Abstract
The normal neonate’s immune system is anatomically intact, antigenically naive, and shows somewhat decreased role of a number of immunological pathways. Aside from anatomic characteristics (eg, thin skin and mucosal barriers) of newborn, weakened proinflammatory and T helper cell type 1 (Th1) cytokine release and lessened cell-mediated immunity predispose the neonate more susceptible to all types of infections. However, most of the newborn stand this period without sickness due to intact innate immunity with other adaptive defense mechanisms, and maternally transferred immunoglobulin G (IgG).
Besides unique immunity of the premature baby and normal newborn; risk factors, clinical features and laboratory evaluation of primary immunodeficiency diseases (PIDs) are told in this presentation. Moreover, most important PIDs of the newborn including antibody deficiencies, cellular/combined immunodeficiencies, phagocytic diseases, complemento-pathies and innate immune system disorders are briefly mentioned here as well.
Birincil Dil | İngilizce |
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Konular | Sağlık Kurumları Yönetimi |
Bölüm | Konferans Bildirisi (Tam Metin) |
Yazarlar | |
Yayımlanma Tarihi | 10 Aralık 2019 |
Kabul Tarihi | 16 Ocak 2020 |
Yayımlandığı Sayı | Yıl 2019 Cilt: 7 Sayı: Ek - IRUPEC 2019 Kongresi Tam Metin Bildirileri |