D Vitamini Eksikliğinin ve Obezitenin Koronavirüs Hastalığı Enfeksiyonu ile İlişkisi

Zainab Gholami; Havva Sert

doi:10.54803/sauhsd.1011965

Derleme

D Vitamini Eksikliğinin ve Obezitenin Koronavirüs Hastalığı Enfeksiyonu ile İlişkisi

Yıl 2022, Cilt: 5 Sayı: 1, 76 - 84, 15.04.2022

Zainab Gholami Havva Sert

https://doi.org/10.54803/sauhsd.1011965

Öz

Koronavirüs hastalığı, dünyada pek çok ülkede halk sağlığını tehdit eden ve ölümle sonuçlanabilen önemli bir halk sağlığı sorunudur. Pandeminin başından itibaren hastalığın risk faktörleri, belirtileri ve destek tedavi yöntemleri araştırılmaktadır. Araştırmalarda D vitamini eksikliğinin ve obezitenin birbiri ile ilişkisi ve Koronavirüs hastalığında etkileri sıklıkla belirtilmektedir.
D vitaminin, virüslere karşı fiziksel bariyeri güçlendirme ve hiperinflamatuar yanıtları durdurmadaki üstünlüğü kanıtlanmıştır. Özellikle üst solunum yolu enfeksiyonlarında etkin bir immünomodülatör hormondur. D vitamini eksikliğinin eşlik ettiği Koronavirüs hastalığı hastalarında, hastalığın şiddetini ve yoğun bakımda yatma durumunu olumsuz etkilendiği pek çok çalışma ile desteklenmiştir. Öte yandan obezite genel sağlığı olumsuz etkileyen, çeşitli mekanik ve tıbbi sorunlara yol açarak Koronavirüs hastalığında morbidite ve mortaliteyi etkilemektedir. Obezite ve D vitamini eksikliği birbirini etkileyen bir durumdur ve her iki durumun bir arada görülmesi, enflamasyon cevabı ve hastalığın seyrinde önemli bir yere sahiptir.
Bu derlemede, obezite ve D vitamini eksikliğinin Koronavirüs hastalığının seyrindeki etkilerinden bahsedilecektir. Konu gelecekte Koronavirüs hastalığı tedavi stratejilerine rehberlik edecektir.

Anahtar Kelimeler

D vitamini eksikliği, Koronavirüs hastalığı, obezite

Destekleyen Kurum

Makaleye destekleyen herhangi bir kurum bulunmamaktadır.

