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Investigation Of Clinical, Laboratory and Radiological Results of Novel Coronavirus Disease (Covid-19) Novel Coronavirus Disease

Yıl 2021, Cilt: 43 Sayı: 4, 332 - 340, 18.05.2021
https://doi.org/10.20515/otd.867956

Öz

Covid-19, which emerged in China in December 2019 and spread to the whole world in a short time, has been a serious public health problem threatening humanity. In this study, we aimed to reveal demographic, clinical, laboratory and radiological features of patients diagnosed with Covid-19. The study is a retrospective cross-sectional study consisting of patients who were hospitalized in health institutions in Bolu, Turkey between 11.03.2020 and 19.04.2020 with a definitive or probable diagnosis of Covid-19. The number of patients in the study was 262. The mean age of the patients participating in the study was 57.39 ± 19.85, the youngest patient was 19 and the oldest was 94 years old. Of the patients, 40.1% was between the ages of 18-50, 59.9% were over 50 years old. 55.3% of the patients were women and 44.7% were men. Most common symptoms were fever (75.6%), cough (71.8%) and dyspnea (46.9%). Elevated CRP (in 71.3%), elevated LDH (in 56.9%), elevated D-DIMER (in 56.4%) and lymphopenia (in 30.5) were most detected laboratory abnormalities. The result of the real-time reverse-transcription polymerase chain reaction (RT-PCR) test was positive in 35.5% of 262 patients. 88.5% of the patients had chest CT findings compatible with Covid-19. Additionally, 24% had both positive RT-PCR results and CT findings compatible with Covid-19. Expected findings were found to be in older patients more than younger ones. We suggest that clinical features, laboratory abnormalities and radiological findings can be used to provide an early diagnosis and treatment of Covid-19.

Destekleyen Kurum

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Proje Numarası

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Kaynakça

  • 1. Zhu, N. et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa2001017 (2020).
  • 2. Coronavirus latest: WHO officially names disease COVID-19. https://www.nature.com/ Erişim Tarihi: 12.02.2020.
  • 3. World Health Organization (2020). Novel Coronavirus (2019- nCoV) situation reports [online]. Website: https://www.who. int/emergencies/diseases/novel-coronavirus-2019/situationreports [accessed 17April 2020].
  • 4. World Health Organization (2020). Coronavirus Disease (COVID-19) events as they happen [online]. Website: https:// www.who.int/emergencies/diseases/novel-coronavirus-2019/ events-as-they-happen [accessed 17April 2020].
  • 5. McIntosh K, Peiris J. Coronaviruses. In: Richman D, Whitley R, Hayden F (editos). Clinical Virology, 3rd Edition. Washington, DC, USA: ASM Press; 2009. Pp. 1155-1171.
  • 6. Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods in Molecular Biology 2015; 1282: 1‐23. doi: 10.1007/978-1-4939-2438-7_1.
  • 7. Zhou P, Yang XL, Wang XG, Hu B, Zhang L et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579 (7798): 270-273. doi: 10.1038/s41586-020-2012-7
  • 8. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 Cases from the Chinese Center for Disease Control and Prevention. JAMA 2020; 323 (13): 1239-1242. doi: 10.1001/jama.2020.2648
  • 9. Fang F, Zhao D, Chen Y et al. Recommendations for the diagnosis, prevention and control of the 2019 novel coronavirus infection in children (first interim edition). Chinese Journal of Pediatrics 2020; 58 (3): 169-174 (in Chinese). doi: 10.3760/cm a.j.issn.0578-1310.2020.03.001
  • 10. World Health Organization. Questions & Answers On Coronavirus. https://www.who.int/emergencies/diseases/novel-Coronavirus-2019. Erişim Tarihi: 08.02.2020.
  • 11. Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel CoronavirusInfected Pneumonia. N Engl J Med. 2020.
  • 12. Büyüköztürk, Ş. Veri Analizi El Kitabı, Pegem Akademi, 2015. / Büyüköztürk (2015: 40).
  • 13. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020 February 7 (Epub ahead of print).
  • 14. Pan L, Mu M, Yang P, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. Am J Gastroenterol 2020 April 14 (Epub ahead of print).
  • 15. Rodriguez-Morales A.J., Cardona-Ospina J.A., Gutiérrez-Ocampo E. Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis. 2020:10162
  • 16. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28;395(10229):1054-1062
  • 17. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel Coronavirus in Wuhan, China. Lancet. 2020
  • 18. Fan BE, Chong VCL, Chan SSW, Lim GH, Lim KGE, Tan GB, Mucheli SS, Kuperan P, Ong KH. Hematologic parameters in patients with COVID-19 infection. Am J Hematol. 2020 Mar 4.
  • 19. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta. 2020 Mar 13;506:145-148
  • 20. Li Y, Xia L. Coronavirus Disease 2019 (COVID-19): Role of chest CT in diagnosis and management. AJR Am J Roentgenol. 2020
  • 21. Al-Tawfiq JA, Memish ZA. Diagnosis of SARS-CoV-2 Infection based on CT scan vs. RT-PCR: Reflecting on Experience from MERS-CoV [published online ahead of print, 2020 Mar 5]. J Hosp Infect. 2020.
  • 22. Fang Y, Zhang H, Xie J, et al. Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR [published online ahead of print, 2020 Feb 19]. Radiology. 2020;200432.
  • 23. Shi H, Han X, Jiang N. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis. 2020;20:425–434.
  • 24. Zhou S, Wang Y, Zhu T, Xia L. CT Features of Coronavirus Disease 2019 (COVID-19) Pneumonia in 62 Patients in Wuhan, China. AJR Am J Roentgenol. 2020 Mar 5:1-8.

