Abstract
References
- 1. Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RA. The 2018 World Health Organization classification of cutaneous, mucosal, and uveal melanoma: detailed analysis of 9 distinct subtypes defined by their evolutionary pathway. Arch Pathol Lab Med 2020;144:500-522.
- 2. Hicks MJ, Flaitz CM. Oral mucosal melanoma: epidemiology and pathobiology. Oral Oncol 2000;36:152-159.
- 3. Limongelli L, Cascardi E, Capodiferro S, Favia G, Corsalini M, Tempesta A, et al. Multifocal amelanotic melanoma of the hard palate: a challenging case. Diagnostics 2020;10:424.
- 4. Freedman DM, Sigurdson A, Doody MM, Rao RS, Linet MS. Risk of melanoma in relation to smoking, alcohol intake, and other factors in a large occupational cohort. Cancer Causes Control 2003;14:847-857.
- 5. Wagner M, Morris CG, Werning JW, Mendenhall WM. Mucosal melanoma of the head and neck. Am J Clin Oncol 2008;31:43-48.
- 6. Xu Z, Shi P, Yibulayin F, Feng L, Zhang H, Wushou A. Spindle cell melanoma: incidence and survival, 1973-2017. Oncol Lett 2018;16:5091-5099.
- 7. Solomon MC, Mathew M. Spindle cell lipoma of the buccal mucosa: a case report. Cumhuriyet Dent J. 2019;22:369-373.
- 8. Rapidis AD, Apostolidis C, Vilos G, Valsamis S. Primary malignant melanoma of the oral mucosa. J Oral Maxillofac Surg 2003;61:1132-1139.
- 9. Bijou W, Laachoubi M, Oukessou Y, Rouadi S, Abada R, Roubal M, et al. Extensive primary oral malignant melanoma: a case report with review of literature. Adv Oral Maxillofac Surg 2022;6:100274.
- 10. Paruhan N, Kelavari F. Malignant melanoma of the oral cavity: a case report. Int J Surg Case Rep 2025;128:110902.
- 11. Tanaka N, Mimura M, Kimijima Y, Amagasa T. Clinical investigation of amelanotic malignant melanoma in the oral region. J Oral Maxillofac Surg 2004;62:933-937.
- 12. De Andrade BA, Toral-Rizo VH, León JE, Contreras E, Carlos R, Delgado-Azañero W, et al. Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America. Med Oral Patol Oral Cir Bucal 2012;17:e383-388.
- 13. Sharma N. Primary oral malignant melanoma: two case reports and review of literature. Case Rep Dent. 2012;2012:975358.
- 14. Ohnishi Y, Watanabe M, Fujii T, Sunada N, Yoshimoto H, Kubo H, et al. A rare case of amelanotic malignant melanoma in the oral region: clinical investigation and immunohistochemical study. Oncol Lett 2015;10:3761-3764.
- 15. Şahin S, Gözlü M, Saygun I, Keskiner İ, Günhan Ö. Primary malignant melanoma of the maxillary gingiva: a case report. Gulhane Med J 2010;52:208-211.
- 16. Jasper P, Jungbauer WN, Poupore NS, Nguyen SA, Howell J, Neville BW, et al. Mucosal melanoma in situ of the oral cavity: a case report and systematic review of the literature. Turk Arch Otorhinolaryngol 2022;60:161-169.
Abstract
ABSTRACT
Spindle cell melanoma, a rare morphological subtype of malignant melanoma, is a potentially aggressive neoplasm of melanocytic origin. It commonly occurs on the skin and rarely manifests in the head and neck region especially in the oral cavity and has varied clinical presentations. It is of diagnostic challenge especially to dentists and tumor size, metastases, special laboratory diagnostic tests are required to assess the prognosis, overall survival rate. This comprehensive case report analyzes a middle aged female patient diagnosed with an oral spindle cell melanoma variant, exploring its unique histopathological characteristics, diagnostic challenges, and potential treatment strategies.
