Term gebelerde doğum indüksiyonu için kullanılan vajinal Prostaglandin E2’nin başarısını etkileyen faktörler
Öz
Amaç: Doğum indüksiyonu için
vajinal prostaglandin E2 (dinoproston) kullanılan gebelerde indüksiyon
başarısını etkileyen faktörleri belirlemek
Bulgular: Çalışmamıza dahil
edilen 186 hastadan 127 (%68.2)’sinde vajinal prostaglandin E2 uygulaması ile
indüksiyon başarılı sonuçlandı ve doğum vajinal yoldan gerçekleşti. Her iki grupta da yaş, doğum anındaki gebelik
haftası, fetal cinsiyet, oksitosin ihtiyacı ve indüksiyon endikasyonları
açısından anlamlı fark bulunmadı (p>0.05). İndüksiyonun başarılı olduğu
grupta ortalama parite değeri başarısız grup ile karşılaştırıldığında anlamlı
olarak yüksek (p<0.05) bulundu. Benzer şekilde multipar gebelerde
indüksiyonun başarı oranı nullipar gebelere göre yüksekti (p<0.05). Vücut
kitle indeksi (VKİ) ortanca değeri indüksiyonun başarılı olduğu grupta daha
düşük bulunurken (p<0.05), her iki grupta VKİ 30’un altında ve üstünde olan
gebelerin oranı istatistiksel olarak anlamlı farklılık göstermedi (p>0.05). Her
iki grupta indüksiyon öncesi bishop skoru karşılaştırıldığında başarılı grupta
bishop skorunun daha yüksek olduğu gözlendi (p<0.05).
Anahtar Kelimeler
doğum indüksiyonu prostaglandin E2 vajinal doğum sezaryen doğum
Kaynakça
- American College of Obstetricians and Gynecologists: Induction of labor. Practice Bulletin No. 107, August 2009, Reaffirmed 2013b.
- NICE guideline. Induction of labour. National Collaborating Centre for Women’s and Children’s Health. National Institute for Health and Clinical Excellence 2008; www.nice.org.uk/nicemedia/live/12012/41255.pdf
- WHO recommendations for induction of labour 2011. http://whqlibdoc.who.int/publication s/2011/9789241501156_eng.pdf
- Caughey AB, Sundaram V, Kaimal AJ, and et al. Maternal and neonatal outcomes of elective induction of labor. Evid Rep Technol Assess (Full Rep) 2009 ;176:1-257.
- Guerra GV, Cecatti JG, Souza JP, Faúndes A, Morais SS, Gülmezoglu AM, et al. Elective induction versus spontaneous labour in Latin America. Bull World Health Organ 2011;89:657-65.
- Crane JM. Factors predicting labor induction success: a critical analysis. Clin Obstet Gynecol 2006;49:573-584.
- Kubli F, Boos R, Rüttgers H, Hagens C von, Vanselow H. Antepartum FHR-Monitoring. In R. W. Beard and S. Campbell (Eds.), Current status of FHR-Monitoring and Ultrasound in Obstetrics, Royal College of Obstetricians and Gynaecologists, London, 1978:671-2.
- Bortolus R. Determinants of response to intracervical prostaglandin E2 for cervical ripening. Gruppo di Studio sull’Induzione del Travaglio di Parto. Eur J Obstet Gynecol Reprod Biol 1999;87:137–41.
- Melamed, N, Ben-Haroush A, Kremer S, Hod M, Yogev Y. Failure of cervical ripening with prostaglandin E2 can it be predicted? J Matern Fetal Neonatal Med 2010;23:536-40.
- Karaiskakis PT, Rayburn WF, Smith CV, Woods RE. Failed induction of labor despite sequential prostaglandin E2 therapy. Am J Perinatol 1991;8:128–30.
- Kelly AJ, Kavanagh J, Thomas J. Vaginal Prostaglandin (PGE2 and PGEF2a) for Induction of Labor at Term. Cochrane Database Syst Rev, 4;2003.
- Calder A, MacKenzie I. Review of Propess–A controlled release Dinoproston (prostaglandin E2) Pessary. J. Obstet. Gynecol 1997;63-67.
- Prysak M, Castronova FC. Elective induction versus spontaneous labor: a case-control analysis of safety and efficacy. Obstet Gynecol 1998;92:47–52.
- Melamed N, Yogev Y, Hadar E, Hod M, BenHaroush A. Preinduction cervical ripening with prostaglandin E2 at preterm. Acta Obstet Gynecol Scand 2008;87:63–7.
