Öz
Objective: Famotidine is an H2 receptor antagonist (H2RA) and has been shown to have antiviral properties in in-vitro studies. Pantoprazole is one of the proton pump inhibitors (PPI). In this study, it was aimed to compare the efficacy of Famotidine with Pantoprazole in the treatment of COVID-19.
Material-method: Patients who were hospitalized and given famotidine and pantoprazole treatment for at least 48 hours were included in the study. Demographic, clinical and laboratory findings of the patients were analyzed retroprospectively from the patient files. While the primary endpoints were the need for an intensive care unit (ICU) and death, the secondary endpoints were the absence of the need for oxygen support, fever to normal levels, and length of hospital stay.
Results: A total of 179 Covid-19 patients (85 (47.5%) famotidine, 94 (52.5%) pantoprazole) were included in the study. Demographic findings and other symptoms except dyspnea were similar in both groups (p> 0.05). Dyspnea, chronic diseases, and the number of patients given steroids were higher in those who were given pantoprazole (p <0.05). Mortality and ICU need was similar in both groups (p> 0.05). The number of days with fever, duration of hospitalization, and the number of days requiring oxygen support was less in those given famotidine (p <0.05).
Conclusion: Famotidine did not reduce the need for intensive care and mortality in COVID-19 patients treated in the hospital. New antivirals are needed to reduce disease severity and mortality.
Anahtar Kelimeler
COVID-19 Famotidin pantoprazole mortality Intensive care unit
Kaynakça
- 1. García LF. Immune response, inflammation, and the clinical spectrum of COVID-19. Frontiers in immunology. 2020;11:1441.
- 2. World Health Organization (WHO). WHO Coronavirus Disease (COVID-19) Dashboard. Available from: https://covid19.who.int/
- 3. WHO. Coronavirus disease (COVID-19). Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/coronavirus-disease-covid-19
- 4. Fajgenbaum DC, June CH. Cytokine Storm. N Engl J Med. 2020 Dec 3;383(23):2255-2273. doi: 10.1056/NEJMra2026131.Trivedi N, Verma A, Kumar D. Possible treatment and strategies for COVID-19: review and assessment. Eur Rev Med Pharmacol Sci 2020; 24: 12593-12608.
- 5. Bourinbair AS, Fruhstorfer EC. The effect of histamine type 2 receptor antagonists on human immunudeficiency virüs(HIV) replication: Identification of a new class of antiviral agents. Life Sciances.1996;59(23):365-370.
- 6. Kalpaklıoglu F, Koca Kalkan İ, Baccıoglu Kavut A. Histamin ve antihistaminler. Türkiye Klinikleri İmmünoloji Allerji- Özel Konular. 2012;5(1):12-24
- 7. Branco ACCC, Yoshikawa FSY, Pietrobon AJ, Sato MN. Role of Histamine in Modulating the Immune Response and Inflammation. Mediators Inflamm. 2018;2018:9524075.
- 8. Ennis M, Tiligada K. Histamine receptors and COVID‑19. Inflammation Research. 2021;70:67–75.
- 9. Loffredo M, Lucero H, Chen DY, O’Connell A, Bergqvist S, Munawar A, et al. The effect of famotidine on SARS-Cov-2 proteases and virus replication. https://www.biorxiv.org/content/10.1101/2020.07.15.203059v1.full.pdf
- 10. Freedberg DE, Conigliaro J, Wang TC, et al. Famotidine Use Is Associated with Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study. Gastroenterology. 2020;159(3):1129-1131.e3.
- 11. Li, Xiaochen et al. “Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan.” The Journal of allergy and clinical immunology vol. 146,1 (2020): 110-118.
- 12. Güçlü E, Kocayiğit H, Okan HD, Erkorkmaz U, Yürümez Y, Yaylacı S, Koroglu M, Uzun C, Karabay O. Effect of COVID-19 on platelet count and its indices. Rev Assoc Med Bras. 2020;66(8):1122-1127.
Öz
Amaç: Famotidin, bir H2 reseptör antagonistidir ve in vitro çalışmalarda antiviral özelliklere sahip olduğu gösterilmiştir. Pantoprazol, proton pompası inhibitörlerinden biridir. Bu çalışmada, COVID-19 tedavisinde Famotidinin ile Pantaprazolun etkinliğinin karşılaştırılması amaçlanmıştır.
