Olgu Sunumu
MANDİBULADA GÖRÜLEN SANTRAL DEV HÜCRELİ GRANÜLOMUN SİSTEMİK KALSİTONİN UYGULAMASI İLE TEDAVİSİ: BİR OLGU SUNUMU
Öz
Amaç: Çene
kemiklerinde görülen santral dev hücreli granulom (SDHG) çoğunlukla kadınlarda
ve 30 yaş öncesinde görülen, iyi huylu, agresif seyreden, intraosseöz bir
lezyondur. Tedavisinde sıklıkla küretaj tercih edilmesinin yanında, son
yıllarda intralezyonel steroid ve interferon- α (IFN-α) uygulaması, sistemik
kalsitonin kullanılması gibi yöntemlerden de faydalanılmaktadır. Bu olgu
raporunda 11 yaşında erkek hastanın, mandibular molar bölgesinde teşhis edilen SDHG’
ye tedavi yaklaşımından bahsedilecektir.
Gereç ve Yöntemler:Hasta
klinik ve radyolojik değerlendirildikten sonra, hiperparatiroidizmin (brown tumor) elimine
edilmesi için kan testi de yaptırılmış ve kan değerleri normal bulunmuştur.
Kesin teşhis konulması için mevcut lezyondan insizyonel biyopsi yapılmış ve ön
teşhisde düşünülen SDHG doğrulanmıştır. Hastanın tedavisi haftada 1 kez beş
hafta süreyle intralezyonel steroid uygulaması şeklinde başlamıştır. Ancak kontrol
radyograflarında lezyonda herhangi bir rezolusyona veya yeni kalsifiye alana
rastlanmamıştır. Bu sebeple alternative tedavi olarak hasta 6 ay boyunca günde
bir kez olacak şekilde intranasal kalsitonin kullanmaya başlamıştır.
Bulgular:6
ayın sonunda alınan son kontrol
radyografında lezyonda belirgin küçülme olduğu ve kallus formasyonunun
başladığı gözlenmiştir. 6 yıllık takipte herhangi bir rekürrense
rastlanmamıştır.
Sonuçlar:Genç
hastalarda fonksiyonel ve estetik
deformitelerden kaçınmak için sistemik kalsitonin ile SDHG tedavisi, cerrahi
olmayan, minimal girişimsel ve tercih edilebilir bir tedavi yöntemidir.
Anahtar Kelimeler: Kalsitonin,
santral dev hücreli granulom, mandibula
Anahtar Kelimeler
Kaynakça
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- de Lange J, Rosenberg AJ, van den Akker HP, Koole R, Wirds JJ, van den Berg H. Treatment of central giant cell granuloma of the jaw with calcitonin, 1999. Int J Oral Maxillofac Surg, 28, 372-376.
- de Lange J, van den Akker HP, Klip H. Incidence and disease-free survival after surgical therapy of central giant cell granulomas of the jaw in The Netherlands: 1990-1995, 2004. Head & Neck, 26, 792-795.
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- de Lange J, van den Akker HP, van den Berg H. Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options, 2007. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 104, 603-615.
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- Eisenbud L, Stern M, Rothberg M, Sachs SA. Central giant cell granuloma of the jaws: experiences in the management of thirty-seven cases, 1988. J Oral Maxillofac Surg, 46, 376-384.
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Toplam 34 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Diş Hekimliği |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Nisan 2018 |
| Gönderilme Tarihi | 12 Şubat 2018 |
| Yayımlandığı Sayı | Yıl 2018 Cilt: 5 Sayı: 1 |
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