Lack of Association between Enamel Gene Variants and Dental Caries in Adults

Gül Yıldız Telatar; Faruk Saydam

doi:10.7126/cumudj.690129

EN

Lack of Association between Enamel Gene Variants and Dental Caries in Adults

Abstract

Objectives: Studies report that gene polymorphisms associated with mineralization may change the structure of enamel and create a predisposition for developing dental caries. The aim of the study was to evaluate the VDR and TFIP11 gene variants in adults with caries experience and to investigate their interactions with the environmental factors. Materials and Methods: A total of 160 individuals at the age of 24-40 years were included in the study and they were assigned to two groups according to decayed-missing-filled teeth index (DMFT); namely the low caries experience (LCE, DMFT≤4) and high caries experience (HCE, DMFT> 9.13). DNA was isolated from buccal swab samples to genotype the VDR (TaqI; rs731236) and TFIP11 (rs5997096) gene variants. The real-time PCR was used for genotyping. The frequency of tooth brushing, carbohydrate intake, smoking, and the dental plaques were evaluated as environmental risk factors. Results: Between the caries groups and the distribution of the genotypes and alleles of the VDR rs731236 and TFIP11 rs5997096 gene variants were not statistically different. There was also no significant difference when homozygous, heterozygous, dominant, and recessive models were evaluated for the two variants. The frequency of tooth brushing was significantly higher in the LCE group. According to the regression analysis; the amount of plaque explained the high caries experience at a rate of 51.4%. Conclusions: The study findings indicated that common variants in the VDR and TFIP11 genes were not associated with high caries experiences in Turkish adults.

Keywords

Dental caries,enamel,genes,vitamin D receptor

Supporting Institution

Recep Tayyip Erdogan University Scientific Research Projects Foundation

Project Number

TSA-2017-772

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Gül Yıldız Telatar ^*
0000-0001-5137-9282
Türkiye

Faruk Saydam
0000-0003-2358-8719
Türkiye

Publication Date

June 30, 2020

Submission Date

February 17, 2020

Acceptance Date

April 19, 2020

Published in Issue

Year 1970 Volume: 23 Number: 2

DOI

https://doi.org/10.7126/cumudj.690129

IZ

https://izlik.org/JA29GS25WL

Cite

RIS / Bibtex

EndNote

Yıldız Telatar G, Saydam F (June 1, 2020) Lack of Association between Enamel Gene Variants and Dental Caries in Adults. Cumhuriyet Dental Journal 23 2 96–106.

Lack of Association between Enamel Gene Variants and Dental Caries in Adults

Öz

Lack of Association between Enamel Gene Variants and Dental Caries in Adults

Abstract

Keywords

Supporting Institution

Project Number

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

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Association between Genetic Polymorphisms in Enamel Formation Genes and Environmental Factors with Caries Experience

Evaluation of the MTHFR rs1801133 Gene Polymorphism and Its Association with Dental Caries