Öz
Kaynakça
- Ngugi AK, Bottomley C, Kleinschmidt I, Sander JW, Newton CR. Estimation of the burden of active and lifetime epilepsy: a meta-analytic approach. Epilepsia 2010; 51: 883-90.
- Shen C, Chen F, Zhang Y, Guo Y, Ding M. Association between use of antiepileptic drugs and fracture risk: a systematic review and meta-analysis. Bone 2014; 64: 246–53.
- Eddy CM, Rickards HE, Cavanna AE. Behavioral adverse effects of antiepileptic drugs in epilepsy. J Clin Psychopharmacol 2012; 32: 362-75.
- Mintzer S. Metabolic consequences of antiepileptic drugs. Curr Opin Neurol 2010; 23: 164-69.
- Perucca P, Gilliam FG. Adverse effects of antiepileptic drugs. Lancet Neurol 2012; 11: 792-02
- Chang CS, Liao CH, Lin CC, Lane HY, Sung FC, Kao CH. Patients with epilepsy are at an increased risk of subsequent stroke: a population-based cohort study. Seizure 2014; 23: 377-81.
- Hsieh CY, Lai EC, Yang YH, Lin SJ. Comparative stroke risk of antiepileptic drugs in patients with epilepsy. Epilepsia 2013; 54: 172-80.
- Mahmoudian T, Iranpour R, Messri N. Serum lipid levels during carbamazepine therapy in epileptic children. Epilepsy Behav 2005; 6: 257-9.
- Karabiber H, Sonmezgoz E, Ozerol E, Yakinci C, Otlu B, Yologlu S. Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid. Brain Dev 2003; 25: 113-5.
- Talaat FM, Kamel T, Rabah AM, Ahmed SM, El-Jaafary SI, Abdelaziz GH. Epilepsy and antiepileptic drugs: risk factors for atherosclerosis. Int J Neurosci 2015; 125: 507-11.
- Hamed SA. Atherosclerosis in epilepsy: its causes and implications. Epilepsy Behav 2014; 41: 290-96.
- Polak JF, Pencina MJ, Pencina KM, O'Donnell CJ, Wolf PA, D'Agostino RB Sr. Carotid-wall intima-media thickness and cardiovascular events. New Engl J Med 2011; 21; 365: 213-21.
- Hermann DM, Gronewold J, Lehmann N, et al. Intima-media thickness predicts stroke risk in the Heinz Nixdorf Recall study in association with vascular risk factors, age and gender. Atherosclerosis 2012; 224: 84-9.
- Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for classification and terminology. Epilepsia 2017; 58: 512-21.
- Lai Q, Shen C, Zheng Y, Zhang Y, Guo Y, Ding M. Effects of antiepileptic drugs on the carotid artery ıntima-media thickness in epileptic patients. J Clin Neurol 2017; 13: 371-9.
- Mehrpour M, Shojaie M, Zamani B, Gharibzadeh S, Abbasi M. Atherogenic consequence of antiepileptic drugs: a study of intima-media thickness. Neurol Sci 2014; 35: 253-7.
- Karatoprak E, Tosun O. Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy. Brain Dev 2020; 42: 165-70.
- Calik M, Ozkan HY, Ethemoglu O, et al. The measurement of both carotid intima-media thickness and epicardial adipose tissue thickness in children with epilepsy receiving antiepileptic drug therapy. Epilepsy Behav 2018; 85: 110-4.
- Tan TY, Lu CH, Chuang HY, et al. Long-term antiepileptic drug therapy contributes to the acceleration of atherosclerosis. Epilepsia 2009; 50: 1579-86.
- Erdemir A, Cullu N, Yiş U, et al. Evaluation of serum lipids and carotid artery intima-media thickness in epileptic children treated with valproic acid. Brain Dev 2009; 31: 713-6.
Assessment of carotid-intima media thickness in patients with epilepsy receiving antiepileptic drugs
Öz
Aim: This study aims to investigate whether there is an increase in carotid-intima media thickness (C-IMT) in epilepsy patients using antiepileptic drugs when compared to the normal control group and whether there is a difference when we group them as monotherapy and polytherapy.
Material and Method: 68 people were included in the prospective cross-sectional study. 38 epilepsy and 30 healthy control groups that were matched in terms of demographic characteristics
Results: C-IMT was statistically higher in the epilepsy group (p<0.001). When carotid USG results are analyzed as control, monotherapy, and polytherapy, there was no difference between control and monotherapy, there was statistical significance between the control group and polytherapy (p<0.001), and between monotherapy and polytherapy (p:0.010)
Conclusions: According to our study result, polytherapy should be avoided as much as possible, especially in patients with vascular risk factors.
Anahtar Kelimeler
Carotid-Intima media thickness Epilepsy Monotherapy-Polytherapy
Kaynakça
- Ngugi AK, Bottomley C, Kleinschmidt I, Sander JW, Newton CR. Estimation of the burden of active and lifetime epilepsy: a meta-analytic approach. Epilepsia 2010; 51: 883-90.
