Clinicopathological Parameters Related to Malignant Transformation of Oral Leukoplakia: A Meta-Analysis

Alberto Rodriguez-archilla; Cristina Fuentes-perez

doi:10.7126/cumudj.853865

EN

Clinicopathological Parameters Related to Malignant Transformation of Oral Leukoplakia: A Meta-Analysis

Abstract

Objective. To assess the clinical-pathological factors related to the malignant transformation of oral leukoplakia. Materials and Methods. A search for articles on malignant transformation factors related to oral leukoplakia was conducted in the following electronic databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS) and Google Scholar. Thirty-seven articles with a low-moderate risk of bias according to the Newcastle-Ottawa methodological quality scale were included in this meta-analysis. The data were analyzed using the statistical programs RevMan 5.4 (The Cochrane Collaboration, Oxford, UK) and MedCalc Statistical Software version 16.4.3 (MedCalc Software Ltd. Ostend, Belgium) programs. The estimated prevalence was calculated according to DerSimonian and Laird random method. For dichotomous outcomes, the estimates of effects of an intervention were expressed as odds ratios (OR) using the Mantel-Haenszel (M-H) method with 95% confidence intervals. Results. The estimated global prevalence of malignant transformation of oral leukoplakia was 9.15%. The factors with the highest malignant transformation risk of oral leukoplakia were: non-homogeneous clinical types (OR: 5.41; p<0.001); leukoplakias with moderate-severe dysplasia (OR: 3.43; p<0.001); lesions located on the tongue and/or the floor of the mouth (OR: 3.19; p<0.001); leukoplakias in non-smokers (OR: 2.08; p<0.001) and lesions in women (OR: 1.73; p<0.001). In contrast, older age or regular alcohol intake were factors without significant influence (p>0.05).Conclusions. Non-homogenous oral leukoplakias and with moderate-severe dysplasia are those with the highest probability of malignant transformation.

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Review

Authors

Alberto Rodriguez-archilla ^*
0000-0003-1023-943X
Spain

Cristina Fuentes-perez
0000-0002-5764-1525
Spain

Publication Date

May 31, 2021

Submission Date

January 4, 2021

Acceptance Date

April 1, 2021

Published in Issue

Year 2021 Volume: 24 Number: 2

DOI

https://doi.org/10.7126/cumudj.853865

IZ

https://izlik.org/JA72WN35GP

Cite

RIS / Bibtex

APA

Rodriguez-archilla, A., & Fuentes-perez, C. (2021). Clinicopathological Parameters Related to Malignant Transformation of Oral Leukoplakia: A Meta-Analysis. Cumhuriyet Dental Journal, 24(2), 197-204. https://doi.org/10.7126/cumudj.853865

AMA

1.Rodriguez-archilla A, Fuentes-perez C. Clinicopathological Parameters Related to Malignant Transformation of Oral Leukoplakia: A Meta-Analysis. Cumhuriyet Dent J. 2021;24(2):197-204. doi:10.7126/cumudj.853865

Chicago

Rodriguez-archilla, Alberto, and Cristina Fuentes-perez. 2021. “Clinicopathological Parameters Related to Malignant Transformation of Oral Leukoplakia: A Meta-Analysis”. Cumhuriyet Dental Journal 24 (2): 197-204. https://doi.org/10.7126/cumudj.853865.

EndNote

Rodriguez-archilla A, Fuentes-perez C (May 1, 2021) Clinicopathological Parameters Related to Malignant Transformation of Oral Leukoplakia: A Meta-Analysis. Cumhuriyet Dental Journal 24 2 197–204.

IEEE

[1]A. Rodriguez-archilla and C. Fuentes-perez, “Clinicopathological Parameters Related to Malignant Transformation of Oral Leukoplakia: A Meta-Analysis”, Cumhuriyet Dent J, vol. 24, no. 2, pp. 197–204, May 2021, doi: 10.7126/cumudj.853865.

ISNAD

Rodriguez-archilla, Alberto - Fuentes-perez, Cristina. “Clinicopathological Parameters Related to Malignant Transformation of Oral Leukoplakia: A Meta-Analysis”. Cumhuriyet Dental Journal 24/2 (May 1, 2021): 197-204. https://doi.org/10.7126/cumudj.853865.

JAMA

1.Rodriguez-archilla A, Fuentes-perez C. Clinicopathological Parameters Related to Malignant Transformation of Oral Leukoplakia: A Meta-Analysis. Cumhuriyet Dent J. 2021;24:197–204.

MLA

Rodriguez-archilla, Alberto, and Cristina Fuentes-perez. “Clinicopathological Parameters Related to Malignant Transformation of Oral Leukoplakia: A Meta-Analysis”. Cumhuriyet Dental Journal, vol. 24, no. 2, May 2021, pp. 197-04, doi:10.7126/cumudj.853865.

Vancouver

1.Alberto Rodriguez-archilla, Cristina Fuentes-perez. Clinicopathological Parameters Related to Malignant Transformation of Oral Leukoplakia: A Meta-Analysis. Cumhuriyet Dent J. 2021 May 1;24(2):197-204. doi:10.7126/cumudj.853865