Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing

Sıdıka Beril Falay; Burcu Güçyetmez Topal; Sefa Çelik; Serkan Şen

Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing

Abstract

Objectives: The aim of this study is to compare the cytotoxicity of teething gels with different contents and their effects on in vitro wound healing. Materials and Methods: The viability values of teething gels applied on human gingival fibroblast cells were evaluated and their cytotoxicity and effects on wound healing were investigated by scratch test. Results: The cytotoxicity of 9 different teething gels on human gingival fibroblast cells and their effects on in-vitro wound healing at 24 and 48 hours were compared. The Lidocaine hydrochloride+cetylpridinium chloride based gel group had the most cytotoxic effect on human gingival fibroblast cells among teething gels. Conclusion: Considering the results of our study, the necessity of using teething gels during the eruption period is controversial.

Keywords

Supporting Institution

Afyonkarahisar Health Sciences University

Project Number

20.DUS.005

Thanks

This study was supported by Afyonkarahisar Health Sciences University Scientific Research Projects Coordination Unit project number .20.DUS.==5

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Details

Primary Language

English

Subjects

Paedodontics, Dental Materials

Journal Section

Research Article

Authors

Sıdıka Beril Falay
0000-0003-2318-9398
Türkiye

Burcu Güçyetmez Topal ^*
0000-0002-9932-9169
Türkiye

Sefa Çelik
0000-0003-2625-4482
Türkiye

Serkan Şen
0000-0002-2884-4753
Türkiye

Publication Date

March 27, 2026

Submission Date

July 8, 2025

Acceptance Date

November 24, 2025

Published in Issue

Year 2026 Volume: 29 Number: 1

IZ

https://izlik.org/JA37MT37YE

Cite

RIS / Bibtex

APA

Falay, S. B., Güçyetmez Topal, B., Çelik, S., & Şen, S. (2026). Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing. Cumhuriyet Dental Journal, 29(1), 32-39. https://izlik.org/JA37MT37YE

AMA

1.Falay SB, Güçyetmez Topal B, Çelik S, Şen S. Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing. Cumhuriyet Dent J. 2026;29(1):32-39. https://izlik.org/JA37MT37YE

Chicago

Falay, Sıdıka Beril, Burcu Güçyetmez Topal, Sefa Çelik, and Serkan Şen. 2026. “Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing”. Cumhuriyet Dental Journal 29 (1): 32-39. https://izlik.org/JA37MT37YE.

EndNote

Falay SB, Güçyetmez Topal B, Çelik S, Şen S (March 1, 2026) Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing. Cumhuriyet Dental Journal 29 1 32–39.

IEEE

[1]S. B. Falay, B. Güçyetmez Topal, S. Çelik, and S. Şen, “Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing”, Cumhuriyet Dent J, vol. 29, no. 1, pp. 32–39, Mar. 2026, [Online]. Available: https://izlik.org/JA37MT37YE

ISNAD

Falay, Sıdıka Beril - Güçyetmez Topal, Burcu - Çelik, Sefa - Şen, Serkan. “Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing”. Cumhuriyet Dental Journal 29/1 (March 1, 2026): 32-39. https://izlik.org/JA37MT37YE.

JAMA

1.Falay SB, Güçyetmez Topal B, Çelik S, Şen S. Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing. Cumhuriyet Dent J. 2026;29:32–39.

MLA

Falay, Sıdıka Beril, et al. “Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing”. Cumhuriyet Dental Journal, vol. 29, no. 1, Mar. 2026, pp. 32-39, https://izlik.org/JA37MT37YE.

Vancouver

1.Sıdıka Beril Falay, Burcu Güçyetmez Topal, Sefa Çelik, Serkan Şen. Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing. Cumhuriyet Dent J [Internet]. 2026 Mar. 1;29(1):32-9. Available from: https://izlik.org/JA37MT37YE