Successful Treatment of Intractable Case of Granulomatous Cheilitis with a Modified Treatment Protocol "Case Report"

Wadhah Akhajj

doi:10.7126/cumudj.1654059

Successful Treatment of Intractable Case of Granulomatous Cheilitis with a Modified Treatment Protocol "Case Report"

Abstract

Granulomatous cheilitis (GC) is a rare, idiopathic, inflammatory disorder which usually affects young adults. It is characterized by persistent, cosmetically disturbing and persistent idiopathic lip swelling. Multiple treatment modalities have been suggested. In spite of the treatment used, recurrence of the disease is very common. We reported an intractable and recurrent case of GC characterized by a large swelling of upper lip. The diagnosis is confirmed with a combination of history, clinical examination, radiographical and histopathological evaluation. This patient was treated with modified treatment protocol with a combination of intralesional steroids, prednisolone, systemic metronidazole, and doxycycline and maintenance drug therapy with approximately no signs of relapse at twelve months’ follow-up. In conclusion, the mentioned therapeutic protocol proved a success in the treatment this an intractable case of GC with a long follow up period with no relapse. More clinical trials and case control trials are needed for enhancing our understanding of this disease for evaluating the efficacy of the various treatments and establishing a universally accepted protocol for management of GC.

Keywords

Supporting Institution

Thamar University

Project Number

3/2024

Ethical Statement

This research was approved by the ethics committee at Thamar University (Faculty of Dentistry) with a reference number (3/2024)

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Details

Primary Language

English

Subjects

Oral Medicine and Pathology

Journal Section

Case Report

Authors

Wadhah Akhajj ^*
0000-0003-2831-8646
Yemen

Publication Date

December 29, 2025

Submission Date

March 13, 2025

Acceptance Date

November 19, 2025

Published in Issue

Year 2025 Volume: 28 Number: 4

DOI

https://doi.org/10.7126/cumudj.1654059

IZ

https://izlik.org/JA34ZN56CC

Cite

RIS / Bibtex

EndNote

Akhajj W (December 1, 2025) Successful Treatment of Intractable Case of Granulomatous Cheilitis with a Modified Treatment Protocol "Case Report". Cumhuriyet Dental Journal 28 4 627–632.