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Dental Stem Cells

Yıl 2020, Cilt: 7 Sayı: 1, 60 - 64, 28.04.2020

Anıl Çağlayan Hülya Elbe

Öz

Recently, tooth tissue engineering has attracted more and more attention. Teeth exhibit limited repair in response to damage, and dental pulp stem cells provide a source of cells to replace those damaged and to facilitate repair. Mesenchymal stem cells (MSCs) are multipotent stem cells which can be differentiated into a variety of cell types. The potential sources of MSCs for tooth regeneration mainly include stem cells from human exfoliated deciduous teeth (SHEDs), dental pulp stem cells (DPSCs), and stem cells from the apical part of the papilla (SCAPs), stem cells from the dental follicle (DFSCs), and periodontal ligament stem cells (PDLSCs). As dental stem cells share similar properties with mesenchymal stem cells, there is also considerable interest in their wider potential to treat disorders involving mesenchymal cell derivatives. This review outlines the recent progress in the dental stem cells used in tooth regeneration.

Anahtar Kelimeler

Regeneration Repair Stem Cell Tooth

Kaynakça

  • 1. Verfaillie CM, Pera MF, Lansdorp PM. Stem cells hype and reality. Hematology Am Soc Hematol Educ Program. 2002;369-91.
  • 2. Ural AU. Kök hücreler. Türk Orto Travm Bir Dern Derg. 2006;5:3-4.
  • 3. Peng L, Ye L, Zhou X-D. Mesenchymal stem cells and tooth engineering. Int J Oral Sci. 2009;1(1):6-12.
  • 4. Volponi AA, Pang Y, Sharpe PT. Stem cell based biological tooth repair and regeneration. Trends Cell Biol. 2010;20-206(12-6):715-22.
  • 5. Nela P, Jakub S. Cryopreservation of dental stem cells. Acta Medica 2018;61(1): 1–7.
  • 6. Yu T, Volponi AA, Babb R, An Z, Sharpe PT. Stem cells in tooth development, growth, repair, and regeneration. Curr Top Dev Biol. 2015;115:187-212.
  • 7. Aydin S, Şahin F. Stem cells derived from dental tissues. Adv Exp Med Biol. 2019;1144:123-32.
  • 8. Kang J, Fan W, Deng Q, He H, Huang F. Stem cells from the apical papilla: a promising source for stem cell-based therapy. 2019;2019:6104738.
  • 9. Zhai Q, Dong Z, Wang W, Li B, Jin Y. Dental stem cell and dental tissue regeneration. Front Med. 2019;13(2):152-9.
  • 10. Zavan B, Bressan E. Dental Stem Cells: Regenerative potential stem cell biology and regenerative medicine. Humana Press Cham 2016;27-56.
  • 11. Zhang Q, Shi S, Liu Y, et al. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol. 2009;183(12):7787–98.
  • 12. Khojasteh A, Nazeman P, Rad MR. In: F, Doğan A, eds.Dental Stem Cells in Oral, Maxillofacial and Craniofacial Regeneration. Springer. 2016; 143-66.
  • 13. Botelho J, Cavacas MA, Machado V, Mendes JJ. Dental stem cells: recent progresses in tissue engineering and regenerative medicine. Ann Med. 2017;49(8):644-51.
  • 14. Leyendecker A, Gomes CC, Lazzaretti FT, Franco BD. The use of human dental pulp stem cells for in vivo bone tissue engineering: A systematic review. J Tissue Eng. 2018;9:2041731417752766.
  • 15. Karamzadeh R, Eslaminejad MB. Dental-related stem cells and their potential in regenerative medicine. Regen Med TissEng. 2013;4:95-116.
  • 16. Liu J, Yu F, Sun Y, et al. Concise reviews: Characteristics and potential applications of human dental tissue-derived mesenchymal stem cells. Stem Cells. 2015;33(3):627-38.
  • 17. Tatullo M, Marrelli M, Shakesheff KM, White LJ. Dental pulp stem cells: function, isolation and applications in regenerative medicine. J Tissue Eng Regen Med. 2015;9:1205–16.
  • 18. Gronthos S, Mankani M, Brahim J, et al. Postnatal human dental pulp stemcells (DPSCs)in vitroandin vivo. Proc NatlAcad Sci. 2000;97:13625–30.
