Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing

Sıdıka Beril Falay; Burcu Güçyetmez Topal; Sefa Çelik; Serkan Şen

Research Article

Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing

Year 2026, Volume: 29 Issue: 1, 32 - 39, 27.03.2026

Sıdıka Beril Falay , Burcu Güçyetmez Topal , Sefa Çelik , Serkan Şen

https://izlik.org/JA37MT37YE

Abstract

Objectives: The aim of this study is to compare the cytotoxicity of teething gels with different contents and their effects on in vitro wound healing.
Materials and Methods: The viability values of teething gels applied on human gingival fibroblast cells were evaluated and their cytotoxicity and effects on wound healing were investigated by scratch test.
Results: The cytotoxicity of 9 different teething gels on human gingival fibroblast cells and their effects on in-vitro wound healing at 24 and 48 hours were compared. The Lidocaine hydrochloride+cetylpridinium chloride based gel group had the most cytotoxic effect on human gingival fibroblast cells among teething gels.
Conclusion: Considering the results of our study, the necessity of using teething gels during the eruption period is controversial.

Keywords

Wound healing , fibroblasts , tooth eruption

Supporting Institution

Afyonkarahisar Health Sciences University

Project Number

20.DUS.005

Thanks

This study was supported by Afyonkarahisar Health Sciences University Scientific Research Projects Coordination Unit project number .20.DUS.==5

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There are 47 citations in total.

Details

Primary Language	English
Subjects	Paedodontics, Dental Materials
Journal Section	Research Article
Authors	Sıdıka Beril Falay 0000-0003-2318-9398 Burcu Güçyetmez Topal 0000-0002-9932-9169 Sefa Çelik 0000-0003-2625-4482 Serkan Şen 0000-0002-2884-4753
Project Number	20.DUS.005
Submission Date	July 8, 2025
Acceptance Date	November 24, 2025
Publication Date	March 27, 2026
IZ	https://izlik.org/JA37MT37YE
Published in Issue	Year 2026 Volume: 29 Issue: 1

Cite

EndNote	Falay SB, Güçyetmez Topal B, Çelik S, Şen S (March 1, 2026) Evaluation Of The Cytotoxicity Of Different Teething Gels On Human Gingival Fibroblast Cells And Their Effects On In Vitro Wound Healing. Cumhuriyet Dental Journal 29 1 32–39.

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