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DİŞHEKİMLİĞİNDE BİYOUYUMLULUK VE DEĞERLENDİRME YÖNTEMLERİ

Yıl 2017, Cilt: 4 Sayı: 3, 162 - 169, 01.12.2017

Zehra Süsgün Yıldırım Elif Pınar Bakır Şeyhmus Bakır Mehmet Salih Aydın

https://doi.org/10.15311/selcukdentj.302915

Öz

Dental materyallerin
biyouyumluluğu; oral dokular üzerine zararlı etkilerinin minimum olması
şeklinde tarif edilmektedir. Bu etkinin
derecesi; hastaya, materyalin fonksiyonuna, gücüne, yerleştirildiği koşullara
ve zamana bağlı olarak değişir. Kullanıma sunulacak materyallerin güvenilirliğinin
hangi testlerle değerlendirildiği önem taşımaktadır. Dental materyallerin biyouyumluluğunu değerlendirmede genellikle; in-vitro testler → hayvan deneyleri →
klinik kullanım testleri şeklinde, sıralı klasik bir paradigma
kullanılmaktadır.











Diş hekimi yeni bir
materyali kullanmaya karar verirken, farklı araştırma sonuçlarını incelemeli ve
hastanın taleplerinin yanı sıra risk-yarar analizi yapmalıdır.

Anahtar Kelimeler

Dental materyal; Biyouyumluluk; In-vitro testler.

Kaynakça

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  • 4. Cao T, Saw TY, Heng BC, Liu H, Yap AUJ, Ng ML. Comparison of different test models for the assesment of cytotoxicity of composite resins. Journal of Applied Toxicology 2005;25:101-8.
  • 5. Saw TY, Cao T, Yap AUJ, Ng MML. Tooth slice organ culture and established cell line culture models for cytotoxicity assesment of dental materials. Toxicol In Vitro 2005;19:145-54.
  • 6. Annunziata M, Aversa R, Apicella A, Annunziata A, Apicella D, Buonaiuto C, et al. In vitro biological response to a light-cured composite when used for cementation of composite inlays. Dent Materials 2006;22:1081-5.
  • 7. Sengün A, Buyukbas S, Hakki SS. Cytotoxic effects of dental desensitizers on human gingival fibroblasts. J Biomed Mater Res B Appl Biomater 2006;78:131-7.
  • 8. Moharamzadeh K, Brook IM, Noort RV. Biocompatibility of resin-based dental materials. Materials 2009;2:514-48.
  • 9. Wataha JC, Lockwood PE, Schedle A, Noda M, Bouillaguet S. Ag, Cu, Hg, and Ni ions alter the metabolism of human monocytes during extended low-dose exposures. J Oral Rehabil 2002;29:133-9.
  • 10. Maxwell P, Salnikow K. HIF: an oxygen and metal responsive transcription factor. Cancer Biol Ther 2004;3:29-35.
  • 1. Wataha JC, Lewis JB, Volkmann KR, Lockwood PE, Messer RLW, Bouillaguet S. Sublethal concentrations of Au(III), Pd(II), and Ni(II) differentially alter inflammatory cytokine secretion from activated monocytes. J BIomed Mater Res B Appl Biomater 2004;69:11-7.
  • 2. Freshney Ian R. Culture of Animal Cells: A Manual of Basic Technique, Fifth Edition,. Haboken; John Wiley & Sons: 2005. p.1-216.
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  • 5. Schweikl H, Hiller KA, Bolay C, Kreissl M, Kreismann W, Nusser A, et al. Cytotoxic and mutagenic effects of dental composite materials. Biomaterials 2005;26:1713-9.
  • 6. Murray PE, Lumley PJ, Ross HF, Smith AJ. Tooth slice organ culture for cytotoxicity assesment of dental materials. Biomaterials 2000;21:1711-21.
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  • 8. Erdemir EO, Şengün A, Ülker M. Cytotoxicity of mouthrinses on epiteheliel cells by micronucleus test. European Journal of Dentistry 2007;1(2):80-5.
  • 9. Ergün G, Sağsen LM, Doğan A, Özkul A, Demirel E. [Examination of cytotoxicity of denture base resins, by agar diffusion and filter diffusion test methods]. Gazi Üniversitesi Diş Hekimliği Fakültesi Dergisi 2006;23:31-7.
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  • 10. Schweikl H, Schmalz G, Spruss T. The induction of micronuclei in vitro by unpolymerized resin monomers. J Dent Res 2001;80:1615-20.
  • 1. Schweikl H, Schmalz G, Weinmann W. Mutagenic acitivity of structurally related oxiranes and siloranes in Salmonella typhimurium. Mutat Res 2002;521:19-27.
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  • 8. About I, Murray PE, Franquin JC, Remusat M, Smith AJ. Pulpal inflammatory responses following non-carious class V restorations. Oper Dent 2001;26:336-42.
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Toplam 54 adet kaynakça vardır.

Ayrıntılar

Konular Diş Hekimliği
Bölüm Derleme
Yazarlar

Zehra Süsgün Yıldırım

Elif Pınar Bakır

Şeyhmus Bakır

Mehmet Salih Aydın Bu kişi benim

Yayımlanma Tarihi 1 Aralık 2017
Gönderilme Tarihi 30 Mart 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 4 Sayı: 3

Kaynak Göster

Vancouver Süsgün Yıldırım Z, Bakır EP, Bakır Ş, Aydın MS. DİŞHEKİMLİĞİNDE BİYOUYUMLULUK VE DEĞERLENDİRME YÖNTEMLERİ. Selcuk Dent J. 2017;4(3):162-9.

Selcuk Dental Journal Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı (CC BY NC) ile lisanslanmıştır.