Kaynakça

1. Söbü E, Karaaslan A, Çetin C, Akın Y. Vitamin D levels of COVID-19 positive sypmtomatic pediatric cases. J Curr Pediatr. 2021;19:9-14. doi:10.4274/jcp.2021.0002
2. Gonçalves TJM, Gonçalves SEAB, Guarnieri A, et. al. Prevalence of obesity and hypovitaminosis D in elderly with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical Nutrition ESPEN. 2020;40:110-114. doi:10.1016/j.clnesp.2020.10.008
3. Li S, Cao Z, Yang H, Zhang Y, Xu F, Wang Y. Metabolic healthy obesity, vitamin D status, and risk of COVID-19. Aging and Disease. 2021;12(1):61-71. doi:10.14336/AD.2020.1108
4. AlSafar H, Grant WB, Hijazi R, et al. COVID-19 disease severity and death in relation to vitamin D status among SARS-CoV-2-positive UAE residents. Nutrients. 2021;13(5):1714. doi:10.3390/nu13051714
5. Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA Netw Open. 2020;3(9):e2019722. doi:10.1001/jamanetworkopen.2020.19722.
6. Morgante, G, Troìa L, De Leo V. Coronavirus Disease 2019 (SARS-CoV-2) and polycystic ovarian disease: Is there a higher risk for these women? J Steroid Biochem Mol Biol. 2021;205:105770. doi:10.1016/j.jsbmb.2020.105770
7. Mohan M, Cherian JJ, Sharma A. Exploring links between vitamin D deficiency and COVID-19. PloS Pathog. 2020;16(9):e1008874. doi:10.1371/journal.ppat.1008874
8. Boulkrane MS, Ilina V, Melchakov R, et al. COVID-19 Disease and vitamin D: A mini-review. Front Pharmacol 2020;11:604579. doi:10.3389/fphar.2020.604579
9. Bleizgys A. Vitamin D and COVID-19: It is time to act. Int J Clin Pract. 2021;75(3):e13748. doi:10.1111/ijcp.13748
10. Biesalski HK. Vitamin D deficiency and co-morbidities in COVID-19 patients – A fatal relationship? Nfs Journal. 2020;20:10–21. doi:10.1016/j.nfs.2020.06.001
11. Bikdeli B, Madhavan MV, Jimenez D, et al. COVID-19 and Thrombotic or Thromboembolic Disease: Implications for prevention, antithrombotic therapy, and follow-Up: JACC state-of- the-art review. J Am Coll Cardiol. 2020;75(23):2950-2973. doi:10.1016/j.jacc.2020.04.031
12. Gao YD, Ding M, Dong X, et al. Risk factors for severe and critically ill COVID-19 patients: A review. Allergy. 2021;76(2):428-455. doi:10.1111/all.14657
13. Fedele D, Francesco AD, Riso S, Collo A. Obesity, malnutrition, and trace element deficiency in the coronavirus disease (COVID-19) pandemic: An overview. Nutrition. 2021;81:111016. doi:10.1016/j.nut.2020.111016
14. Gu SX, Tyagi T, Jain K, et al. Thrombocytopathy and endotheliopathy: Crucial contributors to COVID-19 thromboinflammation. Nature Reviews Cardiology. 2021;18:194–209. doi:10.1038/s41569-020-00469-1
15. Santaolalla A, Beckmann K, Kibaru J, Josephs D, Hemelrijck MV, Irshad S. Association between vitamin D and novel SARS-CoV-2 respiratory dysfunction – a scoping review of current evidence and its implication for COVID-19 Pandemic. Front Physiol. 2020;11:564387. doi:10.3389/fphys.2020.564387
16. Rychter AM, Zawada A, Ratajczak AE, Dobrowolska A, Krela‐Kaźmierczak I. Should patients with obesity be more afraid of COVID‐19? Obes Rev. 2020;1-8. doi:10.1111/obr.13083
17. Çıtar Daziroğlu ME, Yıldız M, Akbulut G. COVID-19 pandemisine diyetetik bakış: Besin, besin destekleri ve tıbbi beslenme tedavisi. ERÜ Sağlık Bilimleri Fakültesi Dergisi. 2021;8(1):13-22.
18. Merzon E, Tworowski D, Gorohovski A, et al. Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: An Israeli population-based study. FEBS J. 2020;287(17):3693-3702. doi:10.1111/febs.15495
19. Townsend MJ, Kyle TK, Stanford FC. Outcomes of COVID-19: Disparities in obesity and by ethnicity/race. International Journal of Obesity. 2020;44:1807–1809. doi: 10.1038/s41366-020-0635-2
20. Mancin S, Vecchio F. Vitamin D and SARS-CoV-2: A review of the literature. Authorea. 2020. doi:10.22541/au.160529100.01945700/v1
21. Li Y, Tong CH, Bare LA, Devlin JJ. Assessment of the association of vitamin D level with SARS-CoV-2 seropositivity among working-age adults. JAMA Network Open. 2021;4(5):e2111634. doi:10.1001/jamanetworkopen.2021.11634
22. Alipio M. Vitamin D supplementation could possibly improve clinical outcomes of patients infected with Coronavirus-2019 (COVID-19). SSRN Electronic Journal. 2020. doi:10.2139/ssrn.3571484
23. Abdollahi A, Sarvestani HK, Rafat Z, et al. The association between the level of serum 25(OH) vitamin D, obesity, and underlying diseases with the risk of developing COVID‐19 infection: A case–control study of hospitalized patients in Tehran, Iran. J Med Virol. 2021;93(4): 2359–2364. doi:10.1002/jmv.26726
24. Campi I, Gennari L, Merlotti D, et al. Vitamin D and COVID-19 severity and related mortality: A prospective study in Italy. BMC Infectious Diseases. 2021;21(1):566. doi:10.1186/s12879-021-06281-7
25. D’Avolio A, Avataneo V, Manca A, et al. 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients. 2020;12(5):1359. doi:10.3390/nu12051359
26. Faul JL, Kerley CP, Love B, et al. Vitamin D deficiency and ARDS after SARS-CoV-2 infection. Ir Med J. 2020;113(5): 84.
27. Eroğlu E, Balcı H, Baskın V, Aktuna Z. COVID-19 tedavisine yönelik güncel farmakolojik yaklaşımlar. YIU Saglik Bil Derg. 2021;2:1-15. https://doi.org/10.51261/yiu.2021.00018.
28. Kazemi A, Mohammadi V, Aghababaee SK. Golzarand M, Clark CC, Babajafari S. Association of vitamin D status with SARS-CoV-2 infection or COVID-19 severity: A systematic review and meta-analysis. Adv Nutr. 2021;12(5):1636-1658. doi:10.1093/advances/nmab012
29. Lighter J, Phillips M, Hochman S, et al. Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission. Clin Infect Dis. 2020;71(15):896-897. doi:10.1093/cid/ciaa415
30. Frydrych LM, Bian G, O’Lone DE, Ward PA, Delano MJ. Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality. J Leukoc Biol. 2018;104(3):525–534. doi:10.1002/JLB.5VMR0118-021RR
31. Korakas E, Ikonomidis I, Kousathana F, et al. Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes. Am J Physiol Endocrinol Metab. 2020;319(1):E105–E109. doi:10.1152/ajpendo.00198.2020
32. Biesalski HK. Obesity, vitamin D deficiency and old age a serious combination with respect to coronavirus disease-2019 severity and outcome. Curr Opin Clin Nutr Metab Care. 2021;24(1):18–24. doi:10.1097/MCO.0000000000000700
33. Özalp BB, Seremet Kürklü N. Obezite ve COVID-19. İzmir Kâtip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi. 2020;5(2):211-214.
34. Simonnet A, Chetboun M, Poissy J, et al. High prevalence of obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obesity. 2020;28(7):1195-1199. doi:10.1002/oby.22831
35. Michalakis K, Panagiotou G, Ilias I, Pazaitou-Panayiotou K. Obesity and COVID-19: A jigsaw puzzle with still missing pieces. Clin Obes. 2021;11(1):e12420. doi:10.1111/cob.12420
36. Bahrikarehmi L, Fallah A, Yiğit S. (2020). SARS-COV-2’nin gelişimi. BSJ Health Sci. 2020;3(3):94-101.
37. Topuz HŞ. COVID-19 enfeksiyonunda beslenme. Med Res Rep. 2020;3(1):176-180.
38. Somasundaram NP, Ranathunga I, Ratnasamy V, et al. The impact of SARS-Cov-2 virus infection on the endocrine system. J Endocr Soc. 2020;4(8):082. doi:10.1210/jendso/bvaa082

