Abstract
References
- 1. Cortellini P, Tonetti MS. Clinical concepts for regenerative therapy in intrabony defects. Periodontology 2000 2015;68(1):282-307.
- 2. Sculean A, Nikolidakis D, Nikou G, Ivanovic A, Chapple IL, Stavropoulos A. Biomaterials for promoting periodontal regeneration in human intrabony defects: a systematic review. Periodontology 2000 2015;68(1):182-216.
- 3. Karcı B, Savas HB. Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study. BMC Oral Health 2024;24(1):527.
- 4. Niemczyk W, Janik K, Żurek J, Skaba D, Wiench R. Platelet-Rich Plasma (PRP) and injectable Platelet-Rich Fibrin (i-PRF) in the non-surgical treatment of periodontitis-a systematic review. Int J Mol Sci 2024;25(12):6319.
- 5. Chang J, Blanchard SB, Windsor LJ, Gregory RL, Hamada Y. Levels of growth factors from platelet-rich fibrin from chronic periodontitis versus periodontally healthy subjects: a pilot study. Clin Oral Investig 2020;24(2):823-832.
- 6. Goel A, Windsor LJ, Gregory RL, Blanchard SB, Hamada Y. Effects of platelet-rich fibrin on human gingival and periodontal ligament fibroblast proliferation from chronic periodontitis versus periodontally healthy subjects. Clin Exp Dent Res 2021;7(4):436-442.
- 7. Gummaluri SS, Bhattacharya HS, Astekar M, Cheruvu S. Evaluation of titaniumprepared platelet-rich fibrin and leucocyte platelet-rich fibrin in the treatment of intrabony defects: A randomized clinical trial. J Dent Res Dent Clin Dent Prospects 2020;14(2):83-91.
- 8. Arabaci T, Albayrak M. Titanium‐prepared platelet‐rich fibrin provides advantages on periodontal healing: a randomized split‐mouth clinical study. J Periodontol 2018;89(3):255-264.
- 9. Chatterjee A, Pradeep AR, Garg V, Yajamanya S, Ali MM, Priya VS. Treatment of periodontal intrabony defects using autologous platelet‐rich fibrin and titanium platelet‐rich fibrin: a randomized, clinical, comparative study. J Investig Clin Dent 2017;8(3):e12231.
- 10. OzkalEminoglu D, Arabaci T, OztasSahiner GA. The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study. PLoS One 2024;19(6):e0304970.
- 11. De Lauretis A, Øvrebø Ø, Romandini M, Lyngstadaas SP, Rossi F, Haugen HJ. From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials. Adv Sci (Weinh) 2024;11(17):e2308848.
- 12. Badran Z, Abdallah MN, Torres J, Tamimi F. Platelet concentrates for bone regeneration: Current evidence and future challenges. Platelets 2018;29(2):105-112.
- 13. Ajwani H, Shetty S, Gopalakrishnan D, Kathariya R, Kulloli A, Dolas RS, Pradeep AR. Comparative evaluation of platelet-rich fibrin biomaterial and open flap debridement in the treatment of two and three wall intrabony defects. J Int Oral Health. 2015;7(4):32-37.
- 14. Tunalı M, Özdemir H, Küçükodacı Z, Akman S, Fıratlı E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg 2013;51(5):438-443.
- 15. Haripriya N, Kumar PM, Penmetsa GS, Gottumukkala SNVS, Ramesh KSV, Keerthi V. Comparison of the effectiveness of DFDBA and T-PRF in the regeneration of intra-bony defects-a randomized split-mouth study. J Stomatol Oral Maxillofac Surg 2024;125(2):101668.
- 16. Caton JG, Armitage G, Berglundh T, Chapple IL, Jepsen S, Kornman KS, et al. A new classification scheme for periodontal and peri‐implant diseases and conditions–Introduction and key changes from the 1999 classification. J Periodontol 2018;89:S1-8.
- 17. Shirbhate U, Bajaj P. Third-generation platelet concentrates in periodontal regeneration: gaining ground in the field of regeneration. Cureus 2022;14(8):e28072.
- 18. Ravi S, Santhanakrishnan M. Mechanical, chemical, structural analysis and comparative release of PDGF-AA from L-PRF, A-PRF and T-PRF - an in vitro study. Biomater Res 2020;24:16.