  • 19. Gronthos S, Brahim J, Li W, et al. Stemcell properties of human dental pulp stemcells. J Dent Res. 2002; 81:531–5.
  • 20. Shi S, Bartold PM, Miura M, et al. The efficacy of mesenchymal stem cells to regenerate and repair dental structures. Orthod Craniofac Res. 2005;8(3):191–9.
  • 21. Morsczeck C, Schmalz G, Reichert TE, et al. Somatic stem cells for regenerative dentistry. Clin Oral Investig. 2008;12(2):113–8.
  • 22. Cordeiro MM, Dong Z, Kaneko T, et al. Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. J Endod. 2008;34(8):962–9.
  • 23. Mao JJ, Giannobile WV, Helms JA, et al. Craniofacial tissue engineering by stem cells. J Dent Res. 2006;85(11):966-79.
  • 24. Kuo TF, Lee SY, Wu HD, et al. An in vivo swine study for xeno-grafts of calcium sulfate-based bone grafts with human dental pulp stem cells (hDPSCs). Mater Sci Eng C Mater Biol Appl. 2015;50:19–23.
  • 25. Luo L, He Y, Wang X, et al. Potential roles of dental pulp stem cells in neural regeneration and repair. Stem Cells Int. 2018(2-3):1-15.
  • 26. Bianco J, De Berdt P, Deumens R, des Rieux A. Taking a bite out of spinal cord injury: do dental stem cells have the teeth for it? Cell Mol Life Sci 2016;73(7):1413–37.
  • 27. Zhang J, Lu X, Feng G, et al. Chitosan scaffolds induce human dental pulp stem cells to neural differentiation: potential roles for spinal cord injury therapy. Cell Tissue Res. 2016;366(1):129–42.
  • 28. Sugiyama M, Iohara K, Wakita H, et al. Dental pulpderived CD31-/CD146- side population stem/progenitor cells enhance recovery of focal cerebral ischemia in rats. Tiss Engin. 2011;17(9-10):1303–11.
  • 29. Leong WK, Henshall TL, Arthur A, et al. Human adult dental pulp stem cells enhance poststroke functional recovery through non-neural replacement mechanisms. Stem Cells Translat Med. 2012;1(3):177–87.
  • 30. Leong WK, Lewis MD, Koblar SA. Concise review preclinical studies on human cell-based therapy in rodent ischemic stroke models: where are we now after a decade? Stem Cells. 2013;31(6):1040–3.
  • 31. Song M, Jue SS, Cho YA, Kim EC. Comparison of the effects of human dental pulp stem cells and human bone marrow-derived mesenchymal stem cells on ischemic human astrocytes in vitro. J Neurosci Res. 2015;93(6):973–83.
  • 32. Wang F, Jia Y, Liu J et al. Dental pulp stem cells promote regeneration of damaged neuron cells on the cellular model of Alzheimer’s disease. Cell Biol Int. 2017;41(6):639–50.
  • 33. Salehi H, Al-Arag S, Middendorp E, Gergely C, Cuisinier F, Orti V. Dental pulp stem cells used to deliver the anticancer drug paclitaxel. Stem Cell Res Ther. 2018;9(1):103.

Her Yönüyle Dental Kök Hücreler

Yıl 2020, Cilt: 7 Sayı: 1, 60 - 64, 28.04.2020

Anıl Çağlayan Hülya Elbe

Öz

Son zamanlarda, diş ile alakalı doku mühendisliği giderek daha fazla dikkat çekmektedir. Dişler hasara yanıt olarak sınırlı onarım sergiler ve dental pulpa kök hücreleri hasarlı olanların yerini almak ve onarımı kolaylaştırmak için bir hücre kaynağı sağlar. Mezenkimal kök hücreler (MSCs), çeşitli hücre tiplerine farklılaşabilen kök hücrelerdir. Diş rejenerasyonu için potansiyel MSCs kaynakları; insan dökülen süt dişleri kök hücreleri (SHEDs), dental pulpa kök hücreleri (DPSCs), apikal papilla kök hücreleri (SCAPs), diş folikülü kök hücreleri (DFSCs) ve periodontal ligament kök hücreleri (PDLSCs)’dir. Dental kök hücreler mezenkimal kök hücrelerle benzer özellikleri paylaştığından, mezenkimal kök hücre hastalıklarının tedavisi için büyük ilgi görmektedir. Bu derleme, diş rejenerasyonunda kullanılan dental kök hücrelerdeki son ilerlemeleri anlatmaktadır.

