CLINICAL ANALYSIS OF DESQUAMATIVE GINGIVITIS RELATED ORAL MUCOCUTANEOUS DISEASES

Özlem Daltaban; Aslı Özçentik; Ayşe Akman-karakaş; Kemal Üstün; Mükerrem Hatipoğlu; Soner Uzun

doi:10.7126/cumudj.779519

EN

CLINICAL ANALYSIS OF DESQUAMATIVE GINGIVITIS RELATED ORAL MUCOCUTANEOUS DISEASES

Abstract

Objectives: Several mucocutaneous diseases are responsible for desquamative gingivitis (DG) and diagnostic delays are common in these diseases due to non-specific clinical oral presentations. The present study aimed to analyze the clinical features of DG-related mucocutaneous diseases with oral manifestations and compare the findings with previous reports. Materials and Methods: Thirty newly diagnosed patients with oral mucocutaneous disease in the Dermatology and Venereology Department of Akdeniz University Medical School, between January 2018 and January 2020, and referred to the Periodontology Department for periodontal treatment were evaluated retrospectively. Patients demographic data (age and gender), medical comorbidities, primary lesion site (oral or skin), and clinical features of gingival and oral lesions (location and symptoms) were examined. Results: There were 18 oral lichen planus (OLP), 8 pemphigus vulgaris (PV), and 4 mucous membrane pemphigoid (MMP) patients with oral involvements. The mean age of the patients was 50.03 ± 9.71 years with a female predominance (male to female ratio 1:1.7). All patients suffered from chronic burning sensation and oral pain. DG was detected in all three mucocutaneous diseases but OLP was the main disease associated with DG (60%). However other oral mucosal lesions and extraoral involvements were more frequent in PV patients. Conclusions: According to these results, OLP, MMP, and PV are the mucocutaneous diseases responsible for DG, and OLP is the most common cause of DG. Clinicans should be familiar with the clinical presentations and signs (patient complaints) of DG-related mucocutaneous disease for early diagnosis, proper treatment, and quality of life of the patient.

Keywords

References

1. Maderal AD, Lee Salisbury P, 3rd, Jorizzo JL. Desquamative gingivitis: Diagnosis and treatment. J Am Acad Dermatol 2018;78:851-861.
2. Lo Russo L, Fedele S, Guiglia R, et al. Diagnostic pathways and clinical significance of desquamative gingivitis. J Periodontol 2008;79:4-24.
3. Rashid H, Lamberts A, Diercks GFH, et al. Oral Lesions in Autoimmune Bullous Diseases: An Overview of Clinical Characteristics and Diagnostic Algorithm. Am J Clin Dermatol 2019; 20:847-861
4. Leuci S, Ruoppo E, Adamo D, Calabria E, Mignogna MD. Oral autoimmune vesicobullous diseases: Classification, clinical presentations, molecular mechanisms, diagnostic algorithms, and management. Periodontology 2000 2019;80:77-88.
5. Sciubba JJ. Autoimmune oral mucosal diseases: clinical, etiologic, diagnostic, and treatment considerations. Dent Clin North Am 2011;55:89-103.
6. Suresh L, Neiders ME. Definitive and differential diagnosis of desquamative gingivitis through direct immunofluorescence studies. J Periodontol 2012;83:1270-1278.
7. Hassona Y, Cirillo N. Diagnostic patterns and delays in autoimmune blistering diseases of the mouth: A cross-sectional study. Oral Dis 2018;24:802-808.
8. Sirois DA, Fatahzadeh M, Roth R, Ettlin D. Diagnostic patterns and delays in pemphigus vulgaris: experience with 99 patients. Arch Dermatol 2000;136:1569-1570.

9. Saha M, Bhogal B, Black MM, Cooper D, Vaughan RW, Groves RW. Prognostic factors in pemphigus vulgaris and pemphigus foliaceus. Br J Dermatol 2014;170:116-122.
10. Ghodsi SZ, Chams-Davatchi C, Daneshpazhooh M, Valikhani M, Esmaili N. Quality of life and psychological status of patients with pemphigus vulgaris using Dermatology Life Quality Index and General Health Questionnaires. J Dermatol 2012;39:141-144.
11. Gomez I, Warnakulasuriya S, Varela-Centelles PI, et al. Is early diagnosis of oral cancer a feasible objective? Who is to blame for diagnostic delay? Oral Dis 2010;16:333-342.
12. Ergun S, Ozel S, Koray M, Kurklu E, Ak G, Tanyeri H. Dentists' knowledge and opinions about oral mucosal lesions. Int J Oral Maxillofacial Surg 2009;38:1283-1288.
13. Scott SE, Grunfeld EA, Main J, McGurk M. Patient delay in oral cancer: a qualitative study of patients' experiences. Psychooncology 2006;15:474-485.
14. Scully C, Porter SR. The clinical spectrum of desquamative gingivitis. Seminars in cutaneous medicine and surgery 1997;16:308-313.
15. Murrell DF, Dick S, Ahmed AR, et al. Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus. J Am Acad Dermatol 2008;58:1043-1046.
16. Leao JC, Ingafou M, Khan A, Scully C, Porter S. Desquamative gingivitis: retrospective analysis of disease associations of a large cohort. Oral Dis 2008;14:556-560.
17. Lo Russo L, Fierro G, Guiglia R, et al. Epidemiology of desquamative gingivitis: evaluation of 125 patients and review of the literature. Int J Dermatol 2009;48:1049-1052.
18. Alrashdan MS, Cirillo N, McCullough M. Oral lichen planus: a literature review and update. Arch Dermatol Res 2016;308:539-551.
19. Mignogna MD, Lo Russo L, Fedele S. Gingival involvement of oral lichen planus in a series of 700 patients. J Clin Periodontol 2005;32:1029-1033.
20. Black M, Mignogna MD, Scully C. Number II. Pemphigus vulgaris. Oral Dis 2005;11:119-130.
21. Mignogna MD, Lo Muzio L, Bucci E. Clinical features of gingival pemphigus vulgaris. J Clin Periodontol 2001;28:489-493.
22. Bagan J, Lo Muzio L, Scully C. Mucosal disease series. Number III. Mucous membrane pemphigoid. Oral Dis 2005;11:197-218.
23. Sultan AS, Villa A, Saavedra AP, Treister NS, Woo SB. Oral mucous membrane pemphigoid and pemphigus vulgaris-a retrospective two-center cohort study. Oral Dis 2017;23:498-504.
24. Mignogna MD, Fortuna G, Leuci S, Ruoppo E, Marasca F, Matarasso S. Nikolsky's sign on the gingival mucosa: a clinical tool for oral health practitioners. J Periodontol 2008;79:2241-2246.
25. Bystryn JC, Rudolph JL. Pemphigus. Lancet (London, England) 2005;366:61-73.
26. Endo H, Rees TD, Hallmon WW, et al. Disease progression from mucosal to mucocutaneous involvement in a patient with desquamative gingivitis associated with pemphigus vulgaris. J Periodontol 2008;79:369-375.

Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Özlem Daltaban ^*
0000-0003-2246-8782
Türkiye

Aslı Özçentik
0000-0003-2026-1120
Türkiye

Ayşe Akman-karakaş
0000-0002-5113-4178
Türkiye

Kemal Üstün
0000-0001-9696-2041
Türkiye

Mükerrem Hatipoğlu
0000-0003-4698-292X
Türkiye

Soner Uzun
0000-0001-7059-5474
Türkiye

Publication Date

December 31, 2020

Submission Date

August 12, 2020

Acceptance Date

October 6, 2020

Published in Issue

Year 2020 Volume: 23 Number: 4

DOI

https://doi.org/10.7126/cumudj.779519

IZ

https://izlik.org/JA83NG74TA

Cite

RIS / Bibtex

APA

Daltaban, Ö., Özçentik, A., Akman-karakaş, A., Üstün, K., Hatipoğlu, M., & Uzun, S. (2020). CLINICAL ANALYSIS OF DESQUAMATIVE GINGIVITIS RELATED ORAL MUCOCUTANEOUS DISEASES. Cumhuriyet Dental Journal, 23(4), 325-330. https://doi.org/10.7126/cumudj.779519

AMA

1.Daltaban Ö, Özçentik A, Akman-karakaş A, Üstün K, Hatipoğlu M, Uzun S. CLINICAL ANALYSIS OF DESQUAMATIVE GINGIVITIS RELATED ORAL MUCOCUTANEOUS DISEASES. Cumhuriyet Dent J. 2020;23(4):325-330. doi:10.7126/cumudj.779519

Chicago

Daltaban, Özlem, Aslı Özçentik, Ayşe Akman-karakaş, Kemal Üstün, Mükerrem Hatipoğlu, and Soner Uzun. 2020. “CLINICAL ANALYSIS OF DESQUAMATIVE GINGIVITIS RELATED ORAL MUCOCUTANEOUS DISEASES”. Cumhuriyet Dental Journal 23 (4): 325-30. https://doi.org/10.7126/cumudj.779519.

EndNote

Daltaban Ö, Özçentik A, Akman-karakaş A, Üstün K, Hatipoğlu M, Uzun S (December 1, 2020) CLINICAL ANALYSIS OF DESQUAMATIVE GINGIVITIS RELATED ORAL MUCOCUTANEOUS DISEASES. Cumhuriyet Dental Journal 23 4 325–330.

IEEE

[1]Ö. Daltaban, A. Özçentik, A. Akman-karakaş, K. Üstün, M. Hatipoğlu, and S. Uzun, “CLINICAL ANALYSIS OF DESQUAMATIVE GINGIVITIS RELATED ORAL MUCOCUTANEOUS DISEASES”, Cumhuriyet Dent J, vol. 23, no. 4, pp. 325–330, Dec. 2020, doi: 10.7126/cumudj.779519.

ISNAD

Daltaban, Özlem - Özçentik, Aslı - Akman-karakaş, Ayşe - Üstün, Kemal - Hatipoğlu, Mükerrem - Uzun, Soner. “CLINICAL ANALYSIS OF DESQUAMATIVE GINGIVITIS RELATED ORAL MUCOCUTANEOUS DISEASES”. Cumhuriyet Dental Journal 23/4 (December 1, 2020): 325-330. https://doi.org/10.7126/cumudj.779519.

JAMA

1.Daltaban Ö, Özçentik A, Akman-karakaş A, Üstün K, Hatipoğlu M, Uzun S. CLINICAL ANALYSIS OF DESQUAMATIVE GINGIVITIS RELATED ORAL MUCOCUTANEOUS DISEASES. Cumhuriyet Dent J. 2020;23:325–330.

MLA

Daltaban, Özlem, et al. “CLINICAL ANALYSIS OF DESQUAMATIVE GINGIVITIS RELATED ORAL MUCOCUTANEOUS DISEASES”. Cumhuriyet Dental Journal, vol. 23, no. 4, Dec. 2020, pp. 325-30, doi:10.7126/cumudj.779519.

Vancouver

1.Özlem Daltaban, Aslı Özçentik, Ayşe Akman-karakaş, Kemal Üstün, Mükerrem Hatipoğlu, Soner Uzun. CLINICAL ANALYSIS OF DESQUAMATIVE GINGIVITIS RELATED ORAL MUCOCUTANEOUS DISEASES. Cumhuriyet Dent J. 2020 Dec. 1;23(4):325-30. doi:10.7126/cumudj.779519