The Relationship of Vitamin D Deficiency and Obesity with Coronavirus Disease Infection

Yıl 2022, Cilt: 5 Sayı: 1, 76 - 84, 15.04.2022

Zainab Gholami Havva Sert

https://doi.org/10.54803/sauhsd.1011965

Öz

Coronavirus disease is an important public health problem that threatens public health in many countries around the world and can result in death. Since the beginning of the pandemic, the risk factors, symptoms and supportive treatment methods of the disease have been investigated. In studies, the relationship between vitamin D deficiency and obesity and its effects on Coronavirus disease are frequently stated.
The superiority of vitamin D in strengthening the physical barrier against viruses and stopping hyper-inflammatory responses has been proven. It is an effective immunomodulatory hormone especially in upper respiratory tract infections. It has been supported by many studies that the severity of the disease and hospitalization in the intensive care unit are negatively affected in patients with Coronavirus disease accompanied by vitamin D deficiency. On the otherhand, obesity also affects morbidity and mortality in Coronavirus disease by causing various mechanical and medical problems that negatively affect general health. Obesity and vitamin D deficiency are conditions that affect each other, and the combination of both conditions plays an important role in the course of the disease.
In this review, the effects of obesity and vitamin D deficiency on the course of Coronavirus disease will be discussed. The subject will guide future Coronavirus disease treatment strategies.

