GIANT CELLS AND GIANT CELL LESIONS OF ORAL CAVITY- A REVIEW

Volume: 17 Number: 2 May 2, 2014
EN

GIANT CELLS AND GIANT CELL LESIONS OF ORAL CAVITY- A REVIEW

Abstract

Giant cells are large mononucleated or multinucleated cells that are seen in a variety of physiological as well as pathological conditions. Multinucleated giant cells (MGCs) are important mediators of tissue remodeling and repair and also for removal of foreign materials and various pathogens.  The commonly encountered giant cells arise from monocyte precursors, formed due to different mechanisms. Depending upon the mechanism of their formation these cells assume distinctly variable phenotypes.  The giant cell lesions of oral cavity have been classified on the basis of etio-pathogenesis, the presence of which at times being pathognomic. We attempt to review the basic information regarding the mechanism of formation and morphology of giant cells and its significance in the associated giant cell lesions. Also we have tried to describe the clinical, histopathological and immunohistochemical aspects of various giant cell lesions of the oral cavity.

Keywords

References

  1. Ross MH and Pawlina W. Histology. A text and atlas with correlated cell and molecular biology. 5th Edition; Lippincott Williams & Wilkins. 2006.
  2. Quinn TM, Schepetkin IA. Role of NADPH Oxidase in formation and function of multinucleated giant cells. J Innate Immun 2009; 1: 509-526.
  3. Postlethwaite AE, Jackson BK, Beachey EH, Kang AH. Formation of multinucleated giant cells from human monocyte precursors. J Exp Med 1982; 155: 168-178.
  4. Helming L, Gordon S. The molecular basis of macrophage fusion. Immunobiology 2007; 219: 785-793.
  5. Anderson JM. Multinucleated giant cells. Curr Opin Hematol 2000; 7: 40-47.
  6. Forkner CE. The origin and fate of two types of multinucleated giant cells in the circulating blood. J Exp Med 1930; 52(2): 279-297.
  7. Maarsseveen TC, Vos W, Van Diest PJ. Giant cell formation in sarcoidosis: cell fusion or proliferation with non-division? Clin Exp Immunol 2008; 155: 476-486.
  8. Chambers TJ. Multinucleate Giant cells. J Path. 1976; 126(3): 1-24.

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Vinay Marla

Sushmita Shrestha

Manisha Neupane

Publication Date

May 2, 2014

Submission Date

October 23, 2013

Acceptance Date

-

Published in Issue

Year 1970 Volume: 17 Number: 2

EndNote
Shrestha A, Marla V, Shrestha S, Neupane M (May 1, 2014) GIANT CELLS AND GIANT CELL LESIONS OF ORAL CAVITY- A REVIEW. Cumhuriyet Dental Journal 17 2 192–204.

Cited By

Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.


CDJ accepts articles in English. Submitting a paper to CDJ is free of charges. In addition, CDJ has not have article processing charges.

Frequency: Four times a year (March, June, September, and December)

IMPORTANT NOTICE

All users of Cumhuriyet Dental Journal should visit to their user's home page through the "https://dergipark.org.tr/tr/user" " or "https://dergipark.org.tr/en/user" links to update their incomplete information shown in blue or yellow warnings and update their e-mail addresses and information to the DergiPark system. Otherwise, the e-mails from the journal will not be seen or fall into the SPAM folder. Please fill in all missing part in the relevant field.

Please visit journal's AUTHOR GUIDELINE to see revised policy and submission rules to be held since 2020.