Anahtar Kelimeler

Diş Kök Hücre Rejenerasyon Yenilenme

Kaynakça

  • 1. Verfaillie CM, Pera MF, Lansdorp PM. Stem cells hype and reality. Hematology Am Soc Hematol Educ Program. 2002;369-91.
  • 2. Ural AU. Kök hücreler. Türk Orto Travm Bir Dern Derg. 2006;5:3-4.
  • 3. Peng L, Ye L, Zhou X-D. Mesenchymal stem cells and tooth engineering. Int J Oral Sci. 2009;1(1):6-12.
  • 4. Volponi AA, Pang Y, Sharpe PT. Stem cell based biological tooth repair and regeneration. Trends Cell Biol. 2010;20-206(12-6):715-22.
  • 5. Nela P, Jakub S. Cryopreservation of dental stem cells. Acta Medica 2018;61(1): 1–7.
  • 6. Yu T, Volponi AA, Babb R, An Z, Sharpe PT. Stem cells in tooth development, growth, repair, and regeneration. Curr Top Dev Biol. 2015;115:187-212.
  • 7. Aydin S, Şahin F. Stem cells derived from dental tissues. Adv Exp Med Biol. 2019;1144:123-32.
  • 8. Kang J, Fan W, Deng Q, He H, Huang F. Stem cells from the apical papilla: a promising source for stem cell-based therapy. 2019;2019:6104738.
  • 9. Zhai Q, Dong Z, Wang W, Li B, Jin Y. Dental stem cell and dental tissue regeneration. Front Med. 2019;13(2):152-9.
  • 10. Zavan B, Bressan E. Dental Stem Cells: Regenerative potential stem cell biology and regenerative medicine. Humana Press Cham 2016;27-56.
  • 11. Zhang Q, Shi S, Liu Y, et al. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol. 2009;183(12):7787–98.
  • 12. Khojasteh A, Nazeman P, Rad MR. In: F, Doğan A, eds.Dental Stem Cells in Oral, Maxillofacial and Craniofacial Regeneration. Springer. 2016; 143-66.
  • 13. Botelho J, Cavacas MA, Machado V, Mendes JJ. Dental stem cells: recent progresses in tissue engineering and regenerative medicine. Ann Med. 2017;49(8):644-51.
  • 14. Leyendecker A, Gomes CC, Lazzaretti FT, Franco BD. The use of human dental pulp stem cells for in vivo bone tissue engineering: A systematic review. J Tissue Eng. 2018;9:2041731417752766.
  • 15. Karamzadeh R, Eslaminejad MB. Dental-related stem cells and their potential in regenerative medicine. Regen Med TissEng. 2013;4:95-116.
  • 16. Liu J, Yu F, Sun Y, et al. Concise reviews: Characteristics and potential applications of human dental tissue-derived mesenchymal stem cells. Stem Cells. 2015;33(3):627-38.
  • 17. Tatullo M, Marrelli M, Shakesheff KM, White LJ. Dental pulp stem cells: function, isolation and applications in regenerative medicine. J Tissue Eng Regen Med. 2015;9:1205–16.
  • 18. Gronthos S, Mankani M, Brahim J, et al. Postnatal human dental pulp stemcells (DPSCs)in vitroandin vivo. Proc NatlAcad Sci. 2000;97:13625–30.
  • 19. Gronthos S, Brahim J, Li W, et al. Stemcell properties of human dental pulp stemcells. J Dent Res. 2002; 81:531–5.
  • 20. Shi S, Bartold PM, Miura M, et al. The efficacy of mesenchymal stem cells to regenerate and repair dental structures. Orthod Craniofac Res. 2005;8(3):191–9.
  • 21. Morsczeck C, Schmalz G, Reichert TE, et al. Somatic stem cells for regenerative dentistry. Clin Oral Investig. 2008;12(2):113–8.
  • 22. Cordeiro MM, Dong Z, Kaneko T, et al. Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. J Endod. 2008;34(8):962–9.
  • 23. Mao JJ, Giannobile WV, Helms JA, et al. Craniofacial tissue engineering by stem cells. J Dent Res. 2006;85(11):966-79.
  • 24. Kuo TF, Lee SY, Wu HD, et al. An in vivo swine study for xeno-grafts of calcium sulfate-based bone grafts with human dental pulp stem cells (hDPSCs). Mater Sci Eng C Mater Biol Appl. 2015;50:19–23.
  • 25. Luo L, He Y, Wang X, et al. Potential roles of dental pulp stem cells in neural regeneration and repair. Stem Cells Int. 2018(2-3):1-15.
  • 26. Bianco J, De Berdt P, Deumens R, des Rieux A. Taking a bite out of spinal cord injury: do dental stem cells have the teeth for it? Cell Mol Life Sci 2016;73(7):1413–37.
  • 27. Zhang J, Lu X, Feng G, et al. Chitosan scaffolds induce human dental pulp stem cells to neural differentiation: potential roles for spinal cord injury therapy. Cell Tissue Res. 2016;366(1):129–42.
  • 28. Sugiyama M, Iohara K, Wakita H, et al. Dental pulpderived CD31-/CD146- side population stem/progenitor cells enhance recovery of focal cerebral ischemia in rats. Tiss Engin. 2011;17(9-10):1303–11.
  • 29. Leong WK, Henshall TL, Arthur A, et al. Human adult dental pulp stem cells enhance poststroke functional recovery through non-neural replacement mechanisms. Stem Cells Translat Med. 2012;1(3):177–87.
  • 30. Leong WK, Lewis MD, Koblar SA. Concise review preclinical studies on human cell-based therapy in rodent ischemic stroke models: where are we now after a decade? Stem Cells. 2013;31(6):1040–3.
  • 31. Song M, Jue SS, Cho YA, Kim EC. Comparison of the effects of human dental pulp stem cells and human bone marrow-derived mesenchymal stem cells on ischemic human astrocytes in vitro. J Neurosci Res. 2015;93(6):973–83.
  • 32. Wang F, Jia Y, Liu J et al. Dental pulp stem cells promote regeneration of damaged neuron cells on the cellular model of Alzheimer’s disease. Cell Biol Int. 2017;41(6):639–50.
  • 33. Salehi H, Al-Arag S, Middendorp E, Gergely C, Cuisinier F, Orti V. Dental pulp stem cells used to deliver the anticancer drug paclitaxel. Stem Cell Res Ther. 2018;9(1):103.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Derleme
Yazarlar

