. Healing of bone defects by guided tissue regeneration. Plast Reconstr Surg 1988;81:672-676.
- Referans3. Buser D, Braegger U, Lang NP, Nyman S. Regeneration and enlargement of jaw bone using guided tissue regeneration. Clin Oral Implants Res 1990;1:22-32.
- Referans4. Chiapasco M, Casentini P, Zaniboni M. Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants 2009; 24:237-259. Referans5. Hanes PJ. Bone replacement grafts for the treatment of periodontal intrabony defects. Oral Maxillofac Surg Clin North Am 2007;19:499-512.
- Referans6. Kumar RV, Shubhashini N. Platelet rich fibrin: A new paradigm in periodontal regeneration. Cell Tissue Bank 2013;14:453-463.
- Referans7. Kang YH, Jeon SH, Park JY, Chung JH, Choung YH, Choung HW et al. Platelet-rich fibrin is a bioscaffold and reservoir of growth factors for tissue regeneration. Tissue Eng Part A 2011;17:349-359.
- Referans8. Wang Z, Weng Y, Lu S, Zong C, Qiu J, Liu Y, et al. Osteoblastic mesenchymal stem cell sheet combined with Choukroun platelet-rich fibrin induces bone formation at an ectopic site. J Biomed Mater Res B Appl Biomater 2015;103:1204-1216.
- Referans9. Davis VL, Abukabda AB, Radio NM, Witt-Enderby PA, Clafshenkel WP, Cairone JV et al. Platelet-rich preparations to improve healing. Part II: Platelet activation and enrichment, leukocyte inclusion, and other selection criteria. J Oral Implantol 2014;40:511-521.
- Referans10. Cancienne JM, Tyrrell Burrus M, Weiss DB, Yarboro SR. Applications of Local Antibiotics in Orthopedic Trauma. Orthop Clin North Am 2015;46:495-510.
- Referans11. Kaya A, Kaya B, Aktaş A, Fırat ET. Effect of rifampin in combination with allogeneic, alloplastic, and heterogenous bone grafts on bone regeneration in rat tibial bone defects. J Oral Maxillofac Surg Med Pathol 2015;27:20-28.
- Referans12. Taşdemir U, Özeç İ, Esen HH, Avunduk MC. The influence of rifamycin decontamination on incorporation of autologous onlay bone grafts in rats: A histometric and immunohistochemical evaluation. Arch Oral Biol 2015;60:724-729.
- Referans13. Donath K, Breuner G. A method for the study of undecalcified bones and teeth with attached soft tissues. The Säge-Schliff (sawing and grinding) technique. J Oral Pathol 1982;11:318-326.
- Referans14. Van Steenberghe D, Johansson C, Quirynen M, Molly L, Albrektsson T, Naert I.. Bone augmentation by means of a stiff occlusive titanium barrier. Clinical Oral Implants Research 2003;14:63-71.
- Referans15. Min S, Sato S, Saito M, Ebihara H, Arai Y, Ito K. Micro-computerized tomography analysis: dynamics of bone augmentation within a titanium cap in rabbit calvarium. Oral Surgery Oral Medicine Oral Pathology Oral Radiology Endodontology 2008;106: 892-895.
- Referans16. Simion M, Trisi P, Piattelli A. Vertical ridge augmentation using a membrane technique associated with osseointegrated implants. Int J Periodontics Restorative Dent 1994;14:496-511.
- Referans17. Misch CM, Jensen OT, Pikos MA, Malmquist JP. Vertical bone augmentation using recombinant bone morphogenetic protein, mineralized bone allograft, and titanium mesh: a retrospective cone beam computed tomography study. Int J Oral Maxillofac Implants 2015;30: 202-207.
- Referans18. Casap N, Laviv A, Debecco M, Alterman M, Laster Z, Jensen OT. Imperforate titanium shell enclosing recombinant human bone morphogenetic protein-2-induced bone formation for high-profile dental implants in rabbit tibia. J Oral Maxillofac Surg 2015;73:245-252.
- Referans19. Marx RE, Armentano L, Olavarria A, Samaniego J. rhBMP-2/ACS grafts versus autogenous cancellous marrow grafts in large vertical defects of the maxilla: an unsponsored randomized open-label clinical trial. Int J Oral Maxillofac Implants 2013;28:243-251.
- Referans20. Ozdemir H, Ezirganli S, Kara M, Mihmanli A, Baris E. Effects of platelet rich fibrin alone used with rigid titanium barrier. Arch Oral Biol 2013;58:537-544.
- Referans21. Shah M, Patel J, Dave D, Shah S. Comparative evaluation of platelet-rich fibrin with demineralized freeze-dried bone allograft in periodontal infrabony defects: A randomized controlled clinical study. J Indian Soc Periodontol 2015;19:56-60.
- Referans22. Agarwal A, Gupta ND, Jain A. Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: a randomized split mouth clinical trail. Acta Odontol Scand 2016;74:36-43.
