Araştırma Makalesi
EVALUATION OF THE EFFECT OF VITAMIN D REPLACEMENT ON WEIGHT LOSS AND ANTIOXIDANT BALANCE IN OBESE AND OVERWEIGHT INDIVIDUALS WHO EXERCISE REGULARLY
Öz
It is emphasized that obesity and exercise increase free radical formation and oxidative stress as a result of the proportional increase in metabolic processes and O2 use. In our study, it was aimed to investigate the effects of vitamin D replacement on weight loss and antioxidant balance in individuals with a Body Mass Index (BMI)≥25 kg/m2 who exercise regularly. 44 volunteers registered in a gym in Kayseri, exercising regularly, and confirmed to have vitamin D deficiency (serum 25(OH)D<30 ng/ml) were divided into two groups as study (n=26) and control (n=18) groups. Vitamin D ampoules containing 300,000 IU/ml D3 was given orally once a month to the individuals in the study group for 3 months, the individuals in the control group did not receive any replacement. As a result of the research, it was observed a statistically non-significant increase in the total antioxidant level (TAS) of the study group; a statistically significant decrease in total oxidant levels (TOS). In the control group, it was found a significant decrease in serum 25(OH)D and TAS levels; a non-significant increase in the TOS level. In addition, there was a significant negative correlation between serum 25(OH)D level and BMI and body fat ratio; a significant positive correlation was found between TAS level. As a result, it was observed that vitamin D replacement did not have a significant effect on weight loss in people who regularly exercise, but had a positive effect on the antioxidant balance of individuals.
Anahtar Kelimeler
Proje Numarası
TYL-2019-8706
Kaynakça
- Baser, H., Can, U., Baser, S., Hidayetoglu, B. T., Aslan, U., Buyuktorun, I., & Yerlikaya, F. H. (2015). Serum total oxidant/anti-oxidant status, ischemia-modified albumin and oxidized-low density lipoprotein levels in patients with vitamin D deficiency. Archives of endocrinology and metabolism, 59, 318-324.
- Chen, L., Yang, R., Qiao, W., Yuan, X., Wang, S., Goltzman, D., & Miao, D. (2018). 1, 25‐Dihydroxy vitamin D prevents tumorigenesis by inhibiting oxidative stress and inducing tumor cellular senescence in mice. International journal of cancer, 143(2), 368-382. Chen, L., Yang, R., Qiao, W., Zhang, W., Chen, J., Mao, L., Goltzman, D., & Miao, D. (2019). 1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16/p53-senescence signaling. Aging Cell, 18(3), e12951. Costa, P., Santos, C., & Santos, D. (2015). Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obesity Reviews, 16(4), 341-349.
- Duarte, J., Pérez‐Palencia, R., & Vargas, F., Angeles Ocete, M., Pérez‐Vizcaino, F., Zarzuelo, A., & Tamargo, J. (2001). Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. British journal of pharmacology, 133(1), 117-124.
- Duthie, G.G., Robertson, J.D., Maughan, R.J., & Morrice, P.C. (1990). Blood antioxidant status and erythrocyte lipid peroxidation following distance running. Archives of Biochemistry and Biophysics, 282(1), 78-83.
- Farrokhyar, F., Tabasinejad, R., Dao, D., Peterson, D., Ayeni, O.R., Hadioonzadeh, R., & Bhandari, M. (2015). Prevalence of vitamin D inadequacy in athletes: a systematic-review and meta-analysis. Sports Medicine, 45, 365-378.
- Ferrari, D., Lombardi, G., Strollo, M., Pontillo, M., Motta, A., & Locatelli, M. (2020). A possible antioxidant role for vitamin D in soccer players: a retrospective analysis of psychophysical stress markers in a professional team. International Journal of Environmental Research and Public Health, 17(10), 3484.
- Gu, J. C., Wu, Y. G., Huang, W. G., Fan, X. J., Chen, X. H., Zhou, B., ... & Feng, X. L. (2022). Effect of vitamin D on oxidative stress and serum inflammatory factors in the patients with type 2 diabetes. Journal of Clinical Laboratory Analysis, 36(5), e24430.
