Investigation of Antifungal Effects of Different Remineralization Agents on Salivary Candida amount in children with Early Childhood Caries

Figen Eren Giray; Ceren Güven Özşahin; Nursen Topcuoğlu; Betul Kargul

doi:10.7126/cumudj.1590989

EN

Investigation of Antifungal Effects of Different Remineralization Agents on Salivary Candida amount in children with Early Childhood Caries

Abstract

Objectives: In recent years, Candida has been associated with dental caries in children. The association of Candida albicans with the onset of ECC is well known. In addition to mutans streptococci and lactobacilli, Candida spp. is frequently present in the oral cavity of children with ECC. The purpose of this study was to compare different remineralization agents for Candida count in children with Severe Early Childhood Caries (S-ECC). Materials and Methods: Fifty-four healthy children aged 3 to 5 years, diagnosed with S-ECC, were examined, and 21 candida-positive children were included in the study. Children were randomly assigned to 3 groups; 500 ppm NaF toothpaste (Control) group; 10% CPP-ACP group and CaGP and 12% Xylitol group. Oral hygiene training was given to the children and they were told to use remineralization agents 3 times a day for 3-5 min for 2 weeks. Unstimulated saliva was quantitatively cultured for Candida counts. The number of colonies of Candida species was determined at the baseline, 2nd week, 1st and 4th months. All analyses were performed with SPSS statistics version 23. A p-value of less than 0.05 was considered statistically significant. Results: A statistically significant difference was found between baseline and 1st and 4th month Candida count in CaGP + 12% Xylitol group (p <0.05). CaGP group showed a significant reduction in salivary Candida count (P = 0.028) after 4-months application. However, despite the reduction in Candida count in the NaF toothpaste and CPP-ACP groups, these improvements did not display statistically significant differences. (p>0,05). Conclusions: These results suggest that remineralization agents can reduce the count of Candida, thus it can be effective in caries management.

Keywords

References

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Details

Primary Language

English

Subjects

Paedodontics

Journal Section

Research Article

Authors

Figen Eren Giray ^*
0000-0001-8359-5377
Türkiye

Ceren Güven Özşahin
0000-0003-2675-9528
Türkiye

Nursen Topcuoğlu
0000-0002-5041-1129
Türkiye

Betul Kargul
0000-0002-3294-8846
Türkiye

Publication Date

December 30, 2024

Submission Date

November 25, 2024

Acceptance Date

December 13, 2024

Published in Issue

Year 2024 Volume: 27 Number: 4

DOI

https://doi.org/10.7126/cumudj.1590989

IZ

https://izlik.org/JA54PP77WD

Cite

RIS / Bibtex

EndNote

Eren Giray F, Güven Özşahin C, Topcuoğlu N, Kargul B (December 1, 2024) Investigation of Antifungal Effects of Different Remineralization Agents on Salivary Candida amount in children with Early Childhood Caries. Cumhuriyet Dental Journal 27 4 245–251.