- Referans23. Rathbone CR, Cross JD, Brown KV, Murray CK, Wenke JC Effect of various concentrations of antibiotics on osteogenic cell viability and activity. J Orthop Re 2011; 29:1070-1074.
- Referans24. Mabbry TW, Yukna RA, Sepe WW. Freeze dried allografts combined with tetracycline in the treatment of juvenile periodontitis. J Periodontol 1985;56:74-81.
- Referans25. Masters LB, Mellonig JT, Brunsvold MA, Nummikoski PV. A clinical evaluation of demineralized freeze-dried bone allograft in combination with tetracycline in the treatment of periodontal osseous defects. J Periodontol 1996;67:770-781.
- Referans26. Tabrizi R, Khorshidi H, Shahidi S, Gholami M, Kalbasi S, Khayati A. Use of lincomycin-impregnated demineralized freeze-dried bone allograft in the periodontal defect after third molar surgery. J Oral Maxillofac Surg 2014;72:850-857.
- Referans27. Rossi F, Botticelli D, Pantani F, Pereira FP, Salata LA, Lang NP. Bone healing pattern in surgically created circumferential defects around submerged implants: an experimental study in dog. Clin Oral Implants Res 2012;23:41-48.
A HISTOMORPHOMETRIC EVALUATION OF THE EFFECTS OF PLATELET-RICH FIBRIN AND RIFAMYCIN IN COMBINATION WITH AN ALLOGRAFT ON BONE AUGMENTATION WITH SIMULTANEOUS IMPLANT PLACEMENT IN RABBIT TIBIA
Abstract
Objective: To evaluate the
potential of platelet-rich fibrin (PRF) and rifamycin to enhance guided bone
augmentation with simultaneous high-profile dental implant placement in a
rabbit tibia model.
Materials and Methods: Dental implants
protruding 2 mm were covered with dome-shaped stiff occlusive titanium barriers
filled with demineralized freeze-dried bone allograft (DFDBA)+saline (7
rabbits), DFDBA + rifamycin (8 rabbits), or DFDB +PRF (8 rabbits). After 4
weeks, the animals were sacrificed, and undecalcified histomorphometric
examination with toluidine blue staining was performed.
Results: The
bone-to-implant contact (BIC) was 58.43 ± 1.92% in the saline group, 68.3 ±20.37%
in the rifamycin group, and 80.70±2.55% in the PRF group, and the percentage of
new bone formation was 36.90 ± 0.94%, 45.26±0.60%, and 51.82±0.82%,
respectively. Conclusions: Both PRF and rifamycin have potential to enhance
GBA, and using DFDBA + PRF or DFDBA+rifamycin beneath a stiff occlusive
titanium barrier next to a high-profile implant may enhance both BIC and new
bone formation.
Keywords: Guided bone augmentation, platelet-rich fibrin, rifamycin, allograft,
high-profile dental implants
Keywords
Guided bone augmentation platelet-rich fibrin rifamycin allograft high-profile dental implants
References
- Referans1. Rocchietta I, Fontana F, Simion M. Clinical outcomes of vertical bone augmentation to enable dental implant placement: a systematic review. J Clin Periodontol 2008;35:203-215.
- Referans2. Dahlin C, Linde A, Gottlow J, Nyman S. Healing of bone defects by guided tissue regeneration. Plast Reconstr Surg 1988;81:672-676.
- Referans3. Buser D, Braegger U, Lang NP, Nyman S. Regeneration and enlargement of jaw bone using guided tissue regeneration. Clin Oral Implants Res 1990;1:22-32.
- Referans4. Chiapasco M, Casentini P, Zaniboni M. Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants 2009; 24:237-259. Referans5. Hanes PJ. Bone replacement grafts for the treatment of periodontal intrabony defects. Oral Maxillofac Surg Clin North Am 2007;19:499-512.
- Referans6. Kumar RV, Shubhashini N. Platelet rich fibrin: A new paradigm in periodontal regeneration. Cell Tissue Bank 2013;14:453-463.
- Referans7. Kang YH, Jeon SH, Park JY, Chung JH, Choung YH, Choung HW et al. Platelet-rich fibrin is a bioscaffold and reservoir of growth factors for tissue regeneration. Tissue Eng Part A 2011;17:349-359.
- Referans8. Wang Z, Weng Y, Lu S, Zong C, Qiu J, Liu Y, et al. Osteoblastic mesenchymal stem cell sheet combined with Choukroun platelet-rich fibrin induces bone formation at an ectopic site. J Biomed Mater Res B Appl Biomater 2015;103:1204-1216.
- Referans9. Davis VL, Abukabda AB, Radio NM, Witt-Enderby PA, Clafshenkel WP, Cairone JV et al. Platelet-rich preparations to improve healing. Part II: Platelet activation and enrichment, leukocyte inclusion, and other selection criteria. J Oral Implantol 2014;40:511-521.