- Güleken, N. (2012). Kanser hastalarında D vitamini, kalsiyum ve fosfor düzeyleri ile D vitamini reseptörü polimorfizminin araştırılması. Yayımlanmış Yüksek Lisans Tezi. Gaziantep Üniversitesi Sağlık Bilimleri Enstitüsü, Gaziantep.
- Higdon, J. V., & Frei, B. (2003). Obesity and oxidative stress: a direct link to CVD?. Arteriosclerosis, thrombosis, and vascular biology, 23(3), 365-367.
- Karampela, I., Sakelliou, A., Vallianou, N., Christodoulatos, G.S., Magkos, F., & Dalamaga, M. (2021). Vitamin D and obesity: current evidence and controversies. Current Obesity Reports, 10(2), 162-180.
- Ke, C. Y., Yang, F. L., Wu, W. T., Chung, C. H., Lee, R. P., Yang, W. T., ... & Liao, K. W. (2016). Vitamin D3 reduces tissue damage and oxidative stress caused by exhaustive exercise. International journal of medical sciences, 13(2), 147-153.
- Łagowska, K., Bajerska, J., & Jamka, M. (2018). The role of vitamin D oral supplementation in ınsulin resistance in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Nutrients, 10(11), 1637.
- Lee, R., Margaritis, M.M., Channon, K., & Antoniades, C. (2012). Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations. Current Medicinal Chemistry, 19(16), 2504–2520.
- Li, H., Miao, W., Ma, J., Xv, Z., Bo, H., Li, J., ... & Ji, L. L. (2016). Acute exercise-induced mitochondrial stress triggers an inflammatory response in the myocardium via NLRP3 inflammasome activation with mitophagy. Oxidative Medicine and Cellular Longevity, 2016, 1-11.
- Lütfioğlu, M., Özden, F. O., & Atabey, V. (2019). Obezite, oksidatif stres ve periodontal hastalık ilişkisi. Ege Üniversitesi Diş Hekimliği Fakültesi Dergisi, 40(1), 9-16.
- Mercan, U. (2004). Toksikolojide serbest radikallerin önemi. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi, 15(1), 91-96.
- Mirhosseini, N., Rainsbury, J., & Kimball, S. M. (2018). Vitamin D supplementation, serum 25 (OH) D concentrations and cardiovascular disease risk factors: a systematic review and meta-analysis. Frontiers in cardiovascular medicine, 5, 87.
- Naghibi, S. (2014). The effect of short-term creatine supplementation on cardiovascular damage markers after an exhaustive exercise session in elite karate athletes. Sport Physiology, 6(22), 15-28.
- Nemes, R., & Koltai, E. (2018). Reactive oxygen and nitrogen species regulate key metabolic, anabolic, and catabolic pathways in skeletal muscle. Antioxidants, 7(7), 1-13.
- Oecd Health Statistics. (2017). Health at a glance. 26.04.2020, https://www.oecd.org/health/obesity-update.htm.
- Omar, H. S., Taha, F. M., Fouad, S., Ibrahim, F. A., El Gendy, A., Bassyouni, I. H., & El-Shazly, R. (2022). The association between vitamin D levels and oxidative stress markers in Egyptian Behcet’s disease patients. Orphanet Journal of Rare Diseases, 17(1), 1-9.
- Powers, S.K., Ji, L.L., Kavazis, A.N., & Jackson, M.J. (2011). Reactive oxygen species: Impact on skeletal muscle. Comprehensive Physiology, 1(2), 941–969.
- Rebolledo, B. J., Bernard, J. A., Werner, B. C., Finlay, A. K., Nwachukwu, B. U., Dare, D. M., ... & Rodeo, S. A. (2018). The association of vitamin D status in lower extremity muscle strains and core muscle injuries at the National Football League Combine. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 34(4), 1280-1285.
- T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü Sağlıklı Beslenme ve Hareketli Hayat Dairesi Başkanlığı. (2017). Türkiye’de Obezitenin Görülme Sıklığı. 26.04.2020, https://hsgm.saglik.gov.tr/tr/obezite/turkiyede-obezitenin-gorulme-sikligi.html.
