Öz
Kaynakça
- 1. World Health Organization (WHO). COVID-19 pandemic data in the world. https://covid19.who.int (accessed on 23/January/2022).
- 2. Korkusuz R, Karandere F, Senoglu S, Kocoglu H, Yasar KK. The prognostic role of D-dimer in hospitalized COVID-19 patients. Bratisl Lek Listy. 2021;122(11):811-815. doi.org /10.4149/BLL_2021_129.
- 3. Centers for Disease Control and Prevention. People WhoAre at Higher Risk for Severe Illness. 2020; https://www.cdc.gov/coronavirus/2019-ncov/need- extra-precautions/people-at-higher-risk.html. Accessed April 8, 2020.
- 4. Serin I, Sari ND, Dogu MH, Acikel SD, Babur G, Ulusoy A, et all. A newparameter in COVID-19 pandemic: initial lactate dehydrogenase (LDH)/Lymphocyte ratio for diagnosis and mortality. J Infect Public Health. 2020 Nov;13(11):1664-1670. doi.org/10.1016/j.jiph.2020.09.009.
- 5. Wang B, Chen G, Cao Y, Xue J, Li J, Wu Y. Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock. J Crit Care. 2015 Apr;30(2):271-5. doi.org/10.1016/j.jcrc.2014.10.030.
- 6. Soeters PB, Wolfe RR, Shenkin A. Hypoalbuminemia: Pathogenesis and Clinical Significance. JPEN J Parenter Enteral Nutr. 2019; 43(2): 181- 193. doi.org/10.1002/jmv.26003.
- 7. Huang J, Cheng A, Kumar R, Fang Y, Chen G, Zhu Y, et all. Hypoalbuminemia predicts the outcome of COVID-19 independent of ageandco-morbidity. J MedVirol. 2020 Oct;92(10):2152-2158. doi.org/10.1097/MD.0000000000027538.
- 8. Jeon SY, Ryu S, Oh SK, Park JS, You YH, Jeong WJ, et all. Lactate dehydrogenase to albumin ratio as a prognostic factor for patients with severe infection requiring intensive care. Medicine (Baltimore). 2021 Oct 15;100(41):e27538. doi.org/10.1002/jpen.1451.
- 9. Henry BM, Aggarwal G, Wong J, Benoit S, Vikse J, Plebani M, et al. Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis. Am J Emerg Med. 2020;38(9):1722-1726. doi.org/10.1016/j.ajem.2020.05.073.
- 10. Wu MY, Yao L, Wang Y, Zhu XY, Wang XF, Tang PJ, et all. Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia. Respir Res. 2020 Jul 6;21(1):171. doi.org/10.1186/s12931-020-01427-8.
- 11. Aday U, Boyuk A, AkkoC H. The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer. Ann Surg Treat Res. 2020 Sep;99(3):161-170. doi.org/10.4174/astr.2020.99.3.161.
- 12. Wu MA, Fossali T, Pandolfi L, Carsana L, Ottolina D, Frangipane V, et all. Hypoalbuminemia in COVID-19: assessing the hypothesis for underlying pulmonary capillary leakage. J Intern Med. 2021 Jun;289(6):861-872. doi.org/10.1111/joim.13208.
- 13. Paliogiannis P, Mangoni AA, Cangemi M, Fois AG, Carru C, Zinellu A. Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis. Clin Exp Med. 2021 Aug;21(3):343-354. doi.org/10.1007/s10238-021-00686-z.
- 14. Yan D, Huang Q, Dai C, Ren W, Chen S. Lactic Dehydrogenase to Albumin Ratio Is Associated With the Risk of Stroke-Associated Pneumonia in Patients With Acute Ischemic Stroke. Front Nutr. 2021 Sep 16;8:743216. doi: 10.3389/fnut.2021.743216.
- 15. Lee BK, Ryu S, Oh SK, Ahn HJ, Jeon SY, Jeong WJ, et all. Lactate dehydrogenase to albumin ratio as a prognostic factor in lower respiratory tract infection patients. Am J Emerg Med. 2022 Feb;52:54-58. doi: 10.1016/j.ajem.2021.11.028.
- 16. Tan C, Huang Y, Shi F, Tan K, Ma Q, Chen Y, et all. C-reactive protein correlates with computed tomographic findings and predicts severe COVID-19 early. J Med Virol. 2020 Jul;92(7):856-862. doi.org/10.1002/jmv.25871.
Öz
Objective: An acute respiratory disease caused by a novel coronavirus emerged in December 2019. This disease associated with the novel coronavirus quickly spread across the world, leading to significant fatalities. Reliable predictors of disease mortality and severity are therefore needed in order to decide on clinical follow-up or earlier clinical intervention. This study was performed around the hypothesis that the LDH/ALB ratio would yield more sensitive results in predicting the potential relationship between disease severity and mortality in patients with COVID-19 aged over 65.
Methods: COVID-19 patients aged over 65 presenting to a tertiary emergency department between August and October 2021, were investigated in this single-center, retrospective study. All patients over 65 presenting to the emergency department and diagnosed with COVID-19 were included. The study population was constituted following the application of the inclusion and exclusion criteria. Pulmonary involvement percentages and laboratory parameters were compared against patient mortality and thoracic tomography.