- Referans10. Cancienne JM, Tyrrell Burrus M, Weiss DB, Yarboro SR. Applications of Local Antibiotics in Orthopedic Trauma. Orthop Clin North Am 2015;46:495-510.
- Referans11. Kaya A, Kaya B, Aktaş A, Fırat ET. Effect of rifampin in combination with allogeneic, alloplastic, and heterogenous bone grafts on bone regeneration in rat tibial bone defects. J Oral Maxillofac Surg Med Pathol 2015;27:20-28.
- Referans12. Taşdemir U, Özeç İ, Esen HH, Avunduk MC. The influence of rifamycin decontamination on incorporation of autologous onlay bone grafts in rats: A histometric and immunohistochemical evaluation. Arch Oral Biol 2015;60:724-729.
- Referans13. Donath K, Breuner G. A method for the study of undecalcified bones and teeth with attached soft tissues. The Säge-Schliff (sawing and grinding) technique. J Oral Pathol 1982;11:318-326.
- Referans14. Van Steenberghe D, Johansson C, Quirynen M, Molly L, Albrektsson T, Naert I.. Bone augmentation by means of a stiff occlusive titanium barrier. Clinical Oral Implants Research 2003;14:63-71.
- Referans15. Min S, Sato S, Saito M, Ebihara H, Arai Y, Ito K. Micro-computerized tomography analysis: dynamics of bone augmentation within a titanium cap in rabbit calvarium. Oral Surgery Oral Medicine Oral Pathology Oral Radiology Endodontology 2008;106: 892-895.
- Referans16. Simion M, Trisi P, Piattelli A. Vertical ridge augmentation using a membrane technique associated with osseointegrated implants. Int J Periodontics Restorative Dent 1994;14:496-511.
- Referans17. Misch CM, Jensen OT, Pikos MA, Malmquist JP. Vertical bone augmentation using recombinant bone morphogenetic protein, mineralized bone allograft, and titanium mesh: a retrospective cone beam computed tomography study. Int J Oral Maxillofac Implants 2015;30: 202-207.
- Referans18. Casap N, Laviv A, Debecco M, Alterman M, Laster Z, Jensen OT. Imperforate titanium shell enclosing recombinant human bone morphogenetic protein-2-induced bone formation for high-profile dental implants in rabbit tibia. J Oral Maxillofac Surg 2015;73:245-252.
- Referans19. Marx RE, Armentano L, Olavarria A, Samaniego J. rhBMP-2/ACS grafts versus autogenous cancellous marrow grafts in large vertical defects of the maxilla: an unsponsored randomized open-label clinical trial. Int J Oral Maxillofac Implants 2013;28:243-251.
- Referans20. Ozdemir H, Ezirganli S, Kara M, Mihmanli A, Baris E. Effects of platelet rich fibrin alone used with rigid titanium barrier. Arch Oral Biol 2013;58:537-544.
- Referans21. Shah M, Patel J, Dave D, Shah S. Comparative evaluation of platelet-rich fibrin with demineralized freeze-dried bone allograft in periodontal infrabony defects: A randomized controlled clinical study. J Indian Soc Periodontol 2015;19:56-60.
- Referans22. Agarwal A, Gupta ND, Jain A. Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: a randomized split mouth clinical trail. Acta Odontol Scand 2016;74:36-43.
- Referans23. Rathbone CR, Cross JD, Brown KV, Murray CK, Wenke JC Effect of various concentrations of antibiotics on osteogenic cell viability and activity. J Orthop Re 2011; 29:1070-1074.
- Referans24. Mabbry TW, Yukna RA, Sepe WW. Freeze dried allografts combined with tetracycline in the treatment of juvenile periodontitis. J Periodontol 1985;56:74-81.
- Referans25. Masters LB, Mellonig JT, Brunsvold MA, Nummikoski PV. A clinical evaluation of demineralized freeze-dried bone allograft in combination with tetracycline in the treatment of periodontal osseous defects. J Periodontol 1996;67:770-781.
- Referans26. Tabrizi R, Khorshidi H, Shahidi S, Gholami M, Kalbasi S, Khayati A. Use of lincomycin-impregnated demineralized freeze-dried bone allograft in the periodontal defect after third molar surgery. J Oral Maxillofac Surg 2014;72:850-857.
- Referans27. Rossi F, Botticelli D, Pantani F, Pereira FP, Salata LA, Lang NP. Bone healing pattern in surgically created circumferential defects around submerged implants: an experimental study in dog. Clin Oral Implants Res 2012;23:41-48.
Details
| Subjects | Health Care Administration |
|---|---|
| Journal Section | Original Research Articles |
| Authors | |
| Publication Date | May 12, 2017 |
| Submission Date | April 20, 2017 |
| Published in Issue | Year 2017 |
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
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