Yeni Koronavirüs Hastalığının (Covid-19) Klinik, Laboratuvar ve Radyolojik Sonuçlarının İncelenmesi

Yıl 2021, Cilt: 43 Sayı: 4, 332 - 340, 18.05.2021
https://doi.org/10.20515/otd.867956

Öz

Aralık 2019'da Çin'de ortaya çıkan ve kısa sürede tüm dünyaya yayılan Covid-19, insanlığı tehdit eden ciddi bir halk sağlığı sorunu olmuştur. Bu çalışmada Covid-19 tanısı alan hastaların demografik, klinik, laboratuvar ve radyolojik özelliklerini ortaya çıkarmayı amaçladık. Çalışma, 11.03.2020 ile 19.04.2020 tarihleri arasında Bolu ilindeki sağlık kuruluşlarında kesin veya olası Covid-19 tanısı ile hastaneye yatırılan hastalardan oluşan retrospektif kesitsel bir çalışmadır. Çalışmaya katılan hasta sayısı 262 idi. Çalışmaya katılan hastaların yaş ortalaması 57.39 ± 19.85, en genç hasta 19 ve en yaşlı hasta 94 idi. Hastaların% 40.1'i 18-50 yaş aralığında,% 59.9'u 50 yaşın üzerindeydi. Hastaların% 55,3'ü kadın,% 44,7'si erkekti. En sık görülen semptomlar ateş (% 75,6), öksürük (% 71,8) ve nefes darlığı (% 46,9) idi. Yüksek CRP (% 71.3'te), yüksek LDH (% 56.9'da), yükselmiş D-DIMER (% 56.4'te) ve lenfopeni (30.5'te) saptanan laboratuar anormallikleriydi. Gerçek zamanlı ters transkripsiyon polimeraz zincir reaksiyonu (RT-PCR) testinin sonucu 262 hastanın% 35,5'inde pozitifti. Hastaların% 88,5'inde Covid-19 ile uyumlu göğüs BT bulguları vardı. Ek olarak,% 24'ü hem pozitif RT-PCR sonuçlarına hem de Covid-19 ile uyumlu BT bulgularına sahipti. Beklenen bulguların, gençlere göre yaşlı hastalarda daha fazla olduğu bulundu. Covid-19'un erken tanı ve tedavisi için klinik özelliklerin, laboratuvar anormalliklerinin ve radyolojik bulguların kullanılabileceğini önermekteyiz