- Tofas, T., Draganidis, D., Deli, C.K., Georgakouli, K., Fatouros, I.G., & Jamurtas, A.Z. (2019) Exercise induced regulation of redox status in cardiovascular diseases: the role of exercise training and detraining. Antioxidants, 9(1), 13.
- Türkiye Endokrinoloji ve Metabolizma Derneği, Obezite, Lipid Metabolizması, Hipertansiyon Çalışma Grubu. (2019). Obezite tanı ve tedavi kılavuzu (8. Baskı). 31.01.2021, https://temd.org.tr/admin/uploads/tbl_kilavuz/20190506163904-2019tbl_kilavuz5ccdcb9e5d.pdf
- Wiseman, H. (1993). Vitamin D is a membrane antioxidant Ability to inhibit iron‐dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action. FEBS letters, 326(1-3), 285-288.
- Yoon, S., Kwon, O., & Kim, J. (2021). Vitamin D in athletes: focus on physical performance and musculoskeletal injuries. Physical Activity and Nutrition, 25(2), 20-25.
DÜZENLİ EGZERSİZ YAPAN OBEZ VE FAZLA KİLOLU BİREYLERDE D VİTAMİNİ REPLASMANININ KİLO KAYBI VE ANTİOKSİDAN DENGE ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ
Öz
Obezite ve egzersizin, metabolik süreçler ve O2 kullanımının orantısal artışı sonucunda serbest radikal oluşumunu ve oksidatif stresi artırdığı vurgulanmaktadır. Çalışmamızda düzenli egzersiz yapan, Beden Kütle İndeksi (BKİ)≥25 kg/m2 bireylerde D vitamini takviyesinin kilo kaybı ve antioksidan denge üzerine etkisini araştırmak amaçlanmıştır. Kayseri’de bir spor salonuna kayıtlı, düzenli egzersiz yapan, D vitamini yetersizliği saptanmış (serum 25(OH)D<30 ng/ml) 44 gönüllü, çalışma (n=26) ve kontrol (n=18) grubu olmak üzere ikiye ayrılmıştır. Çalışma grubundaki bireylere 3 ay süresince, ayda bir defa 300.000 IU/ml D3 içeren D vitamini ampulü oral yoldan verilmiş; kontrol grubundaki bireylere ise herhangi bir replasman uygulanmamıştır. Araştırma sonucunda, çalışma grubunun total antioksidan seviyesinde (TAS) istatistiksel olarak anlamlı olmayan bir artış; total oksidan seviyelerinde (TOS) ise istatistiksel olarak anlamlı düzeyde düşüş gözlemlenmiştir. Kontrol grubunda, serum 25(OH)D ve TAS seviyelerinde anlamlı düzeyde azalma; TOS seviyesinde ise anlamlı olmayan bir artış saptanmıştır. Ayrıca serum 25(OH)D seviyesi ile BKİ ve vücut yağ oranı arasında anlamlı negatif korelasyon; TAS seviyesi arasında ise anlamlı düzeyde pozitif korelasyon saptanmıştır. Sonuç olarak, düzenli spor yapan kişilerde D vitamini replasmanının, kilo kaybı üzerinde anlamlı bir etkisi olmamakla birlikte bireylerin antioksidan dengesi üzerinde olumlu etki gösterdiği gözlemlenmiştir.
Anahtar Kelimeler
Destekleyen Kurum
Erciyes Üniversitesi Bilimsel Araştırma Projeleri Birimi
Proje Numarası
TYL-2019-8706
Teşekkür
Bu çalışma, Prof. Dr. Sabahattin Muhtaroğlu danışmanlığında, Venher Dimaze Akça Kaya tarafından Erciyes Üniversitesi Sağlık Bilimleri Enstitüsü Tıbbi Biyokimya Anabilim Dalı’nda Yüksek Lisans Tezi olarak hazırlanmış ve Erciyes Üniversitesi Bilimsel Araştırma Projeleri Birimi tarafından TYL-2019-8706 kodlu proje ile desteklenmiştir. Ayrıca çalışmanın kurumlarında yürütülmesi konusunda desteklerini esirgemeyen Fier Life Center Yönetim Kurulu’na teşekkürü borç biliriz.