- Daskalakis G, Thomakos N, Hatziioannou L, Mesogitis S, Papantoniou N, Antsaklis A. Sonographic cervical length measurement before labor induction in term nulliparouswomen. Fetal Diagn Ther 2006;21:34–38.
- Grigsby PL, Sooranna SR, Adu-Amankwa B, Pitzer B, Brockman DE, Johnson MR, et al. Regional expression of prostaglandin E2 and F2 alpha receptors in human myometrium, amnion, and choriodecidua with advancing gestation and labor. Biol Reprod 2006;75:297–305.
- Memon F, Wijesiriwardana A, Jonker L. Maternal and prenatal factors influencing the outcome of prostaglandin E2 induced labour. J Obstet Gynaecol 2011;31:220-3.
- Laczna MK, Kallen K, Marsal K, et al. Skewed fetal gender distribution in prolonged pregnancy: a fallacy with consequences. Ultrasound Obstet Gynecol 2003;21: 262-6.
- Gümüş İ, Kamalak Z, Simavli S, et al. Fetal Cinsiyetin Gebeliklerin Uzamasında Rolü Var Mı? Yeni Tıp Dergisi 2009;26:111-3.
- Maged AM, El-Semary AM, Marie HM, Belal DS, Hany A, Taymour MA, et al. Effect of maternal obesity on labor induction in postdate pregnancy. Arch Gynecol Obstet 2018;2:1-6.
- Torricelli M, Voltolini C, Vellucci FL, Conti N, Bocchi C, Severi FM, et al. Fetal gender effects on induction of labor in postdate pregnancies. Reprod Sci 2013;20(6):670-4.
- Bishop EH. Pelvic scoring for elective induction. Obstet Gynecol 1964;24:266.
- Freidman EA, Nisvander KR, Bayonet-Rivera NP. Relation of prelabor evaluation to inducibility and course of labor. Obstet Gynecol 1996;28-495.
- Rouse D, Owen J, Hauth JC. Criteria for failed labor induction: Prospective evaluation of a standardized protocol. Am J Obstet Gynecol 2000;182:132.
- Atad J, Hallak M, Auslender R, Porat-Packet T, et al. A randomized comparison of prostoglandin E2, oxytocin and double-ballon device in inducting labor. Obstet Gynecol 1996;87:223-7.
Factors affecting the success of vaginal Prostaglandin E2 used for labour induction in term pregnants
Öz
Objective: To identify the factors
affecting the success rate of vaginal prostaglandin E2 (dinoproston) used to
induct the labour in term pregnancies
Material and Method: We
included in our study term pregnant women who underwent vaginal prostaglandin
E2 for induction of labor between January 2016 and March 2019.The cases who had
vaginal delivery after induction were categorized as successful, while cesarean
section cases were grouped as unsuccessfull. The patients in both groups were
compared in terms of age, parity, body-mass index (BMI), gestational week,
fetal birthweight, fetal gender, bishop score before induction
and indication for labour induction as the factors affecting the success of the
method.
Results: In 127
(68.2%) of total 187 patients in our study gave birth vaginally by the
application of vaginal prostaglanding E2. There was no difference between two
groups in regards to age, gestational week, fetal gender, oxytocin need and the
indications for labour induction (p>0.05). Mean parity was found to be
significantly higher in successful induction group than failed group
(p<0.05). Similarly, the success rate of induction in multiparous women was
higher than nulliparous ones (p<0.05). Mean value for BMI was found higher
in successful group (p<0.05). When bishop score was compared, it was found
to be higher in the successful induction group (p<0.05).
Conclusion: As the
factors such as multiparity, lower BMI, lower fetal birthweight and higher bishop
scores before induction were found to raise the success of vaginal progesteron
E2 for labour induction, age, gestational week at birth, fetal gender and
indication for labour induction did not affect its success rate.
Anahtar Kelimeler
labour induction prostaglandin E2 vaginal birth caesarean section
Kaynakça
- American College of Obstetricians and Gynecologists: Induction of labor. Practice Bulletin No. 107, August 2009, Reaffirmed 2013b.
- NICE guideline. Induction of labour. National Collaborating Centre for Women’s and Children’s Health. National Institute for Health and Clinical Excellence 2008; www.nice.org.uk/nicemedia/live/12012/41255.pdf
- WHO recommendations for induction of labour 2011. http://whqlibdoc.who.int/publication s/2011/9789241501156_eng.pdf
- Caughey AB, Sundaram V, Kaimal AJ, and et al. Maternal and neonatal outcomes of elective induction of labor. Evid Rep Technol Assess (Full Rep) 2009 ;176:1-257.