Anahtar Kelimeler

Coronavirus disease, vitamin D deficiency, obesity

Kaynakça

1. Söbü E, Karaaslan A, Çetin C, Akın Y. Vitamin D levels of COVID-19 positive sypmtomatic pediatric cases. J Curr Pediatr. 2021;19:9-14. doi:10.4274/jcp.2021.0002
2. Gonçalves TJM, Gonçalves SEAB, Guarnieri A, et. al. Prevalence of obesity and hypovitaminosis D in elderly with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical Nutrition ESPEN. 2020;40:110-114. doi:10.1016/j.clnesp.2020.10.008
3. Li S, Cao Z, Yang H, Zhang Y, Xu F, Wang Y. Metabolic healthy obesity, vitamin D status, and risk of COVID-19. Aging and Disease. 2021;12(1):61-71. doi:10.14336/AD.2020.1108
4. AlSafar H, Grant WB, Hijazi R, et al. COVID-19 disease severity and death in relation to vitamin D status among SARS-CoV-2-positive UAE residents. Nutrients. 2021;13(5):1714. doi:10.3390/nu13051714
5. Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of vitamin D status and other clinical characteristics with COVID-19 test results. JAMA Netw Open. 2020;3(9):e2019722. doi:10.1001/jamanetworkopen.2020.19722.
6. Morgante, G, Troìa L, De Leo V. Coronavirus Disease 2019 (SARS-CoV-2) and polycystic ovarian disease: Is there a higher risk for these women? J Steroid Biochem Mol Biol. 2021;205:105770. doi:10.1016/j.jsbmb.2020.105770
7. Mohan M, Cherian JJ, Sharma A. Exploring links between vitamin D deficiency and COVID-19. PloS Pathog. 2020;16(9):e1008874. doi:10.1371/journal.ppat.1008874
8. Boulkrane MS, Ilina V, Melchakov R, et al. COVID-19 Disease and vitamin D: A mini-review. Front Pharmacol 2020;11:604579. doi:10.3389/fphar.2020.604579
9. Bleizgys A. Vitamin D and COVID-19: It is time to act. Int J Clin Pract. 2021;75(3):e13748. doi:10.1111/ijcp.13748
10. Biesalski HK. Vitamin D deficiency and co-morbidities in COVID-19 patients – A fatal relationship? Nfs Journal. 2020;20:10–21. doi:10.1016/j.nfs.2020.06.001
11. Bikdeli B, Madhavan MV, Jimenez D, et al. COVID-19 and Thrombotic or Thromboembolic Disease: Implications for prevention, antithrombotic therapy, and follow-Up: JACC state-of- the-art review. J Am Coll Cardiol. 2020;75(23):2950-2973. doi:10.1016/j.jacc.2020.04.031
12. Gao YD, Ding M, Dong X, et al. Risk factors for severe and critically ill COVID-19 patients: A review. Allergy. 2021;76(2):428-455. doi:10.1111/all.14657
13. Fedele D, Francesco AD, Riso S, Collo A. Obesity, malnutrition, and trace element deficiency in the coronavirus disease (COVID-19) pandemic: An overview. Nutrition. 2021;81:111016. doi:10.1016/j.nut.2020.111016
14. Gu SX, Tyagi T, Jain K, et al. Thrombocytopathy and endotheliopathy: Crucial contributors to COVID-19 thromboinflammation. Nature Reviews Cardiology. 2021;18:194–209. doi:10.1038/s41569-020-00469-1
15. Santaolalla A, Beckmann K, Kibaru J, Josephs D, Hemelrijck MV, Irshad S. Association between vitamin D and novel SARS-CoV-2 respiratory dysfunction – a scoping review of current evidence and its implication for COVID-19 Pandemic. Front Physiol. 2020;11:564387. doi:10.3389/fphys.2020.564387
16. Rychter AM, Zawada A, Ratajczak AE, Dobrowolska A, Krela‐Kaźmierczak I. Should patients with obesity be more afraid of COVID‐19? Obes Rev. 2020;1-8. doi:10.1111/obr.13083
17. Çıtar Daziroğlu ME, Yıldız M, Akbulut G. COVID-19 pandemisine diyetetik bakış: Besin, besin destekleri ve tıbbi beslenme tedavisi. ERÜ Sağlık Bilimleri Fakültesi Dergisi. 2021;8(1):13-22.
18. Merzon E, Tworowski D, Gorohovski A, et al. Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: An Israeli population-based study. FEBS J. 2020;287(17):3693-3702. doi:10.1111/febs.15495
19. Townsend MJ, Kyle TK, Stanford FC. Outcomes of COVID-19: Disparities in obesity and by ethnicity/race. International Journal of Obesity. 2020;44:1807–1809. doi: 10.1038/s41366-020-0635-2
20. Mancin S, Vecchio F. Vitamin D and SARS-CoV-2: A review of the literature. Authorea. 2020. doi:10.22541/au.160529100.01945700/v1