References
- 1. Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RA. The 2018 World Health Organization classification of cutaneous, mucosal, and uveal melanoma: detailed analysis of 9 distinct subtypes defined by their evolutionary pathway. Arch Pathol Lab Med 2020;144:500-522.
- 2. Hicks MJ, Flaitz CM. Oral mucosal melanoma: epidemiology and pathobiology. Oral Oncol 2000;36:152-159.
- 3. Limongelli L, Cascardi E, Capodiferro S, Favia G, Corsalini M, Tempesta A, et al. Multifocal amelanotic melanoma of the hard palate: a challenging case. Diagnostics 2020;10:424.
- 4. Freedman DM, Sigurdson A, Doody MM, Rao RS, Linet MS. Risk of melanoma in relation to smoking, alcohol intake, and other factors in a large occupational cohort. Cancer Causes Control 2003;14:847-857.
- 5. Wagner M, Morris CG, Werning JW, Mendenhall WM. Mucosal melanoma of the head and neck. Am J Clin Oncol 2008;31:43-48.
- 6. Xu Z, Shi P, Yibulayin F, Feng L, Zhang H, Wushou A. Spindle cell melanoma: incidence and survival, 1973-2017. Oncol Lett 2018;16:5091-5099.
- 7. Solomon MC, Mathew M. Spindle cell lipoma of the buccal mucosa: a case report. Cumhuriyet Dent J. 2019;22:369-373.
- 8. Rapidis AD, Apostolidis C, Vilos G, Valsamis S. Primary malignant melanoma of the oral mucosa. J Oral Maxillofac Surg 2003;61:1132-1139.
- 9. Bijou W, Laachoubi M, Oukessou Y, Rouadi S, Abada R, Roubal M, et al. Extensive primary oral malignant melanoma: a case report with review of literature. Adv Oral Maxillofac Surg 2022;6:100274.
- 10. Paruhan N, Kelavari F. Malignant melanoma of the oral cavity: a case report. Int J Surg Case Rep 2025;128:110902.
- 11. Tanaka N, Mimura M, Kimijima Y, Amagasa T. Clinical investigation of amelanotic malignant melanoma in the oral region. J Oral Maxillofac Surg 2004;62:933-937.
- 12. De Andrade BA, Toral-Rizo VH, León JE, Contreras E, Carlos R, Delgado-Azañero W, et al. Primary oral melanoma: a histopathological and immunohistochemical study of 22 cases of Latin America. Med Oral Patol Oral Cir Bucal 2012;17:e383-388.
- 13. Sharma N. Primary oral malignant melanoma: two case reports and review of literature. Case Rep Dent. 2012;2012:975358.
- 14. Ohnishi Y, Watanabe M, Fujii T, Sunada N, Yoshimoto H, Kubo H, et al. A rare case of amelanotic malignant melanoma in the oral region: clinical investigation and immunohistochemical study. Oncol Lett 2015;10:3761-3764.
- 15. Şahin S, Gözlü M, Saygun I, Keskiner İ, Günhan Ö. Primary malignant melanoma of the maxillary gingiva: a case report. Gulhane Med J 2010;52:208-211.
- 16. Jasper P, Jungbauer WN, Poupore NS, Nguyen SA, Howell J, Neville BW, et al. Mucosal melanoma in situ of the oral cavity: a case report and systematic review of the literature. Turk Arch Otorhinolaryngol 2022;60:161-169.
Details
| Primary Language | English |
|---|---|
| Subjects | Oral and Maxillofacial Surgery, Oral and Maxillofacial Radiology, Oral Medicine and Pathology |
| Journal Section | Case Report |
| Authors | |
| Submission Date | July 24, 2025 |
| Acceptance Date | September 30, 2025 |
| Publication Date | December 29, 2025 |
| Published in Issue | Year 2025 Volume: 28 Issue: 4 |
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
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