- Guerra GV, Cecatti JG, Souza JP, Faúndes A, Morais SS, Gülmezoglu AM, et al. Elective induction versus spontaneous labour in Latin America. Bull World Health Organ 2011;89:657-65.
- Crane JM. Factors predicting labor induction success: a critical analysis. Clin Obstet Gynecol 2006;49:573-584.
- Kubli F, Boos R, Rüttgers H, Hagens C von, Vanselow H. Antepartum FHR-Monitoring. In R. W. Beard and S. Campbell (Eds.), Current status of FHR-Monitoring and Ultrasound in Obstetrics, Royal College of Obstetricians and Gynaecologists, London, 1978:671-2.
- Bortolus R. Determinants of response to intracervical prostaglandin E2 for cervical ripening. Gruppo di Studio sull’Induzione del Travaglio di Parto. Eur J Obstet Gynecol Reprod Biol 1999;87:137–41.
- Melamed, N, Ben-Haroush A, Kremer S, Hod M, Yogev Y. Failure of cervical ripening with prostaglandin E2 can it be predicted? J Matern Fetal Neonatal Med 2010;23:536-40.
- Karaiskakis PT, Rayburn WF, Smith CV, Woods RE. Failed induction of labor despite sequential prostaglandin E2 therapy. Am J Perinatol 1991;8:128–30.
- Kelly AJ, Kavanagh J, Thomas J. Vaginal Prostaglandin (PGE2 and PGEF2a) for Induction of Labor at Term. Cochrane Database Syst Rev, 4;2003.
- Calder A, MacKenzie I. Review of Propess–A controlled release Dinoproston (prostaglandin E2) Pessary. J. Obstet. Gynecol 1997;63-67.
- Prysak M, Castronova FC. Elective induction versus spontaneous labor: a case-control analysis of safety and efficacy. Obstet Gynecol 1998;92:47–52.
- Melamed N, Yogev Y, Hadar E, Hod M, BenHaroush A. Preinduction cervical ripening with prostaglandin E2 at preterm. Acta Obstet Gynecol Scand 2008;87:63–7.
- Daskalakis G, Thomakos N, Hatziioannou L, Mesogitis S, Papantoniou N, Antsaklis A. Sonographic cervical length measurement before labor induction in term nulliparouswomen. Fetal Diagn Ther 2006;21:34–38.
- Grigsby PL, Sooranna SR, Adu-Amankwa B, Pitzer B, Brockman DE, Johnson MR, et al. Regional expression of prostaglandin E2 and F2 alpha receptors in human myometrium, amnion, and choriodecidua with advancing gestation and labor. Biol Reprod 2006;75:297–305.
- Memon F, Wijesiriwardana A, Jonker L. Maternal and prenatal factors influencing the outcome of prostaglandin E2 induced labour. J Obstet Gynaecol 2011;31:220-3.
- Laczna MK, Kallen K, Marsal K, et al. Skewed fetal gender distribution in prolonged pregnancy: a fallacy with consequences. Ultrasound Obstet Gynecol 2003;21: 262-6.
- Gümüş İ, Kamalak Z, Simavli S, et al. Fetal Cinsiyetin Gebeliklerin Uzamasında Rolü Var Mı? Yeni Tıp Dergisi 2009;26:111-3.
- Maged AM, El-Semary AM, Marie HM, Belal DS, Hany A, Taymour MA, et al. Effect of maternal obesity on labor induction in postdate pregnancy. Arch Gynecol Obstet 2018;2:1-6.
- Torricelli M, Voltolini C, Vellucci FL, Conti N, Bocchi C, Severi FM, et al. Fetal gender effects on induction of labor in postdate pregnancies. Reprod Sci 2013;20(6):670-4.
- Bishop EH. Pelvic scoring for elective induction. Obstet Gynecol 1964;24:266.
- Freidman EA, Nisvander KR, Bayonet-Rivera NP. Relation of prelabor evaluation to inducibility and course of labor. Obstet Gynecol 1996;28-495.
- Rouse D, Owen J, Hauth JC. Criteria for failed labor induction: Prospective evaluation of a standardized protocol. Am J Obstet Gynecol 2000;182:132.
- Atad J, Hallak M, Auslender R, Porat-Packet T, et al. A randomized comparison of prostoglandin E2, oxytocin and double-ballon device in inducting labor. Obstet Gynecol 1996;87:223-7.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 18 Aralık 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 7 Sayı: 3 |