Results: The relationship between patients’ lactate dehydrogenase/albumin ratios and mortality status was evaluated. The optimal cut-off value for the lactate dehydrogenase/albumin ratio in predicting mortality was 9.6 (AUC:0.815, sensitivity 75.9%, specificity 76.3%, p=0.001). The relationship between patients’ lactate dehydrogenase/albumin ratios and severity of pulmonary involvement was also examined. The cut-off value for severe pulmonary involvement was 11.2 (AUC:0.946, sensitivity 93.6%, specificity 87.4%, p=0.001).
Conclusion: In conclusion, LDH/ALB ratio could be used to predict mortality and severity of pulmonary involvement in elderly COVID-19 patients.
Anahtar Kelimeler
Emergency medicine COVID-19 Elderly patient Albumin Lactate Dehydrogenase
Kaynakça
- 1. World Health Organization (WHO). COVID-19 pandemic data in the world. https://covid19.who.int (accessed on 23/January/2022).
- 2. Korkusuz R, Karandere F, Senoglu S, Kocoglu H, Yasar KK. The prognostic role of D-dimer in hospitalized COVID-19 patients. Bratisl Lek Listy. 2021;122(11):811-815. doi.org /10.4149/BLL_2021_129.
- 3. Centers for Disease Control and Prevention. People WhoAre at Higher Risk for Severe Illness. 2020; https://www.cdc.gov/coronavirus/2019-ncov/need- extra-precautions/people-at-higher-risk.html. Accessed April 8, 2020.
- 4. Serin I, Sari ND, Dogu MH, Acikel SD, Babur G, Ulusoy A, et all. A newparameter in COVID-19 pandemic: initial lactate dehydrogenase (LDH)/Lymphocyte ratio for diagnosis and mortality. J Infect Public Health. 2020 Nov;13(11):1664-1670. doi.org/10.1016/j.jiph.2020.09.009.
- 5. Wang B, Chen G, Cao Y, Xue J, Li J, Wu Y. Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock. J Crit Care. 2015 Apr;30(2):271-5. doi.org/10.1016/j.jcrc.2014.10.030.
- 6. Soeters PB, Wolfe RR, Shenkin A. Hypoalbuminemia: Pathogenesis and Clinical Significance. JPEN J Parenter Enteral Nutr. 2019; 43(2): 181- 193. doi.org/10.1002/jmv.26003.
- 7. Huang J, Cheng A, Kumar R, Fang Y, Chen G, Zhu Y, et all. Hypoalbuminemia predicts the outcome of COVID-19 independent of ageandco-morbidity. J MedVirol. 2020 Oct;92(10):2152-2158. doi.org/10.1097/MD.0000000000027538.
- 8. Jeon SY, Ryu S, Oh SK, Park JS, You YH, Jeong WJ, et all. Lactate dehydrogenase to albumin ratio as a prognostic factor for patients with severe infection requiring intensive care. Medicine (Baltimore). 2021 Oct 15;100(41):e27538. doi.org/10.1002/jpen.1451.
- 9. Henry BM, Aggarwal G, Wong J, Benoit S, Vikse J, Plebani M, et al. Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis. Am J Emerg Med. 2020;38(9):1722-1726. doi.org/10.1016/j.ajem.2020.05.073.
- 10. Wu MY, Yao L, Wang Y, Zhu XY, Wang XF, Tang PJ, et all. Clinical evaluation of potential usefulness of serum lactate dehydrogenase (LDH) in 2019 novel coronavirus (COVID-19) pneumonia. Respir Res. 2020 Jul 6;21(1):171. doi.org/10.1186/s12931-020-01427-8.
- 11. Aday U, Boyuk A, AkkoC H. The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer. Ann Surg Treat Res. 2020 Sep;99(3):161-170. doi.org/10.4174/astr.2020.99.3.161.
- 12. Wu MA, Fossali T, Pandolfi L, Carsana L, Ottolina D, Frangipane V, et all. Hypoalbuminemia in COVID-19: assessing the hypothesis for underlying pulmonary capillary leakage. J Intern Med. 2021 Jun;289(6):861-872. doi.org/10.1111/joim.13208.
- 13. Paliogiannis P, Mangoni AA, Cangemi M, Fois AG, Carru C, Zinellu A. Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis. Clin Exp Med. 2021 Aug;21(3):343-354. doi.org/10.1007/s10238-021-00686-z.
- 14. Yan D, Huang Q, Dai C, Ren W, Chen S. Lactic Dehydrogenase to Albumin Ratio Is Associated With the Risk of Stroke-Associated Pneumonia in Patients With Acute Ischemic Stroke. Front Nutr. 2021 Sep 16;8:743216. doi: 10.3389/fnut.2021.743216.
- 15. Lee BK, Ryu S, Oh SK, Ahn HJ, Jeon SY, Jeong WJ, et all. Lactate dehydrogenase to albumin ratio as a prognostic factor in lower respiratory tract infection patients. Am J Emerg Med. 2022 Feb;52:54-58. doi: 10.1016/j.ajem.2021.11.028.
- 16. Tan C, Huang Y, Shi F, Tan K, Ma Q, Chen Y, et all. C-reactive protein correlates with computed tomographic findings and predicts severe COVID-19 early. J Med Virol. 2020 Jul;92(7):856-862. doi.org/10.1002/jmv.25871.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Ağustos 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 8 Sayı: 3 |
