ANIMAL STUDIES IN FIELD OF PERIODONTOLOGY: EXPERIMENTAL PERIODONTAL AND PERIIMPLANT DISEASE INDUCTION
Abstract
Preclinical
studies are crucial in studying the etiology and pathogenesis of human diseases
especially diseases with multifactoriel etiology such as diabetes,
cardiovascular diseases and periodontitis. Studies in animal models are
complementary to in vitro experiments prior to clinical trials. Every model has
its own advantage and disadvantage and there is not any model suitable for all
kinds of studies. To find the optimal experimental model and animal species is
a major issue for researchers. In this mini-review I aimed to review the animal
models used in the field of periodontology and a relatively novel field
implantology and though very little, to provide guidance for researchers
Keywords
References
- Referans1. Wakeman AJ. On the Hexon Bases of Liver Tissue under Normal and Certain Pathological Conditions. The Journal of experimental medicine 1905;7:292-304.
- Referans2. Sognnaes R. Experimental production of periodontal disease in animals fed on a purified, nutritionally adequate diet. Journal of dental research 1947;26:475.
- Referans3. Weinberg MA, Bral M. Laboratory animal models in periodontology. Journal of clinical periodontology 1999;26:335-340.
- Referans4. Socransky SS, Hubersak C, Propas D. Induction of periodontal destruction in gnotobiotic rats by a human oral strain of Actinomyces naeslundii. Archives of oral biology 1970;15:993-995.
- Referans5. Kuhr A, Popa-Wagner A, Schmoll H, Schwahn C, Kocher T. Observations on experimental marginal periodontitis in rats. Journal of periodontal research 2004;39:101-106.
- Referans6. Rovin S, Costich ER, Gordon HA. The influence of bacteria and irritation in the initiation of periodontal disease in germfree and conventional rats. Journal of periodontal research 1966;1:193-204.
- Referans7. Baker PJ, Evans RT, Roopenian DC. Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice. Archives of oral biology 1994;39:1035-1040.
- Referans8. Lalla E, Lamster IB, Feit M, Huang L, Schmidt AM. A murine model of accelerated periodontal disease in diabetes. Journal of periodontal research 1998;33:387-399.
Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Review
Authors
Hatice Balcı Yuce
Türkiye
Publication Date
May 11, 2017
Submission Date
April 20, 2017
Acceptance Date
October 6, 2016
Published in Issue
Year 2017 Volume: 20 Number: 1