Kaynakça
- Baser, H., Can, U., Baser, S., Hidayetoglu, B. T., Aslan, U., Buyuktorun, I., & Yerlikaya, F. H. (2015). Serum total oxidant/anti-oxidant status, ischemia-modified albumin and oxidized-low density lipoprotein levels in patients with vitamin D deficiency. Archives of endocrinology and metabolism, 59, 318-324.
- Chen, L., Yang, R., Qiao, W., Yuan, X., Wang, S., Goltzman, D., & Miao, D. (2018). 1, 25‐Dihydroxy vitamin D prevents tumorigenesis by inhibiting oxidative stress and inducing tumor cellular senescence in mice. International journal of cancer, 143(2), 368-382. Chen, L., Yang, R., Qiao, W., Zhang, W., Chen, J., Mao, L., Goltzman, D., & Miao, D. (2019). 1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16/p53-senescence signaling. Aging Cell, 18(3), e12951. Costa, P., Santos, C., & Santos, D. (2015). Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obesity Reviews, 16(4), 341-349.
- Duarte, J., Pérez‐Palencia, R., & Vargas, F., Angeles Ocete, M., Pérez‐Vizcaino, F., Zarzuelo, A., & Tamargo, J. (2001). Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. British journal of pharmacology, 133(1), 117-124.
- Duthie, G.G., Robertson, J.D., Maughan, R.J., & Morrice, P.C. (1990). Blood antioxidant status and erythrocyte lipid peroxidation following distance running. Archives of Biochemistry and Biophysics, 282(1), 78-83.
- Farrokhyar, F., Tabasinejad, R., Dao, D., Peterson, D., Ayeni, O.R., Hadioonzadeh, R., & Bhandari, M. (2015). Prevalence of vitamin D inadequacy in athletes: a systematic-review and meta-analysis. Sports Medicine, 45, 365-378.
- Ferrari, D., Lombardi, G., Strollo, M., Pontillo, M., Motta, A., & Locatelli, M. (2020). A possible antioxidant role for vitamin D in soccer players: a retrospective analysis of psychophysical stress markers in a professional team. International Journal of Environmental Research and Public Health, 17(10), 3484.
- Gu, J. C., Wu, Y. G., Huang, W. G., Fan, X. J., Chen, X. H., Zhou, B., ... & Feng, X. L. (2022). Effect of vitamin D on oxidative stress and serum inflammatory factors in the patients with type 2 diabetes. Journal of Clinical Laboratory Analysis, 36(5), e24430.
- Güleken, N. (2012). Kanser hastalarında D vitamini, kalsiyum ve fosfor düzeyleri ile D vitamini reseptörü polimorfizminin araştırılması. Yayımlanmış Yüksek Lisans Tezi. Gaziantep Üniversitesi Sağlık Bilimleri Enstitüsü, Gaziantep.
- Higdon, J. V., & Frei, B. (2003). Obesity and oxidative stress: a direct link to CVD?. Arteriosclerosis, thrombosis, and vascular biology, 23(3), 365-367.
- Karampela, I., Sakelliou, A., Vallianou, N., Christodoulatos, G.S., Magkos, F., & Dalamaga, M. (2021). Vitamin D and obesity: current evidence and controversies. Current Obesity Reports, 10(2), 162-180.
- Ke, C. Y., Yang, F. L., Wu, W. T., Chung, C. H., Lee, R. P., Yang, W. T., ... & Liao, K. W. (2016). Vitamin D3 reduces tissue damage and oxidative stress caused by exhaustive exercise. International journal of medical sciences, 13(2), 147-153.
- Łagowska, K., Bajerska, J., & Jamka, M. (2018). The role of vitamin D oral supplementation in ınsulin resistance in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Nutrients, 10(11), 1637.
- Lee, R., Margaritis, M.M., Channon, K., & Antoniades, C. (2012). Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations. Current Medicinal Chemistry, 19(16), 2504–2520.
