Deregulation of Cancer-Associated Genes in Odontogenic Cysts

Bilal Ege; Önder Yumrutaş; İbrahim Bozgeyik

doi:10.7126/cumudj.543875

EN

Deregulation of Cancer-Associated Genes in Odontogenic Cysts

Abstract

Objectives: The aim of the present study was to demonstrate the key role of differential expression levels of RB1, TP53, XIAP, BCL2 AIFM3, BAX, CASP3 and CASP9 genes in odontogenic cysts.

Materials and Methods: A total number of 15 patients who diagnosed with odontogenic cyst were enrolled for the present study. For the quantitative gene expression analysis, cyst and adjacent gingival healthy tissues of patients were collected during surgical assessments. Quantitative analysis of gene expression levels RB1, TP53, XIAP, BCL2 AIFM3, BAX, CASP3 and CASP9 were achieved real-time PCR method. For the optimization of gene expression levels GAPDH reference gene was used.

Results: Expression of both RB1 and TP53 genes were markedly diminished in odontogenic cysts tissues as compared to healthy tissues (p<0.05). Likewise, levels of CASP3 and CASP9 genes were found to be significantly reduced in odontogenic cysts tissues compared to healthy tissues (p<0.05). In contrast, expression levels of XIAP was significantly elevated (p<0.05). Although BCL2, AIFM3, and BAX genes were also differentially expressed in odontogenic cysts tissues, these variations were statistically insignificant (p>0.05).

Conclusions: The findings of the present study indicates that RB1, TP53, XIAP, CASP3 and CASP9 genes might have chief roles in formation odontogenic cysts and responsible for the increased cell proliferation in these tissues.

Keywords

Gene expression,odontojenic cysts,tumor suppressor gene

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Bilal Ege ^*
0000-0002-1279-0893
Türkiye

Önder Yumrutaş
0000-0001-9657-8306
Türkiye

İbrahim Bozgeyik
0000-0003-1483-2580
Türkiye

Publication Date

September 9, 2019

Submission Date

March 24, 2019

Acceptance Date

April 15, 2019

Published in Issue

Year 2019 Volume: 22 Number: 3

DOI

https://doi.org/10.7126/cumudj.543875

IZ

https://izlik.org/JA95KL68LX

Cite

RIS / Bibtex

EndNote

Ege B, Yumrutaş Ö, Bozgeyik İ (September 1, 2019) Deregulation of Cancer-Associated Genes in Odontogenic Cysts. Cumhuriyet Dental Journal 22 3 268–275.

Öz

Deregulation of Cancer-Associated Genes in Odontogenic Cysts

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite