Evaluation of Caffeic Acid Phenethyl Ester Administration in Chronically Stressed Rats with Experimental Periodontitis.

Alper Kızıldağ; Taner Arabacı; Mevlüt Albayrak; Ufuk Taşdemir; Mukaddes Mergen Dalyanoğlu; Canan Aksu Kızıldağ

doi:10.7126/cumudj.513701

TR EN

Evaluation of Caffeic Acid Phenethyl Ester Administration in Chronically Stressed Rats with Experimental Periodontitis.

Abstract

Objectives: The aim of the present study was to investigate the therapeutic effects of systemic caffeic acid phenethyl ester treatment on oxidative stress and alveolar bone destruction in lipopolysaccharide (LPS)-induced periodontitis in chronically stressed rats.

Materials and Methods: Fourty male Sprague Dawley rats were divided into four groups: 1) control group, 2) experimental periodontitis (EP), 3) EP and chronic stress (CS) group (EP-CS), and 4) EP-CS treated with CAPE (EP-CS-CAPE). To induce periodontitis, LPS was administered into the buccal gingiva of the test groups, and pure saline was administered for the control group. Two test groups were exposed to restraint stress and one group of these groups was treated with only a single dose of CAPE (10 mmol/kg). Likewise, saline was administered in the control, EP, and EP-CS groups. After 14 days, serum samples were collected from the heart, and all rats were sacrificed for analyses. Oxidative stress and interleukin (IL)-1β were investigated. The receptor activator of the nuclear factor kappa B ligand (RANKL) and alveolar bone loss were determined by immunohistochemical analysis

Results: The oxidative stress, alveolar bone loss, IL-1β and RANKL levels were found significantly higher in the EP-CS group compared with control and EP groups (p<0.05). However, the administration of CAPE significantly reduced oxidative stress and IL-1β in the EP-CS-CAPE group compared with the EP-CS group (p<0.05). Also, CAPE treatment significantly reduced RANKL and alveolar bone loss in the EP-CS-CAPE group compared with the EP-CS group (p<0.05)

Conclusions: The present results indicated that CAPE may inhibit alveolar bone loss by modulating the immune response and inflammatory process.

Keywords

Alveolar bone loss,antioxidants,periodontitis

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Alper Kızıldağ ^*
0000-0002-1630-3140
Türkiye

Taner Arabacı
0000-0003-0476-1010
Türkiye

Mevlüt Albayrak
0000-0001-8673-6577
Türkiye

Ufuk Taşdemir
0000-0002-0631-1665
Türkiye

Mukaddes Mergen Dalyanoğlu
0000-0002-5862-7792
Türkiye

Canan Aksu Kızıldağ
0000-0002-2687-7551
Türkiye

Publication Date

March 13, 2019

Submission Date

January 16, 2019

Acceptance Date

February 19, 2019

Published in Issue

Year 2019 Volume: 22 Number: 1

DOI

https://doi.org/10.7126/cumudj.513701

IZ

https://izlik.org/JA66RR75HF

Cite

RIS / Bibtex

EndNote

Kızıldağ A, Arabacı T, Albayrak M, Taşdemir U, Mergen Dalyanoğlu M, Aksu Kızıldağ C (March 1, 2019) Evaluation of Caffeic Acid Phenethyl Ester Administration in Chronically Stressed Rats with Experimental Periodontitis. Cumhuriyet Dental Journal 22 1 114–120.

Cited By

Effects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review

Drug Design, Development and Therapy

https://doi.org/10.2147/DDDT.S287280

Evaluation of Caffeic Acid Phenethyl Ester Administration in Chronically Stressed Rats with Experimental Periodontitis.

Öz

Evaluation of Caffeic Acid Phenethyl Ester Administration in Chronically Stressed Rats with Experimental Periodontitis.

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Effects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review