- Li, H., Miao, W., Ma, J., Xv, Z., Bo, H., Li, J., ... & Ji, L. L. (2016). Acute exercise-induced mitochondrial stress triggers an inflammatory response in the myocardium via NLRP3 inflammasome activation with mitophagy. Oxidative Medicine and Cellular Longevity, 2016, 1-11.
- Lütfioğlu, M., Özden, F. O., & Atabey, V. (2019). Obezite, oksidatif stres ve periodontal hastalık ilişkisi. Ege Üniversitesi Diş Hekimliği Fakültesi Dergisi, 40(1), 9-16.
- Mercan, U. (2004). Toksikolojide serbest radikallerin önemi. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi, 15(1), 91-96.
- Mirhosseini, N., Rainsbury, J., & Kimball, S. M. (2018). Vitamin D supplementation, serum 25 (OH) D concentrations and cardiovascular disease risk factors: a systematic review and meta-analysis. Frontiers in cardiovascular medicine, 5, 87.
- Naghibi, S. (2014). The effect of short-term creatine supplementation on cardiovascular damage markers after an exhaustive exercise session in elite karate athletes. Sport Physiology, 6(22), 15-28.
- Nemes, R., & Koltai, E. (2018). Reactive oxygen and nitrogen species regulate key metabolic, anabolic, and catabolic pathways in skeletal muscle. Antioxidants, 7(7), 1-13.
- Oecd Health Statistics. (2017). Health at a glance. 26.04.2020, https://www.oecd.org/health/obesity-update.htm.
- Omar, H. S., Taha, F. M., Fouad, S., Ibrahim, F. A., El Gendy, A., Bassyouni, I. H., & El-Shazly, R. (2022). The association between vitamin D levels and oxidative stress markers in Egyptian Behcet’s disease patients. Orphanet Journal of Rare Diseases, 17(1), 1-9.
- Powers, S.K., Ji, L.L., Kavazis, A.N., & Jackson, M.J. (2011). Reactive oxygen species: Impact on skeletal muscle. Comprehensive Physiology, 1(2), 941–969.
- Rebolledo, B. J., Bernard, J. A., Werner, B. C., Finlay, A. K., Nwachukwu, B. U., Dare, D. M., ... & Rodeo, S. A. (2018). The association of vitamin D status in lower extremity muscle strains and core muscle injuries at the National Football League Combine. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 34(4), 1280-1285.
- T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü Sağlıklı Beslenme ve Hareketli Hayat Dairesi Başkanlığı. (2017). Türkiye’de Obezitenin Görülme Sıklığı. 26.04.2020, https://hsgm.saglik.gov.tr/tr/obezite/turkiyede-obezitenin-gorulme-sikligi.html.
- Tofas, T., Draganidis, D., Deli, C.K., Georgakouli, K., Fatouros, I.G., & Jamurtas, A.Z. (2019) Exercise induced regulation of redox status in cardiovascular diseases: the role of exercise training and detraining. Antioxidants, 9(1), 13.
- Türkiye Endokrinoloji ve Metabolizma Derneği, Obezite, Lipid Metabolizması, Hipertansiyon Çalışma Grubu. (2019). Obezite tanı ve tedavi kılavuzu (8. Baskı). 31.01.2021, https://temd.org.tr/admin/uploads/tbl_kilavuz/20190506163904-2019tbl_kilavuz5ccdcb9e5d.pdf
- Wiseman, H. (1993). Vitamin D is a membrane antioxidant Ability to inhibit iron‐dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action. FEBS letters, 326(1-3), 285-288.
- Yoon, S., Kwon, O., & Kim, J. (2021). Vitamin D in athletes: focus on physical performance and musculoskeletal injuries. Physical Activity and Nutrition, 25(2), 20-25.
Toplam 28 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Spor Hekimliği |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Proje Numarası | TYL-2019-8706 |
| Erken Görünüm Tarihi | 28 Aralık 2023 |
| Yayımlanma Tarihi | 30 Aralık 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 21 Sayı: 4 |
