Salivary Leptin Levels in Children with Early Childhood Caries – An Interventional Study

Pratima R Mokashi; Srikala Bhandary

doi:10.7126/cumudj.1100449

EN

Salivary Leptin Levels in Children with Early Childhood Caries – An Interventional Study

Abstract

Background: Early childhood caries (ECC) is a pathologic condition of multifactorial nature. The diagnosis of the same has been limited to clinical and radiographic aids with very little significance to assess its inflammatory component. objectives: The present study aims to evaluate the role of leptin, an adipocytokine as a non-invasive inflammatory biomarker in ECC. Materials and Method: A total of 60 children between the age of (3-5) years were selected for the study. The study subjects were divided into three groups of 20 each including Group 1 as control, Group 2 with mild to moderate ECC and Group 3 with severe ECC. Saliva samples were taken from all subjects and collected again after 2 months following rehabilitative intervention. Levels of salivary leptin were determined using Enzyme-Linked Immunosorbent Assay (ELISA). Results: Levels of salivary leptin were significantly associated with severity of dental caries. The intragroup comparisons of pre and post treatment levels of salivary leptin showed significant reductions in both mild to moderate ECC and severe ECC groups following caries control. Inter group evaluation between mild to moderate ECC and severe ECC post treatment showed statistically significant decline of leptin levels in comparison to baseline values. Conclusion: There was a statistically significant decline in salivary leptin levels between the mild moderate and severe ECC group, after 2 months following caries control. Thus, leptin holds a potential to be recognized as a reliable future prognostic and diagnostic inflammatory marker in early childhood caries.

Keywords

Supporting Institution

AB Shetty Memorial Institute of Dental Sciences

Project Number

ABSM/EC/56/2018

Thanks

PROF (Dr) Suchetha Kumari, Professor, Department of Biochemistry, KS Hegde Medical Academy

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Pratima R Mokashi
0000-0001-7346-1340
India

Srikala Bhandary ^*
0000-0001-7682-0345
India

Publication Date

December 30, 2022

Submission Date

April 8, 2022

Acceptance Date

December 14, 2022

Published in Issue

Year 2022 Volume: 25 Number: 4

DOI

https://doi.org/10.7126/cumudj.1100449

IZ

https://izlik.org/JA23CL73LG

Cite

RIS / Bibtex

EndNote

Mokashi PR, Bhandary S (December 1, 2022) Salivary Leptin Levels in Children with Early Childhood Caries – An Interventional Study. Cumhuriyet Dental Journal 25 4 302–308.

Öz

Salivary Leptin Levels in Children with Early Childhood Caries – An Interventional Study

Abstract

Keywords

Supporting Institution

Project Number

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

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Acceptance Date

Published in Issue

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IZ

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