21. Li Y, Tong CH, Bare LA, Devlin JJ. Assessment of the association of vitamin D level with SARS-CoV-2 seropositivity among working-age adults. JAMA Network Open. 2021;4(5):e2111634. doi:10.1001/jamanetworkopen.2021.11634
22. Alipio M. Vitamin D supplementation could possibly improve clinical outcomes of patients infected with Coronavirus-2019 (COVID-19). SSRN Electronic Journal. 2020. doi:10.2139/ssrn.3571484
23. Abdollahi A, Sarvestani HK, Rafat Z, et al. The association between the level of serum 25(OH) vitamin D, obesity, and underlying diseases with the risk of developing COVID‐19 infection: A case–control study of hospitalized patients in Tehran, Iran. J Med Virol. 2021;93(4): 2359–2364. doi:10.1002/jmv.26726
24. Campi I, Gennari L, Merlotti D, et al. Vitamin D and COVID-19 severity and related mortality: A prospective study in Italy. BMC Infectious Diseases. 2021;21(1):566. doi:10.1186/s12879-021-06281-7
25. D’Avolio A, Avataneo V, Manca A, et al. 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients. 2020;12(5):1359. doi:10.3390/nu12051359
26. Faul JL, Kerley CP, Love B, et al. Vitamin D deficiency and ARDS after SARS-CoV-2 infection. Ir Med J. 2020;113(5): 84.
27. Eroğlu E, Balcı H, Baskın V, Aktuna Z. COVID-19 tedavisine yönelik güncel farmakolojik yaklaşımlar. YIU Saglik Bil Derg. 2021;2:1-15. https://doi.org/10.51261/yiu.2021.00018.
28. Kazemi A, Mohammadi V, Aghababaee SK. Golzarand M, Clark CC, Babajafari S. Association of vitamin D status with SARS-CoV-2 infection or COVID-19 severity: A systematic review and meta-analysis. Adv Nutr. 2021;12(5):1636-1658. doi:10.1093/advances/nmab012
29. Lighter J, Phillips M, Hochman S, et al. Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission. Clin Infect Dis. 2020;71(15):896-897. doi:10.1093/cid/ciaa415
30. Frydrych LM, Bian G, O’Lone DE, Ward PA, Delano MJ. Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality. J Leukoc Biol. 2018;104(3):525–534. doi:10.1002/JLB.5VMR0118-021RR
31. Korakas E, Ikonomidis I, Kousathana F, et al. Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes. Am J Physiol Endocrinol Metab. 2020;319(1):E105–E109. doi:10.1152/ajpendo.00198.2020
32. Biesalski HK. Obesity, vitamin D deficiency and old age a serious combination with respect to coronavirus disease-2019 severity and outcome. Curr Opin Clin Nutr Metab Care. 2021;24(1):18–24. doi:10.1097/MCO.0000000000000700
33. Özalp BB, Seremet Kürklü N. Obezite ve COVID-19. İzmir Kâtip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi. 2020;5(2):211-214.
34. Simonnet A, Chetboun M, Poissy J, et al. High prevalence of obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obesity. 2020;28(7):1195-1199. doi:10.1002/oby.22831
35. Michalakis K, Panagiotou G, Ilias I, Pazaitou-Panayiotou K. Obesity and COVID-19: A jigsaw puzzle with still missing pieces. Clin Obes. 2021;11(1):e12420. doi:10.1111/cob.12420
36. Bahrikarehmi L, Fallah A, Yiğit S. (2020). SARS-COV-2’nin gelişimi. BSJ Health Sci. 2020;3(3):94-101.
37. Topuz HŞ. COVID-19 enfeksiyonunda beslenme. Med Res Rep. 2020;3(1):176-180.
38. Somasundaram NP, Ranathunga I, Ratnasamy V, et al. The impact of SARS-Cov-2 virus infection on the endocrine system. J Endocr Soc. 2020;4(8):082. doi:10.1210/jendso/bvaa082

Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Konular	Sağlık Kurumları Yönetimi
Bölüm	Derleme
Yazarlar	Zainab Gholami 0000-0001-5497-9873 Havva Sert 0000-0002-1658-6515
Yayımlanma Tarihi	15 Nisan 2022
Gönderilme Tarihi	20 Ekim 2021
Yayımlandığı Sayı	Yıl 2022 Cilt: 5 Sayı: 1

Kaynak Göster

APA	Gholami, Z., & Sert, H. (2022). D Vitamini Eksikliğinin ve Obezitenin Koronavirüs Hastalığı Enfeksiyonu ile İlişkisi. Sakarya Üniversitesi Holistik Sağlık Dergisi, 5(1), 76-84. https://doi.org/10.54803/sauhsd.1011965

Makale Dosyaları

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