A HISTOMORPHOMETRIC EVALUATION OF THE EFFECTS OF PLATELET-RICH FIBRIN AND RIFAMYCIN IN COMBINATION WITH AN ALLOGRAFT ON BONE AUGMENTATION WITH SIMULTANEOUS IMPLANT PLACEMENT IN RABBIT TIBIA

İlker Özeç; Sancar Şimşek; Emre Benlidayı; Mehmet Kürkçü

doi:10.7126/cumudj.307301

TR EN

Trombosit Zengin Fibrin ve Rifamisinin Bir Allogreft ile Kombinasyonda Kemik Büyütme Üzerindeki Etkilerinin Tavşan Tibiasında Eşzamanlı İmplant Yerleştirmesiyle Histomorfometrik Olarak Değerlendirilmesi

Öz

Amaç: Yüksek profilli dental implant yerleştirilmesinde yönlendirilmiş doku augmentasyonunu geliştirmek için plateletten zengin fibrin (PRF) ve rifamisin uygulamasının potansiyelinin değerlendirilmesi.

Materyal ve metod: İki mm’lik koronal kısmı kemik dışında kalan dental implantlar kubbe şeklinde sert kaplayıcı titanyum membran ile kapatılmış ve membranın içi demineralize dondurularak kurutulmuş kemik allogrefti (DFDBA)+salin (7 tavşan), DFDBA+rifamisin (8 tavşan) veya DFDBA+PRF (8 tavşan) ile doldurulmuştur.

Bulgular: Kemik implant kontağı (KİK) salin grubunda 58.43±1.92%, rifamisin grubunda 68.34±20.37% ve PRF grubunda 80.70±2.55% olarak tespit edilmiştir. Sırasıyla yeni kemik oluşum yüzdesi de 36.90±0.94, 45.26±0.60 ve 51.82±0.82 olarak bulunmuştur.

Sonuç: Hem PRF hem de rifamisinin yönlendirilmiş doku augmentasyonunu geliştirici potansiyeli olduğu ve yüksek profilli dental implant uygulamalarında sert kaplayıcı titanyum membran altında DFDBA + PRF veya DFDBA + rifamisin kullanılmasının hem KİK değerini hem de yeni kemik oluşum yüzdesini artırabileceği görülmüştür.

Anahtar Kelimeler

Kemik Takviyesi,Trombosit bakımından zengin fibrin,rifamisin,Yüksek profilli diş implantları

A HISTOMORPHOMETRIC EVALUATION OF THE EFFECTS OF PLATELET-RICH FIBRIN AND RIFAMYCIN IN COMBINATION WITH AN ALLOGRAFT ON BONE AUGMENTATION WITH SIMULTANEOUS IMPLANT PLACEMENT IN RABBIT TIBIA

Abstract

Objective: To evaluate the potential of platelet-rich fibrin (PRF) and rifamycin to enhance guided bone augmentation with simultaneous high-profile dental implant placement in a rabbit tibia model.

Materials and Methods: Dental implants protruding 2 mm were covered with dome-shaped stiff occlusive titanium barriers filled with demineralized freeze-dried bone allograft (DFDBA)+saline (7 rabbits), DFDBA + rifamycin (8 rabbits), or DFDB +PRF (8 rabbits). After 4 weeks, the animals were sacrificed, and undecalcified histomorphometric examination with toluidine blue staining was performed.

Results: The bone-to-implant contact (BIC) was 58.43 ± 1.92% in the saline group, 68.3 ±20.37% in the rifamycin group, and 80.70±2.55% in the PRF group, and the percentage of new bone formation was 36.90 ± 0.94%, 45.26±0.60%, and 51.82±0.82%, respectively. Conclusions: Both PRF and rifamycin have potential to enhance GBA, and using DFDBA + PRF or DFDBA+rifamycin beneath a stiff occlusive titanium barrier next to a high-profile implant may enhance both BIC and new bone formation.

Keywords: Guided bone augmentation, platelet-rich fibrin, rifamycin, allograft, high-profile dental implants

Keywords

Guided bone augmentation,platelet-rich fibrin,rifamycin,allograft,high-profile dental implants

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

İlker Özeç
Türkiye

Sancar Şimşek
Türkiye

Emre Benlidayı
Türkiye

Mehmet Kürkçü
Türkiye

Publication Date

May 12, 2017

Submission Date

April 20, 2017

Acceptance Date

June 29, 2016

Published in Issue

Year 2017 Volume: 20 Number: 1

DOI

https://doi.org/10.7126/cumudj.307301

IZ

https://izlik.org/JA59GW57US

Cite

RIS / Bibtex

EndNote

Özeç İ, Şimşek S, Benlidayı E, Kürkçü M (May 1, 2017) A HISTOMORPHOMETRIC EVALUATION OF THE EFFECTS OF PLATELET-RICH FIBRIN AND RIFAMYCIN IN COMBINATION WITH AN ALLOGRAFT ON BONE AUGMENTATION WITH SIMULTANEOUS IMPLANT PLACEMENT IN RABBIT TIBIA. Cumhuriyet Dental Journal 20 1 45–52.