Proje Numarası

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Kaynakça

  • 1. Zhu, N. et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa2001017 (2020).
  • 2. Coronavirus latest: WHO officially names disease COVID-19. https://www.nature.com/ Erişim Tarihi: 12.02.2020.
  • 3. World Health Organization (2020). Novel Coronavirus (2019- nCoV) situation reports [online]. Website: https://www.who. int/emergencies/diseases/novel-coronavirus-2019/situationreports [accessed 17April 2020].
  • 4. World Health Organization (2020). Coronavirus Disease (COVID-19) events as they happen [online]. Website: https:// www.who.int/emergencies/diseases/novel-coronavirus-2019/ events-as-they-happen [accessed 17April 2020].
  • 5. McIntosh K, Peiris J. Coronaviruses. In: Richman D, Whitley R, Hayden F (editos). Clinical Virology, 3rd Edition. Washington, DC, USA: ASM Press; 2009. Pp. 1155-1171.
  • 6. Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods in Molecular Biology 2015; 1282: 1‐23. doi: 10.1007/978-1-4939-2438-7_1.
  • 7. Zhou P, Yang XL, Wang XG, Hu B, Zhang L et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579 (7798): 270-273. doi: 10.1038/s41586-020-2012-7
  • 8. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 Cases from the Chinese Center for Disease Control and Prevention. JAMA 2020; 323 (13): 1239-1242. doi: 10.1001/jama.2020.2648
  • 9. Fang F, Zhao D, Chen Y et al. Recommendations for the diagnosis, prevention and control of the 2019 novel coronavirus infection in children (first interim edition). Chinese Journal of Pediatrics 2020; 58 (3): 169-174 (in Chinese). doi: 10.3760/cm a.j.issn.0578-1310.2020.03.001
  • 10. World Health Organization. Questions & Answers On Coronavirus. https://www.who.int/emergencies/diseases/novel-Coronavirus-2019. Erişim Tarihi: 08.02.2020.
  • 11. Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel CoronavirusInfected Pneumonia. N Engl J Med. 2020.
  • 12. Büyüköztürk, Ş. Veri Analizi El Kitabı, Pegem Akademi, 2015. / Büyüköztürk (2015: 40).
  • 13. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020 February 7 (Epub ahead of print).
  • 14. Pan L, Mu M, Yang P, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. Am J Gastroenterol 2020 April 14 (Epub ahead of print).
  • 15. Rodriguez-Morales A.J., Cardona-Ospina J.A., Gutiérrez-Ocampo E. Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis. 2020:10162
  • 16. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28;395(10229):1054-1062
  • 17. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel Coronavirus in Wuhan, China. Lancet. 2020
  • 18. Fan BE, Chong VCL, Chan SSW, Lim GH, Lim KGE, Tan GB, Mucheli SS, Kuperan P, Ong KH. Hematologic parameters in patients with COVID-19 infection. Am J Hematol. 2020 Mar 4.
  • 19. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta. 2020 Mar 13;506:145-148
  • 20. Li Y, Xia L. Coronavirus Disease 2019 (COVID-19): Role of chest CT in diagnosis and management. AJR Am J Roentgenol. 2020
  • 21. Al-Tawfiq JA, Memish ZA. Diagnosis of SARS-CoV-2 Infection based on CT scan vs. RT-PCR: Reflecting on Experience from MERS-CoV [published online ahead of print, 2020 Mar 5]. J Hosp Infect. 2020.
  • 22. Fang Y, Zhang H, Xie J, et al. Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR [published online ahead of print, 2020 Feb 19]. Radiology. 2020;200432.
  • 23. Shi H, Han X, Jiang N. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis. 2020;20:425–434.
  • 24. Zhou S, Wang Y, Zhu T, Xia L. CT Features of Coronavirus Disease 2019 (COVID-19) Pneumonia in 62 Patients in Wuhan, China. AJR Am J Roentgenol. 2020 Mar 5:1-8.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm ORİJİNAL MAKALELER / ORIGINAL ARTICLES
Yazarlar

Musa Kaya 0000-0003-4962-2575

Muhammed Emin Demirkol 0000-0001-6262-6103

Proje Numarası -
Yayımlanma Tarihi 18 Mayıs 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 43 Sayı: 4

Kaynak Göster

Vancouver Kaya M, Demirkol ME. Investigation Of Clinical, Laboratory and Radiological Results of Novel Coronavirus Disease (Covid-19) Novel Coronavirus Disease. Osmangazi Tıp Dergisi. 2021;43(4):332-40.


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