- 19. Oza DR, Dhadse DP, Bajaj DP, Bhombe DK, Durge DK, Subhadarsanee DC, et al. Clinical efficacy of titanium prepared platelet rich fibrin in periodontal regeneration: a systematic review and meta-analysis. F1000Res 2024;12:393.
- 20. Pasupuleti MK, Haripriya N, Penmetsa GS, Pasupuleti S, Gottumukkala SN, Ramesh KS, Vivek B. Comparison of structural, mechanical, and histochemical characteristics of L-PRF and T-PRF membranes using different centrifugation protocols–an ex-vivo observational study. J Oral Maxillofac Surg Med Pathol 2024;36(4):507-511.
- 21. Simões-Pedro M, Tróia PM, Dos Santos NB, Completo AM, Castilho RM, de Oliveira Fernandes GV. Tensile strength essay comparing three different platelet-rich fibrin membranes (L-PRF, A-PRF, and A-PRF+): a mechanical and structural in vitro evaluation. Polymers 2022;14(7):1392.
- 22. Keşir SS, Hendek M, Kısa Ü, Olgun E. Effects of T-PRF and A-PRF on the osteogenic biomarkers in intrabony defects of periodontitis patients. Cumhuriyet Dent J 2023;26(3):248-254.
Structural and Mechanical Characterization of Titanium-Reinforced PlateletRich Fibrin (T- PRF) in Healthy and Periodontitis affected Patients
Abstract
Objectives: The purpose of this study was to examine the mechanical and structural characteristics of titanium-reinforced platelet-rich fibrin (T-PRF) in individuals with and without periodontitis.
Methods: Twenty-one healthy individuals and twenty-one patients with periodontitis had their T-PRF samples taken. Haematological study of the entire blood picture, mechanical qualities (tensile strength), and structural characteristics (predominant cell types and fibrin network) were assessed.
Results: T-PRF's mechanical and structural properties differed between patients with and without periodontitis. Individuals with periodontitis had lower fibrin networks and T-PRF tensile strengths than those who were healthy.
Conclusions: This study shows whether periodontitis influences the mechanical and structural properties of T-PRF, which could affect its efficacy in clinical applications. Understanding these differences is critical for maximising T-PRF's regenerative capabilities in periodontal treatment.
Keywords
Growth factors white blood cells platelets periodontitis Titanium reinforced platelet rich fibrin
Ethical Statement
Uploaded
References
- 1. Cortellini P, Tonetti MS. Clinical concepts for regenerative therapy in intrabony defects. Periodontology 2000 2015;68(1):282-307.
- 2. Sculean A, Nikolidakis D, Nikou G, Ivanovic A, Chapple IL, Stavropoulos A. Biomaterials for promoting periodontal regeneration in human intrabony defects: a systematic review. Periodontology 2000 2015;68(1):182-216.
- 3. Karcı B, Savas HB. Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study. BMC Oral Health 2024;24(1):527.
- 4. Niemczyk W, Janik K, Żurek J, Skaba D, Wiench R. Platelet-Rich Plasma (PRP) and injectable Platelet-Rich Fibrin (i-PRF) in the non-surgical treatment of periodontitis-a systematic review. Int J Mol Sci 2024;25(12):6319.
- 5. Chang J, Blanchard SB, Windsor LJ, Gregory RL, Hamada Y. Levels of growth factors from platelet-rich fibrin from chronic periodontitis versus periodontally healthy subjects: a pilot study. Clin Oral Investig 2020;24(2):823-832.
- 6. Goel A, Windsor LJ, Gregory RL, Blanchard SB, Hamada Y. Effects of platelet-rich fibrin on human gingival and periodontal ligament fibroblast proliferation from chronic periodontitis versus periodontally healthy subjects. Clin Exp Dent Res 2021;7(4):436-442.
- 7. Gummaluri SS, Bhattacharya HS, Astekar M, Cheruvu S. Evaluation of titaniumprepared platelet-rich fibrin and leucocyte platelet-rich fibrin in the treatment of intrabony defects: A randomized clinical trial. J Dent Res Dent Clin Dent Prospects 2020;14(2):83-91.
- 8. Arabaci T, Albayrak M. Titanium‐prepared platelet‐rich fibrin provides advantages on periodontal healing: a randomized split‐mouth clinical study. J Periodontol 2018;89(3):255-264.
