EN
Spindle Cell Melanoma with an Insight and Review of Literature - Case Report
Abstract
ABSTRACT
Spindle cell melanoma, a rare morphological subtype of malignant melanoma, is a potentially aggressive neoplasm of melanocytic origin. It commonly occurs on the skin and rarely manifests in the head and neck region especially in the oral cavity and has varied clinical presentations. It is of diagnostic challenge especially to dentists and tumor size, metastases, special laboratory diagnostic tests are required to assess the prognosis, overall survival rate. This comprehensive case report analyzes a middle aged female patient diagnosed with an oral spindle cell melanoma variant, exploring its unique histopathological characteristics, diagnostic challenges, and potential treatment strategies.
Keywords
References
- 1. Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RA. The 2018 World Health Organization classification of cutaneous, mucosal, and uveal melanoma: detailed analysis of 9 distinct subtypes defined by their evolutionary pathway. Arch Pathol Lab Med 2020;144:500-522.
- 2. Hicks MJ, Flaitz CM. Oral mucosal melanoma: epidemiology and pathobiology. Oral Oncol 2000;36:152-159.
- 3. Limongelli L, Cascardi E, Capodiferro S, Favia G, Corsalini M, Tempesta A, et al. Multifocal amelanotic melanoma of the hard palate: a challenging case. Diagnostics 2020;10:424.
- 4. Freedman DM, Sigurdson A, Doody MM, Rao RS, Linet MS. Risk of melanoma in relation to smoking, alcohol intake, and other factors in a large occupational cohort. Cancer Causes Control 2003;14:847-857.
- 5. Wagner M, Morris CG, Werning JW, Mendenhall WM. Mucosal melanoma of the head and neck. Am J Clin Oncol 2008;31:43-48.
- 6. Xu Z, Shi P, Yibulayin F, Feng L, Zhang H, Wushou A. Spindle cell melanoma: incidence and survival, 1973-2017. Oncol Lett 2018;16:5091-5099.
- 7. Solomon MC, Mathew M. Spindle cell lipoma of the buccal mucosa: a case report. Cumhuriyet Dent J. 2019;22:369-373.
- 8. Rapidis AD, Apostolidis C, Vilos G, Valsamis S. Primary malignant melanoma of the oral mucosa. J Oral Maxillofac Surg 2003;61:1132-1139.
Details
Primary Language
English
Subjects
Oral and Maxillofacial Surgery, Oral and Maxillofacial Radiology, Oral Medicine and Pathology
Journal Section
Case Report
Publication Date
December 29, 2025
Submission Date
July 24, 2025
Acceptance Date
September 30, 2025
Published in Issue
Year 2025 Volume: 28 Number: 4
APA
Tirumani, A., Kavya Keerthika, N., Usha Kiranmai, A., & Tirumani, T. (2025). Spindle Cell Melanoma with an Insight and Review of Literature - Case Report. Cumhuriyet Dental Journal, 28(4), 639-643. https://doi.org/10.7126/cumudj.1748961
AMA
1.Tirumani A, Kavya Keerthika N, Usha Kiranmai A, Tirumani T. Spindle Cell Melanoma with an Insight and Review of Literature - Case Report. Cumhuriyet Dent J. 2025;28(4):639-643. doi:10.7126/cumudj.1748961
Chicago
Tirumani, Ananya, N Kavya Keerthika, A Usha Kiranmai, and Tejaswini Tirumani. 2025. “Spindle Cell Melanoma With an Insight and Review of Literature - Case Report”. Cumhuriyet Dental Journal 28 (4): 639-43. https://doi.org/10.7126/cumudj.1748961.
EndNote
Tirumani A, Kavya Keerthika N, Usha Kiranmai A, Tirumani T (December 1, 2025) Spindle Cell Melanoma with an Insight and Review of Literature - Case Report. Cumhuriyet Dental Journal 28 4 639–643.
IEEE
[1]A. Tirumani, N. Kavya Keerthika, A. Usha Kiranmai, and T. Tirumani, “Spindle Cell Melanoma with an Insight and Review of Literature - Case Report”, Cumhuriyet Dent J, vol. 28, no. 4, pp. 639–643, Dec. 2025, doi: 10.7126/cumudj.1748961.
ISNAD
Tirumani, Ananya - Kavya Keerthika, N - Usha Kiranmai, A - Tirumani, Tejaswini. “Spindle Cell Melanoma With an Insight and Review of Literature - Case Report”. Cumhuriyet Dental Journal 28/4 (December 1, 2025): 639-643. https://doi.org/10.7126/cumudj.1748961.
JAMA
1.Tirumani A, Kavya Keerthika N, Usha Kiranmai A, Tirumani T. Spindle Cell Melanoma with an Insight and Review of Literature - Case Report. Cumhuriyet Dent J. 2025;28:639–643.
MLA
Tirumani, Ananya, et al. “Spindle Cell Melanoma With an Insight and Review of Literature - Case Report”. Cumhuriyet Dental Journal, vol. 28, no. 4, Dec. 2025, pp. 639-43, doi:10.7126/cumudj.1748961.
Vancouver
1.Ananya Tirumani, N Kavya Keerthika, A Usha Kiranmai, Tejaswini Tirumani. Spindle Cell Melanoma with an Insight and Review of Literature - Case Report. Cumhuriyet Dent J. 2025 Dec. 1;28(4):639-43. doi:10.7126/cumudj.1748961