Gereç ve Yöntem: Çalışmaya en az 48 saat famotidin ve pantaprazol tedavisi verilen ve hastanede yatan hastalar dâhil edildi. Hastaların demografik, klinik ve laboratuvar bulguları hasta dosyalarından geriye dönük olarak incelendi. Hastalar famotidin grubu ve pantoprazol grubu olarak iki gruba ayrıldı. Gruplar yoğun bakım ihtiyacı ve ölüm oranları açısından karşılaştırıldı. Ayrıca gruplar arasında taburculukta oksijen saturasyonu normal olan hasta sayısı, oksijen desteğine ihtiyaç duyulan gün sayısı, ateşli gün sayısı ve hastanede kalış süresi değerlendirildi.
Bulgular: Çalışmaya toplam 179 Covid-19 hastası (85 famotidin grubu, 94 pantoprazol grubu) dâhil edildi. Demografik bulgular ve dispne dışındaki diğer semptomlar her iki grupta benzerdi. Pantoprazol verilenlerde dispne, kronik hastalıklar ve steroid verilen hasta sayısı daha yüksekti. Mortalite ve YBÜ ihtiyacı her iki grupta benzerdi (sırasıyla; p=0.25, p=0.26). Famotidin verilenlerde ateşli gün sayısı, hastanede kalış süresi ve oksijen desteği gerektiren gün sayısı daha azdı (sırasıyla; p=0.04, p=0.003, p=0.014).
Sonuç: Famotidin, hastanede tedavi gören COVID-19 hastalarında yoğun bakım ihtiyacını ve mortaliteyi azaltmadı. Hastalık şiddetini ve ölüm oranını azaltmak için yeni tedavilere ihtiyaç vardır.
Anahtar Kelimeler
Kaynakça
- 1. García LF. Immune response, inflammation, and the clinical spectrum of COVID-19. Frontiers in immunology. 2020;11:1441.
- 2. World Health Organization (WHO). WHO Coronavirus Disease (COVID-19) Dashboard. Available from: https://covid19.who.int/
- 3. WHO. Coronavirus disease (COVID-19). Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/coronavirus-disease-covid-19
- 4. Fajgenbaum DC, June CH. Cytokine Storm. N Engl J Med. 2020 Dec 3;383(23):2255-2273. doi: 10.1056/NEJMra2026131.Trivedi N, Verma A, Kumar D. Possible treatment and strategies for COVID-19: review and assessment. Eur Rev Med Pharmacol Sci 2020; 24: 12593-12608.
- 5. Bourinbair AS, Fruhstorfer EC. The effect of histamine type 2 receptor antagonists on human immunudeficiency virüs(HIV) replication: Identification of a new class of antiviral agents. Life Sciances.1996;59(23):365-370.
- 6. Kalpaklıoglu F, Koca Kalkan İ, Baccıoglu Kavut A. Histamin ve antihistaminler. Türkiye Klinikleri İmmünoloji Allerji- Özel Konular. 2012;5(1):12-24
- 7. Branco ACCC, Yoshikawa FSY, Pietrobon AJ, Sato MN. Role of Histamine in Modulating the Immune Response and Inflammation. Mediators Inflamm. 2018;2018:9524075.
- 8. Ennis M, Tiligada K. Histamine receptors and COVID‑19. Inflammation Research. 2021;70:67–75.
- 9. Loffredo M, Lucero H, Chen DY, O’Connell A, Bergqvist S, Munawar A, et al. The effect of famotidine on SARS-Cov-2 proteases and virus replication. https://www.biorxiv.org/content/10.1101/2020.07.15.203059v1.full.pdf
- 10. Freedberg DE, Conigliaro J, Wang TC, et al. Famotidine Use Is Associated with Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study. Gastroenterology. 2020;159(3):1129-1131.e3.
- 11. Li, Xiaochen et al. “Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan.” The Journal of allergy and clinical immunology vol. 146,1 (2020): 110-118.
- 12. Güçlü E, Kocayiğit H, Okan HD, Erkorkmaz U, Yürümez Y, Yaylacı S, Koroglu M, Uzun C, Karabay O. Effect of COVID-19 on platelet count and its indices. Rev Assoc Med Bras. 2020;66(8):1122-1127.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Ağustos 2021 |
| Kabul Tarihi | 12 Temmuz 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 13 Sayı: S1 |