- 9. Chatterjee A, Pradeep AR, Garg V, Yajamanya S, Ali MM, Priya VS. Treatment of periodontal intrabony defects using autologous platelet‐rich fibrin and titanium platelet‐rich fibrin: a randomized, clinical, comparative study. J Investig Clin Dent 2017;8(3):e12231.
- 10. OzkalEminoglu D, Arabaci T, OztasSahiner GA. The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study. PLoS One 2024;19(6):e0304970.
- 11. De Lauretis A, Øvrebø Ø, Romandini M, Lyngstadaas SP, Rossi F, Haugen HJ. From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials. Adv Sci (Weinh) 2024;11(17):e2308848.
- 12. Badran Z, Abdallah MN, Torres J, Tamimi F. Platelet concentrates for bone regeneration: Current evidence and future challenges. Platelets 2018;29(2):105-112.
- 13. Ajwani H, Shetty S, Gopalakrishnan D, Kathariya R, Kulloli A, Dolas RS, Pradeep AR. Comparative evaluation of platelet-rich fibrin biomaterial and open flap debridement in the treatment of two and three wall intrabony defects. J Int Oral Health. 2015;7(4):32-37.
- 14. Tunalı M, Özdemir H, Küçükodacı Z, Akman S, Fıratlı E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg 2013;51(5):438-443.
- 15. Haripriya N, Kumar PM, Penmetsa GS, Gottumukkala SNVS, Ramesh KSV, Keerthi V. Comparison of the effectiveness of DFDBA and T-PRF in the regeneration of intra-bony defects-a randomized split-mouth study. J Stomatol Oral Maxillofac Surg 2024;125(2):101668.
- 16. Caton JG, Armitage G, Berglundh T, Chapple IL, Jepsen S, Kornman KS, et al. A new classification scheme for periodontal and peri‐implant diseases and conditions–Introduction and key changes from the 1999 classification. J Periodontol 2018;89:S1-8.
- 17. Shirbhate U, Bajaj P. Third-generation platelet concentrates in periodontal regeneration: gaining ground in the field of regeneration. Cureus 2022;14(8):e28072.
- 18. Ravi S, Santhanakrishnan M. Mechanical, chemical, structural analysis and comparative release of PDGF-AA from L-PRF, A-PRF and T-PRF - an in vitro study. Biomater Res 2020;24:16.
- 19. Oza DR, Dhadse DP, Bajaj DP, Bhombe DK, Durge DK, Subhadarsanee DC, et al. Clinical efficacy of titanium prepared platelet rich fibrin in periodontal regeneration: a systematic review and meta-analysis. F1000Res 2024;12:393.
- 20. Pasupuleti MK, Haripriya N, Penmetsa GS, Pasupuleti S, Gottumukkala SN, Ramesh KS, Vivek B. Comparison of structural, mechanical, and histochemical characteristics of L-PRF and T-PRF membranes using different centrifugation protocols–an ex-vivo observational study. J Oral Maxillofac Surg Med Pathol 2024;36(4):507-511.
- 21. Simões-Pedro M, Tróia PM, Dos Santos NB, Completo AM, Castilho RM, de Oliveira Fernandes GV. Tensile strength essay comparing three different platelet-rich fibrin membranes (L-PRF, A-PRF, and A-PRF+): a mechanical and structural in vitro evaluation. Polymers 2022;14(7):1392.
- 22. Keşir SS, Hendek M, Kısa Ü, Olgun E. Effects of T-PRF and A-PRF on the osteogenic biomarkers in intrabony defects of periodontitis patients. Cumhuriyet Dent J 2023;26(3):248-254.
Details
| Primary Language | English |
|---|---|
| Subjects | Periodontics |
| Journal Section | Research Article |
| Authors | |
| Submission Date | March 28, 2025 |
| Acceptance Date | December 14, 2025 |
| Publication Date | March 27, 2026 |
| DOI | https://doi.org/10.7126/cumudj.1666750 |
| IZ | https://izlik.org/JA42GH65WU |
| Published in Issue | Year 2026 Volume: 29 Issue: 1 |
Cumhuriyet Dental Journal (Cumhuriyet Dent J, CDJ) is the official publication of Cumhuriyet University Faculty of Dentistry. CDJ is an international journal dedicated to the latest advancement of dentistry. The aim of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of dentistry. First issue of the Journal of Cumhuriyet University Faculty of Dentistry was published in 1998. In 2010, journal's name was changed as Cumhuriyet Dental Journal. Journal’s publication language is English.
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