Anıl Çağlayan Bu kişi benim 0000-0002-2543-3481

Hülya Elbe 0000-0001-7283-2461

Yayımlanma Tarihi 28 Nisan 2020
Gönderilme Tarihi 28 Şubat 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 7 Sayı: 1

Kaynak Göster

APA Çağlayan, A., & Elbe, H. (2020). Her Yönüyle Dental Kök Hücreler. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, 7(1), 60-64.
AMA Çağlayan A, Elbe H. Her Yönüyle Dental Kök Hücreler. MMJ. Nisan 2020;7(1):60-64.
Chicago Çağlayan, Anıl, ve Hülya Elbe. “Her Yönüyle Dental Kök Hücreler”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 7, sy. 1 (Nisan 2020): 60-64.
EndNote Çağlayan A, Elbe H (01 Nisan 2020) Her Yönüyle Dental Kök Hücreler. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 7 1 60–64.
IEEE A. Çağlayan ve H. Elbe, “Her Yönüyle Dental Kök Hücreler”, MMJ, c. 7, sy. 1, ss. 60–64, 2020.
ISNAD Çağlayan, Anıl - Elbe, Hülya. “Her Yönüyle Dental Kök Hücreler”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 7/1 (Nisan 2020), 60-64.
JAMA Çağlayan A, Elbe H. Her Yönüyle Dental Kök Hücreler. MMJ. 2020;7:60–64.
MLA Çağlayan, Anıl ve Hülya Elbe. “Her Yönüyle Dental Kök Hücreler”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, c. 7, sy. 1, 2020, ss. 60-64.
Vancouver Çağlayan A, Elbe H. Her Yönüyle Dental Kök Hücreler. MMJ. 2020;7(1):60-4.
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