- Shen C, Chen F, Zhang Y, Guo Y, Ding M. Association between use of antiepileptic drugs and fracture risk: a systematic review and meta-analysis. Bone 2014; 64: 246–53.
- Eddy CM, Rickards HE, Cavanna AE. Behavioral adverse effects of antiepileptic drugs in epilepsy. J Clin Psychopharmacol 2012; 32: 362-75.
- Mintzer S. Metabolic consequences of antiepileptic drugs. Curr Opin Neurol 2010; 23: 164-69.
- Perucca P, Gilliam FG. Adverse effects of antiepileptic drugs. Lancet Neurol 2012; 11: 792-02
- Chang CS, Liao CH, Lin CC, Lane HY, Sung FC, Kao CH. Patients with epilepsy are at an increased risk of subsequent stroke: a population-based cohort study. Seizure 2014; 23: 377-81.
- Hsieh CY, Lai EC, Yang YH, Lin SJ. Comparative stroke risk of antiepileptic drugs in patients with epilepsy. Epilepsia 2013; 54: 172-80.
- Mahmoudian T, Iranpour R, Messri N. Serum lipid levels during carbamazepine therapy in epileptic children. Epilepsy Behav 2005; 6: 257-9.
- Karabiber H, Sonmezgoz E, Ozerol E, Yakinci C, Otlu B, Yologlu S. Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid. Brain Dev 2003; 25: 113-5.
- Talaat FM, Kamel T, Rabah AM, Ahmed SM, El-Jaafary SI, Abdelaziz GH. Epilepsy and antiepileptic drugs: risk factors for atherosclerosis. Int J Neurosci 2015; 125: 507-11.
- Hamed SA. Atherosclerosis in epilepsy: its causes and implications. Epilepsy Behav 2014; 41: 290-96.
- Polak JF, Pencina MJ, Pencina KM, O'Donnell CJ, Wolf PA, D'Agostino RB Sr. Carotid-wall intima-media thickness and cardiovascular events. New Engl J Med 2011; 21; 365: 213-21.
- Hermann DM, Gronewold J, Lehmann N, et al. Intima-media thickness predicts stroke risk in the Heinz Nixdorf Recall study in association with vascular risk factors, age and gender. Atherosclerosis 2012; 224: 84-9.
- Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for classification and terminology. Epilepsia 2017; 58: 512-21.
- Lai Q, Shen C, Zheng Y, Zhang Y, Guo Y, Ding M. Effects of antiepileptic drugs on the carotid artery ıntima-media thickness in epileptic patients. J Clin Neurol 2017; 13: 371-9.
- Mehrpour M, Shojaie M, Zamani B, Gharibzadeh S, Abbasi M. Atherogenic consequence of antiepileptic drugs: a study of intima-media thickness. Neurol Sci 2014; 35: 253-7.
- Karatoprak E, Tosun O. Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy. Brain Dev 2020; 42: 165-70.
- Calik M, Ozkan HY, Ethemoglu O, et al. The measurement of both carotid intima-media thickness and epicardial adipose tissue thickness in children with epilepsy receiving antiepileptic drug therapy. Epilepsy Behav 2018; 85: 110-4.
- Tan TY, Lu CH, Chuang HY, et al. Long-term antiepileptic drug therapy contributes to the acceleration of atherosclerosis. Epilepsia 2009; 50: 1579-86.
- Erdemir A, Cullu N, Yiş U, et al. Evaluation of serum lipids and carotid artery intima-media thickness in epileptic children treated with valproic acid. Brain Dev 2009; 31: 713-6.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Orijinal Makale |
| Yazarlar | |
| Yayımlanma Tarihi | 17 Ocak 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 5 Sayı: 1 |
Üniversitelerarası Kurul (ÜAK) Eşdeğerliği: Ulakbim TR Dizin'de olan dergilerde yayımlanan makale [10 PUAN] ve 1a, b, c hariç uluslararası indekslerde (1d) olan dergilerde yayımlanan makale [5 PUAN]
Dahil olduğumuz İndeksler (Dizinler) ve Platformlar sayfanın en altındadır.
Not: Dergimiz WOS indeksli değildir ve bu nedenle Q olarak sınıflandırılmamıştır.
Yüksek Öğretim Kurumu (YÖK) kriterlerine göre yağmacı/şüpheli dergiler hakkındaki kararları ile yazar aydınlatma metni ve dergi ücretlendirme politikasını tarayıcınızdan indirebilirsiniz. https://dergipark.org.tr/tr/journal/2316/file/4905/show
Dergi Dizin ve Platformları
Dizinler; ULAKBİM TR Dizin, Index Copernicus, ICI World of Journals, DOAJ, Directory of Research Journals Indexing (DRJI), General Impact Factor, ASOS Index, WorldCat (OCLC), MIAR, EuroPub, OpenAIRE, Türkiye Citation Index, Türk Medline Index, InfoBase Index, Scilit, vs.
Platformlar; Google Scholar, CrossRef (DOI), ResearchBib, Open Access, COPE, ICMJE, NCBI, ORCID, Creative Commons vs.